Patent application number | Description | Published |
20090004111 | Structure of the Hepatitis C Ns5a Protein - The present invention provides a crystallized N-terminal domain of an NS5A protein of hepatitis C virus, methods of producing the same and methods of use thereof. The present invention also relates to structural elements of the N-terminal domain of hepatitis C virus NS5A protein, and methods of inhibiting hepatitis C virus infection, replication and/or pathogenesis, by interacting with the same. | 01-01-2009 |
20090098123 | HCV CORECEPTOR AND METHODS OF USE THEREOF - The invention relates to the discovery that the Claudin-1 protein functions as a co-receptor for entry of HCV into cells. Methods of inhibiting, preventing or mitigating HCV infections by inhibiting HCV interactions with Claudin-1 are provided. Methods of identifying agents or compounds that interfere with HCV interactions with Claudin-1 are also provided. Finally, useful kits, cell culture compositions, agents, and compounds related to the inhibition of HCV interactions with Claudin-1 are also disclosed. | 04-16-2009 |
20090233266 | STRUCTURE OF THE HEPATITIS C VIRUS NS2 PROTEIN - The present invention provides a crystallized C-terminal domain of an NS2 protein of hepatitis C virus, methods of producing the same and methods of use thereof. The present invention also relates to structural elements of the C-terminal domain of hepatitis C virus NS2 protein, and methods of inhibiting hepatitis C virus infection, replication and/or pathogenesis, by interacting with the same. | 09-17-2009 |
20100062419 | Infectious, Chimeric Hepatitis C Virus, Methods of Producing the Same and Methods of Use Thereof - The present invention provides infectious recombinant Hepatitis C Viruses (HCV), and vectors, cells and animals comprising the same. The present invention provides methods of producing infectious recombinant HCV, and their use in identifying anti-HCV therapeutic agents, as well as sequences of HCV associated with HCV pathogenesis. | 03-11-2010 |
20110271356 | HCV ENTRY FACTOR, OCCLUDIN - The human Occludin protein is identified as an essential Hepatitis C Virus (HCV) cell entry factor. Occludin is shown to render murine and other non-human cells infectable with HCV and to be required for HCV—susceptibility of human cells. Associated methods for inhibiting HCV infection, transgenic animal models for HCV pathogenesis, methods of identifying compounds or agents that prevent or mitigate interaction of HCV with Occludin, and HCV inhibitory agents are also disclosed. Kits and cell culture compositions useful for identifying compounds or agents that prevent or mitigate interaction of HCV with Occludin are also provided. | 11-03-2011 |
Patent application number | Description | Published |
20080306363 | Specialized Human Servo Device And Process For Tissue Modulation Of Human Fingerprints - Apparatus and methods for noninvasive spectroscopic measurement of an analyte in a subject that have been optimized for producing uniform and repeatable tissue modulation across test subjects and for the same test subject on different occasions are provided. The apparatus comprises an ergonomically shaped grip that substantially conforms to a subject's hand; a surface for placement of at least one of the subject's fingertips upon grasping the grip; and an optically transparent aperture, or a plurality of apertures, disposed within the surface. A modification to the surface of the apparatus adjacent to the aperture that is detectable via the tactile sense of the subject can be added to provide tactile feedback to the subject to guide correct placement of the fingertip over the aperture. The apparatus and methods can also incorporate feedback methods to guide and optimize placement and conditions of the fingertip to further improve accuracy of measurements. | 12-11-2008 |
20090244536 | TWO-DIMENSIONAL OPTICAL IMAGING METHODS AND SYSTEMS FOR PARTICLE DETECTION - The present invention provides methods and systems for particle detection and analysis using two-dimensional optical imaging to access enhanced detection sensitivity and expanded sensing functionality relative to conventional point and array detection-based optical particle counters. Methods and systems of the present invention provide a two-dimensional optical imaging-based particle sensing platform wherein system components and specifications are selected to generate reproducible and readily identifiable signals, including particle detection signatures, from optical scattering or emission from particles provided to the system. Systems and methods of the present invention are capable of accurately and sensitively detecting, identifying, and characterizing (e.g., determining the size of) particles in liquid phase or gas phase samples. | 10-01-2009 |
20120140223 | Two-Dimensional Optical Imaging Methods and Systems for Particle Detection - The present invention provides methods and systems for particle detection and analysis using two-dimensional optical imaging to access enhanced detection sensitivity and expanded sensing functionality relative to conventional point and array detection-based optical particle counters. Methods and systems of the present invention provide a two-dimensional optical imaging-based particle sensing platform wherein system components and specifications are selected to generate reproducible and readily identifiable signals, including particle detection signatures, from optical scattering or emission from particles provided to the system. Systems and methods of the present invention are capable of accurately and sensitively detecting, identifying, and characterizing (e.g., determining the size of) particles in liquid phase or gas phase samples. | 06-07-2012 |
