Kelner
Drew N. Kelner, Newbury Park, CA US
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20090258826 | Pituitary adenylate cyclase activating peptide (PACAP) receptor (VPAC2) agonists and their pharmacological methods of use - This invention provides novel peptides that function in vivo as agonists of the VPAC2 receptor. These insulin secretagogue polypeptides are shown to lower blood glucose in vivo more than controls upon glucose challenge. The polypeptides of this invention are also stable in formulation and have long half-lives. The peptides of the present invention provide a new therapy for patients with decreased endogenous insulin secretion, in particular type 2 diabetics. In particular, the invention is a polypeptide selected from a specific group of VPAC2-related polypeptides, or functional equivalents thereof. The invention is also directed to a method of treating a metabolic disease in a mammal comprising administering a therapeutically effective amount of the insulin secretagogue peptides to said mammal. Also disclosed are methods of making the peptides, both recombinant and synthetic. | 10-15-2009 |
Ilya Kelner, Redmond, WA US
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20140257533 | AUTOMATIC EXERCISE SEGMENTATION AND RECOGNITION - A physical activity monitoring device includes a sensor array with one or more sensors configured to measure physical activity attributes of a user. A controller automatically determines time intervals where the user is actively engaged in a physical activity based on the physical activity attributes. The controller also automatically determines a type of physical activity the user in actively engaged in during the determined time intervals based on the physical activity attributes. A reporter outputs information regarding the type of physical activity to the user. | 09-11-2014 |
20140257534 | EXTENDING GAMEPLAY WITH PHYSICAL ACTIVITY MONITORING DEVICE - A physical activity monitoring device receives an indication of one or more physical activities to be performed as an extension of a game being played on a game system and measures physical activity attributes of a user wearing the physical activity monitoring device. The physical activity monitoring device determines the user's progress towards completion of the one or more physical activities based on the physical activity attributes and outputs to the game device an indication of the user's progress towards completion of the one or more physical activities. | 09-11-2014 |
20140257535 | PERSONAL TRAINING WITH PHYSICAL ACTIVITY MONITORING DEVICE - A physical activity monitoring device receives a workout regimen including a plurality of exercises. For each of the plurality of exercises, the physical activity monitoring device indicates that exercise to a user and measures physical activity attributes of the user. The physical activity monitoring device outputs information regarding the user's progress towards completion of that exercise based on the physical activity attributes. | 09-11-2014 |
Ilya Kelner, Bothell, WA US
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20150342533 | MOTION BASED ESTIMATION OF BIOMETRIC SIGNALS - A wearable electronic device, comprising a heart rate sensor to determine a heart rate of the user, a motion sensor to detect motion of a user, the motion sensor operated in an initial calibration phase during which the heart rate sensor is detecting the heart rate of the user, and the motion sensor is detecting the motion of the user, the calibration phase being used to compute a correspondence between motion of the user and the heart rate of the user, the motion sensor being operated in a low power phase during which the heart rate sensor is powered down, and a processor configured to run a heart rate estimation module configured to calculate an estimated heart rate of the user based upon the motion of the user and the correspondence between the heart rate of the user and the motion of the user determined in the calibration phase. | 12-03-2015 |
Jonathan A. Kelner, Boston, MA US
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20090259550 | System and Method for Management of Advertisement Campaign - Disclosed herein are systems and methods for keeping records and managing allocation in advertising campaigns according to rational quantitative models. In one facet, various quantitative methods are presented to efficiently manage experimentation and reallocation of advertising resources among many opportunities, seeking the best available return on investment. In an additional facet, a number of automated tools are described that keep statistics and manipulate bids and active sets in large advertising campaigns. For instance, in one illustrative embodiment, a system is presented for calculating an estimate of the relationship between position and bid for ad sites on an ad service which defines position. In another exemplary embodiment, an ad-campaign management system is presented which includes a cost-side reporter, a revenue-side reporter, a Bayesian value generator, and a bid generator. | 10-15-2009 |
Judith Kelner, Jaboatao Dos Guararapes BR
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20100309817 | METHOD AND APPARATUS FOR USE IN A NETWORK - A decentralised method is disclosed of deciding a common configuration parameter in a network. The network comprises at least one node designated to perform the method. In the method, a designated node makes a local decision relating to the configuration parameter in dependence upon information relating to its local operating environment (M | 12-09-2010 |
