Middleton, GB
Andrew Middleton, Weybridge GB
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20100018533 | Novel Device - A face mask comprising a filter material being a fibrous substrate, especially non-woven polypropylene or polyester, having an acidic polymer, especially of the Carbopol or Gantrez type, deposited on the fibres. The mask has an anti-viral activity against inhaled or exhaled air. A filter material suitable for such a mask, and a process for making it are also described. | 01-28-2010 |
Ashley Paul Middleton, Somerset GB
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20140053742 | BALING PRESSES - A baling press includes a support unit on which first and second strapping mechanisms are mounted, and the support unit is rotatable between a first position in which the first strapping mechanism is operational and a second position in which the second strapping mechanism is operational. | 02-27-2014 |
Dai C. Middleton, Hursley GB
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20100262972 | DEADLOCK AVOIDANCE - A transaction processing system is operated. A first resource is locked as a shared resource by a first task executing on a computing device. The first task attempts to lock a second resource as an exclusive resource. The occurrence of a deadlock is ascertained. A second task that wishes to use the locked first resource is identified. A current position of the first task with respect to the first resource is stored. The lock on the first resource is removed. The second task is prompted to use the first resource. The first task locks the first resource as the shared resource. The first task is repositioned with respect to first resource according to the stored position. The first task locks the second resource as the exclusive resource. The first task is performed. | 10-14-2010 |
Donald Middleton, Sandwich GB
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20140163000 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE - The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. | 06-12-2014 |
20140249157 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE - The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. | 09-04-2014 |
Donald Stuart Middleton, Kent GB
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20090264425 | CHEMICAL COMPOUNDS - This invention relates to biaryl ether derivatives of formula (I) | 10-22-2009 |
Fiona Middleton, South Gosforth GB
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20140134596 | Method for Measuring ATR Inhibition mediated increases in DNA damage - The present relates to methods for detecting DNA damage in subjects treated with an ATR inhibitor. More specifically, this invention relates to a method for measuring changes in levels of γH2AX and/or pChk1 | 05-15-2014 |
20150247866 | Method for Measuring ATR Inhibition Mediated Increases in DNA Damage - The present relates to methods for detecting DNA damage in subjects treated with an ATR inhibitor. More specifically, this invention relates to a method for measuring changes in levels of γH2AX and/or pChk1 | 09-03-2015 |
Helen Middleton, Toton, Beeston GB
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20130306950 | SEMICONDUCTING POLYMER AND ORGANIC ELECTROLUMINESCENCE DEVICE THEREOF - A semiconducting polymer and electronic devices comprising such polymer, in which the polymer has one or more repeat units, a first of the repeat units having the structure | 11-21-2013 |
Helen Middleton, Nottingham GB
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20140299868 | Compound, Device and Method of Making Same - An organic light-emitting device comprises an anode, a cathode and a light-emitting layer between the anode and the cathode. The light-emitting layer comprises a compound of formula (I): | 10-09-2014 |
20140346486 | LIGHT EMITTING COMPOSITION AND DEVICE - A light-emitting composition comprises a polymer and a phosphorescent light-emitting material. The polymer comprises conjugating repeat units of formula (I) and up to 20 mol % of conjugation-blocking repeat units of repeat units of formula (II): | 11-27-2014 |
Ian Middleton, Manchester GB
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20150202418 | MICRONEEDLE-BASED DEVICES AND METHODS FOR THE REMOVAL OF FLUID FROM A BODY - Microneedle-based devices and associated methods for removing fluid from a body are described. The devices incorporate microneedles capable of fluidly linking the body to a high capacity absorbent material capable of absorbing at least 5 times its own weight of said fluid. The microneedles may be conventional hollow microneedles in which the bores are filled with a microporous material, hydrophobic hollow microneedles provided with bores having a hydrophilic lining, hollow hydrogel microneedles or solid microporous microneedles. | 07-23-2015 |
John Colin Middleton, Bedfordshire GB
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20090208390 | MIXING APPARATUS - A mixing apparatus ( | 08-20-2009 |
20130150618 | MIXING APPARATUS - A mixing apparatus | 06-13-2013 |
Max Middleton, London GB
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20100185165 | SILENCER FOR VACUUM SYSTEM OF A WOUND DRAINAGE APPARATUS - Apparatus ( | 07-22-2010 |
