Patent application number | Description | Published |
20120143718 | OPTIMIZATION OF A WEB-BASED RECOMMENDATION SYSTEM - A method for determining product recommendations to be presented to users includes forming, by a formula generation module, a plurality of different recommendation formulas, including, for each recommendation formula, assigning a weight to at least some of a plurality of recommendation characteristics, wherein each recommendation characteristic is representative of at least one of a characteristic of a product, a characteristic of a method for presenting the product recommendations to the users, and a characteristic of a user. The method further includes iteratively performing the steps of: for each of the plurality of recommendation formulas, selecting, by a product recommendation module, at least one product for presentation to the users on the basis of the corresponding recommendation formula; sending, by a communications module, instructions to a server to present the selected product to the users; receiving, by a data evaluation module, data representative of user responses to each of the products presented to the users; evaluating, by the data evaluation module, the received data; and selecting, using the data evaluation module, a subset of the recommendation formulas included in the plurality of recommendation formulas on the basis of the evaluation of the collected data. | 06-07-2012 |
Patent application number | Description | Published |
20090019359 | METHOD AND APPARATUS CREATING NETWORK SERVICES - As supposed to the common hard coding method, the invention provides the ability to create a module/mechanism (a template) that produces code that may be utilized to create a web service. A template has a list of features, and a model (a run time model—RTM) and is utilized to create a model that generates an application or web service. An RTM declares the structure, functionality, and behavior of a web service application. Each feature can generate XML entities in a new RTM, and may obtain input to build an XML entity in a new RTM. Each feature may be processed sequentially and can modify any existing XML entities. Consequently, features can make changes to the entire existing application. In one embodiment, when a condition that may affect an application changes, the template may be utilized to regenerate the RTM to produce a new web service or XML document. | 01-15-2009 |
20100274674 | MEDIA NAVIGATION SYSTEM - A media navigation system provides a user interface for navigating and interacting with streamed media objects, including video. The system may employ media markers representing time locations within a media file in addition to images or other representations derived from the media object. The system displays a tile layout representing a sequence of the media at an interval comprising a set of sub intervals corresponding to the tiles, and enables a user to click on the tiles to navigate to a next set of tiles which correspond to a different interval, and which replace the currently displayed tiles on the display. Navigation can include zooming in (smaller interval), zooming out (larger interval) and “panning” (preceding or succeeding interval) at arbitrary intervals. Individual tiles may also include visual indicators of relative importance or activity such as the number of comments associated with a sub interval. | 10-28-2010 |
20110161409 | MEDIA MASHUP SYSTEM - A media mashup system functions as a virtualizable endpoint called an Intelligent Multimedia Pod, or IMP, that ensures a reliable and high-quality multimedia user-experience for a variety of mobile user devices such as intelligent phones etc. The media mashup platform uses a web 2.0 media mashup model that offers several key features including Near Real Time (NRT) service continuity, control-proxy for a mobile-friendly web-surfing experience, finely-filtered content aggregation based on meta-data, context sensors and buddy blaster content sharing/recommendation. These features are brought together using a web 2.0 service mashup model that integrates media meta-data together with various context sensors including mobility-related sensors such as location and presence, time-of-day, voice commands, as well as time-shifted playback. | 06-30-2011 |
20110313979 | PROCESSING RELATED DATASETS - Processing related datasets includes receiving over an input device or port records from multiple datasets, the records of a given dataset having one or more values for one or more respective fields; and processing records from each of the multiple datasets in a data processing system. The processing includes: analyzing at least one constraint specification stored in a data storage system to determine a processing order for the multiple datasets, the constraint specification specifying one or more constraints for preserving referential integrity or statistical consistency among a group of related datasets that includes the multiple datasets, applying one or more transformations to records from each of the multiple datasets in the determined processing order, where the transformations are applied to records from a first dataset of the multiple datasets before the transformations are applied to records from a second dataset of the multiple datasets, and the transformations applied to the records from the second dataset are applied based at least in part on results of applying the transformations to the records from the first dataset and at least one constraint between the first dataset and the second dataset specified by the constraint specification, and storing or outputting results of the transformations to the records from each of the multiple datasets. | 12-22-2011 |
