Patent application number | Description | Published |
20100296672 | TWO-TO-THREE CHANNEL UPMIX FOR CENTER CHANNEL DERIVATION - A frequency-domain upmix process uses vector-based signal decomposition and methods for improving the selectivity of center channel extraction. The upmix processes described do not perform an explicit primary/ambient decomposition. This reduces the complexity and improves the quality of the center channel derivation. A method of upmixing a two-channel stereo signal to a three-channel signal is described. A left input vector and a right input vector are added to arrive at a sum magnitude. Similarly, the difference between the left input vector and the right input vector is determined to arrive at a difference magnitude. The difference between the sum magnitude and the difference magnitude is scaled to compute a center channel magnitude estimate, and this estimate is used to calculate a center output vector. A left output vector and a right output vector are computed. The method is completed by outputting the left output vector, the center output vector, and the right output vector. | 11-25-2010 |
20100303245 | DIFFUSING ACOUSTICAL CROSSTALK - When two loudspeakers play the same signal, a “phantom center” image is produced between the speakers. However, this image differs from one produced by a real center speaker. In particular, acoustical crosstalk produces a comb-filtering effect, with cancellations that may be in the frequency range needed for the intelligibility of speech. Methods for using phase decorrelation to fill in these gaps and produce a flatter magnitude response are described, reducing coloration and potentially enhancing dialogue clarity. These methods also improve headphone compatibility and reduce the tendency of the phantom image to move toward the nearest speaker. | 12-02-2010 |
20110320209 | FREQUENCY DOMAIN MULTIBAND DYNAMICS COMPRESSOR WITH AUTOMATICALLY ADJUSTING FREQUENCY BAND BOUNDARY LOCATIONS - A multiband dynamics compressor implements a frequency-domain solution for addressing unwanted magnitude peaks which may occur at the crossover frequency (boundary) between two adjacent frequency bands. The solution proposes making slight adjustments to the frequency band boundary locations, for example on a frame-by-frame basis, in order to prevent a spectral peak in the input signal from being located midway between two frequency bands. The adjustment to the boundary location pushes the energy of the spectral peak substantially into one frequency band for compression. | 12-29-2011 |
20110320210 | MULTIBAND DYNAMICS COMPRESSOR WITH SPECTRAL BALANCE COMPENSATION - A multiband dynamics compressor implements a solution for minimizing unwanted changes to the long-term frequency response. The solution essentially proposes undoing the multiband compression in a controlled manner using much slower smoothing times. In this regard, the compensation provided acts more like an equalizer than a compressor. What is applied is a very slowly time-varying, frequency-dependent post-gain (make-up gain) that attempts to restore the smoothed long-term level of each compressor band. | 12-29-2011 |
20120155652 | DIFFUSING ACOUSTICAL CROSSTALK - When two loudspeakers play the same signal, a “phantom center” image is produced between the speakers. However, this image differs from one produced by a real center speaker. In particular, acoustical crosstalk produces a comb-filtering effect, with cancellations that may be in the frequency range needed for the intelligibility of speech. Methods for using phase decorrelation to fill in these gaps and produce a flatter magnitude response are described, reducing coloration and potentially enhancing dialogue clarity. These methods also improve headphone compatibility and reduce the tendency of the phantom image to move toward the nearest speaker. | 06-21-2012 |
20130322636 | Diffusing Acoustical Crosstalk - When two loudspeakers play the same signal, a “phantom center” image is produced between the speakers. However, this image differs from one produced by a real center speaker. In particular, acoustical crosstalk produces a comb-filtering effect, with cancellations that may be in the frequency range needed for the intelligibility of speech. Methods for using phase decorrelation to fill in these gaps and produce a flatter magnitude response are described, reducing coloration and potentially enhancing dialogue clarity. These methods also improve headphone compatibility and reduce the tendency of the phantom image to move toward the nearest speaker. | 12-05-2013 |
Patent application number | Description | Published |
