Patent application number | Description | Published |
20100310604 | RECOMBINANT INFLUENZA VIRUS-LIKE PARTICLES (VLPS) PRODUCED IN TRANSGENIC PLANTS EXPRESSING HEMAGGLUTININ - A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP comprising influenza HA protein and plants lipids. The invention is also directed to a nucleic acid encoding influenza HA as well as vectors. The VLPs may be used to formulate influenza vaccines, or may be used to enrich existing vaccines. | 12-09-2010 |
20110293650 | INFLUENZA VIRUS-LIKE PARTICLES (VLPS) COMPRISING HEMAGGLUTININ - A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA of type A/California/04/09 in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP comprising influenza HA protein of type A/California/04/09 and plants lipids. The invention is also directed to a nucleic acid encoding influenza HA of type A/California/04/09 as well as vectors. The VLPs may be used to formulate influenza vaccines, or may be used to enrich existing vaccines. | 12-01-2011 |
20120178149 | METHOD OF PREPARING PLANT-DERIVED VLPS - Methods of preparing plant-derived virus like particles (VLPs) are provided. The method may comprise obtaining a plant, or plant matter comprising apoplast-localized VLPs, producing a protoplast/spheroplast fraction and apoplast fraction from the plant or plant matter, and recovering the apoplast fraction. The apoplast fraction comprises plant-derived VLPs. Alternatively, VLPs may be obtained from plant or plant matter comprising plant-derived VLPs by digesting the plant matter using a cell wall degrading enzyme composition to produced a digested fraction. The digested fraction is filtered to produced a filtered fraction, and the plant-derived VLPs are recovered from the filtered fraction. | 07-12-2012 |
20120189658 | Chimeric Influenza Virus-Like Particles Comprising Hemagglutinin - A method for synthesizing chimeric influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of chimeric influenza HA in a plant or a portion of a plant. The invention is also directed towards a VLP comprising chimeric influenza HA protein and plants lipids. The invention is also directed to a nucleic acid encoding chimeric influenza HA as well as vectors. The VLPs may be used to formulate influenza vaccines, or may be used to enrich existing vaccines. | 07-26-2012 |
20130067807 | METHOD OF PREPARING PLANT-DERIVED PROTEINS - Methods of preparing plant-derived proteins or suprastructure proteins, are provided. The method may comprise obtaining a plant, or plant matter comprising apoplast-localized proteins, or suprastructure proteins, producing a protoplast/spheroplast fraction and apoplast fraction from the plant or plant matter, and recovering the apoplast fraction. The apoplast fraction comprises plant-derived proteins or suprastructure proteins. Alternatively, the proteins, or suprastructure proteins, may be obtained from plant or plant matter comprising plant-derived proteins or suprastructure proteins, by digesting the plant matter using a cell wall degrading enzyme composition to produced a digested fraction. The digested fraction is filtered to produced a filtered fraction, and the plant-derived proteins or suprastructure proteins, are recovered from the filtered fraction. | 03-21-2013 |
20130142826 | RECOMBINANT INFLUENZA VIRUS-LIKE PARTICLES (VLPS) PRODUCED IN TRANSGENIC PLANTS EXPRESSING HEMAGGLUTININ - A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP comprising influenza HA protein and plant lipids. The invention is also directed to a nucleic acid encoding influenza HA as well as vectors. The VLPs may be used to formulate influenza vaccines, or may be used to enrich existing vaccines. | 06-06-2013 |
20130183341 | INFLUENZA VIRUS-LIKE PARTICLES (VLPS) COMPRISING HEMAGGLUTININ PRODUCED WITHIN A PLANT - A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP comprising influenza HA protein and plant lipids. The invention is also directed to a nucleic acid encoding influenza HA as well as vectors. The VLPs may be used to formulate influenza vaccines, or may be used to enrich existing vaccines. | 07-18-2013 |
20130344100 | VIRUS LIKE PARTICLE PRODUCTION IN PLANTS - A method of producing a virus like particle (VLP) in a plant, and compositions comprising VLPs, are provided. The method involves introducing a nucleic acid comprising a regulatory region active in the plant and operatively linked to a chimeric nucleotide sequence encoding, in series, an ectodomain from a virus trimeric surface protein or fragment thereof, fused to an influenza transmembrane domain and cytoplasmic tail, into the plant, or portion of the plant, the ectodomain is from a non-influenza virus trimeric surface protein and heterologous with respect to the influenza transmembrane domain, and the cytoplasmic tail. The plant or portion of the plant are incubated under conditions that permit the expression of the nucleic acid, thereby producing the VLP. A VLP produced by this method are also provided. | 12-26-2013 |
