Patent application number | Description | Published |
20080312309 | CONTROLLED RELEASE ORAL FORMULATIONS OF ION CHANNEL MODULATING COMPOUNDS AND RELATED METHODS FOR PREVENTING ARRHYTHMIA - The present invention provides methods of treating and preventing arrhythmia and other diseases or disorders, using ion channel modulating compounds, including vernakalant hydrochloride. The present invention further provides controlled release oral formulations and dosages of vernakalant hydrochloride, which are effective in preventing arrhythmia. Certain methods and formulations of the present invention are adapted for the treatment and prevention of arrhythmia and other disease or disorders in subjects identified as having altered drug metabolism due to polymorphism of the gene encoding cytochrome P450 2D6. | 12-18-2008 |
20090041841 | CONTROLLED RELEASE TABLET FORMULATIONS FOR THE PREVENTION OF ARRHYTHMIAS - Methods, formulations, dosing regimes, and routes of administration for the treatment or prevention of arrhythmias, including the treatment or prevention of atrial fibrillation are disclosed. Controlled release tablet formulations comprising a therapeutically effective amount of an ion channel modulating compound, or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable excipients suitable for controlled release formulations are disclosed. In these methods, the disease or condition is treated or prevented by administering one or more ion channel modulating compounds to a subject, where the ion channel modulating compound or compounds produce specific plasma levels in the subject. The ion channel modulating compounds may be cycloalkylamine ether compounds, particularly cyclohexylamine ether compounds. | 02-12-2009 |
20090270478 | ION CHANNEL MODULATING ACTIVITY II - Methods, compositions, dosing regimes, and routes of administration for the treatment or prevention of arrhythmias. In these methods, arrythmias (e.g., atrial fibrillation, atrial flutter, early afterdepolarizations and prolongation of QT interval) may be reduced or eliminated by administering ion channel modulating compounds to a subject in need thereof. The ion channel modulating compounds may be cycloalkylamine ether compounds, particularly cyclohexylamine ether compounds. Also described are compositions of ion channel modulating compounds and drugs which induce early afterdepolarizations, prolongation of QT interval and/or Torsades de Pointes. | 10-29-2009 |
20100029639 | ION CHANNEL MODULATING COMPOUNDS AND USES THEREOF - Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia. | 02-04-2010 |
20100056603 | ION CHANNEL MODULATING COMPOUNDS AND USES THEREOF - Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia. | 03-04-2010 |
20100120890 | ION CHANNEL MODULATING ACTIVITY I - Methods, compositions, dosing regimes, and routes of administration for the treatment or prevention of arrhythmias. In these methods, early afterdepolarizations and prolongation of QT interval may be reduced or eliminated by administering ion channel modulating compounds to a subject in need thereof. The ion channel modulating compounds may be cycloalkylamine ether compounds, particularly cyclohexylamine ether compounds. Also described are compositions of ion channel modulating compounds and drugs which induce early afterdepolarizations, prolongation of QT interval and/or Torsades de Pointes. | 05-13-2010 |
20110118329 | USES OF ION CHANNEL MODULATING COMPOUNDS - Methods, formulations, dosing regimes, and routes of administration for the treatment or prevention of arrhythmias, including the treatment or prevention of atrial fibrillation. In these methods, the disease or condition is treated or prevented by administering one or more ion channel modulating compounds to a subject, where the ion channel modulating compound or compounds produce specific plasma levels in the subject. The ion channel modulating compounds may be cycloalkylamine ether compounds, particularly cyclohexylamine ether compounds. | 05-19-2011 |
20110207730 | ION CHANNEL MODULATING COMPOUNDS AND USES THEREOF - Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia. | 08-25-2011 |
20120095073 | ION CHANNEL MODULATING ACTIVITY II - Methods, compositions, dosing regimes, and routes of administration for the treatment or prevention of arrhythmias. In these methods, arrythmias (e.g. atrial fibrillation, atrial flutter, early afterdepolarizations and prolongation of QT interval) may be reduced or eliminated by administering ion channel modulating compounds to a subject in need thereof. The ion channel modulating compounds may be cycloalkylamine ether compounds, particularly cyclohexylamine ether compounds. Also described are compositions of ion channel modulating compounds and drugs which induce early afterdepolarizations, prolongation of QT interval and/or Torsades de Pointes. | 04-19-2012 |
20130171077 | ION CHANNEL MODULATING COMPOUNDS AND USES THEREOF - Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia. | 07-04-2013 |
20140314685 | ION CHANNEL MODULATING COMPOUNDS AND USES THEREOF - Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia. | 10-23-2014 |
Patent application number | Description | Published |
20130190764 | Fenestration Burr - A cochlear fenestration burr includes a shaft oriented along a longitudinal axis of rotation of the burr, a cylindrical depth stop member oriented along the axis, the depth stop member having a thickness dimension, a diameter dimension and a contact surface, an extension member extended outward from the contact surface and coaxial with the axis, a cutting member having a cutting surface supported by the extension member, and a cutting tip at the end of the cutting member in the center of the cutting surface and coaxial with the axis. A maximum cutting depth is defined by a distance along the axis between an end of the cutting tip and the contact surface. A cutting grit is disposed on the cutting tip and cutting surface. | 07-25-2013 |