20100158272 | ASYMMETRIC POLYNOMIAL PSYCHOACOUSTIC BASS ENHANCEMENT - Psychoacoustic bass audio signal enhancement can be accomplished using a monotonic, asymmetric polynomial distortion. A non-linear process applies a monotonic, asymmetric polynomial distortion function that has continuous first and second derivatives to generate even and odd harmonics of missing fundamental frequencies. This polynomial distortion produces the desired psychoacoustic effect with a fairly rapid roll-off so as to avoid unpleasant aliasing. Moreover, the lack of first-order discontinuities prevents clicks or glitches. | 06-24-2010 |
20130332498 | METHOD AND APPARATUS FOR EFFICIENT FREQUENCY-DOMAIN IMPLEMENTATION OF TIME-VARYING FILTERS - Embodiments are directed to efficient frequency-domain implementations of time-varying FIR filters. More specifically, time-varying FIR filters according to embodiments exploit the duality of the fast Fourier transform that windowing in the time domain equals convolution in the frequency domain. In one embodiment, convolution of the output of the FIR filter and a desired windowing function is performed in the frequency domain instead of taking the output of the FIR filter in the frequency domain, converting this output the time domain via an IFFT, and then windowing this output in the time domain before again converting back to the frequency domain. As long as the windowing function has certain characteristics, then the time-varying FIR filter is computationally efficient and introduces minimal audible artifacts into the output of the filter. Concepts described herein are discussed in terms of audio signals and systems but are not limited to audio signals and systems. | 12-12-2013 |
20140105419 | ASYMMETRIC POLYNOMIAL PSYCHOACOUSTIC BASS ENHANCEMENT - Psychoacoustic bass audio signal enhancement can be accomplished using a monotonic, asymmetric polynomial distortion. A non-linear process applies a monotonic, asymmetric polynomial distortion function that has continuous first and second derivatives to generate even and odd harmonics of missing fundamental frequencies. This polynomial distortion produces the desired psychoacoustic effect with a fairly rapid roll-off so as to avoid unpleasant aliasing. Moreover, the lack of first-order discontinuities prevents clicks or glitches. | 04-17-2014 |
Patent application number | Description | Published |
20140031895 | SYSTEM AND METHOD FOR MANAGING PAIN - A system and method for managing pain, configured to be worn by a patient, comprising an electrode array comprising a first electrode and a second electrode for providing a TENS treatment to the patient; a connector configured to couple at least one of the first electrode and the second electrode to an electronics subsystem; a muscle twitch sensor subsystem configured to detect a muscle twitch profile induced by the electrode array at the patient; and an electronics subsystem comprising a power module configured to power the system, a pulse generator coupled to the electrode array and configured to transmit the TENS treatment, and a control module configured to receive an input, from the muscle twitch sensor subsystem, characterizing the muscle twitch profile, wherein the electronics subsystem is configured to modulate a parameter of the TENS treatment based upon the input, until a threshold is satisfied. | 01-30-2014 |
20140105418 | FREQUENCY DOMAIN MULTIBAND DYNAMICS COMPRESSOR WITH SPECTRAL BALANCE COMPENSATION - A multiband dynamics compressor implements a solution for minimizing unwanted changes to the long-term frequency response. The solution essentially proposes undoing the multiband compression in a controlled manner using much slower smoothing times. In this regard, the compensation provided acts more like an equalizer than a compressor. What is applied is a very slowly time-varying, frequency-dependent post-gain (make-up gain) that attempts to restore the smoothed long-term level of each compressor band. | 04-17-2014 |
20140379045 | SYSTEM AND METHOD FOR MANAGING PAIN - A system and method for managing pain, configured to be worn by a patient, comprising an electrode array comprising a first electrode and a second electrode for providing a TENS treatment to the patient; a connector configured to couple at least one of the first electrode and the second electrode to an electronics subsystem; a muscle twitch sensor subsystem configured to detect a muscle twitch profile induced by the electrode array at the patient; and an electronics subsystem comprising a power module configured to power the system, a pulse generator coupled to the electrode array and configured to transmit the TENS treatment, and a control module configured to receive an input, from the muscle twitch sensor subsystem, characterizing the muscle twitch profile, wherein the electronics subsystem is configured to modulate a parameter of the TENS treatment based upon the input, until a threshold is satisfied. | 12-25-2014 |
