Costanzo, US
Donn J. Costanzo, Tega Cay, SC US
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20120238423 | APPARATUS AND METHODS RELATING TO CORRUGATED MATERIALS, CONTAINERS, AND PACKAGING - A machine for transitioning a box cutout from a flat configuration to a collapsed box configuration includes a first drive wheel configured to drive a box cutout towards a plunging area; a plunger configured to apply force to a central portion of a bottom panel of the box cutout so as to fold the box about a lateral bisecting axis and propel at least a portion of the box cutout downward; and opposed second and third drive wheels configured to grab a box cutout propelled downward by the plunger and further draw the box cutout downward into a collapsed box configuration within a collection area. A box cutout transitioned to a collapsed box configuration in this manner may include a bottom panel having plurality of unbroken minor score lines and broken major score lines. | 09-20-2012 |
20120238424 | APPARATUS AND METHODS RELATING TO CORRUGATED MATERIALS, CONTAINERS, AND PACKAGING - A machine for transitioning a box cutout from a flat configuration to a collapsed box configuration includes a first drive wheel configured to drive a box cutout towards a plunging area; a plunger configured to apply force to a central portion of a bottom panel of the box cutout so as to fold the box about a lateral bisecting axis and propel at least a portion of the box cutout downward; and opposed second and third drive wheels configured to grab a box cutout propelled downward by the plunger and further draw the box cutout downward into a collapsed box configuration within a collection area. A box cutout transitioned to a collapsed box configuration in this manner may include a bottom panel having plurality of unbroken minor score lines and broken major score lines. | 09-20-2012 |
20120238425 | APPARATUS AND METHODS RELATING TO CORRUGATED MATERIALS, CONTAINERS, AND PACKAGING - A machine for transitioning a box cutout from a flat configuration to a collapsed box configuration includes a first drive wheel configured to drive a box cutout towards a plunging area; a plunger configured to apply force to a central portion of a bottom panel of the box cutout so as to fold the box about a lateral bisecting axis and propel at least a portion of the box cutout downward; and opposed second and third drive wheels configured to grab a box cutout propelled downward by the plunger and further draw the box cutout downward into a collapsed box configuration within a collection area. A box cutout transitioned to a collapsed box configuration in this manner may include a bottom panel having plurality of unbroken minor score lines and broken major score lines. | 09-20-2012 |
Frank V. Costanzo, Westport, MA US
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20090245027 | SLOTTED CYLINDER ACOUSTIC TRANSDUCER - A slotted cylinder acoustic transducer has a crescent-shaped insert disposed between a ceramic stack assembly and s cylindrical housing shell. In some embodiments, all of the ceramic elements in the ceramic stack assembly can have the same shape. | 10-01-2009 |
Joseph Costanzo, Hatfield, PA US
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20140012289 | APPARATUS FOR ENDOSCOPIC PROCEDURES - A surgical device is provided. The surgical device includes a jaw assembly defining a first longitudinal axis and including a first jaw and a second jaw moveable relative to the first jaw; an elongated body defining a second longitudinal axis and coupled to a proximal end of the jaw assembly, wherein the jaw assembly is configured to articulate about an articulation axis transverse to the second longitudinal axis relative to the elongated body; and a handle assembly coupled to a proximal end of the elongated body and including at least one motor mechanically coupled to the jaw assembly and a control assembly including a first control button and a second control button, wherein actuation of the first control button moves the second jaw in approximation relative to the first jaw and actuating the second control button moves the second jaw away from the first jaw, and actuating the first and second control buttons moves the jaw assembly to a centered position in which the first and second longitudinal axes are substantially aligned, the handle assembly further includes an illumination member configured to output a light pattern indicative of a status of the surgical instrument. | 01-09-2014 |
20150112317 | INTERNALLY SEALABLE WIRE - An internally sealable wire includes an elongate flexible body having a length and a plurality of electrically conductive strands disposed within an insulation jacket. The body includes an unsealed portion extending along a majority of the length of the body and at least one sealed portion positioned at a point along the length of the body. The unsealed portion includes open internal spaces defined between the strands and the insulation jacket, and the at least one sealed portion includes a filler material disposed within the internal spaces to effect a seal within the body and prevent the passage of fluid through the wire. | 04-23-2015 |
