Patent application number | Description | Published |
20100113781 | SUBSTITUTED HETEROCYCLE GAMMA-CARBOLINES SYNTHESIS - The present invention provides methods for the preparation of substituted heterocycle fused gamma-carbolines, intermediates useful in producing them and methods for producing such intermediates and such heterocycle fused gamma-carbolines. | 05-06-2010 |
20130039853 | EFFICIENT SYNTHESIS OF CHELATORS FOR NUCLEAR IMAGING AND RADIOTHERAPY: COMPOSITIONS AND APPLICATIONS - Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia. | 02-14-2013 |
20130046097 | SUBSTITUTED HETEROCYCLE GAMMA-CARBOLINES SYNTHESIS - The present invention provides methods for the preparation of substituted heterocycle fused gamma-carbolines, intermediates useful in producing them and methods for producing such intermediates and such heterocycle fused gamma-carbolines. | 02-21-2013 |
20130101534 | SKIN TREATMENTS CONTAINING CARBOXYLIC ACID-SUBSTITUTED IDEBENONE DERlVATIVES AND METHODS OF PREPARATION AND USE THEREOF - The present invention relates to novel carboxylic acid-substituted idebenone derivatives, skin treatment compositions containing these carboxylic acid-substituted derivatives, methods of treating skin changes by topical application of these carboxylic acid-substituted idebenone derivatives, and their methods of synthesis. The carboxylic acid-substituted idebenone derivatives of the present invention are unexpectedly effective in treating skin, particularly with respect to skin tolerance. When included in a topical composition, the carboxylic acid-substituted idebenone derivatives of the present invention have an antioxidant effect that is useful in treating a skin change. | 04-25-2013 |
20130211082 | Synthesis of Cyclopentaquinazolines - A method of producing 6-amino-cyclopenta[g]quinazolines, in enantiomerically enriched form, is provided. In particular, the method may be applicable to the synthesis of N-{N-{4-[N-((6S)-2-hydroxymethyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclo-penta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino]benzoyl}-L-γ-glutamyl}-D-glutamic acid (ONX-0801). | 08-15-2013 |
20130345423 | EFFICIENT PEPTIDE COUPLINGS AND THEIR USE IN THE SYNTHESIS AND ISOLATION OF A CYCLOPENTA (G) QUINAZOLINE TRISODIUM SALT - A new method for the synthesis of L-Glutamyl-γ-D-Glutamic acid and its use in the synthesis of (2R)-((4S)-carboxy-4-(4,N-(((6S)-2-(hydroxymethyl)-4-oxo-3,4,7,8-tetrahydro-3H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino)benzamido)butanamido)pentanedioic acid, 1 are provided. Also provided is an efficient method for the isolation and purification of the trisodium salt of the abovementioned acid, 2, in a form suitable for long term storage and use in a parenteral dosing form. | 12-26-2013 |
20140364609 | SUBSTITUTED HETEROCYCLE FUSED GAMMA-CARBOLINES SYNTHESIS - The present invention provides methods for the preparation of substituted heterocycle fused gamma-carbolines, intermediates useful in producing them and methods for producing such intermediates and such heterocycle fused gamma-carbolines. | 12-11-2014 |
20150225384 | PROCESSES FOR PREPARING FUSED HETEROCYCLIC ION CHANNEL MODULATORS - The present disclosure provides processes for the preparation of a compound of formula: | 08-13-2015 |
Patent application number | Description | Published |
20130195785 | ANTIPERSPIRANT EMULSION COMPOSITIONS AND PROCESSES FOR MAKING ANTIPERSPIRANT EMULSION COMPOSITIONS - Processes for making an antiperspirant emulsion composition and antiperspirant emulsion compositions are provided herein. In an embodiment, a process for making an antiperspirant emulsion composition includes combining water and an antiperspirant active component to form a water phase. A hydrophobic carrier and a structurant are combined to form an oil phase. The structurant has a melting point above ambient temperature. The oil phase is heated to a first temperature of at least a melting point of the structurant that is disposed in the oil phase. The water phase and the heated oil phase are mixed to form the antiperspirant emulsion composition. The antiperspirant emulsion composition is cooled under continued mixing. | 08-01-2013 |
20130196092 | ANTIPERSPIRANT COMPOSITIONS HAVING PARTICULATE OPACIFYING AGENT, ANTIPERSPIRANT PRODUCTS INCLUDING THE ANTIPERSPIRANT COMPOSITIONS, AND METHODS OF PREPARING THE ANTIPERSPIRANT COMPOSITIONS - An antiperspirant composition includes an antiperspirant active compound and a particulate opacifying agent. The antiperspirant active compound is based upon an astringent metallic salt. The particulate opacifying agent has a refractive index greater than a comparable antiperspirant composition absent the particulate opacifying agent, provided that a difference in refractive index between the particulate opacifying agent and the comparable antiperspirant composition absent the particulate opacifying agent is less than or equal to about 0.3. An antiperspirant product including a container and the antiperspirant composition disposed in the container is also provided. | 08-01-2013 |