20160065161 | FREQUENCY DOMAIN MULTIBAND DYNAMICS COMPRESSOR WITH SPECTRAL BALANCE COMPENSATION - A multiband dynamics compressor implements a solution for minimizing unwanted changes to the long-term frequency response. The solution essentially proposes undoing the multiband compression in a controlled manner using much slower smoothing times. In this regard, the compensation provided acts more like an equalizer than a compressor. What is applied is a very slowly time-varying, frequency-dependent post-gain (make-up gain) that attempts to restore the smoothed long-term level of each compressor band. | 03-03-2016 |
Patent application number | Description | Published |
20080315196 | TECHNIQUE FOR EVALUATING A FABRICATION OF A DIE AND WAFER - The fabrication of the wafer may be analyzed starting from when the wafer is in a partially fabricated state. The value of a specified performance parameter may be determined at a plurality of locations on an active area of a die of the wafer. The specified performance parameter is known to be indicative of a particular fabrication process in the fabrication. Evaluation information may then be obtained based on a variance of the value of the performance parameter at the plurality of locations. This may be done without affecting a usability of a chip that is created from the die. The evaluation information may be used to evaluate how one or more processes that include the particular fabrication process that was indicated by the performance parameter value was performed. | 12-25-2008 |
20100084729 | INTEGRATED PHOTODIODE FOR SEMICONDUCTOR SUBSTRATES - A substrate section that is at least partially fabricated to include contact elements and materials. The substrate section includes doped regions that have a heavily doped N-type region and a heavily doped P-type region adjacent to one another. An exterior surface of the substrate has a topography that includes a light-transparent region in which light, from a light source, is able to reach a surface of the substrate. An application of light onto the light transparent region is sufficient to cause a voltage potential to form across a junction of the heavily doped regions. The substrate section may further comprise one or more electrical contacts, positioned on the substrate section to conduct current, resulting from the voltage potential created with application of light onto the light transparent region, to a circuit on the semiconductor substrate. | 04-08-2010 |
20130121617 | APPARATUS AND METHOD FOR POLARIZATION DIVERSITY IMAGING AND ALIGNMENT - A method of obtaining two orthogonally polarized super-resolution images is provided. A first diffraction-limited image is obtained using horizontally polarized light; a second diffraction-limited image is obtained using vertically polarized light; and, the first and second images are processed so as to yield a convoluted image having super diffraction-limited performance in both dimensions. Enhanced alignment of CAD image to acquired image is facilitated using the horizontally and vertically polarized images. | 05-16-2013 |
20130314116 | LASER-ASSISTED DEVICE ALTERATION USING SYNCHRONIZED LASER PULSES - A pulsed-laser LADA system is provided, which utilizes temporal resolution to enhance spatial resolution. The system is capable of resolving CMOS pairs within the illumination spot using synchronization of laser pulses with the DUT clock. The system can be implemented using laser wavelength having photon energy above the silicon bandgap so as to perform single-photon LADA or wavelength having photon energy below the silicon bandgap so as to generate two-photon LADA. The timing of the laser pulses can be adjusted using two feedback loops tied to the clock signal of an ATE, or by adjusting the ATE's clock signal with reference to a fixed-pulse laser source. | 11-28-2013 |
20130334644 | INTEGRATED PHOTODIODE FOR SEMICONDUCTOR SUBSTRATES - A substrate section that is at least partially fabricated to include contact elements and materials. The substrate section includes doped regions that have a heavily doped N-type region and a heavily doped P-type region adjacent to one another. An exterior surface of the substrate has a topography that includes a light-transparent region in which light, from a light source, is able to reach a surface of the substrate. An application of light onto the light transparent region is sufficient to cause a voltage potential to form across a junction of the heavily doped regions. The substrate section may further comprise one or more electrical contacts, positioned on the substrate section to conduct current, resulting from the voltage potential created with application of light onto the light transparent region, to a circuit on the semiconductor substrate. | 12-19-2013 |