20150045753 | SILENCER FOR VACUUM SYSTEM OF A WOUND DRAINAGE APPARATUS - Apparatus ( | 02-12-2015 |
20160058926 | SILENCER FOR VACUUM SYSTEM OF A WOUND DRAINAGE APPARATUS - Apparatus ( | 03-03-2016 |
Max William Middleton, London GB
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20100207768 | TOPICAL NEGATIVE PRESSURE SYSTEM WITH STATUS INDICATION - A method and apparatus are disclosed for indicating a status of at least one operating parameter associated with a topical negative pressure (TNP) system. The method includes the steps of generating illumination from at least one LED, the illumination having at least one characteristic corresponding to a status of at least one operating parameter associated with the TNP system and being visible to a user. | 08-19-2010 |
20130046238 | DEVICE FOR THE AUTOMATIC INJECTION OF TWO DOSES OF A MEDICAMENT - A two-dose autoinjector for a medicament wherein the locking and releasing of the drive spring of the autoinjector is controlled through stepped guides with ramps for two successive slidings of slides operated by the spring and connected with the syringe and plunger. The guides and the slides are pivotable relative to one another and the sliding direction, while the syringe can only slide axially To enable or disable the sliding of the slides within the guides an angularly angularly mobile arming member is provided formed with a guide track substantially equal to that of the stationary member where the guides are formed. | 02-21-2013 |
Michael Middleton, Lymm GB
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20160109185 | ENERGY STORAGE SYSTEM - Energy storage system regulating power output of a power generation plant that has a heat exchanger, primary circuit and secondary circuit, primary circuit directs primary fluid flow to components of a primary region and secondary circuit directs a secondary fluid flow to components of a secondary region, the heat exchanger is arranged so the secondary fluid flow is heated from the primary fluid flow. Energy storage arrangement makes a vessel for storing secondary fluid. Fluid transfer arrangement connects the vessel and is connectable to the heat exchanger of the power generation system to arrange the fluid transfer arrangement in fluid communication with the heat exchanger and the vessel. Bidirectional flow arrangement configured to control flow direction of fluid between the vessel and fluid transfer arrangement to selectively store heat energy from the heat exchanger in the vessel, and selectively transfer heat energy stored in the vessel to the heat exchanger. | 04-21-2016 |
Nicholas Middleton, Dorset GB
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20090220244 | Demodulation of Phase Modulated Fibre-Optic Sensor System Signals - Demodulation apparatus for demodulating phase-modulated signals comprises a quadrature signal generator (QSG) for generating in-phase (I) and quadrature-phase (Q) signals in response to an unmodulated input signal. The QSG provides fast frequency tracking of the input signal and excludes any high-frequency content the input signal. | 09-03-2009 |
Nicolas Mark Middleton, Sheffield GB
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20100130299 | Visual Aid - A visual aid for use in a ball game, such as golf, consists of a ball or disc on which a ball can be placed provided with markings on the surface comprising cross-hairs and a circle, which circle in the case of the ball is of a smaller diameter than the diameter of the ball or in the case of the disc is equal to or greater in diameter than the diameter of the golf ball so as to be used in combination with the periphery of the ball to enable the player to position the player's eyes relative to the ball and in respect of the cross-hairs facilitate the adoption by the player of a targeted mode of vision as well as facilitating the alignment of the direction in which the golf ball is to be propelled. | 05-27-2010 |
Paul Anthony Gerald Middleton, Dorset GB
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20080307952 | CARTRIDGE FOR STORE EJECTION FROM AIRCRAFT - The present invention relates to the field of store ejection from aircraft. More specifically it relates to cartridges used in ejector release units for stores. The invention aims to provide a cartridge that can be used in existing ejector release units that overcomes some of the problems (such as; only a one-time use, the need for cleaning of ejector units, the erosion of ejector units and the need for a holder to be used) of pyrotechnic or hot gas cartridges but without compromising performance. The present invention provides a cartridge for use in an ejector release unit, the cartridge comprising a gas chamber for containing gas under pressure, an outlet of the gas chamber for releasing the compressed gas to drive a release mechanism in the ejector release unit, and a release valve associated with the outlet and arranged to be operable to open the outlet upon activation of a firing pin of an ejector release unit. An ejector release unit containing such a cartridge or pair of cartridges is also provided. | 12-18-2008 |
Penny Jane Middleton, Didcot GB
