De La Rosa, US
Abel De La Rosa, Alpharetta, GA US
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20100221217 | THERAPEUTIC COMPOSITION - Embodiments disclosed in the present application relate to a composition that can include a hepatitis C viral polymerase inhibitor, or pharmaceutically acceptable salt or prodrug thereof and a hepatitis C viral protease inhibitor, or pharmaceutically acceptable salt or prodrug thereof. Additional embodiments disclosed relate to methods for treating a disease condition such as a hepatitis C virus infection, liver fibrosis and/or impaired liver function with a hepatitis C viral polymerase inhibitor, or pharmaceutically acceptable salt or prodrug thereof and a hepatitis C viral protease inhibitor, or pharmaceutically acceptable salt or prodrug thereof. | 09-02-2010 |
20120128628 | COMBINATION OF A NUCLEOSIDE POLYMERASE INHIBITOR WITH A MACROCYCLIC PROTEASE INHIBITOR AND USE THEREOF IN THE TREATMENT OF HEPATITIS C, LIVER FIBROSIS AND IMPAIRED LIVER FUNCTION (as amended) - Embodiments disclosed in the present application relate to a composition that can include a hepatitis C viral polymerase inhibitor, or pharmaceutically acceptable salt or prodrug thereof and a hepatitis C viral protease inhibitor, or pharmaceutically acceptable salt or prodrug thereof. Additional embodiments disclosed relate to methods for treating a disease condition such as a hepatitis C virus infection, liver fibrosis and/or impaired liver function with a hepatitis C viral polymerase inhibitor, or pharmaceutically acceptable salt or prodrug thereof and a hepatitis C viral protease inhibitor, or pharmaceutically acceptable salt or prodrug thereof. | 05-24-2012 |
20140038172 | Matrix and System for Preserving Biological Specimens for Qualitative and Quantitative Analysis - The present invention provides a device, system, and methods of use comprising an absorbent hydrophobic polyolefin matrix, and methods of use thereof, for storage, preserving, and recovering liquid suspension of biological specimens containing analytes of interest in a dry state. The dried biological specimens containing analytes of interest absorbed on the polyolefin matrix are reconstituted such as with molecular-grade water and released by compressing the polyolefin matrix. The reconstituted biological analytes are qualified for subsequent analysis, such as for qualitative and quantitative analysis of viral nucleic acids, such a viral load testing, genotyping, and sequencing. Also provided are kits with instructions, and methods of use thereof, for storage, preserving, and recovering biological specimens containing analytes of interest using the compression device of the invention. | 02-06-2014 |
Damian De La Rosa, Martinez, CA US
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20110305498 | NOVELTY SPLIT GOLF BALL WIRELESS MEASUREMENT DEVICE - A novelty golf ball-shaped measuring device is described. The golf ball assembly is split into two halves, one having a wireless receiver and display while the other has a transponder that is activated by an RF transmitter. Distance between the halves is calculated using the received wireless signal and is shown on the display. A pen-shaped device is also described in which the cap houses the display, and the pen barrel houses the transponder. Other sport and household item-shaped devices that split into multiple parts to measure and display distances are envisioned. | 12-15-2011 |
Dan M. De La Rosa, Coral Springs, FL US
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20080289453 | Wrench apparatus with adjustable head - A wrench device having an adjustable head is provided, and the device comprises: a handle having opposing top and bottom ends, the top end having a protrusion, and the protrusion having a plurality of external slots; a wrench head having opposing top and bottom ends, the top end having at least one stationary wrench contact surface and at least one moveable wrench contact surface, and the bottom end of the wrench head comprising a U-shaped component designed to interact with the protrusion of the top end of the handle; a device for controlling the movement of the moveable wrench contact surface to determine a distance between the stationary wrench contact surface and the moveable wrench contact surface; and a device for engaging the slots of the protrusion to thereby allow movement of the wrench head and lock the head to a desired position. | 11-27-2008 |
20090113721 | Clamping and cutting apparatus with interchangeable heads - An interchangeable head system for tools is provided, and the system comprises: a pair of handles having opposing top and bottom ends, and the top end of each of the handles is connected at a pivot point, and each of the top ends of the handles has two generally parallel walls forming a space therebetween, and the first wall has a moveable pin attached therethrough and the second wall has an aperture to receive the moveable pin; a plurality of heads, each head comprising a first and second component, each of the components has opposing top and bottom ends, and the top end of each of the components has at least one contact surface, and the first and second components is connected at a pivot point, and the bottom end of each of the components comprises at least one aperture designed to align with the aperture of the second wall of one of the top ends of the handle and to receive the moveable pin during an installment position, each of the bottom ends of the components of the head is inserted within the space formed by the walls of the top ends of the handles, and the pin is inserted through the aperture of the bottom end of the head and the aperture of the top end of the handle; and a means for securing the pin to the handle to thereby secure the head to the handle, and the handles are designed to be squeezed together to thereby allow the contact surfaces of the first and the second top ends of the first and second components to move towards one another. | 05-07-2009 |
