Bardelli
Achille Bardelli, Buguggiate IT
Achille Angelo Bardelli, Buguggiate IT
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20100298472 | COATING OF ORGANIC AND INORGANIC PIGMENTS WITH ACRYLIC RESINS - Coating of organic and inorganic pigments with acrylic resins, comprising a chemical compound consisting of particles of solid organic and inorganic substances, both defined as pigments, in that they are substances which absorb a fraction of the light and reflect the complementary part thereof, coated with acrylic and, optionally, aldehyde and/or ketone resins. The latter are deposited on the surface of the pigment by means of a process which envisages melting of the resin, consequent wetting and coating of the entire surface of the pigment with the resin in the melted state, the consequent cooling and subsequent step of grinding by means of mechanical systems operating in temperature conditions lower than 20° C., by means of cryogenic processes or granulate by means of a wet method with a water jet cutting action and separation of the granulates by the water on a vibrating screen and then dried on a spiral elevator. The product resulting from this invention will be used as a semifinished product for the colouring and pigmentation of powder paints and plastics as a monochromatic colouring material and or will also be used, after dissolving in a solvent, or in water with basic pH, as a pigmented paste or directly in solvent or water based resins in the liquid paints industry. | 11-25-2010 |
Alberto Bardelli, Turin IT
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20140134158 | KRAS MUTATIONS AND RESISTANCE TO ANTI-EGFR TREATMENT - The disclosure provides compositions and methods for detecting and predicting acquired resistance to anti-EGFR treatment in colorectal cancers. Also provided are compositions and methods of preventing, reversing or delaying the acquired resistance. The present disclosure also provides kits for use in the methods described herein. | 05-15-2014 |
Alberto Bardelli, Baltimore, MD US
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20100184100 | Tyrosine Kinome - Protein kinases are important signaling molecules involved in tumorigenesis. Mutational analysis of the human tyrosine kinase gene family (98 genes) identified somatic alterations in −20% of colorectal cancers, with the majority of mutations occurring in NTRK3, FES, GUCY2F and a previously uncharacterized tyrosine kinase gene called MCCK/MLK4. Most alterations were in conserved residues affecting key regions of the kinase domain. These data represent a paradigm for the unbiased analysis of signal transducing genes in cancer and provide useful targets for therapeutic intervention. | 07-22-2010 |
Alberto Bardelli, Torino IT
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20090075267 | K-ras and B-raf mutations and anti-EGFr antibody therapy - The present application relates to K-ras mutations, to polynucleotides encoding mutant K-ras polypeptides, and to methods of identifying K-ras mutations. The present application also relates to B-raf mutations, to polynucleotides encoding mutant B-raf polypeptides, to vectors containing those polynucleotides, and to methods of identifying B-raf mutations. The present application also relates to methods of diagnosing cancer; and methods and kits for predicting the usefulness of anti-EGFr specific binding agents in the treatment of tumors. | 03-19-2009 |
20090269344 | Anti-EGFR antibody therapy based on an increased copy number of the EGFR gene in tumor tissues - The invention relates to an indidualized and personalized diagnosis and therapy of cancer based on specific molecular alterations which occur in specific tumor tissue of specific tumor patient populations. The therapy and diagnostic is based on the findings that proliferation and tumor growth of specific EGFR bearing tumor tissue expressing an amplified EGFR gene copy number may be abolished by anti-EGFR antibodies, while other individual molecular alterations such as mutations occurring in tumor tissues are unaffected by the same anti-EGFR antibody treatment. | 10-29-2009 |
20110059434 | P13k pathway mutations in cancer - Given the important role of protein kinases in pathways affecting cellular growth and invasion, we have analyzed 340 serine/threonine kinases for genetic mutations in colorectal cancers. Mutations in eight genes were identified, including three members of the phosphatidylinositol-3-kinase (PI3K) pathway; the alterations in the latter genes each occurred in different tumors and did not overlap with mutations in PIK3CA or other non-serine-threonine kinase (STK) members of the PI3K pathway, suggesting that mutations in any of these genes had equivalent tumorigenic effects. These data demonstrate that the PI3K pathway is a major target for mutational activation in colorectal cancers and provide new opportunities for therapeutic intervention. | 03-10-2011 |