20160104812 | INTEGRATED PHOTODIODE FOR SEMICONDUCTOR SUBSTRATES - A substrate section that is at least partially fabricated to include contact elements and materials. The substrate section includes doped regions that have a heavily doped N-type region and a heavily doped P-type region adjacent to one another. An exterior surface of the substrate has a topography that includes a light-transparent region in which light, from a light source, is able to reach a surface of the substrate. An application of light onto the light-transparent region is sufficient to cause a voltage potential to form across a junction of the heavily doped regions. The substrate section may further comprise one or more electrical contacts, positioned on the substrate section to conduct current, resulting from the voltage potential created with application of light onto the light-transparent region, to a circuit on the semiconductor substrate. | 04-14-2016 |
20160109513 | SYSTEMS AND METHOD FOR LASER VOLTAGE IMAGING - An apparatus and method for laser voltage testing of a DUT is disclosed. The system enables laser voltage probing and laser voltage imaging of devices within the DUT. A selected area of the DUT is illuminating a while the DUT is receiving test signals causing certain of the active devices to modulate. Light reflected from the DUT is collected and is converted into an electrical signal. The electrical signal is sampled by an ADC and the output of the ADC is sent to an FPGA. The FPGA operates on the signal so as to provide an output that emulates a spectrum analyzer or a vector analyzer. | 04-21-2016 |
Patent application number | Description | Published |
20100312862 | Method and Apparatus for Usage Estimation and Prediction in Two-Way Communication Networks - Methods, apparatus, and network oriented systems are discussed for estimating system, e.g. web site, usage removed from the web site, as well as scheduling and directing a data broadcast source to provide content based on web site usage estimates and predictions in a broadcast data stream. | 12-09-2010 |
20110173669 | Method and Apparatus for Transmitting Data in a Data Stream - The invention provides a method and apparatus that addresses and resolves the issues currently affecting the ability to offer Enhanced TV, in particular, those issues concerning timing and synchronization, interaction with other modules in the STB, and distribution. | 07-14-2011 |
20110179438 | Method and Apparatus for Transmitting Data in a Data Stream - The invention provides a method and apparatus that addresses and resolves the issues currently affecting the ability to offer Enhanced TV, in particular, those issues concerning timing and synchronization, interaction with other modules in the STB, and distribution. | 07-21-2011 |
20110179457 | Method and Apparatus for Transmitting Data in a Data Stream - The invention provides a method and apparatus that addresses and resolves the issues currently affecting the ability to offer Enhanced TV, in particular, those issues concerning timing and synchronization, interaction with other modules in the STB, and distribution. | 07-21-2011 |
20110282992 | Method and Apparatus for Usage Estimation and Prediction in Two-Way Communication Networks - Methods, apparatus, and network oriented systems are discussed for estimating system, e.g. web site, usage removed from the web site, as well as scheduling and directing a data broadcast source to provide content based on web site usage estimates and predictions in a broadcast data stream. | 11-17-2011 |
20130291045 | Method and Apparatus for Transmitting Data in a Data Stream - The invention provides a method and apparatus that addresses and resolves the issues currently affecting the ability to offer Enhanced TV, in particular, those issues concerning timing and synchronization, interaction with other modules in the STB, and distribution. | 10-31-2013 |
20130312025 | Method and Apparatus for Transmitting Data in a Data Stream - The invention provides a method and apparatus that addresses and resolves the issues currently affecting the ability to offer Enhanced TV, in particular, those issues concerning timing and synchronization, interaction with other modules in the STB, and distribution. | 11-21-2013 |
20130312047 | Transmitting Timing Information for Content in a Data Stream - The invention provides a method and apparatus that addresses and resolves the issues currently affecting the ability to offer Enhanced TV, in particular, those issues concerning timing and synchronization, interaction with other modules in the STB, and distribution. | 11-21-2013 |
