Patent application number | Description | Published |
20140280055 | PERSONALIZED SEARCH RESULT SUMMARY - Provided are techniques for displaying a personalized search result summary for a search result. A search result from executing a search query is received. A category of search for the search query is determined. A summary template is selected from a collection of summary templates based on the category of search. A personalized summary is generated using the selected summary template and the received search result. | 09-18-2014 |
20140280077 | GESTURE-BASED IMAGE SHAPE FILTERING - Provided are techniques for gesture-based image shape filtering. At least one keyword in a search request for an image is received. A first set of images that are candidate matches to the requested image are identified based on the at least one keyword. A gesture-based image for a filter request is received. The first set of images are filtered using the gesture-based image to identify a second set of images that are candidate matches to the requested image. | 09-18-2014 |
20140304218 | AUGMENTING A BUSINESS INTELLIGENCE REPORT WITH A SEARCH RESULT - A computer augments a business intelligence report. The computer populates a business intelligence report with business data imported from business data storage, and with a stored internet search query. The computer causes the display of the business data of the business intelligence report. The computer also transmits one or both of a term of the stored internet search query or of referenced business data of the stored internet search query to a designated search engine, and receives a contemporary search result from the designated search engine. The computer causes the display of the contemporary search result. | 10-09-2014 |
20140331127 | TEMPLATE BASED COPY AND PASTE FUNCTION - The computer transforms text by receiving a command to insert text into a user interface of an application. The computer extracts one or more words from the text, wherein each of the one or more words is associated with a category relevant to the application. The computer transforms the text to fit a template based on the respective associated categories of the one or more words. The computer inserts the transformed text into the user interface. | 11-06-2014 |
20140358957 | PROVIDING SEARCH SUGGESTIONS FROM USER SELECTED DATA SOURCES FOR AN INPUT STRING - Provided are a computer program product for generating suggestions for an input string. A determination is made of strings in a user selected data source having at least a substring matching an input string, from a computer implemented user interface, comprising at least one character for use by a computer implemented process. The determined strings are provided to the user interface and selection is received of one of the determined strings from the user interface to provide to the computer implemented process. | 12-04-2014 |
20140366074 | LOCATION BASED DETERMINATION OF RELATED CONTENT - In a method for determining other content related to location information of program content displayed on a device, one or more processors receive one or more portions of a first content displayed on a first device. One or more processors determine location information of the one or more portions. One or more processors determine a second content based, at least in part, on the location information. One or more processors cause the determined second content to be displayed. | 12-11-2014 |
20150052116 | SEARCHING AND CLASSIFYING INFORMATION ABOUT GEOGRAPHIC OBJECTS WITHIN A DEFINED AREA OF AN ELECTRONIC MAP - Provided are a method, computer program product and system for classifying and displaying information. A boundary within an electronic map is determined, based on a drawn closed shape. At least one geographic object, at least partially within the boundary, is identified. Each geographic object is representable by one or more geographic coordinates. A search is performed, on an external data source, for unstructured information associated with the at least one geographic object and a plurality of search results are received. The plurality of search results are classified and displayed according to a user topic of interest. | 02-19-2015 |
20150052118 | PERSONALIZED SEARCH RESULT SUMMARY - Provided are techniques for displaying a personalized search result summary for a search result. A search result from executing a search query is received. A category of search for the search query is determined. A summary template is selected from a collection of summary templates based on the category of search. A personalized summary is generated using the selected summary template and the received search result. | 02-19-2015 |