20150104480 | INCREASING VIRUS-LIKE PARTICLE YIELD IN PLANTS - A method of producing a virus like particle (VLP) in a plant is provided. The method comprises introducing a first nucleic acid and a second nucleic acid into the plant, or portion of the plant. The first nucleic acid comprises a first regulatory region active in the plant and operatively linked to a nucleotide sequence encoding a structural virus protein. The second nucleic acid comprises a second regulatory region active in the plant and operatively linked to a nucleotide sequence encoding a channel protein, for example but not limited to a proton channel protein. The plant or portion of the plant is incubated under conditions that permit the expression of the nucleic acids, thereby producing the VLP. | 04-16-2015 |
20150218579 | INCREASING PROTEIN YIELD IN PLANTS - A method of increasing the yield, stability, or both of an acid sensitive protein in a plant is provided. The method comprises introducing a first nucleic acid and a second nucleic acid into the plant, or portion of the plant. The first nucleic acid comprises a first regulatory region active in the plant and operatively linked to a nucleotide sequence encoding the acid sensitive protein. The second nucleic acid comprises a second regulatory region active in the plant and operatively linked to a nucleotide sequence encoding a channel protein, for example but not limited to a proton channel protein. The plant or portion of the plant is incubated under conditions that permit the expression of the nucleic acids, thereby increasing the yield of the acid sensitive protein when compared to the yield of the acid sensitive protein produced in the plant or portion of the plant produced under the same conditions, and in the absence of the proton channel protein. | 08-06-2015 |
20150225462 | PICORNAVIRUS-LIKE PARTICLE PRODUCTION IN PLANTS - A method of producing a picornavirus-like particle (PVLP) in a plant is provided. The method comprises introducing a first nucleic acid and a second nucleic acid into the plant, portion of the plant, or a plant cell. The first nucleic acid comprising a first regulatory region active in the plant operatively linked to a nucleotide sequence encoding a polyprotein. The second nucleic acid comprises a second regulatory region active in the plant and operatively linked to a nucleotide sequence encoding one or more protease. The plant, portion of the plant, or plant cell is incubated under conditions that permit the expression of the nucleic acids, thereby producing the PVLP. A PVLP comprising the polyprotein is also provided. | 08-13-2015 |
Patent application number | Description | Published |
20100121334 | UNIVERSAL POSITIONING DEVICE FOR ORTHOPEDIC SURGERY AND METHOD OF USE THEREOF - A positioning device assembly for positioning a tool guide block for use in an orthopedic surgery on a bone element includes a positioning device having a block body with a reference surface adapted to abut the bone element, and first and second adjustment mechanisms that are independently operable. The first adjustment mechanism permits rotation of a tool guide block about a medial-lateral extending axis such as to provide flexion-extension angle adjustment and the second adjustment mechanism permits rotation of a tool guide block about an anterior-posterior extending axis such as to provide varus-valgus angle adjustment. The second adjustment mechanism includes both a coarse and a fine adjustment mechanism integral therewith. A tool guide block assembly mounted to the positioning device, the tool guide block assembly including a platform portion which is engaged to the block body of the positioning device and the tool guide block which is releasably engaged with the platform. | 05-13-2010 |
20100192961 | TRACKABLE REFERENCE DEVICE FOR COMPUTER-ASSISTED SURGERY - A surgical reference device for use with a computer-assisted surgery system comprises an engaging member adapted to engage directly on soft tissue of a body part such that substantially no relative movement is possible between the engaging member and a bone element of the body part. A trackable member is attached to the engaging member and comprises a detectable element for being located and tracked in three-dimensional space by the computer-assisted surgery system to measure a position and an orientation of the trackable member in time, whereby the bone element is tracked as a function of the position and orientation of the trackable member. A method for tracking a position and an orientation of a bone element using a computer-assisted surgery system is also provided. | 08-05-2010 |
20100211077 | SURGICAL UNIVERSAL POSITIONING BLOCK AND TOOL GUIDE - A positioning block for use in knee surgery includes a rotational mounting removably engageable to the bone element by a multi-axial fastener such that the mounting element is selectively rotatable relative to the bone element about at least two substantially perpendicular axes of rotation. A guide body portion is engaged with the rotational mounting element such that it is translatable relative thereto along while being rotationally fixed relative to the mounting element. The guide body portion is moveable relative to the bone element in at least three degrees of freedom, the three degrees of freedom including at least two rotational degrees of freedom and at least one translational degree of freedom. A trackable member on the guide body portion is identified and tracked by a computer assisted surgery system. | 08-19-2010 |
