Bosch, US
Autumn Bosch, Manitowoc, WI US
Patent application number | Description | Published |
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20080315733 | Modular Monitor Support Apparatus - A modular apparatus for supporting a monitor is provided. First and second pairs of substantially vertically oriented and opposed columns are spaced a lateral distance apart. A support member is arranged between and coupled to the first and second pairs of columns. The support member is adapted to support a monitor at a viewing angle. The height and angle of the support member, and thus the monitor, can be easily adjusted via slot and tab connections between the support member and columns and/or by adjusting the lateral distance between the respective pairs of columns. | 12-25-2008 |
Bruce Bosch, Vancouver, WA US
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20130193150 | MOLDED FUEL TANK AND METHOD OF MANUFACTURING THE SAME - One embodiment of a molded fuel tank includes a fuel tank molded from a synthetic material, such as a composite polymer. One embodiment may include molding a fuel tank with metal component fastening structures positioned within the fuel tank as it is molded. One embodiment may include molding a fuel tank and integral component fastening structures simultaneously from synthetic materials. One embodiment of a molded fuel tank may include a fuel tank formed by a rotational molding process. | 08-01-2013 |
Christopher Yannis Bosch, Lafayette, CO US
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20140069969 | Delivery System - A delivery system for delivering a powder, such as chalk. The chalk is retained within a permeable, porous container. The powder is dispersed to an object outside the container upon application of a force. The container includes a plurality of sidewalls. The powder is deliverable when an object applies the force to an outside surface of the sidewalls. The force comprises engaging an outer surface of the sidewalls with an impact, such as a slap. The force generates sufficient kinetic energy to at least partially enable the powder to pass from an inner surface to the outer surface through a permeable portion. The system is useful for quick access to the chalk with one hand. The system can also form a pocket on a garment, whereby applying the force is applied on the pocket for dispersal. | 03-13-2014 |
David Bosch, Phoenix, AZ US
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20090121499 | RELEASABLE TRAILER DOOR - A system of locking a door is disclosed. The system according to the present invention comprises a releasable keeper that secures a door locking mechanism to keep a door secured to an enclosure in a locked position. A release mechanism that is operated from the interior of the enclosure releases the releasable keeper from the enclosure and enable the door to be opened and prevents people from becoming trapped within the enclosure by a locked door. In an exemplary embodiment, the release mechanism is operated by a lever that operates a pulley system to disengage the release mechanism from the releasable keeper. | 05-14-2009 |
Gregory Bosch, Malvern, PA US
Patent application number | Description | Published |
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20090169646 | METHODS OF TREATING CYSTIC FIBROSIS - A method of treating and/or managing cystic fibrosis in a patient by administering an electrolyzed saline solution containing hypohalous acid. Preferably, the hypohalous acid is hypochlorous acid. Also provided is a method of treating and/or managing cystic fibrosis by administering an electrolyzed saline solution at specific pHs such as between 5.0 and 6.2. The present invention also provides a method of administering an electrolyzed saline solution for treating and/or managing cystic fibrosis using a combined electrochemical generator and a vaporizer, humidifier or fogger. Combination therapies are also provided. | 07-02-2009 |
Gregory Kent Bosch, Goshen, OH US
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20090069342 | KV1.5 POTASSIUM CHANNEL INHIBITORS - The present invention relates to 1-N-amino-2-imidazolidinones and derivatives thereof which are effective as Kv1.5 potassium channel inhibitors providing atrial-selective antiarrhythmic agents. The present invention further relates to compositions comprising said Kv1.5 potassium channel inhibitors, and to methods for treating cardiac arrhythmia. | 03-12-2009 |
Hugo Bosch, Miami, FL US
Patent application number | Description | Published |
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20130120148 | Fish ID - A device for identifying marine species. The device allows the fisherman to quickly identify what specie has been caught, its legal size and the amount of that specific specie that can be collected for recreational or commercial purposes, all this while the specie is still alive, allowing enough time to the fisherman to keep or return to the water the specie that has just been caught. | 05-16-2013 |
20130145678 | Fisherman's flute - An apparatus for carrying or transport fishing leaders, with the idea of protecting fishermen from injuries while handling or transporting fishing leaders and also avoid the hassle of tangled fishing leaders. The apparatus will enable the fisherman to have handy and readily available fishing leaders, saving precious time while fishing. The apparatus has several sections in its body so as to house leaders of different sizes. The apparatus is basically two PVC pipes partially sliding one within the other, with a spring in its interior so as to keep the leaders always stretched. | 06-13-2013 |
H. William Bosch, Philadelphia, PA US
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20150246060 | Abiraterone Acetate Formulation and Methods of Use - Pharmaceutical compositions, including unit dosage forms, comprising abiraterone acetate and methods for producing and using such compositions are described. | 09-03-2015 |
Irene Bosch, Brookline, MA US
Patent application number | Description | Published |
