Patent application number | Description | Published |
20090004239 | Dural repair material - Multilayer structures including a porous layer and a non-porous layer having a reinforcement member are useful as dural repair materials. | 01-01-2009 |
20090068250 | Bioresorbable and biocompatible compounds for surgical use - A bioresorbable and biocompatible compound for surgical use is composed of functionalized collagen cross-linked with a glycosaminoglycan. | 03-12-2009 |
20100212829 | MEDICAL DEVICES INCORPORATING FUNCTIONAL ADHESIVES - A method for bonding a polymeric medical device to tissue is provided which includes providing a polymeric medical device having a plurality of reactive members of a specific binding pair attached on a surface of the medical device, and providing tissue with a plurality of complementary reactive members of the specific binding pair, wherein upon contact of the reactive members on the surface of the medical device with the complimentary reactive members on the tissue, covalent bonds are formed between the reactive members and the complementary reactive members, thus adhering the device to the tissue. A kit is provided including a polymeric medical device such as a patch or mesh having a plurality of reactive members of a specific binding pair attached to a surface of the device and an applicator containing a solution or suspension of complementary reactive members of the specific binding pair, the complementary reactive members having a functionality that will adhere them to biological tissue upon contact, said applicator adapted to deliver the solution or suspension to biological tissue. | 08-26-2010 |
20100215659 | FUNCTIONALIZED SURGICAL ADHESIVES - A bioadherent composition includes a first mixture containing a plurality of reactive members of a specific binding pair, said reactive members being bound to a ligand capable of binding a receptor on biological tissue, and a second mixture containing a plurality of complementary reactive members of the specific binding pair, said complementary reactive members being bound to a ligand capable of binding a receptor on biological tissue, said reactive members capable of forming covalent bonds with said complementary reactive members via a reaction selected from Huisgen cycloaddition reactions, Diels-Alder reactions, and/or thiol-alkene reactions. A method for bonding biological tissue involves utilizing the bioadherent composition. | 08-26-2010 |
20100215709 | MEDICAL DEVICE WITH INFLAMMATORY RESPONSE-REDUCING COATING - Implantable non-bioabsorbable medical devices have an amphiphilic coating for reducing the inflammatory response to the device after implantation. | 08-26-2010 |
20100215748 | FUNCTIONALIZED ADHESIVE MEDICAL GEL - A bioadherent substrate includes a medical gel or medical gel precursor having a plurality of reactive members of a specific binding pair attached on or adapted to be attached to a surface of the medical gel, said reactive members being capable of forming covalent bonds with a plurality of complementary reactive members of the specific binding pair via a reaction selected from a Huisgen cycloaddition reaction, a Diels-Alder reaction and a thiol-ene reaction. A method for adhering a medical gel to biological tissue includes providing a medical gel or a medical gel precursor having a plurality of reactive members of a specific binding pair attached on or adapted to be attached to a surface of the medical gel and providing tissue with a plurality of complementary reactive members of the specific binding pair, wherein upon contact of the reactive members on the medical gel with the complimentary reactive members on the tissue, covalent bonds are formed between the reactive members and the complementary reactive members, thus adhering the medical gel to the tissue. | 08-26-2010 |
20100217287 | SELF-ASSEMBLING FIBROUS NETWORKS - A method for in situ formation of a medical device on biological tissue includes attaching a plurality of reactive members of a primary specific binding pair to a surface of the biological tissue, and providing a plurality of fibers having attached thereto a plurality of complementary reactive members of the primary specific binding pair, wherein upon contact of the reactive members on the surface of the biological tissue with the complimentary reactive members on the fibers, covalent bonds are formed between the reactive members and the complementary reactive members, thus adhering the fibers to the tissue. The fibers can incorporate functionalities which may cause them to bind to one another. | 08-26-2010 |
20110262706 | TEMPLATE FOR BACTERIAL CELLULOSE IMPLANT PROCESSED WITHIN BIOREACTOR - The present invention relates to an implant comprising: a sheet of bacterial cellulose having a macro-pattern positioned on at least a portion thereof. The invention also relates to a method for making such an implant. | 10-27-2011 |
20110282464 | Reactive Surgical Implants - The present disclosure relates to a sprayable surgical implant. The implant includes a first component including microparticulates and a second component including at least one cross-linking reagent. The at least one cross-linking reagent reacts with the microparticulates to form the surgical implant. | 11-17-2011 |
20110294962 | CROSS LINKED FIBERS AND METHODS OF MAKING SAME USING TRANSITION METAL IONS - The present disclosure relates to a method of forming fibers. First and second precursors, each possessing a core and at least one functional group known to have click reactivity, are mixed in a hopper. The mixed precursors are then extruded through an extrusion die to crosslink and produce a filament. Polymerization of the first and second precursors is catalyzed by transition metal ions. | 12-01-2011 |