20120179726 | FLOW ANALYSIS INSTRUMENTATION - Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for flow analysis. In one aspect, a method includes modifying a dataflow graph, the dataflow graph including a plurality of paths connecting at least one entry point and at least one exit point, including adding components to the dataflow graph that add flow units to data records and remove flow units from data records, each flow unit identifying a segment of a path traversed by the data record. The method also includes identifying execution paths based on flow units obtained by processing a plurality of data records using the modified dataflow graph. The method also includes determining a subset of the plurality of data records, wherein a selected set of execution paths are represented by the subset. | 07-12-2012 |
20140222752 | DATA RECORDS SELECTION - A computer-implemented method includes accessing a plurality of data records, each data record having a plurality of data fields. The method further includes analyzing values for one or more of the data fields for at least some of the plurality of data records and generating a profile of the plurality of data records based on the analyzing. The method further includes formulating at least one subsetting rule based on the profile; and selecting a subset of data records from the plurality of data records based on the at least one subsetting rule. | 08-07-2014 |
Patent application number | Description | Published |
20120058082 | METHODS AND COMPOSITIONS FOR TREATMENT - The invention provides methods for improving the efficacy and reducing side effects of anti-CD52 antibody treatment. The methods can be used to treat patients who are in need of immunoregulation such as lymphocyte depletion and patients who have cancer. Also included are compositions useful for these methods. | 03-08-2012 |
20120070408 | METHODS AND COMPOSITIONS FOR TREATING LUPUS - The invention provides methods of treating lupus in a patient with an anti-CD52 antibody. Also includes are methods of increasing infiltration of regulatory T cells to affected sides of the patient's body, methods of reducing urine protein and/or albumin levels and methods of depleting lymphocytes to alleviate lupus symptoms. | 03-22-2012 |
20120100152 | ANTI-HUMAN CD52 IMMUNOGLOBULINS - The present invention relates to humanized immunoglobulins, mouse monoclonal antibodies and chimeric antibodies that have binding specificity for human CD52. The present invention further relates to a humanized immunoglobulin light chain and a humanized immunoglobulin heavy chain. The invention also relates to isolated nucleic acids, recombinant vectors and host cells that comprise a sequence which encodes a humanized immunoglobulin or immunoglobulin light chain or heavy chain, and to a method of preparing a humanized immunoglobulin. The humanized immunoglobulins can be used in therapeutic applications to treat, for example, autoimmune disease, cancer, non-Hodgkin's lymphoma, multiple sclerosis and chronic lymphocytic leukemia. | 04-26-2012 |
20140341910 | ANTI-HUMAN CD52 IMMUNOGLOBULINS - The present invention relates to humanized immunoglobulins, mouse monoclonal antibodies and chimeric antibodies that have binding specificity for human CD52. The present invention further relates to a humanized immunoglobulin light chain and a humanized immunoglobulin heavy chain. The invention also relates to isolated nucleic acids, recombinant vectors and host cells that comprise a sequence which encodes a humanized immunoglobulin or immunoglobulin light chain or heavy chain, and to a method of preparing a humanized immunoglobulin. The humanized immunoglobulins can be used in therapeutic applications to treat, for example, autoimmune disease, cancer, non-Hodgkin's lymphoma, multiple sclerosis and chronic lymphocytic leukemia. | 11-20-2014 |
Patent application number | Description | Published |
20080237905 | Preparation of polyphosphazene microspheres - Methods of producing polyphosphazene microspheres comprising admixing aqueous solutions of a water-soluble polyphosphazene and an organic amine, or salt thereof, are disclosed. | 10-02-2008 |
20110009570 | Preparation of polyphosphazene microspheres - Methods of producing polyphosphazene microspheres comprising admixing aqueous solutions of a water-soluble polyphosphazene and an organic amine, or salt thereof, are disclosed. | 01-13-2011 |
20120214951 | PREPARATION OF POLYPHOSPHAZENE MICROSPHERES - Methods of producing polyphosphazene microspheres comprising admixing aqueous solutions of a water-soluble polyphosphazene and an organic amine, or salt thereof, are disclosed. | 08-23-2012 |
20120225116 | BIODEGRADABLE POLYPHOSPHAZENES CONTAINING PYRROLIDONE SIDE GROUPS - Biodegradable polyphosphazene polymers containing pyrrolidone side groups, and the biomedical use of such polyphosphazene polymers are disclosed. | 09-06-2012 |
20130137835 | Preparation of Polyphosphazene Microspheres - Methods of producing polyphosphazene microspheres comprising admixing aqueous solutions of a water-soluble polyphosphazene and an organic amine, or salt thereof, are disclosed. | 05-30-2013 |
Patent application number | Description | Published |
20130215126 | Managing Font Distribution - A system includes a first computing device that includes a memory configured to store instructions. The first computing device also includes a processor to execute the instructions to perform a method that includes receiving, at a font service provider, a request from a second computing device for one or more fonts. The method also includes authenticating the user of the second computing device from the received request, and, providing access to data representative of the one or more fonts identified in the received request for use by the second computing device. The data representative of the one or more fonts resides in a predefined portion of memory assigned to the user of the second computing device. | 08-22-2013 |