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20110045501 | ST2-BASED DENGUE FEVER DIAGNOSTIC - A cytokine receptor family member (ST2), which has membrane bound as well as soluble bound forms, is elevated in patients during acute phase of dengue fever. Moreover, secondary cases of dengue fever had even more pronounced elevation of ST2 in serum in comparison to primary cases. One possible role of soluble ST2 might be to act as decoy for membrane bound ST2 signaling, therefore, promoting a proinflammatory response in secondary dengue infections. Alternatively, ST2 may act as a biomarker for endothelial damage such that ST2 may be useful in identifying severe dengue infections, specifically in dengue hemorrhagic fever. | 02-24-2011 |
20140246334 | SYSTEMS, DEVICES AND METHODS FOR MULTIPLEXED DIAGNOSTICS - Exemplary embodiments provide diagnostic devices, systems and methods for determining the presence or absence of one or more markers or characteristics in one or more samples. An exemplary diagnostic device may display a first two-dimensional machine-readable output to indicate the presence or absence of a first characteristic in a sample. Similarly, the exemplary diagnostic device may display a second two-dimensional machine-readable output to indicate the presence or absence of a second characteristic in a sample. An image capture device may be used to automatically detect the two-dimensional machine-readable output appearing in the diagnostic device. A computational device may be used to automatically determine whether the presence or absence of the first characteristic and/or the second characteristic based on the two-dimensional machine-readable output displayed in the diagnostic device. | 09-04-2014 |
Jacobus J. Bosch, Baltimore, MD US
Patent application number | Description | Published |
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20080206288 | TUMOR CELLS FROM IMMUNE PRIVILEGED SITES AS BASE CELLS FOR CELL-BASED CANCER VACCINES - The present invention relates to tumor cell-based vaccines and methods of using same, wherein the vaccines are based on naturally immune privileged tumor cells that have been genetically modified to express MHC-II restricted peptides derived from endogenously encoded tumor antigens, activate CD | 08-28-2008 |
20110165187 | TUMOR CELLS FROM IMMUNE PRIVILEGED SITES AS BASE CELLS FOR CELL-BASED CANCER VACCINES - The present invention relates to tumor cell-based vaccines and methods of using same, wherein the vaccines are based on naturally immune privileged tumor cells that have been genetically modified to express MHC-II restricted peptides derived from endogenously encoded tumor antigens, activate CD4+ T-lymphocytes, provide an array of antigens to which the host is not tolerized and/or induce immunity against the originating tumor cells as well as against metastatic tumor cells. | 07-07-2011 |
Jerome Bosch, Romeo, MI US
Patent application number | Description | Published |
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20090051146 | Snap-in attachment of inflator for airbag - An airbag module for a vehicle comprises a housing for an airbag and an inflator configured to be mounted on the housing. The housing includes at least one integral locking component to lock the inflator into a mounted, in-use position on the housing. The component comprises an undercut section formed in a back surface of the housing and/or a bendable tab formed in a back surface of the housing. The inflator can be rotated from a first position to a second, mounted position. In the first position, the inflator is located against the back surface but can be freely removed from the housing. In the second position, the inflator flange is held in place in a direction perpendicular to the back surface of the housing by the at least one undercut section. | 02-26-2009 |
20110079988 | PASSIVE AIRBAG VENTING - An occupant protection apparatus comprises an inflatable airbag with a panel, the panel including a first vent opening that permits inflation fluid to escape out of the airbag; and a valve sheet including a second vent opening movable relative to the first vent opening, the valve sheet having opposite ends that are each fixed to a surface of the airbag. One end of the valve sheet moves with the panel during inflation of the airbag to move the second vent opening relative to the first vent opening. The apparatus also includes a valve guide or envelope to guide movement of the valve sheet relative to the panel, the valve sheet is capable of sliding between the valve guide and the panel. Both ends of the valve sheet remain fixed to the panel during and after inflation of the airbag. The valve sheet includes a tear tab to temporarily retain the valve sheet to the panel. | 04-07-2011 |
20110169253 | AIRBAG MODULE - An airbag module for use in a vehicle to provide restraint to an occupant of the vehicle. The module includes a cushion pack having an inflatable airbag cushion configured to inflate to restrain the occupant of the vehicle. An inflator is provided to supply inflation gas for inflating the airbag cushion. The module also includes an annular retaining member engaged with the cushion pack to thereby retain a portion of the cushion pack in the airbag module during deployment of the airbag cushion. An annular locking member is connected to the retaining member and to the inflator and is configured to prohibit substantial displacement of the inflator relative to the locking member during deployment of the airbag. | 07-14-2011 |
20110239731 | FORCE MEASUREMENT SYSTEM - A system for measuring forces during a simulated dynamic vehicle event includes a plurality of sensors, a controller, and a plurality of conductors that electrically couple each sensor to the controller. Each sensor includes a layer of pressure sensitive material arranged between an outer sheet of carrier material and an inner sheet of carrier material. The pressure sensitive material changes resistance in response to forces acting upon the outer sheet of carrier material. Each of the plurality of sensors is configured to be coupled to a surface of a crash test dummy or to a surface of a vehicle. The controller is configured to provide an electrical signal to each sensor, to measure the voltage across each sensor, and to determine the force acting upon each sensor based on the measured voltage. | 10-06-2011 |
20110241850 | STEERING WHEEL SENSORS - A sensor for installation on a steering wheel includes a pressure sensitive material mounted on a base material of the steering wheel. The pressure sensitive material is configured to provide an electrical signal to a controller when pressure is applied. The controller provides a command to a vehicle system based on the electrical signal. The pressure sensitive material has at least one of a variable resistance and a variable capacitance based on the amount or type of pressure that is applied to the material. The electrical signal is based on the at least one of a variable resistance and a variable capacitance. | 10-06-2011 |