20150052130 | SEARCHING AND CLASSIFYING INFORMATION ABOUT GEOGRAPHIC OBJECTS WITHIN A DEFINED AREA OF AN ELECTRONIC MAP - Provided are a method, computer program product and system for classifying and displaying information. A boundary within an electronic map is determined, based on a drawn closed shape. At least one geographic object, at least partially within the boundary, is identified. Each geographic object is representable by one or more geographic coordinates. A search is performed, on an external data source, for unstructured information associated with the at least one geographic object and a plurality of search results are received. The plurality of search results are classified and displayed according to a user topic of interest. | 02-19-2015 |
20150055881 | GESTURE-BASED IMAGE SHAPE FILTERING - Provided are techniques for gesture-based image shape filtering. At least one keyword in a search request for an image is received. A first set of images that are candidate matches to the requested image are identified based on the at least one keyword. A gesture-based image for a filter request is received. The first set of images are filtered using the gesture-based image to identify a second set of images that are candidate matches to the requested image. | 02-26-2015 |
20150066905 | PRESENTING A COMBINED SEARCH RESULTS SUMMARY IN A GRAPHICAL VIEW - Provided are a computer implemented method, computer program product, and system for presenting a combined search results summary in a graphical view. Selection of two or more search results are received, wherein each of the two or more search results has an associated search result summary, and wherein each associated search result summary includes one or more entries. Relationships between the one or more entries of each associated search result summary and strengths of the relationships are identified. A graphical view is displayed that shows the one or more entries of each associated search result summary, the relationships, and the strengths of those relationships. | 03-05-2015 |
20150066908 | PRESENTING A COMBINED SEARCH RESULTS SUMMARY IN A GRAPHICAL VIEW - Provided are a computer implemented method, computer program product, and system for presenting a combined search results summary in a graphical view. Selection of two or more search results are received, wherein each of the two or more search results has an associated search result summary, and wherein each associated search result summary includes one or more entries. Relationships between the one or more entries of each associated search result summary and strengths of the relationships are identified. A graphical view is displayed that shows the one or more entries of each associated search result summary, the relationships, and the strengths of those relationships. | 03-05-2015 |
20150074086 | HEAT MAP OF SUGGESTED SEARCH QUERIES - A search query portion is received. A plurality of suggested search queries is identified based on the search query portion. Feature values are determined for each of the plurality of suggested search queries based on a feature display preference. A heat map of the suggested search queries is transmitted to a client computer system. The heat map contains a plurality of blocks visually representing the plurality of suggested search queries and the determined feature values. | 03-12-2015 |
20150074137 | HEAT MAP OF SUGGESTED SEARCH QUERIES - A search query portion is received. A plurality of suggested search queries is identified based on the search query portion. Feature values are determined for each of the plurality of suggested search queries based on a feature display preference. A heat map of the suggested search queries is transmitted to a client computer system. The heat map contains a plurality of blocks visually representing the plurality of suggested search queries and the determined feature values. | 03-12-2015 |
20150242089 | VISUALIZATION OF OBJECTS ALONG A STREET - For visualization of objects along a length of street, a user selection of a street is received. The selected street is displayed in an above-street view. At least a first plurality of street view images are concurrently displayed for objects along at least a first side of the selected street. | 08-27-2015 |
20150242995 | VISUALIZATION OF OBJECTS ALONG A STREET - For visualization of objects along a length of street, a user selection of a street is received. The selected street is displayed in an above-street view. At least a first plurality of street view images are concurrently displayed for objects along at least a first side of the selected street. | 08-27-2015 |
20160057573 | AGGREGATED GEO-FENCING AREA BASED INFORMATION DELIVERY - Aggregated geo-fencing area based information delivery, in one aspect, may include determining a plurality of first geo-fencing areas of a first user based on monitoring or detecting locations of the first user. The locations may be detected via one or more user selected devices, which include location-aware devices such as GPS receiver/transmitter devices. A second user identifier may be received from the first user. One or more second geo-fencing areas of a second user may be determined, for example, similarly to the first geo-fencing areas. Content may be gathered based on aggregated geo-fencing area comprising the plurality of first geo-fencing areas and the one or more second geo-fencing areas. The content associated with the aggregated geo-fencing area may be presented, for example, for collaborative activity among the users. | 02-25-2016 |