20140047329 | Network Based Font Subset Management - A system includes a first computing device that includes a memory configured to store instructions. The first computing device also includes a processor to execute the instructions to perform a method that includes receiving one or more environment characteristics of a communication connection between a user device and a font provider. The method also includes determining an appropriate amount of font information of a web asset to provide to the user device based upon the one or more environment characteristics, and, providing the appropriate amount of font information of the web asset to the user device for presenting the web asset. | 02-13-2014 |
20140153012 | Network Based Font Management for Imaging Devices - A system includes a computing device that includes a memory configured to store instructions. The computing device also includes a processor to execute the instructions to perform operations that include receiving a request from an imaging device indicating that the imaging device is unable to present textual content of an asset. The request includes one or more attributes of the textual content of the asset and the request is sent from the imaging device absent user input. Operations also include identifying an appropriate amount of font information from the received one or more attributes for the imaging device to present the asset, and, providing the identified font information to the imaging device for presenting the asset. | 06-05-2014 |
Patent application number | Description | Published |
20130254663 | Systems, Methods, Apparatus, and Articles of Manufacture to Provide Guest Access - An example method includes displaying a playback queue for a media playback system to a first and second controller via a first user interface associated with the first controller and a second user interface associated with the second controller, the first controller granted a first access to the system and the second controller granted a second access to the system, the first controller displaying a subset of information available to the second controller. The example method includes displaying a plurality of controls for the system via the second user interface of the second controller, the controls associated with the second access. The example method includes displaying a subset of the controls via the first user interface, the subset including at least one control available via the second controller and associated with the first access. The example method includes facilitating control via the first user interface according to the first access. | 09-26-2013 |
20130346859 | Systems, Methods, Apparatus, and Articles of Manufacture to Provide a Crowd-Sourced Playlist with Guest Access - Systems and methods are provided to offer a restricted playback mode playlist mode to allow one or more participating users to access a host's media playback system and interact with a reduced subset of functions in that system. An example method includes providing, via a local media playback system, a restricted playback mode open to a plurality of participating users, the restricted playback mode providing a subset of playback functions from the local media playback system to the participating users, the subset including addition of content to a playlist for playback via the local media playback system. The example method includes facilitating addition of content to the playlist by at least one participating user. The example method includes facilitating playback of content from the playlist in the restricted playback mode. | 12-26-2013 |
20130347022 | Systems, Methods, Apparatus, and Articles of Manufacture to Provide Guest Access - An example method includes linking a guest controller to a media playback system including a zone player with a playback queue. The playback queue includes information identifying media items to be played by the zone player. The media playback system provides the guest controller with a second access more limited than a first access granted to a local controller associated with the media playback system. The example method includes receiving, by the media playback system, a message sent from the guest controller, the message including a media service credential and an identification of a media item to be played by the zone player. The example method includes placing, by the media playback system, information identifying the media item from the guest controller in the playback queue. The example method includes retrieving media for the media item, by the media playback system, using the media service credential. | 12-26-2013 |
Patent application number | Description | Published |
20110295359 | Stent With Reduced Weld Profiles and a Closed-End Wire Configuration - A method for making an implantable stent includes the steps of (i) providing a plurality of elongate stent wires; (ii) forming said wires into a hollow tubular structure having opposed first and second open ends; (iii) terminating said wires at the second end; (iv) aligning the wires at the second end into a plurality of mated adjacent wires to define a plurality of abutting regions; (v) welding the mated adjacent wires to one and the other at the abutting regions to define a plurality of welds; and optionally (vi) chemically or electro-chemically removing a portion of the welds. The method may further include the steps of (a) extending at least one of the mated stent wires to provide an extended stent wire; (b) looping the extended stent wire so the extended end abuts a proximal pair of stent wires; and (c) welding the extended and looped wire to the proximal pair of wires. The step of looping may include the forming of the wire into a equilaterally arched loop having an apex, but not having other sharp bends. | 12-01-2011 |