20110241860 | OCCUPANT SENSING SYSTEM - An occupant sensing system for a vehicle includes a pressure sensitive material installed in one or more pressure sensing zones in or around at least one vehicle seat. The pressure sensitive material of each zone is configured to provide an electrical signal to a controller when pressure is applied. The controller determines at least one of occupant presence, position, and classification based on the electrical signal. The pressure sensitive material has at least one of a variable resistance and a variable capacitance based on the amount or type of pressure that is applied to the material. The at least one of a variable resistance and a variable capacitance changes characteristics of the electrical signal. | 10-06-2011 |
20110246028 | STEERING WHEEL WITH HAND PRESSURE SENSING - The invention relates to a vehicle safety system includes a steering wheel, a plurality of pressure sensitive sensors located in the steering wheel, and a control unit. The pressure sensitive sensors can be located in different regions of the steering wheel. The pressure sensitive sensors can determine if a driver's hand is pressing upon a respective region of the steering wheel associated with one or more of the plurality of pressure sensitive sensors. The control unit can be configured or programmed to determine if at least one of the driver's hands is pressing upon a region of the steering wheel for a predetermined amount of time. | 10-06-2011 |
20110272930 | STEERING SYSTEM - A steering system for allowing an operator to control the direction of travel of a vehicle propelled on wheels. The steering system comprises a steering input device configured to include a handle pivotally coupled to a linkage assembly configured to swivel, wherein the handle is configured to move in the fore and aft direction, wherein the steering input device generates input data based on the position of the linkage assembly and/or the handle. The steering system further comprises a communication device to communicate the input data received by the steering input device to a lower steering system, wherein the lower steering system is configured to receive the input data from the steering input device and control the direction of the wheels based on the input data received. | 11-10-2011 |
20140210190 | ILLUMINATED EMBLEM ASSEMBLY FOR CONNECTION TO AN AIRBAG COVER - Multi-piece constructions for an illuminated emblem assembly for connection to an airbag cover are provided herein. An airbag assembly can include an airbag cover having front and rear surfaces, an emblem portion having one or more translucent areas and an illumination source. The airbag cover can include attachment elements protruding from the rear surface. The emblem portion and the illumination source can include openings for accommodating attachment elements. The illumination source can include a light guide and light emitting diodes (LEDs), where the LEDs are fitted in recesses formed in the light guide. The emblem portion can be arranged between the airbag cover and the illumination source, and the emblem portion and the illumination source can be aligned such that at least one of the one or more translucent areas is illuminated by light passing through the emblem portion from the illumination source. | 07-31-2014 |
20140210191 | ILLUMINATED EMBLEM ASSEMBLY FOR CONNECTION TO AN AIRBAG COVER - Multi-piece constructions for an illuminated emblem assembly for connection to an airbag cover are provided herein. The multi-piece constructions include non-permanent means for connecting the illuminated emblem assembly to the airbag cover. An example emblem assembly can include an illumination source, an emblem portion having one or more translucent areas and a carrier portion. The emblem portion can include a decorative film and a lens, where the decorative film is coupled to the lens. The carrier portion can be configured to attach to the emblem portion. For example, the illumination source can be arranged between the emblem portion and the carrier portion when the emblem portion and the carrier portion are connected. The emblem portion and the illumination source can also be aligned such that at least one of the one or more translucent areas is illuminated by light passing through the emblem portion from the illumination source. | 07-31-2014 |
20150108742 | ILLUMINATED EMBLEM ASSEMBLY FOR CONNECTION TO AN AIRBAG COVER - Multi-piece constructions for an illuminated emblem assembly for connection to an airbag cover are provided herein. An airbag assembly can include an airbag cover, an emblem portion having one or more translucent areas and an illumination source. The illumination source can include a light guide and one or more light emitting diodes (LEDs) for illuminating the light guide. The light guide can include an illuminated portion for transmitting light emitted from the one or more LEDs. The emblem portion can be arranged between the airbag cover and the illumination source, and the emblem portion and the illumination source can be aligned such that at least one of the one or more translucent areas is illuminated by light passing through the emblem portion from the illuminated portion. | 04-23-2015 |
Jerome Bosch, St. Romeo, MI US
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20090121459 | Lighted airbag module - An airbag module includes an airbag cushion, a cover configured to break open to allow the airbag cushion to deploy into a vehicle occupant compartment, an emblem attached to the cover, and a light source connected to the cover and/or the emblem. The light source can provide a safe aesthetic airbag lighting option. | 05-14-2009 |
John P. Bosch, Scottsdale, AZ US
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20080236558 | PAINTBALL LOADER SYSTEMS - A paintball loader system designed to efficiently deliver paintballs to a paintball gun. The drive mechanism is a screw-type design comprising a resilient auger. A microcontroller is programmed to automatically adjust the rotation of the auger based on data from multiple sensor points within the loader. The auger is mounted such that both rotational axial movements are enabled during operation. The axial movement of the auger is used to maintain a constant force on the paintballs awaiting loading within the paintball gun. | 10-02-2008 |
