Patent application number | Description | Published |
20130089528 | COMPOSITIONS AND METHODS FOR PRESERVING INSULIN-PRODUCING CELLS AND INSULIN PRODUCTION AND TREATING DIABETES - Nuclear Transport Modifiers such as cSN50 and cSN50.1, afford in vivo islet protection following a 2-day course of intense treatment in autoimmune diabetes-prone, non-obese diabetic (NOD) mice, a widely used model of Type 1 diabetes (T1D), which resulted in a diabetes-free state for one year without apparent toxicity and the need to use insulin. cSN50 precipitously reduces the accumulation of islet-destructive autoreactive lymphocytes while enhancing activation-induced cell death of T and B lymphocytes derived from NOD mice. cSN50 attenuated pro-inflammatory cytokine and chemokine production in immune cells in this model of human T1D. cSN50 also provides cytoprotection of beta cells, therefore preserving residual insulin-producing capacity. Because intracellular delivery of a Nuclear Transport Modifier peptide such as cSN50 and cSN50.1 can result in lowering of blood glucose levels and may reducing insulin resistance, the compositions, methods and cells described herein can also be used for treating Type 2 diabetes (T2D). | 04-11-2013 |
20150191522 | COMPOSITIONS FOR PRESERVING INSULIN-PRODUCING CELLS AND INSULIN PRODUCTION AND TREATING DIABETES - Nuclear Transport Modifiers such as cSN50 and cSN50.1, afford in vivo islet protection following a 2-day course of intense treatment in autoimmune diabetes-prone, non-obese diabetic (NOD) mice, a widely used model of Type 1 diabetes (T1D), which resulted in a diabetes-free state for one year without apparent toxicity and the need to use insulin. cSN50 precipitously reduces the accumulation of islet-destructive autoreactive lymphocytes while enhancing activation-induced cell death of T and B lymphocytes derived from NOD mice. cSN50 attenuated pro-inflammatory cytokine and chemokine production in immune cells in this model of human T1D. cSN50 also provides cytoprotection of beta cells, therefore preserving residual insulin-producing capacity. Because intracellular delivery of a Nuclear Transport Modifier peptide such as cSN50 and cSN50.1 can result in lowering of fasting blood glucose levels and may ameliorate (e.g., reduce, eliminate) insulin resistance, the compositions, methods and cells described herein can also be used for treating Type 2 diabetes (T2D). | 07-09-2015 |
Patent application number | Description | Published |
20090296856 | CARRIER PHASE SYNCHRONIZATION SYSTEM FOR IMPROVED AMPLITUDE MODULATION AND TELEVISION BROADCAST RECEPTION - Systems and methods are described for carrier phase synchronization for improved AM and TV broadcast reception. A method includes synchronizing the phase of a carrier frequency of a broadcast signal with the phase of a remote reference frequency. An apparatus includes a receiver to detect the phase of a reference signal; a phase comparator coupled to the reference signal-phase receiver; a voltage controlled oscillator coupled to the phase comparator; and a phase-controlled radio frequency output coupled to the voltage controlled oscillator. | 12-03-2009 |
20100103046 | Robust Low-Frequency Spread-Spectrum Navigation System - Methods and apparatus are described for a navigation system. A process includes providing a plurality of transmitters distributed throughout a desired coverage area; locking the plurality of transmitters to a common timing reference; transmitting a signal from each of the plurality of transmitters. An apparatus includes a plurality of transmitters distributed throughout a desired coverage area; wherein each of the plurality of transmitters comprises a packet generator; and wherein the plurality of transmitters are locked to a common timing reference. | 04-29-2010 |
20100103980 | Robust Low-Frequency Spread-Spectrum Navigation System - Methods and apparatus are described for a navigation system. A process includes providing a plurality of transmitters distributed throughout a desired coverage area; locking the plurality of transmitters to a common timing reference; transmitting a signal from each of the plurality of transmitters. An apparatus includes a plurality of transmitters distributed throughout a desired coverage area; wherein each of the plurality of transmitters comprises a packet generator; and wherein the plurality of transmitters are locked to a common timing reference. | 04-29-2010 |
20100103982 | Robust Low-Frequency Spread-Spectrum Navigation System - Methods and apparatus are described for a navigation system. A process includes providing a plurality of transmitters distributed throughout a desired coverage area; locking the plurality of transmitters to a common timing reference; transmitting a signal from each of the plurality of transmitters. An apparatus includes a plurality of transmitters distributed throughout a desired coverage area; wherein each of the plurality of transmitters comprises a packet generator; and wherein the plurality of transmitters are locked to a common timing reference. | 04-29-2010 |