20160057575 | AGGREGATED GEO-FENCING AREA BASED INFORMATION DELIVERY - Aggregated geo-fencing area based information delivery, in one aspect, may include determining a plurality of first geo-fencing areas of a first user based on monitoring or detecting locations of the first user. The locations may be detected via one or more user selected devices, which include location-aware devices such as GPS receiver/transmitter devices. A second user identifier may be received from the first user. One or more second geo-fencing areas of a second user may be determined, for example, similarly to the first geo-fencing areas. Content may be gathered based on aggregated geo-fencing area comprising the plurality of first geo-fencing areas and the one or more second geo-fencing areas. The content associated with the aggregated geo-fencing area may be presented, for example, for collaborative activity among the users. | 02-25-2016 |
20160091332 | DYNAMIC ATTRACTION INFERENCE IN ROUTE RECOMMENDATIONS - A set of images that each include a time and a date of image capture, a location of image capture, and a directional bearing of image capture are evaluated. The direction bearing of image capture specifies a direction of image capture relative to the respective location of image capture of each image. Images are correlated among the set of images that include a comparable date, time, and location of image capture. By analysis of image content within the correlated images, a determination is made that the correlated images include different directional representations of a single event, and that the single event is distinct from static fixed-location points of interest. Using the directional bearing of image capture of each correlated image, a location of an intersection region that results from intersecting directional bearings of image capture of the correlated images is identified as a dynamic attraction. | 03-31-2016 |
20160092068 | VISUALIZATION OF ADDRESSES - Provided are techniques for visualization of addresses. Search criteria for an entity is received. One or more addresses for the entity are identified based on the search criteria. For each of the one or more addresses, a floor associated with the entity at that address is identified, related information for the floor that includes photographs of views seen from that floor are identified, and, on a 2-dimensional (2-D) electronic map, a 3-dimensional (3-D) structure that indicates the floor and provides access to the related information is plotted. | 03-31-2016 |
20160092470 | VISUALIZATION OF ADDRESSES - Provided are techniques for visualization of addresses. Search criteria for an entity is received. One or more addresses for the entity are identified based on the search criteria. For each of the one or more addresses, a floor associated with the entity at that address is identified, related information for the floor that includes photographs of views seen from that floor are identified, and, on a 2-dimensional (2-D) electronic map, a 3-dimensional (3-D) structure that indicates the floor and provides access to the related information is plotted. | 03-31-2016 |
20160110457 | AUGMENTING SEARCH RESULTS WITH INTERACTIVE SEARCH MATRIX - A computer performs a search. The computer receives a search request including a search term, and determines a plurality of association rules that are each a logical implication that the appearance of the search term follows from the appearance, in a corpus of data, of at least one keyword. The computer generates a search matrix having a plurality of cells, and having axes labeled with a plurality of keywords, wherein at least one cell of the search matrix is associated with an association rule of the plurality of association rules. Based on a cell selection of the search matrix, the computer generates an augmented search string including the search term and at least one keyword of the plurality of association rules. | 04-21-2016 |
Patent application number | Description | Published |
20090269853 | TRIOXYETHYLENE GOLD NANOCLUSTERS FUNCTIONALIZED WITH A SINGLE DNA - A method of making a nanoclusters functionalized with a single DNA strand comprising the steps of providing nanoclusters, combining said nanoclusters with thiolated DNA, incubating said nanoclusters and thiolated DNA mixture, combining said mixture with a solution comprising ethanol and dichloromethane; separating said mixture into an aqueous phase and an organic phase, mixing said aqueous phase with a solution comprising dicholormethane and NaCl, and separating the mixture into an aqueous phase and an organic phase; wherein said organic phase comprises said nanoclusters functionalized with a single DNA strand. Further, provided is a nanocluster functionalized with a single DNA strand comprising a nanocluster, said nanocluster being functionalized with a single DNA strand, said DNA strand having a length of about 10 to about 50 bases. | 10-29-2009 |