20150089552 | System and Method for Providing Synchronized Events to a Television Application - A set top box client in an enhanced television system stores a table associating time references with events. The table is accessed to synchronize the delivery of events to an enhanced television application that is associated with an underlying video program. The enhanced television system delivers broadcast video, video-on-demand and video from a storage component such as a personal video recorder or a digital video disk player. The enhanced television system further provides an application that provides enhancements to an associated video program by overlaying a user interface, by providing overlaid graphical and/or text information or by providing additional audio information. | 03-26-2015 |
20150229976 | Method and Apparatus for Transmitting Data in a Data Stream - The invention provides a method and apparatus that addresses and resolves the issues currently affecting the ability to offer Enhanced TV, in particular, those issues concerning timing and synchronization, interaction with other modules in the STB, and distribution. | 08-13-2015 |
20160037218 | Method and Apparatus for Transmitting Data in a Data Stream - The invention provides a method and apparatus that addresses and resolves the issues currently affecting the ability to offer Enhanced TV, in particular, those issues concerning timing and synchronization, interaction with other modules in the STB, and distribution. | 02-04-2016 |
20160057464 | Method and Apparatus for Transmitting Data in a Data Stream - The invention provides a method and apparatus that addresses and resolves the issues currently affecting the ability to offer Enhanced TV, in particular, those issues concerning timing and synchronization, interaction with other modules in the STB, and distribution. | 02-25-2016 |
Patent application number | Description | Published |
20100308105 | GOLF CLUB APPARATUSES AND METHODS - Apparatuses, methods and systems related to an improved golf data collecting and golf club notification system. The system reminds golfers when a club has been mistakenly left behind on the golf course and notifies the golfer when a golf club or clubs are in or out of the golf bag. The system can notify a golfer if a club or golf bag has been removed without authorization. In one preferred embodiment an apparatus that attaches to a golf club includes dual light sensors—one light sensor configured as a switch and one light sensor configured as a light meter. Algorithms make use of the light sensor data to determine whether a golf club is in or out of a golf bag. | 12-09-2010 |
20110316192 | APPARATUSES, METHODS AND SYSTEMS RELATING TO FINDABLE GOLF BALLS - Golf balls and a system for finding golf balls and methods for making golf balls and methods for using such balls. In the case of one exemplary golf ball, the ball includes a shell and a core material which is encased in the shell and a tag which is disposed within the core material and which has at least one perforation. The tag includes a diode and an antenna which are coupled together. Another exemplary golf ball includes a shell and a core material which is encased within the shell and a tag which is within the core material and which includes an electrical element which is coupled to an antenna; the tag is detectable over a range of at least 20 feet from a handheld device, and the golf ball has high durability and substantially complies with the golf ball specifications of the United States Golf Association. | 12-29-2011 |
20120139729 | GOLF CLUB APPARATUSES AND METHODS - Methods, apparatuses, machine readable non-transitory storage media, and systems which process measured light values in order to determine the status of a golf club relative to a golf club bag are described. In one embodiment, a system uses a floating threshold, which is between a running bright average and a running dark average, to determine whether to add a current light meter value to one or the other of these running averages. In another embodiment, a system resets or re-seeds the running averages so that re-seeded averages are used after exiting from a sleep state such as a dark sleep state. In another embodiment, a system uses light sensor information or other sensor information to determine when a club is in use. In another embodiment, an active golf ball tag includes a sensor (e.g. one or more impact sensors) to detect when a golf ball is hit and to cause an RF transmitter to transmit an RF signal to an RFID reader. | 06-07-2012 |
20120142443 | GOLF CLUB APPARATUSES AND METHODS - Methods, apparatuses, machine readable non-transitory storage media, and systems which process measured light values in order to determine the status of a golf club relative to a golf club bag are described. In one embodiment, a system uses a floating threshold, which is between a running bright average and a running dark average, to determine whether to add a current light meter value to one or the other of these running averages. In another embodiment, a system resets or re-seeds the running averages so that re-seeded averages are used after exiting from a sleep state such as a dark sleep state. In another embodiment, a system uses light sensor information or other sensor information to determine when a club is in use. Other embodiments are also described. | 06-07-2012 |