20100103989 | Robust Low-Frequency Spread-Spectrum Navigation System - Methods and apparatus are described for a navigation system. A process includes providing a plurality of transmitters distributed throughout a desired coverage area; locking the plurality of transmitters to a common timing reference; transmitting a signal from each of the plurality of transmitters. An apparatus includes a plurality of transmitters distributed throughout a desired coverage area; wherein each of the plurality of transmitters comprises a packet generator; and wherein the plurality of transmitters are locked to a common timing reference. | 04-29-2010 |
20120029818 | Triply Redundant Integrated Navigation and Asset Visibility System - Methods and apparatus are described for a navigation system. A method includes providing a global positioning system fix having a plurality of tracking parameters; providing a theater positioning system fix; monitoring the plurality of tracking parameters for predetermined conditions; and, when the predetermined conditions are met, sending a notifying signal and switching to the theater positioning system fix as a primary fix. An apparatus includes a system controller; a global positioning system receiver coupled to the system controller; a radio frequency locating receiver coupled to the system controller; and an operator interface coupled to the system controller. | 02-02-2012 |
20120032842 | Triply Redundant Integrated Navigation and Asset Visibility System - Methods and apparatus are described for a navigation system. A method includes providing a global positioning system fix having a plurality of tracking parameters; providing a theater positioning system fix; monitoring the plurality of tracking parameters for predetermined conditions; and, when the predetermined conditions are met, sending a notifying signal and switching to the theater positioning system fix as a primary fix. An apparatus includes a system controller; a global positioning system receiver coupled to the system controller; a radio frequency locating receiver coupled to the system controller; and an operator interface coupled to the system controller. | 02-09-2012 |
Patent application number | Description | Published |
20120256694 | ORTHOGONALLY REFERENCED INTEGRATED ENSEMBLE FOR NAVIGATION AND TIMING - An orthogonally referenced integrated ensemble for navigation and timing includes a dual-polyhedral oscillator array, including an outer sensing array of oscillators and an inner clock array of oscillators situated inside the outer sensing array. The outer sensing array includes a first pair of sensing oscillators situated along a first axis of the outer sensing array, a second pair of sensing oscillators situated along a second axis of the outer sensing array, and a third pair of sensing oscillators situated along a third axis of the outer sensing array. The inner clock array of oscillators includes a first pair of clock oscillators situated along a first axis of the inner clock array, a second pair of clock oscillators situated along a second axis of the inner clock array, and a third pair of clock oscillators situated along a third axis of the inner clock array. | 10-11-2012 |
20130141172 | Orthogonally Referenced Integrated Ensemble for Navigation and Timing - An orthogonally referenced integrated ensemble for navigation and timing includes a dual-polyhedral oscillator array, including an outer sensing array of oscillators and an inner clock array of oscillators situated inside the outer sensing array. The outer sensing array includes a first pair of sensing oscillators situated along a first axis of the outer sensing array, a second pair of sensing oscillators situated along a second axis of the outer sensing array, and a third pair of sensing oscillators situated along a third axis of the outer sensing array. The inner clock array of oscillators includes a first pair of clock oscillators situated along a first axis of the inner clock array, a second pair of clock oscillators situated along a second axis of the inner clock array, and a third pair of clock oscillators situated along a third axis of the inner clock array. | 06-06-2013 |
20140159824 | Orthogonally referenced integrated ensemble for navigation and timing - An orthogonally referenced integrated ensemble for navigation and timing includes a dual-polyhedral oscillator array, including an outer sensing array of oscillators and an inner clock array of oscillators situated inside the outer sensing array. The outer sensing array includes a first pair of sensing oscillators situated along a first axis of the outer sensing array, a second pair of sensing oscillators situated along a second axis of the outer sensing array, and a third pair of sensing oscillators situated along a third axis of the outer sensing array. The inner clock array of oscillators includes a first pair of clock oscillators situated along a first axis of the inner clock array, a second pair of clock oscillators situated along a second axis of the inner clock array, and a third pair of clock oscillators situated along a third axis of the inner clock array. | 06-12-2014 |