20110212456 | K-ras and B-raf mutations and anti-EGFr antibody therapy - The present application relates to K-ras mutations, to polynucleotides encoding mutant K-ras polypeptides, and to methods of identifying K-ras mutations. The present application also relates to B-raf mutations, to polynucleotides encoding mutant B-raf polypeptides, to vectors containing those polynucleotides, and to methods of identifying B-raf mutations. The present application also relates to methods of diagnosing cancer; and methods and kits for predicting the usefulness of anti-EGFr specific binding agents in the treatment of tumors. | 09-01-2011 |
20120115896 | ISOGENIC HUMAN CELL LINES COMPRISING MUTATED CANCER ALLELES AND PROCESS USING THE CELL LINES - Isogenic human cell lines comprising at least one mutated cancer allele under the control of the cell line endogenous promoter, which corresponds to the wild-type cancer allele promoter are disclosed, as well as an in vitro process for determining sensitivity/resistance of a patient suffering from a tumor to a pharmacological agent comprising the following steps: a) identifying at least one mutated cancer allele in a tissue affected by a tumor of said patient; b) providing an isogenic human cell line representative of the tissue, wherein the cell line comprises at least the identified mutated cancer allele, which is under the control of the cell line endogenous promoter corresponding to the wild-type cancer allele promoter; c) putting in contact said cell line with the pharmacological agent; d) determining a variation of proliferation, apoptosis or cytotoxicity of the cell line in presence of the pharmacological agent; wherein the variation of proliferation, apoptosis car cytotoxicity indicative of the sensitivity/resistance of the patient tumor to the pharmacological agent. | 05-10-2012 |
20130136755 | MLK4 GENE, A NEW DIAGNOSTIC AND PROGNOSTIC MARKER IN CANCERS - An in vitro diagnostic method for determining invasive potential of cancer comprising measuring MLK4 gene expression in a cancer cell sample, wherein MLK4 gene overexpression is indicative of an invasive cancer, preferably a colorectal, bladder, breast, gastric, melanoma, lung, ovary or GMB cancer. | 05-30-2013 |
20130157299 | Tyrosine Kinome - Protein kinases are important signaling molecules involved in tumorigenesis. Mutational analysis of the human tyrosine kinase gene family (98 genes) identified somatic alterations in −20% of colorectal cancers, with the majority of mutations occurring in NTRK3, FES, GUCY2F and a previously uncharacterized tyrosine kinase gene called MCCK/MLK4. Most alterations were in conserved residues affecting key regions of the kinase domain. These data represent a paradigm for the unbiased analysis of signal transducing genes in cancer and provide useful targets for therapeutic intervention. | 06-20-2013 |
Angelo Achille Bardelli, Buguggiate IT
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20100080923 | THERMOSETTING POWDER PAINTS - Thermosetting coloured powder paints to be used in electrostatic painting processes are described. These powder paints comprise not more than 30% by weight of at least one monochromatic pigment coated with at least one aldehyde and/or ketone resin, preferably 5 to 30% by weight, and up to 95% by weight of conversion agent, preferably 70 to 95% by weight; more than 90% of the particles of said at least one coated monochromatic pigment and said conversion agent have a particle size of between 10 and 40 microns, preferably between 15 and 35 microns. The coated monochromatic pigment and the conversion agent have the same specific weight which is between 1.3 and 1.7 g/cc. | 04-01-2010 |
Angelo Achille Bardelli, Buguggiate, VA US
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20080206568 | Coating of Organic and Inorganic Pigments with Aldehyde or Ketone Resins - Coating of organic and inorganic pigments with aldehyde or ketone resins, comprising a chemical compound consisting of particles of solid organic and inorganic substances, both defined as pigments, in that they are substances which absorb a fraction of the light and reflect the complementary part thereof, coated with aldehyde or ketone resins. The latter are deposited on the surface of the pigment by means of a process which envisages melting of the resin, consequent wetting and coating of the entire surface of the pigment with the resin in the melted state, the consequent cooling and subsequent step of atomization by means of mechanical systems operating in temperature conditions lower than 10° C., by means of cryogenic processes. The product resulting from this invention will be used as a semifinished product for the colouring and pigmentation of powder paints and plastics as a monochromatic colouring material and or will also be used, after dissolving in a solvent, as a pigmented paste in the liquid paints industry. | 08-28-2008 |
Anthony J. Bardelli, Derby, CT US