20100004187 | COBALT-AMINE BASED METAL COMPLEX AS AN ANTIBACTERIAL COMPOUND - Disclosed herein is a method of: administering to a subject suspected of being infected with a bacterium, a composition of a cobalt (III) compound having the formula CoR | 01-07-2010 |
20100029921 | Trioxyethylene Gold Nanoclusters Functionalized with a Single DNA - A method of making a nanoclusters functionalized with a single DNA strand comprising the steps of providing nanoclusters, combining said nanoclusters with thiolated DNA, incubating said nanoclusters and thiolated DNA mixture, combining said mixture with a solution comprising ethanol and dichloromethane; separating said mixture into an aqueous phase and an organic phase, mixing said aqueous phase with a solution comprising dicholormethane and NaCl, and separating the mixture into an aqueous phase and an organic phase; wherein said organic phase comprises said nanoclusters functionalized with a single DNA strand. Further, provided is a nanocluster functionalized with a single DNA strand comprising a nanocluster, said nanocluster being functionalized with a single DNA strand, said DNA strand having a length of about 10 to about 50 bases. | 02-04-2010 |
20110027388 | Cobalt Hexammine as a Potential Therapeutic Against HIV and/or Ebola Virus - Hexaamminecobalt(III) chloride, also called Cohex, reduces the extent of viral infection, including difficult to treat infections caused by Ebola virus and HIV. Disclosed are methods for treating a viral infection, comprising administering to a patient a cobalt(III) hexammine compound in an amount effective to reduce an extent of a viral infection. Also disclosed are kits for delivery of a cobalt(III) hexammine compound by injection. | 02-03-2011 |
20120315624 | Using LNA Flow-Fish to Quantitatively Monitor Viral Infections in Infected Cells and Test the Efficacy of Antiviral Medications - As described herein, locked nucleic acids are used with flow cytometric-fluorescence in situ hybridization (LNA flow-FISH) detection of viral RNA in infected cells. This technique represents a straightforward way to monitor viral infection in cells and can be used to measure efficacy of potential antiviral compounds. | 12-13-2012 |
Patent application number | Description | Published |
20080213223 | Systemic viral/ligand gene delivery system and gene therapy - The present invention relates to gene transfer and gene therapy technology. More specifically, the invention provides compositions and methods for targeted virus delivery. The method utilizes a method of mixing the virus, which may be a recombinant virus which will express a protein of interest or a nucleic acid of interest, with a cell-targeting ligand, e.g., transferrin. The virus and ligand are mixed without crosslinkers or agents which would covalently bond the virus and ligand. This simple mixing causes less inactivation than chemically linking the ligand to the virus and therefore results in a more active therapeutic composition than obtained by methods which utilize crosslinking agents. | 09-04-2008 |
20090053299 | Methods for generating immune response using cationic-liposome-mediated nucleic acid delivery - The present invention is in the fields of drug delivery, and specifically, cationic liposome-based vaccines. In embodiments, this invention provides methods of making ligand-targeted (e.g., antibody- or antibody fragment-targeted) liposomes useful for the delivery of molecules to induce immune responses against viral antigens or to treat or prevent viral diseases. The specificity of the delivery system is derived from the targeting ligands. | 02-26-2009 |
20090191261 | Antibody fragment-targeted immunoliposomes for systemic gene delivery - Nucleic acid-immunoliposome compositions useful as therapeutic agents are disclosed. These compositions preferably comprise (i) cationic liposomes, (ii) a single chain antibody fragment which binds to a transferrin receptor, and (iii) a nucleic acid encoding a wild type p53. These compositions target cells which express transferrin receptors, e.g., cancer cells. These compositions can be used therapeutically to treat persons or animals who have cancer, e.g., head and neck cancer, breast cancer or prostate cancer. | 07-30-2009 |