20120249330 | GOLF DATA RECORDER WITH INTEGRATED MISSING CLUB REMINDER AND THEFT PREVENTION SYSTEM - Apparatuses, methods and systems relating to at least one or more of golf club reminding and golf data collecting and recording. In one embodiment an apparatus on a golf club includes an integrated reminder and a stroke cancellation system and is semi-automatic in that the recording of the stroke is directly in response to changing the state (e.g. activating) of a switch which indicates that the golfer has pressed a button on the golf club. The pressing of the button indicates that the golfer will or has taken a stroke with the golf club and that the stroke is to be recorded, with the location of the stroke and an identifier of the club (e.g. 9 iron). The system may also be equipped with a missing club reminder and theft prevention function that notifies the golfer is a golf club has been left behind or if a club or golf bag has been removed without authorization. | 10-04-2012 |
20130144411 | GOLF CLUB APPARATUSES AND METHODS - Methods and systems for managing golf clubs and for collecting golf data, such as golf strokes, are described. In one embodiment, a golf data collection system includes a golf accessory worn on the golfer's wrist, such as a watch, equipped with a GPS receiver, impact sensing and motion sensing means, and a transceiver to communicate with golf club tags (e.g. at 2.4 GHz such as Bluetooth). The golf accessory senses the motion of the golf club being swung by the golf and/or senses the impact of the golf club striking the golf ball. When swinging motion or impact is sensed the device uses the transceiver to communicate with golf club tags. The closest golf club (i.e. the club in the golfer's hand during the swing) is captured as the club used by the swing based on RSSI (Received Signal Strength Indicator). Other embodiments are also described. | 06-06-2013 |
20160063839 | GOLF CLUB APPARATUSES AND METHODS - Methods and systems for managing golf clubs and for collecting golf data, such as golf strokes, are described. In one embodiment, a golf data collection system includes a golf accessory worn on the golfer's wrist, such as a watch, equipped with a GPS receiver, impact sensing and motion sensing means, and a transceiver to communicate with golf club tags (e.g. at 2.4 GHz such as Bluetooth). The golf accessory senses the motion of the golf club being swung by the golf and/or senses the impact of the golf club striking the golf ball. When swinging motion or impact is sensed the device uses the transceiver to communicate with golf club tags. The closest golf club (i.e. the club in the golfer's hand during the swing) is captured as the club used by the swing based on RSSI (Received Signal Strength Indicator). Other embodiments are also described. | 03-03-2016 |
Patent application number | Description | Published |
20090298910 | REGULATION OF EPIGENETIC CONTROL OF GENE EXPRESSION - Methods are provided for the identification of compounds that selectively modulate epigenetic changes in gene expression. Compounds, compositions, kits or assays devices, and methods are provided for modulating the expression, endogenous levels or the function of small non-coding RNAs cognate to or transcribed by heterochromatic regions subject to epigenetic regulation (i.e., promoters, enhancers, centromeres, telomeres, origins of DNA replication, imprinted loci, or loci marked by dosage-compensation), and for modulating the formation or function of heterochromatin in cells, tissues or animals. | 12-03-2009 |
20100041047 | EFFICIENT REDUCTION OF TARGET RNA'S BY SINGLE- AND DOUBLE-STRANDED OLIGOMERIC COMPOUNDS - The present invention provides, inter alia, methods of selecting a single-stranded oligomeric compounds for inhibiting RNA expression, methods of generating double-stranded oligomeric compounds, methods of identifying optimized double-stranded oligomeric compounds, methods of selecting optimized single-stranded oligomeric compounds, methods of selecting optimized double-stranded oligomeric compounds, methods of identifying multifunctional oligomeric compounds, methods for optimizing target region selection for modulation of RNA expression, methods of optimizing expression modulation of RNA, and the like. The present invention further provides oligomeric compounds, 8-80 nucleobases in length targeted to a target RNA, wherein said oligomeric compound hybridizes to said target RNA and inhibits RNA levels by at least 50% in both single-stranded and double-stranded forms, and multifunctional oligomeric compounds. | 02-18-2010 |