20130274685 | RAPID EXCHANGE ENTERAL STENT DELIVERY SYSTEM - Devices for palliating gastrointestinal strictures using rapid exchange type enteral stent placement catheters. The catheter may include an inner member and an outer member, with the two members being slidable with respect to one another. In various device embodiments, a ramp for directing a guidewire out from within the catheter is provided using portions of the outer member or a shaped mandrel. The inner member may take a number of forms, including a tubular distal portion, a skived or integrally attached elongate midsection, and a proximal portion. A mandrel can be used in a portion proximal of the guidewire ramp, with the mandrel taking one of several disclosed forms. | 10-17-2013 |
20140074220 | Stent With Reduced Weld Profiles and a Closed-End Wire Configuration - A prosthesis including a composite wire forming a mesh, the mesh having a variable diameter wherein at least one end region has a larger diameter than a middle portion; the mesh having an exterior surface and an interior surface, wherein at least one of the surfaces is covered with silicone; and a retrieval loop positioned at at least one end of the mesh. | 03-13-2014 |
Patent application number | Description | Published |
20090298622 | Electronic Pitching Trainer and Method for Determining the True Speed of a Sports Projectile - A sensing device obtains range-related data—such as Doppler data or pulse time-of-flight data—from a sports projectile during flight. The time course of the range-related data is employed, in light of predictable characteristics of the projectile trajectory, to determine and output an accurate determination of the projectile speed for one or more points of interest in its flight. Such determination of speed may, for instance, be the speed at the time of projectile release, even though range-related data is gathered later in the flight, when the projectile is traveling neither so fast, nor straight at the sensor. Such sensing device may employ inexpensive short-range acoustic Doppler, and be incorporated into a target device that automatically displays to a pitcher-in-training the speed and ball/strike condition of each pitch. | 12-03-2009 |
20110294607 | Electronic Pitching Trainer and Method for Determining the True Speed of a Sports Projectile - A sensing device obtains range-related data—such as Doppler data or pulse time-of-flight data—from a sports projectile during flight. The time course of the range-related data is employed, in light of predictable characteristics of the projectile trajectory, to determine and output an accurate determination of the projectile speed for one or more points of interest in its flight. Such determination of speed may, for instance, be the speed at the time of projectile release, even though range-related data is gathered later in the flight, when the projectile is traveling neither so fast, nor straight at the sensor. Such sensing device may employ inexpensive short-range acoustic Doppler, and be incorporated into a target device that automatically displays to a pitcher-in-training the speed and ball/strike condition of each pitch. | 12-01-2011 |
20130291636 | Electronic Pitching Trainer and Method for Determining the True Speed of a Sports Projectile - A sensing device obtains range-related data—such as Doppler data or pulse time-of-flight data—from a sports projectile during flight. The time course of the range-related data is employed, in light of predictable characteristics of the projectile trajectory, to determine and output an accurate determination of the projectile speed for one or more points of interest in its flight. Such determination of speed may, for instance, be the speed at the time of projectile release, even though range-related data is gathered later in the flight, when the projectile is traveling neither so fast, nor straight at the sensor. Such sensing device may employ inexpensive short-range acoustic Doppler, and be incorporated into a target device that automatically displays to a pitcher-in-training the speed and ball/strike condition of each pitch. | 11-07-2013 |
Patent application number | Description | Published |
20110048713 | Radiation-Induced Triggering for Set-On-Command Compositions and Methods of Use - The present invention relates to methods useful for isolating a portion of a wellbore. In one embodiment, a method includes preparing a sealant composition containing a set modifier component. The sealant composition is placed into the wellbore and is subjected to ionizing radiation that alters the set modifier component, triggering the thickening of the sealant composition. | 03-03-2011 |
20110054068 | Radiation-Induced Triggering for Set-On-Command Compositions - The present invention relates to compositions useful for isolating a portion of a wellbore. In one embodiment, a composition includes a sealant composition containing a wellbore treatment fluid and a set modifier component. The sealant composition can be placed into the wellbore and subjected to ionizing radiation that alters the set modifier component, triggering the setting of the sealant composition. | 03-03-2011 |
20110272141 | Radiation-Induced Triggering for Set-On-Command Sealant Compositions and Methods of Use - The present invention relates to methods useful for isolating a portion of a wellbore. In one embodiment, a method includes preparing a sealant composition containing a set modifier component. The sealant composition is placed into the wellbore and is subjected to ionizing radiation that alters the set modifier component, triggering the thickening of the sealant composition. | 11-10-2011 |
20130000891 | Radiation-Induced Triggering for Set-On-Command Compositions and Methods of Use - Methods of isolating a portion of a wellbore comprising placing a sealant composition into a subterranean formation after drilling of the wellbore therein and subjecting the sealant composition to ionizing radiation wherein subjecting the sealant composition to the ionizing radiation alters the set modifier. The sealant composition comprises a set modifier selected from the group consisting of an accelerator, an oxidizing agent, a set retarder, and combinations thereof. And the sealant composition comprises a polymeric component. | 01-03-2013 |
