Kiener, US
Peter Kiener, Doylestown, PA US
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20090148459 | Prevention or Treatment of Cancer Using Integrin alphavbeta3 Antagonists in Combination with Other Agents - The present invention relates to methods and compositions designed for the treatment, management or prevention of cancer. The methods of the invention comprise the administration of an effective amount of one or more antagonists of Integrin α | 06-11-2009 |
Peter A. Kiener, Doylestown, PA US
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20090162933 | EPHA2 AND HYPERPROLIFERATIVE CELL DISORDERS - The present invention relates to methods and compositions designed for the treatment, management, or prevention of a non-neoplastic hyperproliferative cell or excessive cell accumulation disorders, particularly those involving hyperproliferation of epithelial or endothelial cells. In one embodiment, the methods of the invention comprise the administration of an effective amount of one or more EphA2 agonistic agents that bind to EphA2 and increase EphA2 cytoplasmic tail phosphorylation and/or increase EphA2 autophosphorylation, in cells which EphA2 has been agonized. In another embodiment, the methods of the invention comprise the administration of an effective amount of one or more EphA2 agonistic agents that bind to EphA2 and reduce EphA2 activity (other than autophosphorylation). In another embodiment, the methods of the invention comprise administration of an effective amount of one or more EphA2 agonistic agents that bind to EphA2 and decrease a pathology-causing cell phenotype (e.g., a pathology-causing epithelial cell phenotype or a pathology-causing endothelial cell phenotype). In another embodiment, the methods of the invention comprise the administration of an effective amount of one or more EphA2 agonistic agents that are EphA2 antibodies that bind to EphA2 with a very low K | 06-25-2009 |
Peter A. Kiener, Potomac, MD US
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20120034212 | Human Anti-IL-6 Antibodies With Extended In Vivo Half-Life And Their Use In Treatment Of Oncology, Autoimmune Diseases And Inflammatory Diseases - The present invention provides human anti-IL-6 antibodies with extended in vivo half-life. The invention further relates to pharmaceutical compositions, therapeutic compositions, and methods using therapeutic antibodies that bind to IL-6 and that has an extended in vivo half-life for the treatment and prevention of IL-6 mediated diseases and disorders, such as, but not limited to, inflammatory diseases and disorders, autoimmune diseases and disorders and tumors. | 02-09-2012 |
Timm Kiener, Lake Orion, MI US
Patent application number | Description | Published |
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20090000297 | Re-Introduction Unit for Lp-Egr Condensate At/Before the Compressor - The present invention is an exhaust gas recirculation system for a motor vehicle, having a turbocharger unit ( | 01-01-2009 |
20090013978 | Integrated Charge Air and Egr Valve - An engine assembly ( | 01-15-2009 |
20090056683 | Two Component Low Pressure Egr Module - An engine ( | 03-05-2009 |
20090071150 | Mixing Unit for LP-EGR Condensate Into the Compressor - The present invention is a an exhaust gas return system ( | 03-19-2009 |
20110061625 | EXHAUST THROTTLE-EGR VALVE MODULE FOR A DIESEL ENGINE - A valve assembly for use in an air management assembly having an engine, an exhaust side, and an intake side, where the valve assembly provides a housing, a plurality of openings in the housing, a valve in the housing, and an actuator operably connected to the valve. The housing is in fluid communication with the exhaust side and the intake side. The plurality of openings in the housing form at least one inlet and at least one outlet in the housing. The valve moves with respect to the plurality of openings. | 03-17-2011 |
20120087785 | MULTI-STAGE TURBOCHARGER ARRANGEMENT - The present invention relates to a multi-stage turbocharger arrangement ( | 04-12-2012 |
20120093631 | MULTI-STAGE TURBOCHARGER ARRANGEMENT - The present invention relates to a multi-stage turbocharger arrangement ( | 04-19-2012 |