20100329981 | SIMPLIFIED AND IMPROVED METHOD FOR PREPARING AN ANTIBODY OR AN ANTIBODY FRAGMENT TARGETED IMMUNOLIPOSOME FOR SYSTEMIC ADMINISTRATION OF A THERAPEUTIC OR DIAGNOSTIC AGENT - A method of preparing an antibody- or antibody fragment-targeted cationic immunoliposome or polymer complex comprises the steps of (a) preparing an antibody or antibody fragment; (b) mixing said antibody or antibody fragment with a cationic liposome to form a cationic immunoliposome or with a cationic polymer to form a polyplex; and (c) mixing said cationic immunoliposome or said polyplex with a therapeutic or diagnostic agent to form said antibody- or antibody fragment-targeted cationic immunoliposome or polymer complex. | 12-30-2010 |
20140120157 | TARGETED LIPOSOMES - The present invention is in the field of drug delivery, and specifically, cationic liposome-based drug delivery. In embodiments, this invention provides methods of making ligand-targeted (e.g., antibody- or antibody fragment-targeted) liposomes useful for the delivery of liposomes to tumors, including brain tumors. In embodiments, the liposomes deliver temozolomide across the blood-brain barrier for treatment of primary or metastatic brain tumors. Additional cancers that can be treated with the liposomes include neuroendocrine tumors, melanoma, prostate, head and neck, ovarian, lung, liver, kidney, breast, urogenital, gastric, colorectal, cervical, vaginal, angiosarcoma, liposarcoma, rhabdomyosarcoma, choriocarcinoma, pancreatic, retinoblastoma and other types of cancer. In another embodiment the liposomes deliver melphalan for the treatment of multiple myeloma, other tumors of the blood or other solid tumors. In still other embodiments the liposomes can deliver other drugs such as pemetrexed or irinotecan for treatment of cancer or drugs including atropine for treatment of organophosphate poisoning. | 05-01-2014 |
20140178296 | TUMOR-TARGETED NANODELIVERY SYSTEMS TO IMPROVE EARLY MRI DETECTION OF CANCER - The present invention is in the fields of drug delivery, cancer treatment and diagnosis and pharmaceuticals. This invention provides a method of making antibody- or antibody fragment-targeted immunoliposomes for the systemic delivery of molecules to treat and image diseases, including cancerous tumors. The invention also provides immunoliposomes and compositions, as well as methods of imaging various tissues. The liposome complexes are useful for encapsulation of imaging agents, for example, for use in magnetic resonance imaging. The specificity of the delivery system is derived from the targeting antibodies or antibody fragments. | 06-26-2014 |
20140294926 | TREATMENT FOR EXPOSURE TO NERVE AGENT - The present application provides methods of preventing and treating the toxic effects of exposure to organophosphate agents. In embodiments, targeted cationic liposome complexes delivering nucleic acid molecules encoding butyrylcholinesterase and a polyproline rich peptide are administered. Suitably, the administration is via inhalation or via aerosol. Also provided are cationic liposome complexes and methods of making the complexes for such administration. | 10-02-2014 |
20150224201 | PREPARATION OF ANTIBODY OR AN ANTIBODY FRAGMENT TARGETED IMMUNOLIPOSOMES FOR SYSTEMIC ADMINISTRATION OF THERAPEUTIC OR DIAGNOSTIC AGENTS AND USES THEREOF - A method of preparing an antibody- or antibody fragment-targeted cationic immunoliposome or polymer complex comprises the steps of (a) preparing an antibody or antibody fragment; (b) mixing said antibody or antibody fragment with a cationic liposome to form a cationic immunoliposome or with a cationic polymer to form a polyplex; and (c) mixing said cationic immunoliposome or said polyplex with a therapeutic or diagnostic agent to form said antibody- or antibody fragment-targeted cationic immunoliposome or polymer complex. | 08-13-2015 |
20150252372 | PREPARATION OF ANTIBODY OR AN ANTIBODY FRAGMENT TARGETED IMMUNOLIPOSOMES FOR SYSTEMIC ADMINISTRATION OF THERAPEUTIC OR DIAGNOSTIC AGENTS AND USES THEREOF - The present invention provides methods of preparing an antibody- or antibody fragment-targeted cationic immunoliposome or polymer complex comprising (a) preparing an antibody or antibody fragment; (b) mixing said antibody or antibody fragment with a cationic liposome to form a cationic immunoliposome or with a cationic polymer to form a polyplex; and (c) mixing said cationic immunoliposome or said polyplex with a therapeutic or diagnostic agent to form said antibody- or antibody fragment-targeted cationic immunoliposome or polymer complex. The present invention also provides cationic immunoliposome or polymer complexes produced by such methods and compositions comprising such complexes. The present invention also provides methods for treating various diseases and disorders, including cancers, by administering the complexes and compositions of the invention to a patient. | 09-10-2015 |
Patent application number | Description | Published |