20110220086 | PAINTBALL LOADER SYSTEMS - A paintball loader system designed to efficiently deliver paintballs to a paintball gun. The drive mechanism is a screw-type design comprising a resilient auger. A microcontroller is programmed to automatically adjust the rotation of the auger based on data from multiple sensor points within the loader. The auger is mounted such that both rotational axial movements are enabled during operation. The axial movement of the auger is used to maintain a constant force on the paintballs awaiting loading within the paintball gun. | 09-15-2011 |
Jonathan H. Bosch, Hillsboro, OR US
Patent application number | Description | Published |
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20090287562 | ANONYMOUS MERCHANT-CUSTOMER LOYALTY REWARDS PROGRAM - A system of and method for rewarding an anonymous merchant-customer for performing multiple debit transactions on a defined set of merchant debit-machines comprises receiving data associated with a discrete one of the multiple debit transactions, generating and updating data associated with the anonymous customer without having the anonymous customer provide personally identifiable information, determining whether to reward the anonymous customer for performing one or more debit transactions, and if so, rewarding the anonymous customer. The method may be implemented on or by one or more merchant debit machines (e.g., automated teller machines (ATMs) and point-of-sale (POS) terminals), remote processors, financial institutions, general-purpose computers, or special-purpose computers. | 11-19-2009 |
20100241562 | CURRENCY DISPENSE AND CONTROL SYSTEM WITH ANTI-THEFT FEATURES - A cost-effective, currency dispense and control system (CDCS) securely dispenses paper money in one of the following modes: (1) an ATM system and (2) a currency control system that allows a merchant or merchant-approved employee to withdraw cash from the CDCS independent of a standard ATM electronic fund transfer (EFT) network. The CDCS may also include the following functionalities: a duress dispensation system that allows the CDCS to activate an alarm and/or otherwise communicate with local police or security services during a robbery, a time-release system that effects a time-delayed dispensation functionality, and a user identification and authentication system for authenticating a user identity and determining eligibility of the user to access the currency control system. | 09-23-2010 |
Jonathan H. Bosch, Pitman, NJ US
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20130151407 | REMOTE CURRENCY DISPENSATION SYSTEMS AND METHODS - A currency dispense and control system (CDCS) for securely dispensing paper currency in multiple modes: (1) an ATM system and (2) a currency control system that allows a merchant or merchant-approved employee to withdraw cash from the CDCS independent of a standard ATM electronic fund transfer (EFT) network. The CDCS may be on-site and implemented using standard ATM hardware or may be located remotely. The CDCS may also include one or more of the following functionalities: a duress dispensation system that allows the CDCS to activate an alarm and/or otherwise communicate with local police or security services during a robbery, a time-release system that effects a time-delayed dispensation functionality, and a user identification and authentication system for authenticating a user identity and determining eligibility of the user to access the currency control system. | 06-13-2013 |
Jonathan Vanden Bosch, Santa Monica, CT US
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20140200930 | Methods and Systems for Determining the Importance of Individual Variables in Statistical Models - Methods and systems for determining the importance of each of the variables, or combinations of variables, that contribute to the overall score generated by a predictive statistical model are presented. In a specialized case, for each variable in the model, an importance is calculated based on the calculated slope and deviance of the predictive variable. In a more general case, for each variable in the model, an importance is calculated based on setting that variable to have the average value for the data set, and then calculating the change in score. The totality of variables (or combinations thereof) is then ranked by the Δscore, or a magnitude of it, such as |Δscore|. | 07-17-2014 |
Jose R. Rodriguez Bosch, Gordonsville, VA US
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20160107095 | SUSPENDED PLAY STRUCTURE - A suspended play structure includes a floor, a sidewall, and a roof that defines an inner space. The structure includes top and bottom ring structures that provide additional support to the play structure. The play structure can be suspended from a tree, a stand, a ceiling, or similar structure. The structure is collapsible for easy storage and can also include a removable cushion that can fit within an internal pocket. The structure can also include a removable string of LED lights within the inner space. | 04-21-2016 |
Juan Bosch, Washington, DC US
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20120305487 | Method for Treating Anemia in Hemodialysis Patients - The present invention relates to a method of treating anemia especially in an EPO resistant hemodialysis patient, comprising hemodialysis with a high cut-off dialysis membrane, wherein the hemodialysis membrane is characterized in that it has a molecular weight cut-off in water, based on dextran sieving coefficients, of between 90 and 200 kD and a molecular weight retention onset in water, based on dextran sieving coefficients, of between 10 and 20 kD, and a ΔMW of between 90 and 170 kD. The invention further relates to a high cut-off hemodialysis membrane for the treatment of anemia in hemodialysis patients, especially EPO resistant hemodialysis patients. | 12-06-2012 |
Jürgen Bosch, Pikesville, MD US