20100292703 | PINLESS TECHNIQUE FOR COMPUTER ASSISTED ORTHOPEDIC SURGERY - A method and system ( | 11-18-2010 |
20120010500 | CAS SYSTEM FOR CONDYLE MEASUREMENT - A computer assisted surgery system for conducting orthopedic surgery on a knee joint includes a condyle digitizer having a posterior condyle abutment surface defining a first plane and a distal condyle abutment surface defining a second plane perpendicular to the first plane, and a trackable member which is locatable and trackable in three dimensional space by the computer assisted surgery system to define at least orientation of the condyle digitizer in real time. A computer determines a most remote reference point of the femur of the knee joint lying within at least one of the first and second planes when the condyle digitizer is abutted against condyles of the femur such that the posterior condyle abutment surface abuts a posterior side of the condyles and the distal condyle abutment surface abuts a distal side of the condyles. | 01-12-2012 |
20120220859 | BONE AND TOOL TRACKING WITH MEMS IN COMPUTER-ASSISTED SURGERY - A method tracks a tool with respect to a bone in computer-assisted surgery. A reference tracker with a MEMS unit is secured to the bone. The tracker outputs data relating to its orientation. A tool provided with a MEMS unit and secured to the bone is preset with an initial orientation. The tool outputs tracking data related to orientation of the tool once initialized. A trackable frame of reference relating the bone to the orientation of the tracker is created. The MEMS unit of the tool is initialized. A relation between the initial orientation of the tool and the orientation of the tracker at initialization of the MEMS unit of the tool is recorded. Orientational data of the tool relative to the frame of reference of the bone calculated using the relation is displayed. A computer-assisted surgery system for tracking a tool with respect to a bone after an initialization of a MEMS unit is also described. | 08-30-2012 |
20130060253 | UNIVERSAL POSITIONING DEVICE FOR ORTHOPEDIC SURGERY AND METHOD OF USE THEREOF - A positioning device assembly for positioning a tool guide block for use in an orthopedic surgery includes a positioning device having a block body with a reference surface adapted to abut a bone element, and first and second adjustment mechanisms that are independently operable. The first adjustment mechanism permits rotation of the tool guide block about a medial-lateral extending axis to provide flexion-extension angle adjustment and the second adjustment mechanism permits rotation of the tool guide block about an anterior-posterior extending axis to provide varus-valgus angle adjustment. The second adjustment mechanism includes integral coarse and fine adjustment mechanisms. A tool guide block assembly mounted to the positioning device includes a platform portion which is engaged to the block body of the positioning device and the tool guide block which is releasably engaged with the platform. | 03-07-2013 |
20130274778 | PATIENT SPECIFIC SURGICAL GUIDE - A patient specific instrument (PSI) surgical guide and method for producing same is described. The method includes: obtaining imagery of at least a portion of a patient, and determining one or more surgical targets in the tissue; planning at least a trajectory of the surgical procedure based on a determined surgical target within the tissue; performing segmentation of the imagery; creating a three-dimensional model of the PSI surgical guide, the PSI surgical guide being customized in size and shape and configured to fit on the specific patient. The PSI surgical guide is then produced to correspond to the modeled PSI surgical guide. The PSI surgical guide has a guide element positioned and oriented to guide a surgical implement along the planned trajectory toward the determined surgical target in the tissue. | 10-17-2013 |
20130317510 | PATIENT-SPECIFIC INSTRUMENTATION AND METHOD FOR ARTICULAR JOINT REPAIR - Patient-specific instrumentation for use when performing articular joint repair is provided. A patient-specific jig is adapted to be positioned over a bone at an articular surface thereof for assisting in preparing the bone surface for reception of a prosthesis. The jig comprises a bone contacting portion adapted to matingly contact a portion of the articular surface of the bone and a cutting slot adapted to receive therein a saw blade for resecting the articular surface of the bone. The cutting slot may be press-fitted into the opening of a cut guide. A patient-specific plate and a patient-specific rotational guide are also provided for guiding a positioning of the prosthesis over the resected surface of the bone. A method for manufacturing the patient-specific jig is further provided. | 11-28-2013 |