20140116298 | Radiation-Induced Triggering for Set-on-Command Sealant Compositions - Sealant compositions comprising: a wellbore treatment fluid; a set modifier; and, a polymeric component that inhibits release of the set modifier; wherein exposure to ionizing radiation causes degradation of the polymeric component resulting in release of the set modifier and an increase in the mechanical strength of the sealant composition. | 05-01-2014 |
Patent application number | Description | Published |
20110320040 | Method For Adjusting Concrete Rheology Based Upon Nominal Dose-Response Profile - The invention relates to a method for adjusting concrete rheology requiring only that load size and target rheology value be selected initially rather than requiring inputs into and consultation of a lookup table of parameters such as water and hydration levels, mix components, temperature, humidity, aggregate components, and others. Dosage of particular rheology-modifying agent or combination of rheology-modifying agents is calculated based on a percentage of a nominal dose calculated with reference to a nominal dose response (“NDR”) curve or profile. The NDR profile is based on a correlation between a rheology value (e.g., slump, slump flow, yield stress) and the rheology-modifying agent(s) dose required to change rheology value by one unit (e.g., slump change from 2 to 3 inches) such that exemplary methods can employ corrective dosing based on the NDR and the measured deviation by the system. | 12-29-2011 |
20120250446 | Fluid Dispensing System and Method for Concrete Mixer - System and method for dispensing liquids into concrete mixer drums, particularly suitable for use on concrete mix trucks, involve use of liquid admixtures nozzle that is separate from water conduit and water nozzle, the admixtures nozzle being aimed and focused to spray through drum opening with dispersion pattern substantially within air/concrete interface defined by minimal volume concrete contained within the drum; and the water conduit or nozzle having a dispersion pattern preferably whereby wash water hits a portion of the inner drum wall and a portion of the air/concrete interface defined by a maximum amount of concrete contained within the drum. In preferred embodiments, a check valve assembly is used to connect separate admixture and water lines, so that both admixture and water nozzles can be used simultaneously during purging operation. | 10-04-2012 |
20130145967 | MULTIVARIATE MANAGEMENT OF ENTRAINED AIR AND RHEOLOGY IN CEMENTITIOUS MIXES - The invention relates to a method and system for monitoring and adjusting both air content and rheology (e.g., slump, slump flow) properties of a hydratable concrete mix contained within a concrete mixer. The system simultaneously tracks dosage of both rheology-modifying admixture (e.g., polycarboxylate polymer cement dispersant) and air control agent or “ACA” (e.g., air entraining agent) by reference to at least four nominal dose response (“NDR”) curves or profiles, which at least four NDR profiles are based on the respective behaviors of each of the ACA and rheology-modifying agent on air content and rheology. | 06-13-2013 |
20130272084 | MULTIVARIATE MANAGEMENT OF ENTRAINED AIR AND RHEOLOGY IN CEMENTITIOUS MIXES - The invention relates to a method and system for monitoring and adjusting both air content and rheology (e.g., slump, slump flow) properties of a hydratable concrete mix contained within a concrete mixer. The system simultaneously tracks dosage of both rheology-modifying admixture (e.g., polycarboxylate polymer cement dispersant) and air control agent or “ACA” (e.g., air entraining agent) by reference to at least four nominal dose response (“NDR”) curves or profiles, which at least four NDR profiles are based on the respective behaviors of each of the ACA and rheology-modifying agent on air content and rheology. | 10-17-2013 |
20140104066 | SNEAK WATER DETECTION FOR CONCRETE DELIVERY VEHICLES - The invention provides a method and system for detecting “sneak” additions of water or other fluid into the mixing drum of a concrete delivery vehicle having an automated rheology (e.g., slump) monitoring system. Sneak fluid additions are detected based on continuous rheology monitoring, even where valves and flow meters on the delivery vehicle are not used for the fluid addition. The invention is effective for monitoring additions by truck drivers who might add water from an undocumented water source (e.g., hose) along the delivery route or at the site, to hasten pouring, placement, and finishing at the time of delivery. Once sneak fluid addition is detected, the methods and system provide for reporting in the form of alerts, alarms, or other indications that sneak fluid addition has occurred, including monitor graphs or printouts confirming existence and/or extent of sneak fluid added into the vehicle mixing drum. | 04-17-2014 |
20140104972 | TREATING AND REPORTING VOLUME OF CONCRETE IN DELIVERY VEHICLE MIXING DRUM - Disclosed are method and system for treating concrete in mixing drums of delivery vehicles having automated rheology (e.g., slump) monitoring systems programmed to dose fluids into concrete based on the monitored rheology. The present invention takes into account a Revolution-To-Discharge value (“RTD”) which reflects drum rotations needed to move concrete towards and through the mixing drum opening from which concrete is discharged, and also takes into consideration a Volume-Per-Revolution-Upon-Discharge (“VPRUD”) value which reflects the relation between the rate of discharge and rheology (e.g., slump) of concrete upon discharge. The invention is especially useful for reclaiming concrete in the drum after delivery and can confirm rheology based upon peak (maximum) discharge pressure. The present inventors found surprisingly that discharge pressure readings are useful for recalibrating automated rheology monitoring systems as well as for reporting and/or treating the remainder concrete. | 04-17-2014 |