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20140275088 | SMALL MOLECULE MALARIAL ALDOLASE-TRAP ENHANCERS AND GLIDEOSOME INHIBITORS - In one aspect, the present invention relates to a method of identifying compounds useful in modifying the activity of Aldolase. The method includes providing a first model comprising Aldolase or residues of the amino acid sequence corresponding to SEQ ID NO: 1 said residues being at amino acid positions selected from the group consisting of 10-13, 26, 27, 29, 30, 31, 32, 33, 37, 39, 40, 41, 43, 44, 47, 48, 51, 52, 60, 63, 66, 79, 84, 85, 92, 93, 103, 106-109, 112-117, 138, 142, 146, 148, 151, 153, 179, 182, 183, 185, 186, 194, 196, 197, 198, 199, 208, 226-228, 231-269, 270, 272, 277-283, 285-289, 294, 295, 297-299, 301-304, 306-310 312, 313, 316, 317, 319, 321, 323, 326, 330, 344, 345, and 347, providing one or more candidate compounds, evaluating contact between the candidate compounds and the first model to determine which of the one or more candidate compounds have an ability to bind to and/or fit in the first model, and identifying compounds which, based on said evaluating, have the ability to bind to and/or fit in the first model as compounds potentially useful for modifying the activity of Aldolase. The present invention also discloses compounds and compositions which modify the activity of Aldolase, or a complex between Aldolase and TRAP. Methods of treating or preventing malaria, or an infection by apicomplexan organisms are also disclosed. | 09-18-2014 |
Marcus Bosch, Chicago, IL US
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20080196709 | COMBINATION GRILL HANDLE AND LIGHT - A grill handle and light assembly is disclosed, the handle being attached to the lid of the grill and the light being detachably secured to the handle for use while grilling or, when detached, as an auxiliary light. | 08-21-2008 |
20100237026 | Bicycle Storage System - A storage system for elevating objects from a surface, such as storing a bicycle off the ground, the storage system including a first mounting plate coupled to a wheel; a second mounting plate spaced from the first mounting plate and coupled to a plurality of wheels; a first wheel assembly spaced from the first mounting plate; a second wheel assembly spaced from the second mounting plate; a cable operatively engaging each of the wheels; and a coupler extending from the first wheel assembly and a second coupler extending from the second wheel assembly. Each of the mounting plates may be made from a unitary piece of material, and each plate may include a plurality of arched channels for rotatably adjusting the mounting plates, e.g., to provide for generally linear alignment of pulley wheels when installing the system. | 09-23-2010 |
20100237027 | Bicycle Stand - A stand for supporting at least one bicycle may include a plurality of tubular frame members including a plurality of generally linear portions, a plurality of angled portions and a plurality of U-shaped portions. The stand also may include a foot having a generally planar bottom surface and an upper surface adapted for operatively engaging one of the U-shaped portions, a wall attachment for coupling a top of the stand to a wall, and a plurality of holders slidably coupled to the generally linear portions. Each of the holders may comprise a band surrounding a portion of the generally linear portions, a hook extending downward and outward from the band, and compressible portions that hold the hook at a desired position along the generally linear portion. In addition, the frame members may include swaged ends and spring-loaded pin assemblies for easy assembly and disassembly of the stand. | 09-23-2010 |
20130325670 | SHOWER DOOR ASSEMBLY DISPLAY AND RETAIL - A retail shower door display assembly is provided with a point-of-sale display unit sized to be received within a retail store aisle. An array of various shower door frames is oriented within the display unit. An array of various shower door glass panes is oriented within the display unit. A method for displaying shower door assemblies for retail is provided by displaying various shower door frames for purchaser selection. Various shower door glass panes are provided for purchaser selection independent of the shower door frames. | 12-05-2013 |
Marnix L. Bosch, Clyde Hill, WA US
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20120244620 | COMPOSITIONS AND METHODS FOR INDUCING THE ACTIVATION OF IMMATURE MONOCYTIC DENDRITIC CELLS - The present invention provides methods for inducing the maturation of immature dendritic cells (DC) and for activating those cells without the use of a dendritic cell maturation agent. The activated DC can be used for inducing an antigen specific T cell response. Methods of the invention can also comprise the addition of a directional maturation agent, such as interferon gamma, to induce a Th-1 and/or Th-2 bias in the response obtained. The present invention also provides dendritic cell populations useful for activating and for inducing antigen specific T cells. Similarly, activated antigen specific T cell populations, and methods of making the same are provided. | 09-27-2012 |
20130273654 | Generation of Dendritic Cells from Monocytic Dendritic Precursor Cells with GM-CSF in the Absence of Additional Cytokines - The present invention it was determined that dendritic cells could be derived from various sources including peripheral blood monocytes in the presence of only GM-CSF without other cytokines if the monocytes were not activated. By preventing activation, such as by preventing binding of the cells to the surface of the culture vessel, the monocytes do not require the presence of additional cytokines, such as IL-4 or IL-13, to prevent differentiation into a non-dendritic cell lineage. The immature DCs generated and maintained in this manner were CD14 | 10-17-2013 |
20160024472 | Generation of Dendritic Cells from Monocytic Dendritic Precursor Cells with GM-CSF in the Absence of Additional Cytokines - The present invention it was determined that dendritic cells could be derived from various sources including peripheral blood monocytes in the presence of only GM-CSF without other cytokines if the monocytes were not activated. By preventing activation, such as by preventing binding of the cells to the surface of the culture vessel, the monocytes do not require the presence of additional cytokines, such as IL-4 or IL-13, to prevent differentiation into a non-dendritic cell lineage. The immature DCs generated and maintained in this manner were CD14 and expressed high levels of CD1a. Upon maturation by contact with an agent such as, for example, BCG and IFNγ, the cells were determined to express surface molecules typical of mature dendritic cells purified by prior methods and cultured in the presence of GM-CSF and IL-4. The mature dendritic cells produced from monocytes without activation and cultured in GM-CSF alone are suitable for use in dendritic cell-based immunotherapy methods, such as for use in the treatment of disease, including cancer. | 01-28-2016 |