Patent application number | Description | Published |
20100064767 | Atom-Interferometric, Stepped Gravity Gradient Measuring System - A full-tensor, gravity gradient measuring system is disclosed that is based on atom interferometry. Each axis in the three-axis measuring system is served by a different gravity gradiometer, where each gradiometer comprises three pairs of atom interferometric (AI) accelerometers. The accelerometers in each pair are mounted on opposite sides of the gradiometer's rotation axis from each other. The three AI accelerometer pairs are step-rotated, instead of being continuously rotated, thereby providing enhanced signal-to-noise performance. The three gradiometers in the overall measuring system are mounted orthogonally with respect to one another on a local-level platform, in order to achieve a full-tensor measuring system. The measuring system can be step-rotated as an overall unit around an axis perpendicular to a local level reference. The multiple levels of stepped rotation, as enabled by the atom interferometry being utilized, yields improved results with lower costs than what is achievable with some prior-art techniques. | 03-18-2010 |
20100149541 | Performance of an Atom Interferometric Device through Complementary Filtering - A technique is disclosed which offers an improvement in the performance of an atom interferometric (AI) sensor, such as one that is used in an accelerometer or a gyroscope. The improvement is based on the recognition that the AI-based device, which is associated with superior low-frequency performance, can be augmented with a conventional device having a superior high-frequency performance, as well as a wider frequency response, compared with that of the AI-based device. The disclosed technique combines acceleration measurements from the AI-based device, which is characterized by transfer function G(s), with acceleration measurements from the conventional device that have been adjusted by a complementary function, 1−Ĝ(s), where Ĝ(s) is an approximation of G(s). The conventional device has a considerably wider bandwidth than that of the AI-based device, and the quasi-unity transfer function of the conventional device makes possible the 1−Ĝ(s) adjustment of the measurements provided by the conventional device. | 06-17-2010 |
Patent application number | Description | Published |
20130254772 | VERIFICATION OF COMPLEX WORKFLOWS THROUGH INTERNAL ASSESSMENT OR COMMUNITY BASED ASSESSMENT - A method of implementing verification of a complex workflow includes partitioning the workflow into modules, wherein the modules have inputs, processing steps and outputs; selecting, from the workflow, one of the partitioned modules for independent verification by challenge thereof; running, with a computing device, a challenge of the selected module, the challenge comprising comparing reference outputs to outputs of the selected module, wherein reference inputs are received by the selected module and the reference outputs are generated using the reference inputs and one of an ideal performing module or a well-established module; determining whether outputs of the selected module meet verification criteria with respect to the reference outputs, and based on the determining, implementing one of: declaring the selected module verified; subdividing the selected module into smaller modules and repeating the challenge on the smaller modules; or declaring the selected module not verified. | 09-26-2013 |
20140258589 | RANDOM NUMBER GENERATION - A system for random number generation may include non-volatile memory, and a random number stored on the non-volatile memory. The system may also include a key linked to the random number. The system may further include a computer-apparatus designed to use the random number based upon the key. | 09-11-2014 |
20140258594 | RANDOM NUMBER GENERATION - A system for random number generation may include non-volatile memory, and a random number stored on the non-volatile memory. The system may also include a key linked to the random number. The system may further include a computer-apparatus designed to use the random number based upon the key. | 09-11-2014 |
Patent application number | Description | Published |
20130019013 | Dynamic Provisioning of Service RequestsAANM Rice; Joseph AllenAACI Ballston LakeAAST NYAACO USAAGP Rice; Joseph Allen Ballston Lake NY USAANM Castagna; Brandon MatthewAACI Mount HollyAAST NCAACO USAAGP Castagna; Brandon Matthew Mount Holly NC US - An enhanced service DNS server may receive service requests and interface with an integrated metadata repository/policy definition server to determine service policies associated with the service request. The service policies may aid the enhanced service DNS server in determining if a requestor associated with the service is authorized to receive the service and if the service requestor is authorized to receive the service, the service policies may detail how the enhanced service DNS server may route the service request to the appropriate service provider over the network. This scheme may help to automate the process of implementing changes to services provided over a network. | 01-17-2013 |
20130019018 | OPTIMIZED SERVICE INTEGRATION - An optimized service mediation framework may use customized tokens for reducing cost and latencies per transaction. In particular, a token service and an integration service may function together to generate customized tokens for use by network components within a transaction pathway. Each network component may access information with the token for a predetermined time period and/or for a predetermined number of service calls for service processing tasks related to mapping, security, governing, bridging, transforming, orchestrating, generating events, managing workloads, routing, validating, managing cache, encrypting, queuing and staging, commodity services, transaction management, and quality of service (QoS)/resiliency, among other things. | 01-17-2013 |