20090011006 | Once daily formulations of tetracyclines - Disclosed are once-daily formulations containing tetracyclines, especially doxycycline. Such formulations are useful, for instance, for the treatment of collagenase destructive enzyme-dependent diseases, such as periodontal disease and acne, and acute and chronic inflammatory disease states, such as rosacea and arthritis. | 01-08-2009 |
20110212156 | Use of a mixture of two or more enteric materials to regulate drug release via membrance or matrix for systemic therapeutics - Disclosed are pharmaceutical compositions, particularly oral dosage forms, which comprise two or more enteric coating materials, either as a coating or as part of a matrix dosage form, and methods of making and using the same. The compositions are characterized by having a sustained release profile at lower pH and an accelerated dissolution profile at higher pH. | 09-01-2011 |
20110244042 | STABILIZED FORMULATIONS OF CNS COMPOUNDS - Formulations of molindone having superior stability and methods of administering same are provided. The formulations may be immediate, modified, or otherwise delayed release formulations of molindone. | 10-06-2011 |
20110288056 | Once daily formulations of tetracyclines - Disclosed are once-daily formulations containing tetracyclines, especially doxycycline. Such formulations are useful, for instance, for the treatment of collagenase destructive enzyme-dependent diseases, such as periodontal disease and acne, and acute and chronic inflammatory disease states, such as rosacea and arthritis. | 11-24-2011 |
20110294759 | Once daily formulations of tetracyclines - Disclosed are once-daily formulations containing tetracyclines, especially doxycycline. Such formulations are useful, for instance, for the treatment of collagenase destructive enzyme-dependent diseases, such as periodontal disease and acne, and acute and chronic inflammatory disease states, such as rosacea and arthritis. | 12-01-2011 |
20110319368 | Once daily formulations of tetracyclines - Disclosed are once-daily formulations containing tetracyclines, especially doxycycline. Such formulations are useful, for instance, for the treatment of collagenase destructive enzyme-dependent diseases, such as periodontal disease and acne, and acute and chronic inflammatory disease states, such as rosacea and arthritis. | 12-29-2011 |
20140072626 | ONCE DAILY FORMULATIONS OF TETRACYCLINES - Disclosed are once-daily formulations containing tetracyclines, especially doxycycline. Such formulations are useful, for instance, for the treatment of collagenase destructive enzyme-dependent diseases, such as periodontal disease and acne, and acute and chronic inflammatory disease states, such as rosacea and arthritis. | 03-13-2014 |
20150057254 | ONCE DAILY FORMULATIONS OF TETRACYCLINES - Disclosed are once-daily formulations containing tetracyclines, especially doxycycline. Such formulations are useful, for instance, for the treatment of collagenase destructive enzyme-dependent diseases, such as periodontal disease and acne, and acute and chronic inflammatory disease states, such as rosacea and arthritis. | 02-26-2015 |
20150086629 | STABILIZED FORMULATIONS OF CNS COMPOUNDS - Formulations of molindone having superior stability and methods of administering same are provided. The formulations may be immediate, modified, or otherwise delayed release formulations of molindone. | 03-26-2015 |
Patent application number | Description | Published |
20080286270 | Stabilized liquid anti-RSV antibody formulations - The present invention provides liquid formulations of SYNAGIS® or an antigen-binding fragment thereof that immunospecifically bind to a respiratory syncytial virus (RSV) antigen, which formulations exhibit stability, low to undetectable levels of aggregation, and very little to no loss of the biological activities of SYNAGIS® or an antigen-binding fragment thereof, even during long periods of storage. In particular, the present invention provides liquid formulations of SYNAGIS® or an antigen-binding fragment thereof which immunospecifically binds to a RSV antigen, which formulations are substantially free of surfactant, inorganic salts, and/or other common excipients. Furthermore, the invention provides method of preventing, treating or ameliorating symptoms associated with RSV infection utilizing liquid formulations of the present invention. | 11-20-2008 |
20090175883 | Stabilized anti-respiratory syncytial virus (RSV) antibody formulations - The present invention provides liquid formulations of antibodies or fragments thereof that immunospecifically bind to a respiratory syncytial virus (RSV) antigen, which formulations exhibit stability, low to undetectable levels of aggregation, and very little to no loss of the biological activities of the antibodies or antibody fragments, even during long periods of storage. In particular, the present invention provides liquid formulations of antibodies or fragments thereof that immunospecifically bind to a RSV antigen, which formulations are substantially free of surfactant, inorganic salts, and/or other common excipients. Furthermore, the invention provides methods of preventing, treating or ameliorating one or more symptoms associated with RSV infection utilizing the liquid formulations of the present invention. | 07-09-2009 |