Patent application number | Description | Published |
20120160837 | WOOD HEATER WITH ENHANCED MICROWAVE LAUNCH EFFICIENCY - A microwave heater capable of heating a bundle of wood and equipped with an optimized system for introducing microwave energy into the heater. The system uses a high-efficiency elongated waveguide launcher having a plurality of launch openings defined in relatively thin walls. The waveguide launcher can exhibit a launch efficiency of at least 50 percent, thereby providing substantially energy savings over conventional waveguide launchers. | 06-28-2012 |
20120160841 | WOOD HEATER WITH ENHANCED MICROWAVE CHOKE SYSTEM - A microwave heater equipped with a microwave choke and suitable for heating wood under vacuum. The microwave choke inhibits leakage of microwave energy between a door of the heater and a main vessel body of the heater without causing arcing at the choke, even at low pressures. In certain situations, the microwave choke can be configured with side-by-side choke cavities. In certain situations, the microwave choke can be removably coupled to the door and/or vessel body for easier fabrication, installation, and/or replacement. | 06-28-2012 |
20120160843 | DUAL VESSEL CHEMICAL MODIFICATION AND HEATING OF WOOD WITH OPTIONAL VAPOR CONTAINMENT - A commercial scale system and process for chemically modifying wood and then heating the chemically-modified wood. The system/process separates the chemical modification step from the heating step by utilizing two different vessels for the modification and heating steps. The system and process can, in certain situations, include a containment room for preventing escape of vapors from a chemical wood modification reactor, a wood heater, and/or a chemically-modified bundle of wood as the bundle is transported from the wood modification reactor to the wood heater. | 06-28-2012 |
20120175364 | MICROWAVE CHOKE SYSTEM FOR USE IN HEATING ARTICLES UNDER VACUUM - A microwave heater equipped with a microwave choke and suitable for heating one or more articles under vacuum. The microwave choke inhibits leakage of microwave energy between a door of the heater and a main vessel body of the heater without causing arcing at the choke, even at low pressures. In certain situations, the microwave choke can be configured with side-by-side choke cavities. In certain situations, the microwave choke can be removably coupled to the door and/or vessel body for easier fabrication, installation, and/or replacement. | 07-12-2012 |
20130168387 | WOOD TREATMENT METHOD AND APPARATUS EMPLOYING MULTIPLE VESSELS AND MULTIPLE WOOD-TRANSPORTING CARTS - A wood treatment method and apparatus that utilizes at least two carts for transporting bundles of wood into, out of, and between at least two wood treatment vessels. In certain situations, each of the carts can move along a dedicated path and can be located exterior to the vessels during treatment. As a result, the process can have a minimal cycle time, while maximizing throughput from the facility. | 07-04-2013 |
20130171358 | WOOD TREATMENT METHOD AND APPARATUS EMPLOYING VESSEL WITH BUNDLE STABILIZATION SYSTEM - A wood treatment method and apparatus utilizing a treatment vessel having an integrated bundle hold-down system for securing a bundle of wood within the interior of the vessel during treatment. The bundle hold-down system can be operable to counteract large buoyant forces associated with submersing the bundle of wood in a liquid reagent and/or can be used to maintain the shape and/or position of the bundle during treatment, even if a liquid reagent is not present. | 07-04-2013 |
20130171364 | WOOD TREATMENT METHOD AND APPARATUS EMPLOYING DETACHABLE BUNDLE SUPPORT - A wood treatment method and apparatus employing a bundle support structure to support a bundle of wood during transportation and treatment of the bundle. The bundle support structure rests on a movable cart during transportation of the bundle, but is detached from the movable cart during treatment of the bundle. | 07-04-2013 |
20130171365 | WOOD TREATMENT METHOD AND APPARATUS EMPLOYING BUNDLE LIFT SYSTEM - A wood treatment system that includes at least one wood treatment vessel and a bundle lift system for loading and unloading a bundle of wood from a cart used to transport the bundle into and/or out of the treatment vessel. The lift system vertically disengages the bundle of wood from the cart within the interior of the vessel, thereby allowing the cart to be removed from the vessel prior to initiating treatment. The lift system, which can be physically separate from or physically coupled to the cart, is entirely disposed within a lower portion of the interior volume of the wood treatment vessel. | 07-04-2013 |