20150142362 | Determination of Gyroscopic Based Rotation - A gyroscopic rotational monitoring system may be utilized for monitoring one or more properties of rotatable container or vessel, and/or one or more properties of a displaceable material contained in the rotatable vessels. An exemplary aspect relates to the use of a gyroscope and periodicity sensor (e.g., accelerometer) to determine rotational speed of a concrete mixing drum, so that the slump or other property of the concrete can be monitored or adjusted such as by dosing with water, chemical admixtures, or mixture thereof. | 05-21-2015 |
Patent application number | Description | Published |
20130046598 | METHOD AND SYSTEM FOR PLACING AND COLLECTIVELY DISCOUNTING PURCHASE ORDERS VIA A COMMUNICATIONS NETWORK - Disclosed are a method and system for placing and collectively discounting purchase orders via a communications network. A collective discount platform, comprising engines and components, receives postponable purchase requests from client systems for an identified good with an undetermined transaction date. Once the postponable purchase requests meet an established criterion time constraints for receiving additional purchase requests are determined. When a time constraint is determined additional purchase requests may aggregate and discount the unit sale price for both postponable and additional purchase requests. When time constraints prohibit the aggregation of additional purchase requests individual payments are claimed from participating client systems. | 02-21-2013 |
20140106033 | Beverage Supplement and Method for Making the Same - A beverage supplement and method for making the same is disclosed. In some embodiments the beverage supplement is comprised of a first frozen composition made from at least one additive mixed with at least one liquid and a second frozen composition made from at least one additive mixed with at least one liquid, wherein the resulting frozen compositions may have different/varying surface areas, shapes, volumes, flavors, and concentrations. Varying the combination of surface areas, shapes, volumes, formulas, flavors, and concentrations of frozen compositions influences the duration of complete liquefaction and the release of additives, allowing a user to create an iced beverage with greater flavor control. | 04-17-2014 |
Patent application number | Description | Published |
20080206832 | Selection and Enrichment of Proteins Using in vitro Compartmentalization - Compositions and methods are provided for selection and enrichment of a target gene from a library of polynucleotide sequences such as might be formed from a genome or by random mutagenesis of a genetic sequence. The selection and enrichment occurs in aqueous droplets formed in an emulsion that compartmentalize individual polynucleotides from the library or a plurality of polynucleotides that may include polynucleotides not derived from the library, transcription and translation reagents and optionally additional chemical and enzyme reagents. The selection and enrichment method utilizes a polynucleotide adaptor which when ligated to the polynucleotide fragment enables amplification to occur in the presence of an adaptor specific primer. | 08-28-2008 |
20100167942 | Compositions, Methods and Related Uses for Cleaving Modified DNA - Compositions, methods and related uses are provided relating to cleaving modified DNA. For example, a set of DNA fragments obtainable by enzymatic cleavage of a large DNA is described where at least 50% are similarly sized and have a centrally positioned modified nucleotide. In addition, an enzyme preparation is provided that includes one or more enzymes that recognize a modified nucleotide in a DNA and cleave the DNA at a site that is at a non-random distance from the modified nucleotide. The one or more enzymes are further characterized by an N-terminal conserved domain with greater than 90% amino acid sequence homology to WXD(X) | 07-01-2010 |
20100330551 | Novel Restriction Endonucleases, DNA Encoding These Endonucleases and Methods for Identifying New Endonucleases with the Same or Varied Specificity - Specified restriction endonucleases have been characterized for the first time by their amino acid and DNA sequences. These sequences and those with at least 90% identity thereto have been used as probes in sequence similarity analyses to identify sequence matches in a sequence database that corresponds to novel restriction endonucleases or isoschizomers. The sequence similarity analyses includes selecting a positive sequence match from any sequence producing an expectation value of less than or equal to e-02. | 12-30-2010 |
20120156677 | Detection and Quantification of Hydroxymethylated Nucleotides in a Polynucleotide Preparation - Methods and compositions are described for detecting hydroxymethylated nucleotides (hmNs) in a polynucleotide preparation with a view to mapping the location of hmNs in a genome, quantifying the occurrence of hmNs at selected loci and correlating the occurrence of hmNs with gene expression and phenotypic traits. Embodiments describe the use of modifying enzymes together with site-specific endonucleases to detect the hmNs. | 06-21-2012 |