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20110195929 | COMPOUNDS FOR THE TREATMENT OF FLAVIVIRAL INFECTIONS - Described are various compounds and methods for the treatment of flaviviral infections. In particular, alkaloids and imino sugars in arabinose and/or lyxose stereochemical configuration with antiflaviviral activity are described. | 08-11-2011 |
20110237538 | TREATMENT OF LYSOSOMAL STORAGE DISORDERS AND OTHER PROTEOSTATIC DISEASES - Described are various compounds, in particular iminosugars, and methods for the treatment of proteostatic diseases, in particular lysosomal storage disorders. The compound may be a pharmacoperone of an enzyme selected from: (a) Acid alpha-glucosidase; (b) Acid beta-glucosidase; (c) glucocerebrosidase; (d) alpha-Galactosidase A; (e) Acid beta-galactosidase; (f) beta-Hexosaminidase A; (g) beta-Hexosaminidase B; (h) Acid sphingomyelinase; (i) Galactocerebrosidase; (j) Acid ceramidase; (k) Arylsulfatase A; (l) alpha-L-Iduronidase; (m) Iduronate-2-sulfatase; (n) Heparan N-sulfatase; (o) alpha-N-Acetylglucosaminidase; (p) Acetyl-CoA: alpha-glucosaminide N-acetyltransferase; (q) N-Acetylglucosamine-6-sulfate sulfatase; (r) N-Acetylgalactosamine-6-sulfate sulfatase; (s) Acid beta-galactosidase; (t) Arylsulfatase B; (u) beta-Glucuronidase; (v) Acid alpha-mannosidase; (w) Acid beta-mannosidase; (x) Acid alpha-L-fucosidase; (y) Sialidase; and (z) alpha-N-acetylgalactosaminidase. | 09-29-2011 |
Ricci Middleton, Surrey GB
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20110100879 | IMPROVEMENTS IN OR RELATING TO FILTERS - A magnetic filter device and method for using same, for removing ferromagnetic particles from a liquid, which device comprises a vessel having an inlet for liquid to flow into the vessel and an outlet for the liquid to flow out of the vessel, and the vessel having one or more magnets suspended therein for removing ferromagnetic particles from liquid flowing between the inlet and outlet, characterised in that: the vessel is a horizontal pipe with the inlet at one end and the outlet at the other end, the magnets are suspended transverse to the longitudinal axis of the pipe in one or more sets, and the vessel has one or more helical flow generators which in use, generate helical flow of the liquid as it flows between the inlet and outlet, and/or one or more turbulent flow generators which in use, generate turbulent flow of the liquid as it flows between the inlet and outlet. The helical and/or turbulent flow of the liquid may mitigate the potential problems of liquid and/or particles by-passing the magnet or magnets, for example arising from laminar flow of the liquid and/or uneven distribution of particles in the liquid. | 05-05-2011 |
Richard J. Middleton, Northants GB
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20110081448 | PROCESS FOR TREATING VANILLA BEANS - There is provided a process for the preparation of cured vanilla bean pieces comprising steps of: i) blanching vanilla beans; ii) optionally cooling the blanched vanilla beans of step i); iii) comminuting the blanched vanilla beans of steps i) or ii); iv) incubating the comminuted pieces of step iii); and v) drying the incubated pieces of step iv). | 04-07-2011 |
Richard John Middleton, Nottingham GB
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20110300116 | Method for Generating a Recombinant Clonal Cell Line and Novel Reagents for Use in the Method - A method for generating a recombinant clonal cell line expressing a target cell surface receptor at a specific level of expression from a cell population comprising cells transfected with a plasmid encoding the cDNA sequence of the target receptor and expressing the target cell surface receptor, the method comprising (c) incubating the cell population with a receptor specific fluorescent ligand (d) selecting single cells from step (c) expressing the target cell surface receptor by monitoring the specific binding of the fluorescent ligand using flow cytometry; and novel fluorescent ligands. | 12-08-2011 |
Sarah Margaret Middleton, Nottingham GB
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20150071985 | HAEMOSTATIC WOUND DRESSING - Haemostatic wound dressings are described. The dressings comprise a non-colloidal porous dressing material, and a plurality of fibrinogen-binding peptides immobilised to the non-colloidal porous dressing material, wherein each fibrinogen-binding peptide comprises: an amino acid sequence Gly-Pro-Arg-Xaa (SEQ ID NO: 1) at an amino-terminal end of the peptide, wherein Xaa is any amino acid other than Val, preferably Pro, Sar, or Leu; or an amino acid sequence Gly-His-Arg-Xaa (SEQ ID NO: 2) at an amino-terminal end of the peptide, wherein Xaa is any amino acid other than Pro. The dressings are able to accelerate haemostasis without requiring enzymatic activity. In particular, the dressings to do not rely on the action of exogenous thrombin, and can be stored long-term at room temperature in solution. Methods of making the dressings, and use of the dressings to control bleeding are also described. | 03-12-2015 |
Wayne Middleton, Wigton GB