20130171372 | WOOD TREATMENT METHOD AND APPARATUS EMPLOYING ENHANCED WOOD-TRANSPORTING CART DRIVE SYSTEM - A wood treatment method and apparatus that includes a cart drive system for enabling the movement of at least one wood-transporting cart into and/or out of a wood treatment vessel. The wood-transporting cart can have a length greater than the maximum internal dimension of the wood treatment vessel. The cart drive system can include at least one active drive component and at least one passive drive component. The active drive component can be physically separate from the cart and permanently fixed outside the interior of the wood treatment vessel. The passive drive component can be physically coupled to the cart and operable to move with the cart as it transports the bundle of wood into and/or out of the wood treatment vessel. | 07-04-2013 |
20130172526 | WOOD TREATMENT METHOD AND APPARATUS EMPLOYING LATERALLY SHIFTABLE TRANSPORTATION SEGMENTS - A wood treatment method and apparatus that includes a laterally shiftable transportation segment adjacent a door of a wood treatment vessel. When retracted, the shiftable transportation segment accommodates the opening and/or closing of the door. When aligned, the shiftable transportation segment can support the weight of a cart that transports a bundle of wood into and/or out of the wood treatment vessel. Wood treatment systems described herein may also include a bundle adjustment system for applying an aligning force to at least a portion of the bundle during its loading and/or unloading from the wood treatment vessel. | 07-04-2013 |
Patent application number | Description | Published |
20090247783 | CARBONYLATION PROCESS - Disclosed is an improved carbonylation process for the production of carboxylic acids, carboxylic acid esters, and/or carboxylic acid anhydrides wherein a carbonylation feedstock compound selected from one or more organic oxygenates such as alcohols, ethers, and esters is contacted with carbon monoxide in the presence of a carbonylation catalyst and one or more onium compounds. The carbonylation process differs from known carbonylation processes in that a halide compound, other than the onium salt, such as a hydrogen halide (typically, hydrogen iodide) and/or an alkyl halide (typically, methyl iodide), extraneous or exogenous to the carbonylation process is not fed or supplied to the process. The process can be improved by using a bidentate ligand comprising two functional groups selected from tertiary amines and tertiary phosphines, such as 2,2′-bipyridine and diphosphine derivatives. | 10-01-2009 |
20130172601 | IRIDIUM CATALYSTS FOR CARBONYLATION - A solid catalyst comprising an effective amount of iridium and at least one second metal selected from gallium, zinc, indium and germanium associated with a solid support material is useful for vapor phase carbonylation to produce carboxylic acids and esters from alkyl alcohols, esters, ethers or ester-alcohol mixtures. The iridium and at least one second metal are deposited on a support material. In some embodiments of the invention, the catalyst is useful for vapor phase carbonylation. | 07-04-2013 |
20150182957 | CARBONYLATION CATALYST AND PROCESS USING SAME - Carbonylation catalysts and methods for using them are disclosed. In some embodiments, the carbonylation catalyst includes the contact product of:
| 07-02-2015 |
Patent application number | Description | Published |
20100064943 | LIGHTWEIGHT CONCRETE COMPOSITIONS - A lightweight concrete composition containing from 10 to 90 volume percent of a cement composition, from 10 to 90 volume percent of particles having an average particle diameter of from 0.2 mm to 8 mm, a bulk density of from 0.03 g/cc to 0.64 g/cc, an aspect ratio of from 1 to 3, and from 0 to 50 volume percent of aggregate; where the sum of components used does not exceed 100 volume percent, and where after the lightweight concrete composition is set it has a compressive strength of at least 1700 psi as tested according to ASTM C39 after seven days. The concrete composition can be used to make concrete masonry units, construction panels, road beds and other articles. | 03-18-2010 |
20110214391 | LIGHTWEIGHT COMPOSITIONS AND ARTICLES CONTAINING SUCH - A lightweight cementitious composition containing from 22 to 90 volume percent of a cement composition and from 10 to 78 volume percent of particles having an average particle diameter of from 0.2 mm to 8 mm, a bulk density of from 0.03 g/cc to 0.64 g/cc, an aspect ratio of from 1 to 3, where after the lightweight cementitious composition is set it has a compressive strength of at least 1700 psi as tested according to ASTM C39. The cementitious composition can be used to make concrete masonry units, construction panels, road beds and other articles and can be included as a layer on wall panels and floor panels and can be used in insulated concrete forms. Aspects of the lightweight cementitious composition can be used to make lightweight structural units. | 09-08-2011 |