20120276161 | BIORESORBABLE AND BIOCOMPATIBLE COMPOUNDS FOR SURGICAL USE - A bioresorbable and biocompatible compound for surgical use is composed of functionalized collagen cross-linked with a glycosaminoglycan. | 11-01-2012 |
20130078285 | IMPLANT FOR TISSUE REPAIR - Mono- and multi-layered implants include at least one porous layer made from a freeze dried aqueous solution containing chitosan, the solution having a pH of less than about 5. | 03-28-2013 |
20140013998 | ENZYMATICALLY DEGRADABLE COMPOSITIONS - Enzymatically degradable compositions containing biocompatible polymers reactive with glycosaminoglycan compositions having a first glycosaminoglycan compound having a first degree of acetylation and a second glycosaminoglycan compound having a second degree acetylation different than the first degree of acetylation. | 01-16-2014 |
20140018849 | MEDICAL DEVICES INCORPORATING FUNCTIONAL ADHESIVES - A method for bonding a polymeric medical device to tissue is provided which includes providing a polymeric medical device having a plurality of reactive members of a specific binding pair attached on a surface of the medical device, and providing tissue with a plurality of complementary reactive members of the specific binding pair, wherein upon contact of the reactive members on the surface of the medical device with the complimentary reactive members on the tissue, covalent bonds are formed between the reactive members and the complementary reactive members, thus adhering the device to the tissue. A kit is provided including a polymeric medical device such as a patch or mesh having a plurality of reactive members of a specific binding pair attached to a surface of the device and an applicator containing a solution or suspension of complementary reactive members of the specific binding pair, the complementary reactive members having a functionality that will adhere them to biological tissue upon contact, said applicator adapted to deliver the solution or suspension to biological tissue. | 01-16-2014 |
20140128497 | FUNCTIONALIZED ADHESIVE MEDICAL GEL - A bioadherent substrate includes a medical gel or medical gel precursor having a plurality of reactive members of a specific binding pair attached on or adapted to be attached to a surface of the medical gel, said reactive members being capable of forming covalent bonds with a plurality of complementary reactive members of the specific binding pair via a reaction selected from a Huisgen cycloaddition reaction, a Diels-Alder reaction and a thiol-ene reaction. A method for adhering a medical gel to biological tissue includes providing a medical gel or a medical gel precursor having a plurality of reactive members of a specific binding pair attached on or adapted to be attached to a surface of the medical gel and providing tissue with a plurality of complementary reactive members of the specific binding pair, wherein upon contact of the reactive members on the medical gel with the complimentary reactive members on the tissue, covalent bonds are formed between the reactive members and the complementary reactive members, thus adhering the medical gel to the tissue. | 05-08-2014 |
20140142626 | CROSSLINKED FIBERS AND METHOD OF MAKING SAME BY EXTRUSION - The present disclosure relates to a method of forming fibers. First and second precursors, each possessing a core and at least one functional group known to have click reactivity, are mixed. The mixed precursors are then extruded under heat to cross-link during fiber production. | 05-22-2014 |
Patent application number | Description | Published |
20110238109 | SURGICAL FASTENERS AND METHODS FOR SEALING WOUNDS - A method for closing a wound in tissue is provided which includes providing a surgical fastener having a plurality of reactive members of a specific binding pair attached on a surface of the surgical fastener, and providing tissue with a plurality of complementary reactive members of the specific binding pair, wherein upon contact of the reactive members on the surface of the surgical fastener with the complimentary reactive members on the tissue, covalent bonds are formed between the reactive members and the complementary reactive members, thus adhering the device to the tissue. | 09-29-2011 |
20110251699 | AUTO-SEALANT MATRIX FOR TISSUE REPAIR - Implants for tissue repair/regeneration include a porous layer combined with dry materials that are activated to form a hydrogel upon contact with aqueous physiological fluids. | 10-13-2011 |
20110257666 | SURGICAL PATCH - Multi-layer structures are useful as surgical patches. | 10-20-2011 |
20110257682 | MEDICAL DEVICES INCORPORATING FUNCTIONAL ADHESIVES - Methods for treating a wound at a surgical target site are provided which includes utilizing a surgical access device having a plurality of reactive members of a specific binding pair releasably contained on a surface of the access device, the reactive members having affinity for binding a cellular component of tissue cells located at the target site; contacting the surface of the access device with the tissue cells, wherein upon contact of the reactive members on the surface of the access device with the tissue cells, the reactive members are released from the surface of the access device and bind to the tissue. A surgical access device for use in the minimally invasive surgery is also provided. | 10-20-2011 |
20110262521 | MEDICAL DEVICE INCLUDING BACTERIAL CELLULOSE REINFORCED BY RESORBABLE OR NON RESORBABLE REINFORCING MATERIALS - The present invention relates to a medical device comprising: a reinforcing member; and bacterial cellulose on at least a portion of the reinforcing member. The invention also relates to a method for making such a medical device. | 10-27-2011 |