20120172236 | Selection and Enrichment of Proteins Using In Vitro Compartmentalization - Compositions and methods are provided for selection and enrichment of a target gene from a library of polynucleotide sequences such as might be formed from a genome or by random mutagenesis of a genetic sequence. The selection and enrichment occurs in aqueous droplets formed in an emulsion that compartmentalize individual polynucleotides from the library or a plurality of polynucleotides that may include polynucleotides not derived from the library, transcription and translation reagents and optionally additional chemical and enzyme reagents. The selection and enrichment method utilizes a polynucleotide adaptor which when ligated to the polynucleotide fragment enables amplification to occur in the presence of an adaptor specific primer. | 07-05-2012 |
20120202712 | Compositions, Methods and Related Uses for Cleaving Modified DNA - Compositions, methods and related uses are provided relating to cleaving modified DNA. For example, a set of DNA fragments obtainable by enzymatic cleavage of a large DNA is described where at least 50% are similarly sized and have a centrally positioned modified nucleotide. In addition, an enzyme preparation is provided that includes one or more enzymes that recognize a modified nucleotide in a DNA and cleave the DNA at a site that is at a non-random distance from the modified nucleotide. The one or more enzymes are further characterized by an N-terminal conserved domain with greater than 90% amino acid sequence homology to WXD(X) | 08-09-2012 |
20120254213 | Novel Restriction Endonucleases, DNA Encoding These Endonucleases and Methods for Identifying New Endonucleases with the Same or Varied Specificity - Specified restriction endonucleases have been characterized for the first time by their amino acid and DNA sequences. These sequences and those with at least 90% identity thereto have been used as probes in sequence similarity analyses to identify sequence matches in a sequence database that corresponds to novel restriction endonucleases or isoschizomers. The sequence similarity analyses includes selecting a positive sequence match from any sequence producing an expectation value of less than or equal to e−02. | 10-04-2012 |
20130224832 | Novel Restriction Endonucleases, DNA Encoding These Endonucleases and Methods for Identifying New Endonucleases with the Same or Varied Specificity - Specified restriction endonucleases have been characterized for the first time by their amino acid and DNA sequences. These sequences and those with at least 90% identity thereto have been used as probes in sequence similarity analyses to identify sequence matches in a sequence database that corresponds to novel restriction endonucleases or isoschizomers. The sequence similarity analyses includes selecting a positive sequence match from any sequence producing an expectation value of less than or equal to e−02. | 08-29-2013 |
20130244304 | Novel Restriction Endonucleases, DNA Encoding These Endonucleases and Methods for Identifying New Endonucleases with the Same or Varied Specificity - Specified restriction endonucleases have been characterized for the first time by their amino acid and DNA sequences. These sequences and those with at least 90% identity thereto have been used as probes in sequence similarity analyses to identify sequence matches in a sequence database that corresponds to novel restriction endonucleases or isoschizomers. The sequence similarity analyses includes selecting a positive sequence match from any sequence producing an expectation value of less than or equal to e-02. | 09-19-2013 |
20130331300 | Selection and Enrichment of Proteins Using In Vitro Compartmentalization - Compositions and methods are provided for selection and enrichment of a target gene from a library of polynucleotide sequences such as might be formed from a genome or by random mutagenesis of a genetic sequence. The selection and enrichment occurs in aqueous droplets formed in an emulsion that compartmentalize individual polynucleotides from the library or a plurality of polynucleotides that may include polynucleotides not derived from the library, transcription and translation reagents and optionally additional chemical and enzyme reagents. The selection and enrichment method utilizes a polynucleotide adaptor which when ligated to the polynucleotide fragment enables amplification to occur in the presence of an adaptor specific primer. | 12-12-2013 |
20140106350 | COMPOSITIONS, METHODS AND RELATED USES FOR CLEAVING MODIFIED DNA - Compositions, methods and related uses are provided relating to cleaving modified DNA. For example, a set of DNA fragments obtainable by enzymatic cleavage of a large DNA is described where at least 50% are similarly sized and have a centrally positioned modified nucleotide. In addition, an enzyme preparation is provided that includes one or more enzymes that recognize a modified nucleotide in a DNA and cleave the DNA at a site that is at a non-random distance from the modified nucleotide. The one or more enzymes are further characterized by an N-terminal conserved domain with greater than 90% amino acid sequence homology to WXD(X) | 04-17-2014 |
20140127683 | Compositions and Methods for Oxygenation of Nucleic Acids Containing 5-Methylpyrimidine - 5-methylpyrimidine oxygenases and their use in the modification of nucleic acids are described. | 05-08-2014 |
20140194299 | COMPOSITIONS, METHODS AND RELATED USES FOR CLEAVING MODIFIED DNA - Compositions, methods and related uses are provided relating to cleaving modified DNA. For example, a set of DNA fragments obtainable by enzymatic cleavage of a large DNA is described where at least 50% are similarly sized and have a centrally positioned modified nucleotide. In addition, an enzyme preparation is provided that includes one or more enzymes that recognize a modified nucleotide in a DNA and cleave the DNA at a site that is at a non-random distance from the modified nucleotide. The one or more enzymes are further characterized by an N-terminal conserved domain with greater than 90% amino acid sequence homology to WXD(X) | 07-10-2014 |