Patent application number | Description | Published |
20130197094 | TRPV1 COMPOUNDS IN A BIODEGRADABLE POLYMER CARRIER - Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of a TRPV1 compound (e.g., capsaicinoid compound) at or near a target site, one can relieve pain caused by diverse sources, including but not limited to, postoperative pain, spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain, as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days. | 08-01-2013 |
20130266631 | CLONIDINE COMPOUNDS IN A BIODEGRADABLE MATRIX - Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of clonidine in a matrix at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain, as well as pain that is incidental to surgery. When appropriate matrix formulations are provided within biodegradable polymers, this pain relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days. | 10-10-2013 |
20160095829 | TRPV1 COMPOUNDS IN A BIODEGRADABLE POLYMER CARRIER - Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of a TRPV1 compound (e.g., capsaicinoid compound) at or near a target site, one can relieve pain caused by diverse sources, including but not limited to, postoperative pain, spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain, as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days. | 04-07-2016 |
Patent application number | Description | Published |
20080314295 | LIGHTWEIGHT CONCRETE COMPOSITIONS - A lightweight concrete composition containing from 10 to 90 volume percent of a cement composition, from 10 to 90 volume percent of particles having an average particle diameter of from 0.2 mm to 8 mm, a bulk density of from 0.03 g/cc to 0.64 g/cc, an aspect ratio of from 1 to 3, and from 0 to 50 volume percent of aggregate; where the sum of components used does not exceed 100 volume percent, and where after the lightweight concrete composition is set it has a compressive strength of at least 1700 psi as tested according to ASTM C39 after seven days. The concrete composition can be used to make concrete masonry units, construction panels, road beds and other articles. | 12-25-2008 |
20100064943 | LIGHTWEIGHT CONCRETE COMPOSITIONS - A lightweight concrete composition containing from 10 to 90 volume percent of a cement composition, from 10 to 90 volume percent of particles having an average particle diameter of from 0.2 mm to 8 mm, a bulk density of from 0.03 g/cc to 0.64 g/cc, an aspect ratio of from 1 to 3, and from 0 to 50 volume percent of aggregate; where the sum of components used does not exceed 100 volume percent, and where after the lightweight concrete composition is set it has a compressive strength of at least 1700 psi as tested according to ASTM C39 after seven days. The concrete composition can be used to make concrete masonry units, construction panels, road beds and other articles. | 03-18-2010 |
20100088984 | LIGHTWEIGHT COMPOSITIONS AND ARTICLES CONTAINING SUCH - A lightweight cementitious composition containing from 22 to 90 volume percent of a cement composition and from 10 to 78 volume percent of particles having an average particle diameter of from 0.2 mm to 8 mm, a bulk density of from 0.03 g/cc to 0.64 g/cc, an aspect ratio of from 1 to 3, where after the lightweight cementitious composition is set it has a compressive strength of at least 1700 psi as tested according to ASTM C39. The cementitious composition can be used to make concrete masonry units, construction panels, road beds and other articles and can be included as a layer on wall panels and floor panels and can be used in insulated concrete forms. Aspects of the lightweight cementitious composition can be used to make lightweight structural units. | 04-15-2010 |
20110214391 | LIGHTWEIGHT COMPOSITIONS AND ARTICLES CONTAINING SUCH - A lightweight cementitious composition containing from 22 to 90 volume percent of a cement composition and from 10 to 78 volume percent of particles having an average particle diameter of from 0.2 mm to 8 mm, a bulk density of from 0.03 g/cc to 0.64 g/cc, an aspect ratio of from 1 to 3, where after the lightweight cementitious composition is set it has a compressive strength of at least 1700 psi as tested according to ASTM C39. The cementitious composition can be used to make concrete masonry units, construction panels, road beds and other articles and can be included as a layer on wall panels and floor panels and can be used in insulated concrete forms. Aspects of the lightweight cementitious composition can be used to make lightweight structural units. | 09-08-2011 |