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20080305326 | Labels - There is described a label comprising a self supporting sheet of a biopolymer (preferably cellulose (e.g. regenerated cellulose, cellulose acetate and/or PLA) said sheet being substantially transparent to visible light when uncoated characterized in that the sheet comprises: (a) a first coating on at least one surface thereof to aid printability thereon; (b) a second coating comprising an adhesive dispersible in an aqueous medium; and (c) optionally a third coating to modify water permeability through the sheet. The labels are to be applied to articles such as glass containers. Preferred labels are wet glue cellulose labels for example where the first coating also comprises a copolymer of vinyl chloride and vinyl acetate to aid water permeability and hence rapid drying of the label on an article. | 12-11-2008 |
20110151213 | LABELS - There is described a multi-layer film. The film comprises a biodegradable layer and a metallised layer, wherein the biodegradable layer comprises a biopolymer selected from the group consisting of carbohydrates, polysaccharides, gums, proteins, colloids, polyorganic acids and mixtures thereof. | 06-23-2011 |
20110165388 | LABELS - There is described a multi-layer film. The film comprises a first biodegradable layer and a second biodegradable layer, wherein the first and second biodegradable layers each comprises a biopolymer selected from the group consisting of carbohydrates, polysaccharides, gums, proteins, colloids, polyorganic acids and mixtures thereof. | 07-07-2011 |
20110165417 | LABELS - There is described a multi-layer film. The film comprises a first biodegradable layer, a second biodegradable layer and a metallised layer. Also described is a multi-layer film comprising a first cellulose layer, a second cellulose layer, an adhesive layer between the first and second cellulose layer and a metallised layer. | 07-07-2011 |
20120040123 | LABELS - There is described a label comprising a self supporting sheet of a biopolymer, preferably cellulose (e.g. regenerated cellulose, cellulose acetate and/or PLA) said sheet being substantially transparent to visible light when uncoated characterized in that the sheet comprises: (a) a first coating on at least one surface thereof to aid printability thereon; (b) a second coating comprising an adhesive dispersible in an aqueous medium; and (c) optionally a third coating to modify water permeability through the sheet. The labels are to be applied to articles such as glass containers. Preferred labels are wet glue cellulose labels for example where the first coating also comprises a copolymer of vinyl chloride and vinyl acetate to aid water permeability and hence rapid drying of the label on an article. | 02-16-2012 |
20120045604 | BIODEGRADABLE FILM WITH PRESSURE-SENSITIVE ADHESIVE LAYER - A multi-layer, biodegradable film is disclosed. The multi-layer, biodegradable film contains a biodegradable core layer and a biodegradable pressure sensitive adhesive layer. The film may further contain a biodegradable, printable layer and a release liner. | 02-23-2012 |
20120114893 | LABELS - There is described a label comprising a self supporting sheet of a biopolymer, preferably cellulose (e.g. regenerated cellulose, cellulose acetate and/or PLA) said sheet being substantially transparent to visible light when uncoated characterized in that the sheet comprises: (a) a first coating on at least one surface thereof to aid printability thereon; (b) a second coating comprising an adhesive dispersible in an aqueous medium; and (c) optionally a third coating to modify water permeability through the sheet. The labels are to be applied to articles such as glass containers. Preferred labels are wet glue cellulose labels for example where the first coating also comprises a copolymer of vinyl chloride and vinyl acetate to aid water permeability and hence rapid drying of the label on an article. | 05-10-2012 |
20120177859 | BIODEGRADABLE, PRINTABLE OR FUNCTIONAL FILM - A biodegradable multi-layer film is disclosed. The biodegradable film comprises a biodegradble core layer and a biodegradable, printable or otherwise functional layer comprising PLA or a PLA derivative. The printable or otherwise functional layer may be coated with a biodegradable, sealable coating layer. | 07-12-2012 |
Wayne Middleton, Cumbria GB
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20110020578 | LABELS - There is described a label comprising a self supporting sheet of a biopolymer, preferably cellulose (e.g. regenerated cellulose, cellulose acetate and/or PLA) said sheet being substantially transparent to visible light when uncoated characterized in that the sheet comprises: (a) a first coating on at least one surface thereof to aid printability thereon; (b) a second coating comprising an adhesive dispersible in an aqueous medium; and (c) optionally a third coating to modify water permeability through the sheet. The labels are to be applied to articles such as glass containers. Preferred labels are wet glue cellulose labels for example where the first coating also comprises a copolymer of vinyl chloride and vinyl acetate to aid water permeability and hence rapid drying of the label on an article. | 01-27-2011 |