20110262696 | MEDICAL DEVICE INCLUDING A BACTERIAL CELLULOSE SHEET, PERFORATED OR MICROPERFORATED AS A MESH - The present invention relates to a medical device comprising a bacterial cellulose sheet having perforations. The invention further relates to a method of making such a medical device. | 10-27-2011 |
20110263841 | MEDICAL DEVICES WITH DEFINABLE POROSITY PRODUCED BY BACTERIAL POLYMER BIO-SYNTHESIS - The present invention relates to a method of forming an implantable medical device comprising: culturing polymer-producing bacteria preferably | 10-27-2011 |
20110264119 | MEDICAL IMPLANT INCLUDING A 3D MESH OF OXIDIZED CELLULOSE AND A COLLAGEN SPONGE - The present invention relates to A bioresorbable implant comprising: a bioresorbable porous layer including a biopolymer foam and defining first pores, a bioresorbable porous three-dimensional mesh made from a microbial cellulose and defining second pores, wherein the bioresorbable porous layer is disposed in the bioresorbable porous three-dimensional mesh. The invention also relates to a method of making a bioresorbable implant. | 10-27-2011 |
20110264120 | COMPOSITE MESH INCLUDING A 3D MESH AND A NON POROUS FILM OF OXIDIZED CELLULOSE FROM BACTERIAL CELLULOSE ORIGIN - The present invention relates to a composite implant comprising: a prosthetic fabric having a first side and a second side, a non-porous film of bacterial cellulose secured to the first side of the fabric. The invention further relates to a method of making such an implant. | 10-27-2011 |
20110320009 | MATRIX FOR TISSUE REPAIR - Implants include a porous layer made from a composition including a compound wherein collagen is cross-linked to a glycosaminoglycan, the porous layer being optionally joined to a collagen film. | 12-29-2011 |
20120021015 | CROSSLINKED FIBERS AND METHOD OF MAKING SAME USING UV RADIATION - Cross-linked fibers include first and second precursors, each possessing a core and at least one functional group known to have click reactivity when exposed to UV radiation. Mixtures of the first and second precursors are extruded to produce a filament and irradiated with UV light during the extrusion process. | 01-26-2012 |
20120021037 | MEDICAL DEVICES WITH AN ACTIVATED COATING - Implantable medical devices include a substrate having applied thereto a coating including a polymeric material possessing a core and at least one functional group known to have click reactivity. | 01-26-2012 |
20120021217 | FIBERS WITH AN ACTIVATED SURFACE AND METHOD OF MAKING SAME BY EXTRUSION - The present disclosure relates to a method of forming a medical device comprising: forming a desired shape from a polymer possessing a core and at least one functional group known to have click reactivity, whereby a medical device with an activated surface is produced. | 01-26-2012 |
20120027814 | Polymeric Fibers Having Tissue Reactive Members - A method for bonding a polymeric fiber to tissue is provided which includes providing a polymeric fiber having a plurality of tissue reactive members linked to a surface of the fiber via a specific binding pair, and contacting the polymeric fiber to biological tissue, to covalently bond the fiber to the tissue. | 02-02-2012 |
20120029150 | CROSSLINKED FIBERS AND METHOD OF MAKING SAME BY EXTRUSION - The present disclosure relates to a method of forming fibers. First and second precursors, each possessing a core and at least one functional group known to have click reactivity, are mixed. The mixed precursors are then extruded under heat to cross-link during fiber production. | 02-02-2012 |
20120035321 | COMPOUNDS AND MEDICAL DEVICES ACTIVATED WITH SOLVOPHOBIC LINKERS - The present disclosure relates to compounds and medical devices activated with a solvophobic material functionalized with a first reactive member and methods of making such compounds and devices. | 02-09-2012 |
20120035335 | APPARATUS AND METHOD OF REACTING POLYMERS PASSING THROUGH METAL ION CHELATED RESIN MATRIX TO PRODUCE INJECTABLE MEDICAL DEVICES - The present disclosure relates to an apparatus and process for forming medical devices from an injectable composition. The apparatus includes a supply assembly configured to maintain and selective dispense a first precursor and a second precursor, a mixing assembly configured to mix the first and second precursors, and at least one catalyzing element including a transition metal ion to aid in the polymerization of the first and second precursors. The process includes dispensing a volume of the first precursor and a volume of the second precursor into a mixing assembly and mixing the first and second precursors. The first and second precursors each possess a core and at least one functional group known to have click reactivity with each other. The mixed precursors are contacted with a transition metal catalyst to produce a flowable composition for use as a medical device. | 02-09-2012 |
20120041095 | APPARATUS AND METHOD OF REACTING POLYMERS BY EXPOSURE TO UV RADIATION TO PRODUCE INJECTABLE MEDICAL DEVICES - Cross-linked compositions include a first precursor functionalized with a first reactive member and a second precursor functionalized with a second reactive member, the first and second reactive members covalently bonding with each other when exposed to UV radiation. The compositions are useful in a variety of surgical and wound treatment applications. | 02-16-2012 |
20120071974 | MEDICAL DEVICE WITH DEGRADATION-RETARDING COATING - The present disclosure relates to implantable bioabsorbable medical devices having an amphiphilic coating for delaying the degradation of the device and methods of making such devices. | 03-22-2012 |
20130078285 | IMPLANT FOR TISSUE REPAIR - Mono- and multi-layered implants include at least one porous layer made from a freeze dried aqueous solution containing chitosan, the solution having a pH of less than about 5. | 03-28-2013 |