Marnix L. Bosch, Medina, WA US
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20080254064 | COMPOSITIONS AND METHODS FOR PRIMING MONOCYTIC DENDRITIC CELLS AND T CELLS FOR TH-1 RESPONSE - The present invention provides compositions and methods for inducing maturation of immature dendritic cells (DC) and for priming those cells for inducing a type 1 immune response. The present invention also provides dendritic cell populations useful for activating and for preparing T cells polarized towards production of type 1 cytokines and/or a type 1 response. Similarly, activated, polarized T cell populations, and methods of making the same are provided. | 10-16-2008 |
20080254537 | Compositions and Methods for Inducing the Activation of Immature Monocytic Dendritic Cells - The present invention provides methods for inducing the maturation of immature dendritic cells (DC) and for activating those cells without the use of a dendritic cell maturation agent. The activated DC can be used for inducing an antigen specific T cell response. Methods of the invention can also comprise the addition of a directional maturation agent, such as interferon gamma, to induce a Th-I and/or Th-2 bias in the response obtained. The present invention also provides dendritic cell populations useful for activating and for inducing antigen specific T cells. Similarly, activated antigen specific T cell populations, and methods of making the same are provided. | 10-16-2008 |
20110189150 | TANGENTIAL FLOW FILTRATION DEVICES AND METHODS FOR LEUKOCYTE ENRICHMENT - The present invention provides tangential flow filtration devices and methods for enriching a heterogenous mixture of blood constituents for leukocytes by removal of non-leukocyte blood constituents. In one particular embodiment the device can provide a composition enriched in monocytes. | 08-04-2011 |
20120251561 | ADMINISTRATION OF DENDRITIC CELLS PARTIALLY MATURED IN VITRO FOR THE TREATMENT OF TUMORS - The present invention provides populations of cells comprising partially matured dendritic cells that can be used for administration individuals having a tumor. Partially matured dendritic cells, those contacted with a dendritic cell maturation agent for about 1 to about 10 hours, or more, efficiently take up and process tumor antigens in the area of the tumor site, complete maturation, and can subsequently migrate to the lymph nodes of a treated individual. Once in the lymph node the now fully mature antigen presenting dendritic cells secrete the appropriate cytokines (e.g., TNFα and IL-12) and contact T cells inducing a substantial anti-tumor immune response. | 10-04-2012 |
Marnix Leo Bosch, Clyde Hill, WA US
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20150202291 | COMBINATIONS OF CHECKPOINT INHIBITORS AND THERAPEUTICS TO TREAT CANCER - A combination treatment regimen including one or more cycles and/or doses of a checkpoint inhibitor and a therapeutic, either sequentially, in either order, or substantially simultaneously, can be more effective in treating cancer in some subjects and/or can initiate, enable, increase, enhance or prolong the activity and/or number of immune cells, the efficacy of anti-tumor immune responses or a medically beneficial response by a tumor. | 07-23-2015 |
20150273033 | COMBINATIONS OF CHECKPOINT INHIBITORS AND THERAPEUTICS TO TREAT CANCER - The present disclosure arises at least in part from the seminal recognition that a combination treatment regimen including one or more cycles and/or doses of a checkpoint inhibitor and a therapeutic, either sequentially, in either order, or substantially simultaneously, can be more effective in treating cancer in some subjects and/or can initiate, enable, increase, enhance or prolong the activity and/or number of immune cells, or a medically beneficial response by a tumor. | 10-01-2015 |
Nicholas Bosch, Glenside, PA US
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20150100475 | SYSTEM AND METHOD FOR MANAGING PAYDAY ACCOUNTS OVER A MOBILE NETWORK - Exemplary systems and methods of the disclosure are directed to managing payday accounts over a mobile network. The system includes at least one mobile computing device and at least one host computing device. The mobile computing device is associated with a customer and configured to retrieve customer account information from the host computing device over the network. The mobile computing device generates a customized payday product menu based on the customer account information. The customer account information indicates a status of active payday accounts for the customer or the customer's eligibility for opening new payday accounts. | 04-09-2015 |
Peter Bosch, Murray Hill, NJ US
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20130156006 | METHOD FOR PROVIDING SEAMLESS TRANSITION BETWEEN NETWORKS FOLLOWING DIFFERENT PROTOCOLS - Example embodiments provide methods for handling the transition of a mobile device from a first network to a second network, the second network operating according to a different communications protocol from the first network. One example embodiment includes terminating forwarding of the data packets from the first network to the mobile device; rebuilding headers of unforwarded data packets at the first network; and sending the rebuilt data packets from the first network to the second network. Another example embodiment includes resetting a header compression state at the second network; receiving unforwarded data packets from the first network at the second network, the unforwarded data packets being data packets the first network had not yet forwarded to the mobile device; and sending the unforwarded data packets from the second network to the mobile device. | 06-20-2013 |
Ricardo Bosch, Brooklyn, NY US