20110282998 | Address Allocation in a Network - A method of address allocation in a network comprises determining, from negotiations between nodes, whether a first node shall assume a server role responsible for distribution and management of network addresses to clients. If this determination is made, the first node is provided with a pool of network addresses. The invention provides a method of dynamic re-allocation of address pools between servers of the network, in accordance with, for example, network requirements or traffic load. | 11-17-2011 |
20120224505 | NETWORK ADDRESS ALLOCATION METHOD - A distributed network address allocation method is disclosed. For this purpose, an apparatus is provided for use as or in a node of the network. The apparatus comprises a portion ( | 09-06-2012 |
Michael Kelner, La Jolla, CA US
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20150290152 | AFFINITY MEDICANT CONJUGATE - In an embodiment of the invention, a composition for treating a cell population comprises an Affinity Medicant Conjugate (AMC). The medicant moiety can be a toxin including an acylfulvene or a drug moiety. The affinity moiety can be an antibody, a binding protein, a steroid, a lipid, a growth factor, a protein, a peptide or non peptidic. The affinity moiety can be covalently bound to the medicant via a linker. Novel linkers that can be directed to cysteine, arginine or lysine residues based on solution pH allow greater flexibility in preserving and/or generating specific epitopes in the AMC. | 10-15-2015 |
Michael J. Kelner, La Jolla, CA US
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20080306147 | Illudin Analogs Useful as Anticancer Agents - Acylfulvene analogs, which inhibit tumor growth, especially solid tumor growth, and which have an adequate therapeutic index to be effective for in vivo treatment are provided herein. The compounds described herein are useful as anti-neoplastic agents, i.e., to inhibit tumor cell growth in vitro or in vivo, in mammalian hosts, such as humans or animals, e.g., domestic animals, and are effective against solid tumors, hematologic malignancies and multi-drug resistant cancers/tumors. The present compounds can be used alone or they can be used in combination with one or more anti-cancer or anti-tumor agents. | 12-11-2008 |
Michael J. Kelner, Lajolla, CA US
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20080306013 | ILLUDIN ANALOGS USEFUL AS ANTITUMOR AGENTS - The present invention provides illudin analogs of the general formula (I): | 12-11-2008 |
Roman Kelner, Northbrook, IL US
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20100081721 | TREATMENT OF SKIN AND MUCOSAL SUPERFICIAL WOUNDS USING ADRENERGIC RECEPTOR AGONISTS - The invention generally relates to the compositions and methods related to the use of adrenergic receptor agonists solutions for the treatment of skin and mucosal superficial wounds. Some of the preferred adrenergic receptor agonists include epinephrine, phenylephrine, norepinephrine, methoxamine, and mixtures thereof. The invention also relates to devices suitable for applying these solutions to the skin or the mucosal area. Methods according to the invention are especially effective to control superficial skin and mucosal bleeding and accelerate healing time. | 04-01-2010 |
20100125171 | SURGICAL INSTRUMENTS AND METHODS OF USE - The invention generally relates to novel surgical instruments, including ergonomically designed hand held surgical tissue retractors and a pouch for breast implants. The invention also relates to novel methods of performing surgical operations, in particular, cosmetic and reconstructive surgery using inflatable and pre-filled breast enlargement implants. The retractors and methods of the invention may also be applicable for general, orthopedic, cardio, vascular, microsurgeries, obstetrics/gynecology applications, and veterinary practices. | 05-20-2010 |
20150126556 | Treatment of Skin and Mucosal Superficial Wounds Using Adrenergic Receptor Agonists - The invention generally relates to methods of using adrenergic receptor agonists for the treatment of skin and mucosal superficial wounds. Some of the preferred adrenergic receptor agonists include epinephrine, phenylephrine, norepinephrine, methoxamine, and mixtures thereof. Methods according to the invention are especially effective to control superficial skin and mucosal bleeding and accelerate healing time. | 05-07-2015 |
Vered Kelner, Moshav IL
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20150134857 | System and Method for I/O Optimization in a Multi-Queued Environment - A system and method for I/O optimization in a multi-queued environment are provided. In one embodiment, a host is provided that sorts commands into a plurality of queues, wherein a command is sorted based on its data characteristic. The host receives a read request from a storage module for commands in the plurality of queues and provides the storage module with the requested commands. In another embodiment, a storage module is provided that processes commands from a host based on the data characteristic of the queue that stored the command on the host. In another embodiment, a storage module sorts command completions into a plurality of queues, wherein a command completion is sorted based on its resulting status code. | 05-14-2015 |