Jan De La Rosa, Austin, TX US
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20110173271 | ELECTRONIC MAIL MESSAGING SYSTEM - A method, a system and a computer program product of transmitting availability information in an electronic mail system are disclosed. The system includes a first system including a sender, the first system is adapted to activate an availability indicator having a start date, wherein the activation is performed by the sender and extract availability indicator metadata from the availability indicator. The availability indicator metadata includes the start date, an end date, and at least one availability indicator message. If an e-mail has not been sent to a receiver since activation and if a current date is prior to the start date, the first system is further adapted to attach the availability indicator metadata to the e-mail, and send the e-mail to the receiver. The electronic mail system further includes a scheduling system functionally coupled to the first system, and is adapted to define the availability indicator. | 07-14-2011 |
Jesse Huang De La Rosa, San Diego, CA US
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20140333429 | FRONT AND SIDE VEHICLE BRAKE INDICATOR SYSTEM - Some embodiments of the present disclosure include a front and side viewable brake indicator system for a vehicle. The brake indicator system may include a pair of front mounted brake lights mounted on a vehicle, the first front mounted brake light mounted to a position proximate to a passenger side front corner of the vehicle, and the second front mounted brake light mounted to a position proximate to a driver side front corner of the vehicle. In some embodiments, the system also includes a top mounted brake light mounted on an exterior surface of a roof of the vehicle. Each of the brake lights may be configured to be viewed at a position in front of and to a side of the vehicle and may be configured to illuminate when a driver presses on a brake pedal in the vehicle. | 11-13-2014 |
Luis Bernando De La Rosa, Mason, OH US
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20090311478 | MULTI-PLY FIBROUS STRUCTURES AND METHODS FOR MAKING SAME - Multi-ply fibrous structures and more particularly to multi-ply fibrous structures that employ fibrous structure plies that contain different fiber compositions and methods for making such multi-ply fibrous structures are provided. | 12-17-2009 |
Luis Bernardo De La Rosa, Mason, OH US
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20090117331 | Textured Multi-Ply Sanitary Paper Product Having Optimized Emboss Patterns - A multi-ply paper product having a first ply and a second ply. The first ply has a plurality of first surface features, the first surface features have a number density of from about 5/cm | 05-07-2009 |
Martha De La Rosa, Durham, NC US
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20120122780 | Compounds, Compositions and Methods for Modulating Uric Acid Levels - Described herein are compounds useful in the reduction of blood uric acid levels, formulations containing them and methods of making and using them. In some embodiments, the compounds described herein are used in the treatment or prevention of disorders related to aberrant levels of uric acid. | 05-17-2012 |
20120135929 | Methods Of Modulating Uric Acid Levels - Described herein are compounds useful in the reduction of blood uric acid levels, formulations containing them and methods of making and using them. In some embodiments, a compound disclosed herein are used in the treatment or prevention of disorders related to aberrant levels of uric acid. | 05-31-2012 |
20120283301 | S-TRIAZOLYL ALPHA-MERCAPTO ACETANILIDES AS INHIBITORS OF HIV REVERSE TRANSCRIPTASE - A series of S-triazolyl α-mercaptoacetanilides having general structure (1) are provided, where Q is CO | 11-08-2012 |
20150094284 | S-TRIAZOLYL ALPHA-MERCAPTO ACETANILIDES AS INHIBITORS OF HIV REVERSE TRANSCRIPTASE - A series of S-triazolyl α-mercaptoacetanilides having general structure (1) are provided, where Q is CO | 04-02-2015 |
Martha De La Rosa, San Diego, CA US
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20090170885 | NAPHTHYRIDINE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS - This invention provided compounds of formula I | 07-02-2009 |
20110313157 | S-TRIAZOLYL ALPHA-MERCAPTO ACETANILIDES AS INHIBITORS OF HIV REVERSE TRANSCRIPTASE - A series of S-triazolyl α-mercaptoacetanilides having general structure (1) are provided, where Q is CO | 12-22-2011 |
Martha De La Rosa, Fountain Valley, CA US
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20080319201 | N[S(4-ARYL-TRIAZOL-3-YL)alpha-MERCAPTOACETYL] -P-AMINO BENZOIC ACIDS AS HIV REVERSE TRANSCRIPTASE INHIBITORS - A series of S-triazolyl α-mercaptoacetanilides having N-(α-mercaptoacetyl) p amino benzoic acid derivatives. | 12-25-2008 |
20100137590 | N[S(4-ARYL-TRIAZOL-3-YL)alpha-MERCAPTOACETYL] -P-AMINO BENZOIC ACIDS AS HIV REVERSE TRANSCRIPTASE INHIBITORS - A series of S-triazolyl α-mercaptoacetanilides having N-(α-mercaptoacetyl) p amino benzoic acid derivatives. | 06-03-2010 |
20110190491 | S-TRIAZOLE ALPHA- MERCAPTOACETANILIDES AS INHIBITORS OF HIV REVERSE TRANSCRIPTASE - A series of S-triazolyl α-mercaptoacetanilides having general structure (1) are provided, where Q is CO | 08-04-2011 |
20120077981 | N[S(4-ARYL-TRIAZOL-3-YL)ALPHA-MERCAPTOACETYL]-P-AMINO BENZOIC ACIDS AS HIV REVERSE TRANSCRIPTASE INHIBITORS - A series of S-triazolyl α-mercaptoacetanilides having N-(α-mercaptoacetyl) p amino benzoic acid derivatives. | 03-29-2012 |
