Patent application number | Description | Published |
20080206151 | Liposomes - The present invention relates to a process for the manufacture of targeting liposomes comprising vector compounds conjugated to the hydrophilic part of modified phospholipids. The present invention provides the modified phospholipids and liposomes containing said modified phospholipids. | 08-28-2008 |
20080213174 | Radiolabelled Insulin - The invention relates to in vivo imaging agents, specifically radiolabelled insulin derivatives of formula (III); wherein X is —CO—NH—, —NH—, —O—, —NHCONH—, or —NHCSNH—, and is preferably —CO—NH—, —NH— or —O—; Y is H, alkyl or aryl substituents; R* is a radiolabel moiety suitable for detection by SPECT or PET; and methods for preparing the same as well as their use in in vivo imaging methods. | 09-04-2008 |
20080267881 | IMAGING AGENTS - The invention relates to compounds of formula (I): and their use as targeting vectors that bind to receptors associated with angiogenesis. Such compounds may thus be used for diagnosis or therapy of, for example, malignant diseases, heart diseases, endometriosis, inflammation-related diseases, rheumatoid arthritis and Kaposi's sarcoma. | 10-30-2008 |
20080274052 | RADIOFLORINATION METHODS - The present invention relates to methods and reagents for [ | 11-06-2008 |
20080279769 | Enzyme Inhibitor Imaging Agents - The present invention discloses that imaging agents which comprise a specific type of matrix metalloproteinase inhibitors (MMPi's) of the hydroxamate class labelled with an imaging moiety, are useful diagnostic imaging agents for in vivo imaging and diagnosis of the mammalian body. | 11-13-2008 |
20090004119 | Polymers - The present invention relates to novel linear polymers, compositions comprising said polymers and their use as contrast agents in magnetic resonance (MR) imaging (MRI) and magnetic resonance spectroscopy (MRS). | 01-01-2009 |
20090110640 | CONTRAST AGENTS FOR MAGNETIC RESONANCE IMAGING AND SPECTROSCOPY CONSISTING OF A CYCLIC OLIGOAMID CORE OF 3 TO 4 IDENTICIAL MONOMER UNITS WITH 3 TO 4 PARAMAGNETIC CHELATE SIDE CHAINS - The present invention relates to: Compounds of formula (I) consisting of a cyclic polymer core A and groups -L-X attached to said core A-(L-X) | 04-30-2009 |
20090203584 | Peptide-based Compounds - The invention relates to new peptide-based compounds for use as diagnostic imaging agents or as therapeutic agents wherein the agents comprise targeting vectors which bind to integrin receptors. | 08-13-2009 |
20090232741 | Optical Imaging - This invention relates to a method for imaging of wet age-related macular degeneration (AMD) using a contrast agent comprising a vector attached to an optical imaging reporter, wherein the vector has affinity for receptors associated with angiogenesis. The invention further provides such methods for monitoring the effect of treatment of AMD. | 09-17-2009 |
20090263320 | Peptide-Based Compounds - The invention relates to new peptide-based compounds for use as diagnostic imaging agents or as therapeutic agents wherein the agents comprise targeting vectors which bind to integrin receptors. | 10-22-2009 |
20100034740 | RADIOFLUORINATION METHODS - The invention relates to conjugates of formula (V) or (VI), their use as radiopharmaceuticals, processes for their preparation, and synthetic intermediates used in such processes. | 02-11-2010 |
20100068139 | Methods of radiofluorination of biologically active vectors - The invention relates to conjugates of formula (V) or (VI): wherein X is —CO—NH—, —NH—, —O—, —NHCONH—, or —NHCSNH—; their use as radiopharmaceuticals, processes for their preparation, and synthetic intermediates used in such processes. | 03-18-2010 |
20100111865 | CONTRAST AGENTS - The present invention provides novel compounds and pharmaceutical compositions containing such compounds, wherein the compounds have affinity for proteoglycans. The compounds comprise an amino acid based core unit linked to positively charged moieties. The compounds further comprise at least one imaging moiety detectable in in vivo imaging making the compounds useful as diagnostic contrast agents for imaging of proteoglycans, such as heparan sulphate proteoglycans. | 05-06-2010 |
20100150843 | PEPTIDE IMAGING AGENTS - The present invention relates to labelled cMet binding peptides suitable for optical imaging in vivo. The peptides are labelled with an optical reporter group suitable for imaging in the red to near-infrared region. Also disclosed are pharmaceutical compositions and kits, as well as in vivo imaging methods, especially of use in the detection, staging, diagnosis, monitoring of disease progression or monitoring of treatment of colorectal cancer (CRC). | 06-17-2010 |
20100196270 | RADIOFLUORINATION METHODS - The invention relates to conjugates of formula (V) or (VI), their use as radiopharmaceuticals, processes for their preparation, and synthetic intermediates used in such processes. | 08-05-2010 |
20110286922 | IMAGING AND RADIOTHERAPY METHODS - The present invention relates to in vivo imaging and radiotherapeutic methods and agents which target the enzyme aldehyde dehydrogenase (ALDH) and that are suitable for the in vivo imaging of tumours and treatment of cancer. | 11-24-2011 |
20120020882 | PEPTIDE-BASED COMPOUNDS - The invention relates to new peptide-based compounds for use as diagnostic imaging agents or as therapeutic agents wherein the agents comprise targeting vectors which bind to integrin receptors. | 01-26-2012 |
20120251449 | ALDH: A COMPOUND FOR CANCER STEM CELL IMAGING - The present invention claims fluoro- & iodo-containing aldehydes as ALDH substrates for use as diagnostic imaging agents or as therapeutic agents. The aldehydes are both directly and indirectly attached to an aromatic or a straight chain ring. ALDH activity was monitored either by the formation of acid-product or consumption of aldehyde substrates. | 10-04-2012 |
20120269727 | IMAGING AGENTS WITH IMPROVED PHARMACOKINETIC PROFILES - The invention relates to compounds suitable for use in an imaging agent said imaging agent showing an improved pharmacokinetic profile. | 10-25-2012 |
20120275973 | PURIFICATION METHODS - The invention relates to novel processes for the purification of radiolabelled tracers, using a solid-support bound scavenger group. The general concept being illustrated by the scheme: | 11-01-2012 |
20130101509 | IMAGING AND RADIOTHERAPY METHODS - The present invention relates to in vivo imaging and radiotherapeutic methods and agents which target the enzyme aldehyde dehydrogenase (ALDH) and that are suitable for the in vivo imaging of tumours and treatment of cancer. | 04-25-2013 |
20130343990 | RADIOLABELLED OCTREOTATE ANALOGUES AS PET TRACERS - Novel radiotracer(s) for Positron Emission Tomography (PET) imaging are described. Novel radiotracer(s) for Positron Emission Tomography (PET) imaging of neuorendocrine tumors are described. Specifically the present invention describes novel [18F]Fluoroethyltriazol-[Tyr3]Octreotate analogs; in particular those that target somatostatin receptors found on the cell surface of gastroenteropancreatic neuorendocrine tumors. The present invention also describes intermediate(s), precursor(s), pharmaceutical composition(s), methods of making, and methods of use of the novel radiotracer(s). | 12-26-2013 |
20140286866 | IMAGING AGENTS WITH IMPROVED PHARMACOKINETIC PROFILES - The invention relates to compounds suitable for use in an imaging agent said imaging agent showing an improved pharmacokinetic profile. | 09-25-2014 |