20140005673 | TOOL AND METHOD FOR DIGITAL ACQUISITION OF A TIBIAL MECHANICAL AXIS | 01-02-2014 |
20140364807 | COMPUTER ASSISTED SUBCHONDRAL INJECTION - A method for assisting subchondral injection comprising creating a model of bone and soft tissue of a patient. At least one void is modeled in the bone from the model of bone and soft tissue. An injection site is identified from the model of bone and soft tissue and modeling of the at least one void. Data is output for guiding at least in the locating of the injection site and drilling of the bone to reach the void. A patient-specific jig for subchondral injection may be created based on the injection site location. | 12-11-2014 |
20150073424 | GLENOID IMPLANT SURGERY USING PATIENT SPECIFIC INSTRUMENTATION - A pin placement instrument for placing a pin in a bone comprises an anatomical interface with a hook-like portion being opened in a lateral direction of the instrument to receive a bone therein in a planned position. A drill guide is connected to the anatomical interface and defining at least one guide slot in a longitudinal direction of the instrument. The guide slot has a lateral opening over its full length in the drill guide to allow lateral withdrawal of the instrument in said lateral direction with the pin placed in the bone passing through the lateral opening. A bushing is removably placed in said guide slot via said longitudinal direction in a planned fit, the bushing defining a throughbore aligned with the guide slot and adapted to receive the pin extending in said longitudinal direction when the bushing is in the guide slot for pin placement. | 03-12-2015 |
20150347710 | PATIENT-SPECIFIC CUTTING BLOCK AND METHOD OF MANUFACTURING SAME - A patient-specific cutting assembly comprises a model file including geometrical data of a bone of the patient, of an intramedullary canal of the bone, and a planned orientation of a cutting block. A fixing rod is adapted to be longitudinally inserted in and extending partially from the intramedullary canal. A patient-specific cutting block is connectable to the fixing rod. The patient-specific cutting block includes a structure having a patient specific geometry corresponding to the model file of the patient, the structure configured to be connected to a portion of the fixing rod projecting from the bone in a unique coupling orientation. A cutting guide is connected to the structure, the cutting guide being in the planned orientation when the structure is connected to the portion of the fixing rod projecting from the bone. | 12-03-2015 |
20160089153 | PATIENT SPECIFIC INSTRUMENTATION (PSI) FOR ORTHOPEDIC SURGERY AND SYSTEMS AND METHODS FOR USING X-RAYS TO PRODUCE SAME - A method of creating a patient specific instrument (PSI) for use in knee replacement surgery is described which includes performing at least two X-ray scans of a bone, each of the X-ray scans being taken from different angular positions, generating a digital bone model of the bone based solely on the X-ray scans, planning the PSI based on the digital bone model, including determining locations for one or more anchor points on the PSI which are adapted to abut a surface of the bone, the determined locations of the anchor points being disposed on the PSI at locations corresponding to areas of expected high accuracy on the digital bone model generated by the X-ray scans. The areas of expected high accuracy include at least a peripheral bone contour in at least one of the angular position of the X-ray scans. A suite of such PSI instruments is also described. | 03-31-2016 |
Patent application number | Description | Published |
20100176814 | APPARATUS AND METHOD FOR MONITORING A PHASE LINE OF A SECTION OF AN ELECTRICAL ENERGY TRANSMISSION LINE - An appliance and a method are intended to monitor a phase line of a section of an electrical energy grid line. The appliance comprises a device for monitoring a parameter of a phase line. The parameter is representative of routine operating conditions of the phase line and has a known propagation speed. The appliance also comprises a device for generating an event detection signal each time the parameter has a value that exceeds a threshold, and for storing a reception time when the detection signal is generated. The appliance also has a device for sending a signal representative of a geographic location of the end of the section and a device for performing a geographic location of the event once two consecutive detection signals are generated from the signal representative of the geographic location, and reception times associated with the two detection signals. | 07-15-2010 |