Martha A. De La Rosa, San Diego, CA US
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20080318979 | DERIVATIVES OF 4-(N-AZACYCLOALKYL) ANILIDES AS POTASSIUM CHANNEL MODULATORS - This invention provides potassium channel modulators which are compounds of formula I | 12-25-2008 |
Martha A. De La Rosa, Fountain Valley, CA US
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20080249131 | NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS - Various carbonyl amides are employed in vitro and in vivo as non-nucleoside inhibitors of a reverse transcriptase, and particularly of HIV reverse transcriptase. Therefore, contemplated compounds may be employed in the treatment of HIV infected patients. Further contemplated aspects include pharmaceutical compositions comprising therapeutically effective amounts of contemplated compounds. | 10-09-2008 |
Martha Alicia De La Rosa, Durham, NC US
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20110003850 | DERIVATIVES OF 4-(N-AZACYCLOALKYL) ANILIDES AS POTASSIUM CHANNEL MODULATORS - This invention provides a compound of formula IA | 01-06-2011 |
20130289027 | Isoquinoline Compounds And Methods For Treating HIV - Provided are compounds and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and their use for treating viral infections mediated by a member of the retrovirus family of viruses such as the Human Immunodeficiency Virus (HIV). | 10-31-2013 |
Martha Alicia De La Rosa, Research Triangle Park, NC US
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20130018049 | Azaindole Compounds and Methods for Treating HIV - Provided are compounds and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and their use for treating viral infections mediated by a member of the retrovirus family of viruses such as the Human Immunodeficiency Virus (HIV). | 01-17-2013 |
20150191469 | COMPOUNDS AND METHODS FOR TREATING HIV - Provided are compounds and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and their use for treating viral infections mediated by a member of the retrovirus family of viruses such as the Human Immunodeficiency Virus (HIV). | 07-09-2015 |
Michael Huang De La Rosa, San Diego, CA US
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20140333429 | FRONT AND SIDE VEHICLE BRAKE INDICATOR SYSTEM - Some embodiments of the present disclosure include a front and side viewable brake indicator system for a vehicle. The brake indicator system may include a pair of front mounted brake lights mounted on a vehicle, the first front mounted brake light mounted to a position proximate to a passenger side front corner of the vehicle, and the second front mounted brake light mounted to a position proximate to a driver side front corner of the vehicle. In some embodiments, the system also includes a top mounted brake light mounted on an exterior surface of a roof of the vehicle. Each of the brake lights may be configured to be viewed at a position in front of and to a side of the vehicle and may be configured to illuminate when a driver presses on a brake pedal in the vehicle. | 11-13-2014 |
Oxana Adolfovna De La Rosa, San Diego, CA US
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20160030406 | CORRECTORS ACTING THROUGH MSD1 OF CFTR PROTEIN - The present disclosure provides methods for treating Cystic Fibrosis in a subject by administering to the subject a corrector agent capable of acting through MSD1 during the biosynthesis of CFTR protein. The disclosure also provides methods of screening for new corrector agents capable of acting through MSD1 during the biosynthesis of a CFTR protein. | 02-04-2016 |
Pabilito Arriola De La Rosa, San Diego, CA US
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20110268863 | Flavorful waterless coffee - Traditionally, coffee would be prepared in one of the four basic recipes; black, with sugar, with cream, or with both sugar and cream to be enjoyed as a beverage drink. It is the object of this invention to bring coffee consumption to a new solid foundation so that one can have his/her coffee and eat it too in a delicious and chewy recipe that contains all the ingredients and flavorings that coffee drinkers love but without the hot water. | 11-03-2011 |
Pablito Arriola De La Rosa, San Diego, CA US
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20130177673 | FLAVORFUL WATERLESS COFFEE AND PROCESS FOR MAKING - Traditionally, coffee would be prepared in one of the four basic recipes; black, with sugar, with cream, or with both sugar and cream to be enjoyed as a beverage drink. It is the object of this invention to bring coffee consumption to a new solid foundation so that one can have his/her coffee and eat it too in a delicious and chewy recipe that contains all the ingredients and flavorings that coffee drinkers love but without the hot water. | 07-11-2013 |
20140333429 | FRONT AND SIDE VEHICLE BRAKE INDICATOR SYSTEM - Some embodiments of the present disclosure include a front and side viewable brake indicator system for a vehicle. The brake indicator system may include a pair of front mounted brake lights mounted on a vehicle, the first front mounted brake light mounted to a position proximate to a passenger side front corner of the vehicle, and the second front mounted brake light mounted to a position proximate to a driver side front corner of the vehicle. In some embodiments, the system also includes a top mounted brake light mounted on an exterior surface of a roof of the vehicle. Each of the brake lights may be configured to be viewed at a position in front of and to a side of the vehicle and may be configured to illuminate when a driver presses on a brake pedal in the vehicle. | 11-13-2014 |