20130230475 | ANTIPERSPIRANT EMULSION PRODUCTS AND PROCESSES FOR MAKING THE SAME - A water in oil emulsion composition includes an antiperspirant active, an emulsifier, and a combination of polyalkylene glycols making up between about 1 and about 12 wt. % of the total composition. The combination includes H[OCH | 09-05-2013 |
20140120046 | METHODS FOR MAKING CLEAR STICK ANTIPERSPIRANT COMPOSITIONS AND PRODUCTS - Methods for making clear stick antiperspirant compositions and products are provided herein. In one example, a method for making a clear stick antiperspirant composition comprises the steps of providing a solvent carrier at substantially below room temperature to define a cool solvent carrier. A gelling agent comprising dibenzylidene sorbitol is incorporated into the cool solvent carrier to form a solvent/DBS premix. An active antiperspirant compound and the solvent/DBS premix are combined. | 05-01-2014 |
Patent application number | Description | Published |
20090042892 | Cetp Inhibitors - Compounds having the structure of Formula (I), including pharmaceutically acceptable salts of the compounds, are CETP inhibitors and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In the compounds of Formula (I), B is a cyclic group other than phenyl, and B has a cyclic substituent at a position that is ortho to the position at which B is connected to the remainder of the structure of Formula (I). The 5-membered ring of Formula (I) has a second cyclic substituent in addition to B. | 02-12-2009 |
20090075979 | CETP Inhibitors - Compounds having the structure of Formula (I), including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In the compounds of Formula (I), B or R | 03-19-2009 |
20090264405 | Cetp Inhibitors - Compounds of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. | 10-22-2009 |
20100099716 | CETP INHIBITORS - Compounds having the structures of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis: | 04-22-2010 |
20100249024 | CETP INHIBITORS - Compounds of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In the compounds of Formula 1, A | 09-30-2010 |
Patent application number | Description | Published |
20100305008 | Organophilic Clay Additives And Oil Well Drilling Fluids With Less Temperature Dependent Rheological Properties - An additive composition including a synergistic combination of a hectorite organoclay composition and an attapulgite organoclay composition. The hectorite organoclay composition includes (i) a first organic cation provided by an alkoxylated quaternary ammonium salt; and ii) a second organic cation wherein such second organic cation is not provided by an alkoxylated quaternary ammonium salt. The attapulgite organoclay composition includes (iii) a third organic cation provided by an alkoxylated quaternary ammonium salt; and (iv) a fourth organic cation wherein such third organic cation is not provided by an alkoxylated quaternary ammonium salt. | 12-02-2010 |
20120129735 | NON-AQUEOUS DRILLING ADDITIVE USEFUL TO PRODUCE A FLAT TEMPERATURE-RHEOLOGY PROFILE - A method of providing a substantially constant equivalent circulating density of a drilling fluid over a temperature range of about 120° F. to about 40° F. includes adding a drilling fluid additive to the drilling fluid, wherein the drilling fluid additive includes the reaction product of a carboxylic acid with a single carboxylic moiety; and a polyamine having at least two primary amino functionalities and optionally at least one secondary amino functionality. | 05-24-2012 |
20140066341 | NON-AQUEOUS DRILLING ADDITIVE USEFUL TO IMPROVE LOW SHEAR RATE VISCOSITY - A method to control viscosity with respect to shear rate for an oil based drilling fluid by adding a polyamide drilling fluid additive to the oil based drilling fluid. In some embodiments, a polyamide drilling fluid additive includes a reaction product of (i) a carboxylic acid with a single carboxylic moiety or two carboxylic moieties, and (ii) a polyamine having an amine functionality of two or more; and placing the placing the oil based drilling fluid into the subterranean formation. | 03-06-2014 |
20150051121 | SLURRY CONCENTRATE AND ASSOCIATED METHODS OF USE - The invention relates to a slurry concentrate which contains a viscosity enhancing polymer and organohectorite clay, which exhibits an unexpected improvement in viscosity and syneresis while exhibiting improved safety characteristics. | 02-19-2015 |
20150376490 | Non-Aqueous Drilling Additive Useful To Stabilize Viscosity Over Change In Temperature - A composition and method to control viscosity with respect to temperature for an oil-based drilling fluid by adding a polyamide drilling fluid additive to the oil based drilling fluid. In some embodiments, a polyamide drilling fluid additive includes a reaction product of (i) a carboxylic acid with a single carboxylic moiety; (ii) a carboxylic acid with two carboxylic moieties, a carboxylic acid with three carboxylic moieties and combinations thereof; and (iii) a polyamine having an amine functionality of two or more; and placing the placing the oil based drilling fluid into the subterranean formation. | 12-31-2015 |