20110027272 | STABILIZED LIQUID ANTI-RSV ANTIBODY FORMULATIONS - The present invention provides liquid formulations of SYNAGIS® or an antigen-binding fragment thereof that immunospecifically bind to a respiratory syncytial virus (RSV) antigen, which formulations exhibit stability, low to undetectable levels of aggregation, and very little to no loss of the biological activities of SYNAGIS® or an antigen-binding fragment thereof, even during long periods of storage. In particular, the present invention provides liquid formulations of SYNAGIS® or an antigen-binding fragment thereof which immunospecifically binds to a RSV antigen, which formulations are substantially free of surfactant, inorganic salts, and/or other common excipients. Furthermore, the invention provides method of preventing, treating or ameliorating symptoms associated with RSV infection utilizing liquid formulations of the present invention. | 02-03-2011 |
20120039876 | STABILIZED LIQUID ANTI-RSV ANTIBODY FORMULATIONS - The present invention provides liquid formulations of SYNAGIS® or an antigen-binding fragment thereof that immunospecifically bind to a respiratory syncytial virus (RSV) antigen, which formulations exhibit stability, low to undetectable levels of aggregation, and very little to no loss of the biological activities of SYNAGIS® or an antigen-binding fragment thereof even during long periods of storage. In particular, the present invention provides liquid formulations of SYNAGIS® or an antigen-binding fragment thereof which immunospecifically binds to a RSV antigen, which formulations are substantially free of surfactant, inorganic salts, and/or other common excipients. Furthermore, the invention provides method of preventing, treating or ameliorating symptoms associated with RSV infection utilizing liquid formulations of the present invention. | 02-16-2012 |
20120045456 | STABILIZED ANTI-RESPIRATORY SYNCYTIAL VIRUS (RSV) ANTIBODY FORMULATIONS - The present invention provides liquid formulations of antibodies or fragments thereof that immunospecifically bind to a respiratory syncytial virus (RSV) antigen, which formulations exhibit stability, low to undetectable levels of aggregation, and very little to no loss of the biological activities of the antibodies or antibody fragments, even during long periods of storage. In particular, the present invention provides liquid formulations of antibodies or fragments thereof that immunospecifically bind to a RSV antigen, which formulations are substantially free of surfactant, inorganic salts, and/or other common excipients. Furthermore, the invention provides methods of preventing, treating or ameliorating one or more symptoms associated with RSV infection utilizing the liquid formulations of the present invention. | 02-23-2012 |
20120321616 | STABILIZED LIQUID ANTI-RSV ANTIBODY FORMULATIONS - The present invention provides liquid formulations of SYNAGIS® or an antigen-binding fragment thereof that immunospecifically bind to a respiratory syncytial virus (RSV) antigen, which formulations exhibit stability, low to undetectable levels of aggregation, and very little to no loss of the biological activities of SYNAGIS® or an antigen-binding fragment thereof, even during long periods of storage. In particular, the present invention provides liquid formulations of SYNAGIS® or an antigen-binding fragment thereof which immunospecifically binds to a RSV antigen, which formulations are substantially free of surfactant, inorganic salts, and/or other common excipients. Furthermore, the invention provides method of preventing, treating or ameliorating symptoms associated with RSV infection utilizing liquid formulations of the present invention. | 12-20-2012 |
20140056877 | Stabilized Liquid Anti-RSV Antibody Formulations - The present invention provides liquid formulations of SYNAGIS® or an antigen-binding fragment thereof that immunospecifically bind to a respiratory syncytial virus (RSV) antigen, which formulations exhibit stability, low to undetectable levels of aggregation, and very little to no loss of the biological activities of SYNAGIS® or an antigen-binding fragment thereof, even during long periods of storage. In particular, the present invention provides liquid formulations of SYNAGIS® or an antigen-binding fragment thereof which immunospecifically binds to a RSV antigen, which formulations are substantially free of surfactant, inorganic salts, and/or other common excipients. Furthermore, the invention provides method of preventing, treating or ameliorating symptoms associated with RSV infection utilizing liquid formulations of the present invention. | 02-27-2014 |