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20120211014 | Apparatus For Cutting And Storing A Cigarette - An apparatus has a housing that has a first section and a second section. The first section has a first compartment for storing a cigarette and a second compartment for containing a cutting device having a blade. The first compartment is sealed from the second compartment. A slide button on the housing allows the user to move the cutting device within the second compartment. The second section has an opening and a hollow interior that are sized to allow a user to insert a portion of a cigarette through the opening and into the hollow interior. A user inserts the used portion of a cigarette into the opening and hollow interior and then uses the slide button to move the blade into the hollow interior to cut off the used portion of the cigarette. The user then places the remaining portion of the cigarette in the first compartment. | 08-23-2012 |
20130269718 | Apparatus For Cutting And Storing A Cigarette - The present invention is directed to an apparatus for cutting away a portion of a cigarette and storing the remaining portion of the cigarette. In one embodiment, the apparatus has a housing having a first interior compartment for storing a cigarette and a second interior compartment that is separate and sealed off from the first interior compartment. The housing has a first end that defines openings to the first and second interior compartments and a second end that defines an opening only to the second interior compartment. The housing has an exterior wall that is a part of the second interior compartment. The exterior wall has first and second openings that are located between the first and second ends of the housing. The second opening in the exterior wall is adjacent to the second end of the housing and is sized to receive a portion of a cigarette. The apparatus includes a cutting device movably positioned within the second interior compartment. The cutting device can move in a first direction toward the first end of the housing or in an opposite second direction toward the second end of the housing. The cutting device has a portion accessible through the first opening in the external wall of the housing so as to enable a user to move the cutting device either in the first direction or second direction. The cutting device includes a cutting blade. When a user inserts a portion of a cigarette into the second opening in the exterior wall of the housing and moves the cutting device in the second direction, the cutting blade cuts off a portion of the cigarette. | 10-17-2013 |
20140202473 | Apparatus For Cutting And Storing A Cigarette - An apparatus has a housing that has a first section and a second section. The first section has a first compartment for storing a cigarette and a second compartment for containing a cutting device having a blade. The first compartment is sealed from the second compartment. A slide button on the housing allows the user to move the cutting device within the second compartment. The second section has an opening and a hollow interior that are sized to allow a user to insert a portion of a cigarette through the opening and into the hollow interior. A user inserts the used portion of a cigarette into the opening and hollow interior and then uses the slide button to move the blade into the hollow interior to cut off the used portion of the cigarette. The user then places the remaining portion of the cigarette in the first compartment. | 07-24-2014 |
Anthony John Bardelli, Derby, CT US
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20110203600 | Cutting and storage device - Our invention is a combined cutting and storage device designed for use by a smoker who can not or chooses not to finish an entire cigarette. The device contains a cutting mechanism and a sealed storage compartment with a vertical pop-up lid for use with a single unfinished cigarette. A smoker can simply cut an unfinished cigarette or smoking material with the cutting means and place it in the sealed storage compartment for later use. The sealed storage compartment may be inserted into a box or pack of cigarettes. | 08-25-2011 |
Fabrizio Bardelli, Torino IT
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20130255997 | PROCESSES FOR PRODUCING CONDUCTIVE AND/OR PIEZORESISTIVE TRACES ON POLYMERIC SUBSTRATES - Process for producing conductive and/or piezoresistive traces in a non-conductive polymeric substrate through laser irradiation, characterised in that said substrate is a composite polymeric material, comprising the matrix of a polymer not susceptible to carbonisation through laser irradiation and a dispersed phase comprising carbon nano fibres and/or nanotubes. | 10-03-2013 |
Guido Bardelli, Carpi IT
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20150292228 | ANCHORING SYSTEM OF OBJECTS IN THE GROUND - A system of anchorage of objects in grounds, includes an anchor base provided with tilted guides for rods or pins to be inserted upon assembly; said base being rigidly connected or having a releasable connection with the object or the structure to be anchored to the ground; and said base being provided with tilted guides in minimum number of three; said guides having parallelepiped crossing section in such a way as to house a rod, each guide, presenting a corresponding section and being inserted when assembling the anchorage to the ground; the single rod having hollow section shape, obtained by folding a sheet of rigid material; the hollow section being open at the folding ends of the rod with a minimum distance equal or higher to a fourth of the length of the side of the parallelepiped section on which it is made. | 10-15-2015 |