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20110131451 | METHODS AND SYSTEM FOR TESTING AN ENTERPRISE SYSTEM - A computer storage medium having a computer-readable code segment for performing a method may be provided. The method may include receiving inputs from a user using an interface, the inputs define a test that is run against the application software; associating a resource with the test, the resource selected by the user using the interface; executing the test against the application software; comparing an outputted value of the application software with an expected value; and outputting a result. | 06-02-2011 |
Ronald O. Bosch, Houston, TX US
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20140217033 | INHIBITORS FOR ORGANICS SOLUBILIZED IN PRODUCED WATER - A surface active compound is supplied into contact with an oilfield production fluid that comprises a mixture of water and oil including water soluble organics. The surface active compound comprises at least one alkoxylate chain and at least one end group attached to each of the at least one alkoxylate chain. The surface active compound is supplied into the oilfield production fluid at a dosage rate that is effective to self-associate at interfaces between the water and oil and inhibit the water soluble organics in the oil from entering the water when the oilfield production fluid is depressurized. | 08-07-2014 |
Russell Bosch, Holley, NY US
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20140217932 | MAGNETOSTRICTIVE ACTUATOR - A method of minimizing the cold start delay and impact fatigue of an actuator includes calibrating the actuator by initially raising the temperature to a desired operating temperature through induction heating of the actuator rod. Additionally, a control system for a magnetostrictive actuator includes a rod of magnetostrictive material, a solenoid coil wrapped at least once around said rod, and a controller operatively connected to said solenoid coil wherein the controller detects an impact of the rod with another surface and adjusts the operation of the actuator to minimize the potential for additional future impacts. The rod may be segmented and include end caps to further reduce the potential for impact fatigue. | 08-07-2014 |
Russell H. Bosch, Gaines, MI US
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20090004544 | Glass seal with ceramic fiber for a solid-oxide fuel cell stack - A glass ceramic composition for sealing adjacent metal cassettes in an SOFC stack. The seal composition comprises an alumina-silicate glass ceramic matrix and a ceramic fiber aggregate dispersed in the matrix. Preferably, the fiber is selected from the group consisting of zirconium oxide fiber, alumina fiber, and combinations thereof. Preferably, the fiber is present at 1-60 weight percent with respect to the weight of glass ceramic, preferably about 30 weight percent. Preferably, the zirconia is stabilized by up to about 10% yttria. Alumina fiber may substitute for a portion of the zirconia fiber. Preferably, a green seal is die cut from a green tape sheet formed by extrusion of a slurry comprising water and a latex binder. The green seal is sintered during the final SOFC stack assembly process to form the final stack seal. | 01-01-2009 |
20090294556 | Encapsulating arrangement for an electrical component - The invention provides an encapsulating arrangement for an electrical component comprising first and second insulating layers and an electrically charged conductive layer, preferably in the form of a metal foil, intermediate the first and second insulating layers, and arranged to prevent the passage of ionic species across the encapsulating arrangement. The encapsulating arrangement of the invention has particular application to piezoelectric actuator arrangements for fuel injectors of internal combustion engines. | 12-03-2009 |
20100075191 | Textured solid oxide fuel cell having reduced polarization losses - An improved SOFC including textural features pressed into a structural anode and electrolyte bi-layer laminate to increase the active surface area of the finished fuel cell anode and cathode. This arrangement reduces current losses from ohmic, concentration, and activation polarization. In a presently preferred embodiment, an array of dimples is formed during manufacture of the bi-layer laminate by isostatically pressing an array of steel balls against the laminate before firing thereof. The dimples or other features may be varied in depth and spacing as may be desired to optimize gas flow through the SOFC and fuel efficiency thereof. The array may be close-spaced or not and may have any desired geometric packing form, including rectangular and hexagonal. | 03-25-2010 |
20100237751 | PIEZOELECTRIC ACTUATOR - A piezoelectric actuator comprises a co-fired stack of piezoelectric elements formed from a piezoelectric material and a plurality of positive internal electrodes interdigitated with a plurality of negative internal electrodes throughout the stack to define active regions of the piezoelectric material which are responsive to a voltage applied across the internal electrodes, in use. An external positive electrode connects with the positive internal electrodes and an external negative electrode connects with the negative internal electrodes. The actuator is characterised in that the stack further comprises means for deliberately creating artificial cracks within the stack at a location at which the artificial cracks do not give rise to a short circuit between the internal electrodes but serve to relieve stresses within the piezoelectric material. | 09-23-2010 |
Samuel H. Bosch, Portland, OR US
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20090287562 | ANONYMOUS MERCHANT-CUSTOMER LOYALTY REWARDS PROGRAM - A system of and method for rewarding an anonymous merchant-customer for performing multiple debit transactions on a defined set of merchant debit-machines comprises receiving data associated with a discrete one of the multiple debit transactions, generating and updating data associated with the anonymous customer without having the anonymous customer provide personally identifiable information, determining whether to reward the anonymous customer for performing one or more debit transactions, and if so, rewarding the anonymous customer. The method may be implemented on or by one or more merchant debit machines (e.g., automated teller machines (ATMs) and point-of-sale (POS) terminals), remote processors, financial institutions, general-purpose computers, or special-purpose computers. | 11-19-2009 |