20120070903 | METHOD AND APPARATUS FOR MEASURING THE HOT-SPOT TEMPERATURE IN AN ELECTRIC APPARATUS CONTAINING AN OIL - A method for measuring the real hot-spot temperature in an electric apparatus containing an oil, such as an electric power transformer. The electric apparatus is operated under predetermined and modifiable operating conditions. This method comprises the use of one or several chemical compounds or tracers present and soluble in the oil. Each tracer may transform, at a given temperature, in order to form a residue, such as a soluble gas. From the presence of the residue in the oil, the operator will be able to determine under which predetermined operating condition the hot-spot has been reached and to deduce the hot-spot for a given condition. Among different used compounds, there are diazoic compounds, carbonyl metals, colorants, pigments, liquid crystals and albumins. The method also allows to check the quality of the apparatus on the market and to estimate its life span. | 03-22-2012 |
20130088314 | Electrical Transformer Assembly - A support frame for an electrical transformer assembly, comprising two loop-shaped parts, each loop-shaped part having a plurality of limbs, each limb having a peripheral recessed portion in which a primary electrical coil is mountable, and at least one secondary coil is mountable in piggyback on the primary electrical coil, one limb of each loop-shaped part having a straight section. The frame also includes an adjustable attaching means for attaching one of the loop-shaped parts with respect to the other loop-shaped part and adjusting a distance therebetween, so that only the straight sections are adjacent and form a central leg, the central leg being for receiving a magnetic core distinct from the attaching means. The frame provides a means and a method to efficiently secure adjacent windings in a circular core transformer kernel. | 04-11-2013 |
20130139929 | SYSTEM AND METHOD FOR TREATING AN AMORPHOUS ALLOY RIBBON - A method and a system for continuously in-line annealing a forwarding ferromagnetic amorphous alloy ribbon in a curved shape to improve its magnetic properties without causing the ribbon to become brittle and which operates at significant high ribbon feeding rates. The amorphous alloy ribbon is fed forward, tensioned and guided along a path at a preset feeding rate and is heated at a point along the path at a rate greater than 10 | 06-06-2013 |
20140097286 | FERROMAGNETIC METAL RIBBON TRANSFER APPARATUS AND METHOD - Apparatus, system and methods for transferring of a ferromagnetic metal ribbon from a roll mounted on a mandrel to another mandrel, including a mandrel located around electrical coils of a transformer. The system includes an apparatus for securing a free end of a ribbon roll including a reel onto which the ribbon roll is mounted and a ribbon retention mechanism having retaining elements movable between a retaining position in which the free end of the ribbon roll is secured on the reel and a releasing position in which the free end of the ribbon roll is free from the reel. An apparatus and method for rolling up a cuttable ferromagnetic ribbon on a mandrel are also disclosed. An apparatus and method for rolling up a cuttable ferromagnetic ribbon on a mandrel are also disclosed. An apparatus and method for manipulating and displacing ferromagnetic material along a path are also disclosed. | 04-10-2014 |
20140125137 | SWITCHING APPARATUS, CONTROL SYSTEM AND METHOD FOR VARYING AN IMPEDANCE OF A PHASE - An apparatus and a method are for varying an impedance of a phase line of a segment of a first electrical power line, the phase line including n conductors electrically insulated from each other and short-circuited together at two ends of the segment. The apparatus includes at least one controllable switching device for connection with at least one of the conductors. The apparatus also includes a controller for performing control of the at least one controllable switching device, the controller having at least one optical port for receiving first optical signals on which the control is based, and for sending second optical signals to adjacent switching apparatuses, the second optical signals including status information of the one switching apparatus, upon which control of adjacent switching apparatuses is based. | 05-08-2014 |
20160086712 | ELECTRICAL TRANSFORMER ASSEMBLY - A support frame for an electrical transformer assembly, comprising two loop-shaped parts, each loop-shaped part having a plurality of limbs, each limb having a peripheral recessed portion in which a primary electrical coil is mountable, and at least one secondary coil is mountable in piggyback on the primary electrical coil, one limb of each loop-shaped part having a straight section. The frame also includes an adjustable attaching means for attaching one of the loop-shaped parts with respect to the other loop-shaped part and adjusting a distance therebetween, so that only the straight sections are adjacent and form a central leg, the central leg being for receiving a magnetic core distinct from the attaching means. The frame provides a means and a method to efficiently secure adjacent windings in a circular core transformer kernel. | 03-24-2016 |