20150086544 | STABILIZED LIQUID ANTI-RSV ANTIBODY FORMULATIONS - The present invention provides liquid formulations of SYNAGIS® or an antigen-binding fragment thereof that immunospecifically bind to a respiratory syncytial virus (RSV) antigen, which formulations exhibit stability, low to undetectable levels of aggregation, and very little to no loss of the biological activities of SYNAGIS® or an antigen-binding fragment thereof, even during long periods of storage. In particular, the present invention provides liquid formulations of SYNAGIS® or an antigen-binding fragment thereof which immunospecifically binds to a RSV antigen, which formulations are substantially free of surfactant, inorganic salts, and/or other common excipients. Furthermore, the invention provides method of preventing, treating or ameliorating symptoms associated with RSV infection utilizing liquid formulations of the present invention. | 03-26-2015 |
Patent application number | Description | Published |
20080254008 | Lentiviral Vectors and Their Use - The present invention relates to lentiviral vectors for gene therapy, cancer treatment, producing recombinant proteins, such as antibodies and vaccines, and other therapeutic purposes. Novel lentiviral vectors are disclosed, e.g., comprising helper sequences in opposite orientations and/or minimally functional LTR sequences, which can be used to prepare high efficiency transduction vectors. Vectors are also designed to express silencing RNA and antisense polynucleotides. | 10-16-2008 |
20090305358 | DNA Vector Production System - The invention discloses the production of double stranded DNA (dsDNA) vectors capable of delivering nucleic acids, including cDNA, antisense, ribozyme, and small interference RNA into cells. The invention also describes nucleic acid constructs as well as methods for the production of the dsDNA vectors. | 12-10-2009 |
20110053244 | NOVEL PROTEIN DELIVERY SYSTEM TO GENERATE INDUCED PLURIPOTENT STEM (iPS) CELLS OR TISSUE-SPECIFIC CELLS - A novel protein delivery system to generate induced pluripotent stem (iPS) cells is described. The delivery system comprises a construct with a receptor binding domain that recognizes a receptor in a somatic cell, a translocation domain that allows the transfer of an inducer into the cytosolic space, and a cargo bearing domain to which the inducer is attached and facilitates transfer of the inducer into the cell. | 03-03-2011 |
20110143362 | METHOD FOR IDENTIFICATION OF PROTEASE ACTIVITY INHIBITORS AND ASSAYING THE PRESENCE OF PROTEASE ACTIVITY - A system for the identification of proteases and protease inhibitors is provided. The system has at least two components. The first component is a reporter construct with at least one binding site, a transcriptional promoter, an inducible promoter region, and at least one reporter gene, all functionally connected for expression of the reporter gene(s) in functional coordination with a transcriptional activation agent. The second component is a transcriptional activation agent comprising a nucleic acid binding domain, at least one protease substrate domain, and at least one transcriptional activation domain for an inducible promoter. The system allows detection and evaluation of agents affecting protease activity directed to the protease substrate domain. The system also allows for the detection of the presence of proteases in environmental samples. | 06-16-2011 |
20130288374 | PROTEIN DELIVERY SYSTEM TO GENERATE INDUCED PLURIPOTENT STEM (iPS) CELLS OR TISSUE-SPECIFIC CELLS - A novel protein delivery system to generate induced pluripotent stem (iPS) cells is described. The delivery system comprises a construct with a receptor binding domain that recognizes a receptor in a somatic cell, a translocation domain that allows the transfer of an inducer into the cytosolic space, and a cargo bearing domain to which the inducer is attached and facilitates transfer of the inducer into the cell. | 10-31-2013 |
20140017697 | METHOD FOR IDENTIFICATION OF PROTEASE ACTIVITY INHIBITORS AND ASSAYING THE PRESENCE OF PROTEASE ACTIVITY - A system for the identification of proteases and protease inhibitors is provided. The system has at least two components. The first component is a reporter construct with at least one binding site, a transcriptional promoter, an inducible promoter region, and at least one reporter gene, all functionally connected for expression of the reporter gene(s) in functional coordination with a transcriptional activation agent. The second component is a transcriptional activation agent comprising a nucleic acid binding domain, at least one protease substrate domain, and at least one transcriptional activation domain for an inducible promoter. The system allows detection and evaluation of agents affecting protease activity directed to the protease substrate domain. The system also allows for the detection of the presence of proteases in environmental samples. | 01-16-2014 |