Guido Bardelli US
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20150292228 | ANCHORING SYSTEM OF OBJECTS IN THE GROUND - A system of anchorage of objects in grounds, includes an anchor base provided with tilted guides for rods or pins to be inserted upon assembly; said base being rigidly connected or having a releasable connection with the object or the structure to be anchored to the ground; and said base being provided with tilted guides in minimum number of three; said guides having parallelepiped crossing section in such a way as to house a rod, each guide, presenting a corresponding section and being inserted when assembling the anchorage to the ground; the single rod having hollow section shape, obtained by folding a sheet of rigid material; the hollow section being open at the folding ends of the rod with a minimum distance equal or higher to a fourth of the length of the side of the parallelepiped section on which it is made. | 10-15-2015 |
Julien Bardelli, Colomiers FR
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20150211848 | DEVICE AND METHOD FOR LOCATING IMPACTS ON THE OUTER SURFACE OF A BODY - A method and device to locate an impact on an outer surface of a body including: locating the impact on the outer surface of a virtual model of the body; selecting a first and a second visual reference element on the virtual model; positioning an acquisition module on the outer surface of the actual body at the impact; measuring, using an acquisition module, measuring distances between the impact and the first visual reference element and between the impact and the second visual reference element; calculating a first arc around the first visual reference element and a second contour around the second visual reference element wherein each arc has a radius equal to one of the measured distances; determining a point of intersection of the first and second contours; and calculating coordinates of the point of intersection on the virtual model to locate the impact on the virtual body. | 07-30-2015 |
Lodovico Bardelli, Scandiano IT
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20140141961 | APPARATUSES, SYSTEM AND METHODS FOR FORMING PRESSED ARTICLES AND PRESSED ARTICLES FORMED THEREBY - The invention relates to a method and a system ( | 05-22-2014 |
Roberto Giorgio Bardelli, Fino Mornasco IT
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20120262240 | OSCILLATOR, TIME-DIGITAL CONVERTER CIRCUIT AND RELATING METHOD OF TIME-DIGITAL MEASURE - A ring oscillator has a plurality of elementary units connected in cascade and linked in order to make a chain with the respective output terminals connected to the input terminals of the successive elementary units of the chain, the elementary units being crossed by a cyclic signal during a time period of activation, each of said elementary units comprising an auxiliary recovery terminal for temporarily resetting each elementary unit during each loop of said cyclic signal, said auxiliary recovery terminal being connected to an output terminal of a successive elementary unit of the chain. | 10-18-2012 |
20140323871 | METHOD OF SETTING A WAVEFORM SIGNAL IN AN ULTRASOUND IMAGING APPARATUS AND APPARATUS FOR SETTING AN ULTRASONIC WAVEFORM SIGNAL USING SUCH METHOD - A digital representation of a waveform is generated based on signals received during a recording period. The received signals include a digital clock signal providing a determined number of clock pulses during the recording period, a plurality of binary digital signals defining, for each clock pulse of the determined number of clock pulses, a waveform state associated with the clock pulse. A digital representation of the waveform is generated and storing. The waveform has a duration based on the recording period and a profile based on the defined waveform states associated with the clock pulses of the determined number of clock pulses. | 10-30-2014 |
Roberto Giorgio Bardelli, Fino Mornasco (como) IT
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20110156789 | CONTROL SYSTEM FOR A PHASE GENERATOR AND CORRESPONDING CONTROL METHOD - A control system for a phase generator including a delay block including delay units, and first and second multiplexers configured to receive output signals of each of the delay units and to respectively supply first and second output signals. The control system may include a controller configured to drive the first multiplexer and the second multiplexer respectively with a first select signal and a second select signal, a detection module configured to detect a phase difference between the first output signal and the second output signal and to generate a corresponding digital phase shift signal, the detection module including a phase comparator, and a Time-Digital converter circuit coupled thereto and having logic elements configured to generate the digital phase shift signal, and a logic circuit connected to the detection module and configured to process the digital phase shift signal and to generate a signal indicative of a control executed. | 06-30-2011 |