20100267149 | METHODS OF DETERMINING POTENCY OF CHEMICALLY-SYNTHESIZED OLIGONUCLEOTIDES - Provided herein are methods for determining potency of RNAi agents. Such methods include, but are not limited to, cell-based and cell-free assays that measure binding of an RNAi agent with Ago2 or that measure Ago2 activity in the presence of such RNAi agents. Also provided are assays that determine potency of RNAi agents by assessing their ability to compete with other RNAi agents, including control RNAi agents, for binding and/or activation of Ago2. | 10-21-2010 |
20110092573 | MODIFICATION OF MYD88 SPLICING USING MODIFIED OLIGONUCLEOTIDES - Antisense compounds, compositions and methods are provided for modulating the expression of MyD88. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding MyD88. Methods of using these compounds for modulation of MyD88 expression and for treatment of diseases associated with expression of MyD88 are provided. | 04-21-2011 |
20110124715 | Antiviral Oligonucleotides Having a Conserved G4 Core Sequence - Modified oligonucleotides having a conserved G | 05-26-2011 |
20120077276 | METHODS OF DETERMINING POTENCY OF CHEMICALLY-SYNTHESIZED OLIGONUCLEOTIDES - Provided herein are methods for determining potency of RNAi agents. Such methods include, but are not limited to, cell-based and cell-free assays that measure binding of an RNAi agent with Ago2 or that measure Ago2 activity in the presence of such RNAi agents. Also provided are assays that determine potency of RNAi agents by assessing their ability to compete with other RNAi agents, including control RNAi agents, for binding and/or activation of Ago2. | 03-29-2012 |
20130252243 | METHODS OF DETERMINING POTENCY OF CHEMICALLY-SYNTHESIZED OLIGONUCLEOTIDES - Provided herein are methods for determining potency of RNAi agents. Such methods include, but are not limited to, cell-based and cell-free assays that measure binding of an RNAi agent with Ago2 or that measure Ago2 activity in the presence of such RNAi agents. Also provided are assays that determine potency of RNAi agents by assessing their ability to compete with other RNAi agents, including control RNAi agents, for binding and/or activation of Ago2. | 09-26-2013 |
Patent application number | Description | Published |
20090286969 | Oligomeric Compounds And Compositions For Use In Modulation Of Small Non-Coding RNAs - Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided. | 11-19-2009 |
20090291906 | Oligomeric Compounds And Compositions For Use In Modulation Of Small Non-Coding RNAs - Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided. | 11-26-2009 |
20090291907 | Oligomeric Compounds And Compositions For Use In Modulation Of Small Non-Coding RNAs - Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided. | 11-26-2009 |
20090298174 | Oligomeric Compounds And Compositions For Use In Modulation Of Small Non-Coding RNAs - Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided. | 12-03-2009 |
20090317907 | Oligomeric Compounds And Compositions For Use In Modulation Of Small Non-Coding RNAs - Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided. | 12-24-2009 |
20100267813 | Oligomeric Compounds And Compositions For Use In Modulation Of Small Non-Coding RNAs - Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided. | 10-21-2010 |
20110224277 | Oligomeric Compounds And Compositions For Use In Modulation Of Small Non-Coding RNAs - Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided. | 09-15-2011 |
20120122216 | OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN MODULATION OF SMALL NON-CODING RNAS - Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided. | 05-17-2012 |
20120157514 | OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN MODULATION OF SMALL NON-CODING RNAS - Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided. | 06-21-2012 |
20120283319 | OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN MODULATION OF SMALL NON-CODING RNAS - Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided. | 11-08-2012 |
20140057963 | OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN MODULATION OF SMALL NON-CODING RNAS - Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided. | 02-27-2014 |
20140121364 | OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN MODULATION OF SMALL NON-CODING RNAS - Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided. | 05-01-2014 |
20140121365 | OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN MODULATION OF SMALL NON-CODING RNAS - Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided. | 05-01-2014 |
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