20150132750 | Compositions and Methods for Oxygenation of Nucleic Acids Containing 5-Methylpyrimidine - 5-methylpyrimidine oxygenases and their use in the modification of nucleic acids are described. | 05-14-2015 |
20150218530 | Compositions and Methods for Oxygenation of Nucleic Acids Containing 5-Methylpyrimidine - 5-methylpyrimidine oxygenases and their use in the modification of nucleic acids are described. | 08-06-2015 |
20150240310 | Detection and Quantification of Hydroxymethylated Nucleotides in a Polynucleotide Preparation - Methods and compositions are described for detecting hydroxymethylated nucleotides (hmNs) in a polynucleotide preparation with a view to mapping the location of hmNs in a genome, quantifying the occurrence of hmNs at selected loci and correlating the occurrence of hmNs with gene expression and phenotypic traits. Embodiments describe the use of modifying enzymes together with site-specific endonucleases to detect the hmNs. | 08-27-2015 |
Patent application number | Description | Published |
20120274217 | HYBRID REFLECTOR INCLUDING LIGHTGUIDE FOR SENSOR - A luminaire is providing, having a substrate of a particular shape and a plurality of solid state light sources mounted thereon. The plurality has a measurable characteristic and includes an adjustable solid state light source, such that the characteristic changes in response to adjustment thereof. The luminaire also includes a sensor that detects the characteristic from outputted light, compares it to a baseline value and, based on the comparison, so adjusts the adjustable solid state light source. The luminaire also includes a reflector with a lower edge that conforms to the particular shape of the substrate, and reflects outputted light from the plurality so that it exits past the reflector's upper edge. The luminaire also includes a lightguide having an input that is surrounded by the reflector and captures a portion of the outputted light so as to provide the captured outputted light to the sensor. | 11-01-2012 |
20130214118 | TORSION-BASED LUMINAIRE SUSPENSION MECHANISM - A luminaire suspension mechanism is provided. The mechanism includes two arms, two friction elements, and a compression element. Each arm includes three segments and two connection points. For each arm, a first segment attaches to a second segment at a connection point, forming a first angle, while the second segment attaches to a third segment at another connection point, forming a second angle. Each friction element is connected to a respective arm's third segment. Each arm's first segment is compressably attached to the compression element, such that a force applied to at least one of the arm-friction element pairs results in the compression element and that at least one pair exerting a suspending force that suspends a luminaire to which the luminaire suspension mechanism is attached within a cavity. The compression element may be a torsion spring, and the angles formed by the arm segments may be obtuse. | 08-22-2013 |
Patent application number | Description | Published |
20090005321 | Phenylazetidinone Derivatives - Various azetidinone derivatives are described, as are pharmaceutical compositions containing these compounds and methods of treatment of diseases using these compounds. Other embodiments are also described. | 01-01-2009 |
20090054319 | Methods and Compositions for the Treatment of Hypertension and Gastrointestinal Disorders - The use of guanylin potentiating agents for treating various disorders, including hypertension as well as IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, chronic intestinal pseudo-obstruction, colonic pseudo-obstruction, Crohn's disease, duodenogastric reflux, dyspepsia, functional dyspepsia, nonulcer dyspepsia, a functional gastrointestinal disorder, functional heartburn, gastroesophageal reflux disease (GERD), gastroparesis, inflammatory bowel disease, irritable bowel syndrome, post-operative ileus, ulcerative colitis, chronic constipation, and disorders and conditions associated with constipation is described. | 02-26-2009 |
20090253634 | Methods and Compositions for the Treatment of Gastrointestinal Disorders - The present invention features compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastnoesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, Inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), and disorders and conditions associated with constipation, e.g. constipation associated with use of opiate pain killers, post-surgical constipation (post-operative ileus), and constipation associated with neuropathic disorders as well as other conditions and disorders using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor. | 10-08-2009 |
Patent application number | Description | Published |
20100098830 | High satiety, low calorie solid food product with high protein and fiber content - Low sugar solid food product such as a cracker, chip, shelf-stable bread or crouton, that promotes satiety primarily as a result of its high fiber and protein content. The fiber plus protein content, expressed in grams, times n=kcal per portion, where n is from 5 to 10 gives a result from 1 to 3. | 04-22-2010 |
20110008906 | Genetic Association of Polymorphisms in Perilipin (PLIN) Gene With Resistance to Weight Loss - Diagnostics and therapeutics for resistance to weight-loss, which are based upon the identification of a subject's PLIN polymorphisms, haplotype and genotype pattern, are described in this invention. | 01-13-2011 |
20130011841 | Genetic Association of Polymorphisms in Perilipin (PLIN) Gene With Resistance to Weight Loss - Diagnostics and therapeutics for resistance to weight-loss, which are based upon the identification of a subject's PLIN polymorphisms, haplotype and genotype pattern, are described in this invention. | 01-10-2013 |