20130019282 | Service Mediation FrameworkAANM Rice; Joseph AllenAACI Ballston LakeAAST NYAACO USAAGP Rice; Joseph Allen Ballston Lake NY USAANM Castagna; Brandon MatthewAACI Mount HollyAAST NCAACO USAAGP Castagna; Brandon Matthew Mount Holly NC US - A service mediation framework may allow each component within a computer network to perform common service processing tasks driven by standardized service policies stored within a centralized repository. In particular, an enhanced service domain name system (DNS) server, an enhanced service router, and/or an enhanced service gateway within the network may each access relevant service policies stored within an enhanced service repository to implement tasks such as security, content-based routing, logging, message format translation, and protocol bridging for each service request processed by the network. In addition, each network component may communicate through standardized formats, such as Extensible Markup Language (XML), to realize the end-to-end network solution. | 01-17-2013 |
20130019283 | Virtual Private InternetAANM Rice; Joseph AllenAACI Ballston LakeAAST NYAACO USAAGP Rice; Joseph Allen Ballston Lake NY USAANM Castagna; Brandon MatthewAACI Mount HollyAAST NCAACO USAAGP Castagna; Brandon Matthew Mount Holly NC US - A virtual private internet may include various network components, including an enhanced service domain name server (DNS), an enhanced service router, and an enhanced service gateway, which all access service policy information stored in an enhanced service repository. The network components in the virtual private internet perform common service processing tasks for routing service requests across firewalls and other network boundaries. The network components also execute other service policies, such as logging, message format translation, and protocol bridging for each service request processed by the network. Updates to services may be implemented in the virtual private internet via changes to service policy information stored in the enhanced service repository. | 01-17-2013 |
Patent application number | Description | Published |
20100055534 | ELECTROLYTE MEMBRANE, METHODS OF MANUFACTURE THEREOF AND ARTICLES COMPRISING THE SAME - Disclosed herein is a method of forming an electrolyte membrane comprising forming a mixture; the mixture comprising a polyhydroxy compound, an aromatic polyhalide compound and an alkali metal hydroxide; disposing the mixture on a porous substrate; reacting the mixture to form a crosslinked proton conductor; and sulfonating the proton conductor. Disclosed herein too is an article comprising a porous substrate; and a sulfonated crosslinked proton conductor disposed within pores of the porous substrate. | 03-04-2010 |
20100055535 | ELECTROLYTE MEMBRANE, METHODS OF MANUFACTURE THEREOF AND ARTICLES COMPRISING THE SAME - Disclosed herein is a method of forming an electrolyte membrane comprising forming a mixture; the mixture comprising a polyhydroxy compound, an aromatic polyhalide compound and an alkali metal hydroxide; disposing the mixture on a porous substrate; reacting the mixture to form a proton conductor; and crosslinking the proton conductor to form a cross-linked proton-conducting network. Disclosed herein too is an article comprising a porous substrate; and a crosslinked proton conductor disposed on the porous substrate. | 03-04-2010 |
20100297429 | COMPOSITE MEMBRANE AND METHOD OF MAKING - The present invention provides a composite membrane comprising a porous base membrane and a polyamide coating disposed on said porous base membrane, said polyamide coating comprising a C | 11-25-2010 |
20120080380 | THIN FILM COMPOSITE MEMBRANES INCORPORATING CARBON NANOTUBES - Processes for manufacturing a thin film composite membrane comprising multi-walled carbon nanotubes include contacting under interfacial polymerization conditions an organic solution comprising a polyacid halide with an aqueous solution comprising a polyamine to form a thin film composite membrane on a surface of a porous base membrane; at least one of the organic solution and the aqueous solution further including multi-walled carbon nanotubes having an outside diameter of less than about 30 nm. | 04-05-2012 |
20120080381 | THIN FILM COMPOSITE MEMBRANES INCORPORATING CARBON NANOTUBES - Processes for manufacturing a thin film composite membrane comprising multi-walled carbon nanotubes include contacting under interfacial polymerization conditions an organic solution comprising a polyacid halide and carbon nanotubes with an aqueous solution comprising a polyamine to form a thin film composite membrane on a surface of a porous base membrane, wherein the organic solution additionally comprises a saturated cyclic C | 04-05-2012 |
20120292249 | COMPOSITE MEMBRANE AND METHOD OF MAKING - The present invention provides a composite membrane comprising a porous base membrane and a polyamide coating disposed on said porous base membrane, said polyamide coating comprising a C | 11-22-2012 |
20130146530 | MEMBRANE, WATER TREATMENT SYSTEM, AND METHOD OF MAKING - One aspect of the present invention includes a membrane. The membrane includes a porous support and a polymeric layer disposed on the porous support. The membrane further includes a plurality of substantially hydrophobic mesoporous nanoparticles disposed within the polymeric layer. A water treatment system and a method of making a membrane are also presented. | 06-13-2013 |