20100241562 | CURRENCY DISPENSE AND CONTROL SYSTEM WITH ANTI-THEFT FEATURES - A cost-effective, currency dispense and control system (CDCS) securely dispenses paper money in one of the following modes: (1) an ATM system and (2) a currency control system that allows a merchant or merchant-approved employee to withdraw cash from the CDCS independent of a standard ATM electronic fund transfer (EFT) network. The CDCS may also include the following functionalities: a duress dispensation system that allows the CDCS to activate an alarm and/or otherwise communicate with local police or security services during a robbery, a time-release system that effects a time-delayed dispensation functionality, and a user identification and authentication system for authenticating a user identity and determining eligibility of the user to access the currency control system. | 09-23-2010 |
20110258090 | SYSTEMS AND METHODS FOR SERVICING CASH HANDLING DEVICES - Systems and methods are provided for servicing a currency dispensing device, such as an automated teller machine, and a currency receiving device, such as a provisional cash safe, disposed at a merchant location. The method may comprise transporting dispensable currency to the merchant location, inserting the dispensable currency into the currency dispensing device during a site visit to the merchant location, removing merchant currency from the currency receiving device during the first site visit, the merchant currency having been previously inserted into the currency receiving device over a period of time by a merchant, and transporting the merchant currency from the merchant location to a currency processing location. The currency receiving device may transmit an indication of an amount of merchant currency inserted therein so that the merchant is provided a credit by a financial institution for the merchant currency before it is transported to the financial institution. | 10-20-2011 |
20130151407 | REMOTE CURRENCY DISPENSATION SYSTEMS AND METHODS - A currency dispense and control system (CDCS) for securely dispensing paper currency in multiple modes: (1) an ATM system and (2) a currency control system that allows a merchant or merchant-approved employee to withdraw cash from the CDCS independent of a standard ATM electronic fund transfer (EFT) network. The CDCS may be on-site and implemented using standard ATM hardware or may be located remotely. The CDCS may also include one or more of the following functionalities: a duress dispensation system that allows the CDCS to activate an alarm and/or otherwise communicate with local police or security services during a robbery, a time-release system that effects a time-delayed dispensation functionality, and a user identification and authentication system for authenticating a user identity and determining eligibility of the user to access the currency control system. | 06-13-2013 |
20130232064 | CASH HANDLING DEVICES - A currency receiving device (CRD) includes a currency recycler configured to accept, count, deposit, and withdraw merchant currency inserted into the CRD, a network interface, and a processor in communication with the currency recycler and the network interface. The processor is configured to transmit to a financial institution or a home office, via the network interface, an indication of an amount of merchant currency inserted into the CRD over a predetermined period of time. In some embodiments, the processor determines whether a second predetermined period of time passes during which no merchant currency is inserted into the CRD. In some embodiments, the processor determines an amount of deposited merchant currency does not meet a predetermined minimum deposit corresponding to the predetermined period of time. Alert messages, based on insufficient or untimely deposits, duress, or tampering, are optionally produced. | 09-05-2013 |
Terry Bosch, Manitowoc, WI US
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20080315733 | Modular Monitor Support Apparatus - A modular apparatus for supporting a monitor is provided. First and second pairs of substantially vertically oriented and opposed columns are spaced a lateral distance apart. A support member is arranged between and coupled to the first and second pairs of columns. The support member is adapted to support a monitor at a viewing angle. The height and angle of the support member, and thus the monitor, can be easily adjusted via slot and tab connections between the support member and columns and/or by adjusting the lateral distance between the respective pairs of columns. | 12-25-2008 |
Warren Bosch, Ashburn, VA US
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20090011797 | Walkie-talkie with screen to show a list of other walkie-talkies within communication range - A device, method, and computer program product for identifying and communicating with digital communication devices within a communication range that includes a transmitter configured to transmit a control signal and a voice signal, a receiver configured to receive the control signal and the voice signal, a user interface unit having a display area, and a computational unit configured to control the transmitter to periodically transmit identifying information as the control signal. The control signal is received as remote identifying information by the other digital communication devices within the communication range. The remote identifying information is displayed on the display area of each of the digital communication devices receiving the control signal. | 01-08-2009 |
William H. Bosch, Bryn Mawr, PA US
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20140065219 | Inhalable Pharmaceutical Compositions - Methods for making inhalable composite particles comprising a pharmaceutically-active agent, the method comprising: a) providing composite particles comprising a millable grinding matrix and a solid pharmaceutically-active agent, wherein the pharmaceutically-active agent has an median particle size on a volume average basis between 50 nm and 3 μm; and b) milling the composite particles in a mill without milling bodies for a time period sufficient to produce inhalable composite particles having a mass median aerodynamic diameter between 1 μm and 20 μm are described. | 03-06-2014 |