20130315426 | Implantable Microphone - A hearing aid microphone assembly is configured for implantation into a subject and includes a microphone housing, the housing having a generally conical sound gathering portion with a proximal end and a distal end and a microphone support portion with one or more ports configured to receive a microphone and acoustically coupled to the distal end. A diaphragm is disposed over the proximal end of the housing to hermetically seal the sound gathering portion of the housing and create a first chamber. The microphone assembly is configured with either: (1) at least a first and a second port each coupled to a microphone; or (2) at least a first port coupled to a microphone and an accelerometer coupled to the housing. Each of the ports is configured to communicate acoustically with the first chamber. Any unused ports are sealed. | 11-28-2013 |
20130315427 | Implantable Microphone - A hearing aid microphone assembly is configured for implantation into a subject and includes a microphone housing, the housing having a generally conical sound gathering portion with a proximal end and a distal end and a microphone support portion with one or more ports configured to receive a microphone and acoustically coupled to the distal end. A diaphragm is disposed over the proximal end of the housing to hermetically seal the sound gathering portion of the housing and create a first chamber. The microphone assembly is configured with either: (1) at least a first and a second port each coupled to a microphone; or (2) at least a first port coupled to a microphone and an accelerometer coupled to the housing. Each of the ports is configured to communicate acoustically with the first chamber. Any unused ports are sealed. | 11-28-2013 |
20140073840 | Implantable Receptacle for a Hearing Aid Component - An implantable receptacle for receiving a hearing aid component includes a body having a proximal portion, a distal cylindrical portion and a joining portion joining the proximal portion to the distal cylindrical portion. First flexible tines extending from an outer wall of the distal cylindrical portion in the general direction of the proximal portion are configured to engage with and lock the distal cylindrical portion to a wall of a fenestration in a bone of the patient in a permanent fashion in response to pressing the sleeve into the fenestration. Second flexible tines extending from an outer wall of the distal cylindrical portion in a direction generally tangential to the circumference of the distal cylindrical portion are configured to engage with and prevent rotation of the distal cylindrical portion within the wall of the fenestration. | 03-13-2014 |
20140172099 | Techniques For Increasing The Acoustic Impedance Of The Cochlea's Round Window Membrane - A method for increasing the acoustic impedance of the round window membrane of the cochlea in a human patient includes surgically opening access to the round window membrane and placing a packing layer over the round window membrane. Optionally a layer of collagen graft may be obtained from the patient and placed between the round window membrane and the packing layer. Optionally the packing layer may be enclosed within the collagen graft. Optionally bone paté may be obtained from the patient and used to form at least a portion of the packing layer. Optionally a silastic buttress may be placed under compression between the packing layer and the bone of sinus tympani of the patient. | 06-19-2014 |
20140275728 | Wireless Microactuator - According to an exemplary embodiment the hearing of a patient may be improved by providing the patient with a wearable package having a microphone, a wireless transmitter circuit responsive to the microphone to transmit a wireless transducer signal, a power storage device configured to provide power to the transmitter circuit; and a wireless power transmission circuit configured to transmit a wireless power signal and implanting into the patient an electrically powered microactuator having: a wireless receiver circuit to receive the wireless transducer signal; a transducer drive circuit coupled to the wireless receiver circuit to convert the received transducer signal into a transducer drive signal; a transducer coupled to the transducer drive circuit to convert the transducer drive signal into motion; and a wireless power reception circuit configured to receive the wireless power signal to power the transducer drive circuit. | 09-18-2014 |
Patent application number | Description | Published |
20100224385 | APPARATUS, METHOD, AND SYSTEM FOR GROUNDING SUPPORT STRUCTURES USING AN INTEGRATED GROUNDING ELECTRODE - Disclosed herein are apparatus, methods, and systems for grounding outdoor light poles, as well as other structures, which may be exposed to lightning or other adverse electrical effects and may require a low impedance path to ground. Inventive aspects include a combination of apparatus integral to the pole or other structure and installation considerations whereby the ease of installation, reduction of onsite installation error, and reduction of impedance may be tailored to each installation. An apparatus can include a pre-installed earth grounding electrode at the lower end of the pole or structure to be inserted into the earth. A method can include installing an earth grounding electrode to/on/in a lower end of a pole or structure prior to insertion into the earth. | 09-09-2010 |
20120168195 | APPARATUS, METHOD, AND SYSTEM FOR GROUNDING SUPPORT STRUCTURES USING AN INTEGRATED GROUNDING ELECTRODE - Disclosed herein are apparatus, methods, and systems for grounding outdoor light poles, as well as other structures, which may be exposed to lightning or other adverse electrical effects and may require a low impedance path to ground. Inventive aspects include a combination of apparatus integral to the pole or other structure and installation considerations whereby the ease of installation, reduction of onsite installation error, and reduction of impedance may be tailored to each installation. An apparatus can include a pre-installed earth grounding electrode at the lower end of the pole or structure to be inserted into the earth. A method can include installing an earth grounding electrode to/on/in a lower end of a pole or structure prior to insertion into the earth. | 07-05-2012 |