Kosty R. Costanzo, Port Charlotte, FL US
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20150202502 | BALL RETRIEVING RETRACTABLE CLAW - An apparatus for retrieving an object: more than two claws mounted to a plunger that is movably housed within a cup, the claws extending through a lid of the cup. With the plunger at the bottom of the cup, each claw is retracted into the lid; with the plunger at the top of the cup, each claw extends beyond the lid to a ball-grasping position. At least one claw is bent and resilient. On pressing the tips of the claws against an object, the at least one claw bends apart from the other claws to admit the object between the claws, and on passing beyond a diameter of the object, the tip of the at least one claw springs back toward the other claws to capture the object between the claws. | 07-23-2015 |
Mark Costanzo, River Ridge, LA US
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20080289936 | ROLLER-BELT CONVEYOR FOR MOVING ARTICLES ACROSS THE CONVEYOR - A conveyor using a roller belt with rollers arranged to rotate on oblique axes to urge articles toward a side guide. The conveyor includes an oblique-roller belt supported on a carryway for running in a direction of belt travel. Rollers extend above an outer conveying surface of the belt without contact with the carryway. Each roller rotates on an axis oblique to the direction of belt travel and intersects the side guide downstream of the roller's position. A retractable stop is movable to and from a blocking position along the carryway. In the blocking position, the stop blocks the conveyed articles from advancing in the direction of belt travel. The rollers underlying the blocked articles rotate as the belt runs by contact with the articles. The rotating rollers provide a component of force to the blocked articles directed toward the side guide to push the articles against the side guide or other articles as they accumulate under low pressure upstream of the stop. The conveyor may be used to register articles single file against the side guide or to group the articles for palletizing. For palletizing applications, an infeed conveyor feeds articles onto the belt at the side opposite the side guide. | 11-27-2008 |
20080302634 | Conveyor Switch - A sorting switch for diverting articles from one or more infeed conveyors to two or more outfeed conveyors. A pre-alignment conveyor receives articles from one or more infeed conveyors and selectively diverts individual articles into two or more lateral regions for delivery to an alignment conveyor downstream. The alignment conveyor more precisely aligns the articles within each of the regions for delivery to outfeed conveyors at the downstream end of the alignment conveyor. The alignment and pre-alignment conveyors are realized as belt conveyors with rollers arranged to rotate universally or on axes in specific orientations. In some versions, a belt's rollers roll on bearing surfaces whenever the belt is advancing. In other versions, rollers are selective actuated by moving bearing surfaces. In yet other versions, rollers are not contacted by bearing surfaces at all. | 12-11-2008 |
20100059334 | ROLLER-BELT CONVEYOR FOR MOVING ARTICLES ACROSS THE CONVEYOR - A conveyor using a roller belt with rollers arranged to rotate on oblique axes to urge articles toward a side guide. The conveyor includes an oblique-roller belt supported on a carryway for running in a direction of belt travel. Rollers extend above an outer conveying surface of the belt without contact with the carryway. Each roller rotates on an axis oblique to the direction of belt travel and intersects the side guide downstream of the roller's position. A retractable stop is movable to and from a blocking position along the carryway. In the blocking position, the stop blocks the conveyed articles from advancing in the direction of belt travel. The rollers underlying the blocked articles rotate as the belt runs by contact with the articles. The rotating rollers provide a component of force to the blocked articles directed toward the side guide to push the articles against the side guide or other articles as they accumulate under low pressure upstream of the stop. The conveyor may be used to register articles single file against the side guide or to group the articles for palletizing. For palletizing applications, an infeed conveyor feeds articles onto the belt at the side opposite the side guide. | 03-11-2010 |
20100200365 | CONVEYOR AND METHOD FOR SPACING PACKAGES - A spacing conveyor having article-accelerating rollers and selectively retractable stops to control the gaps between consecutive conveyed packages. A sensor measures the length of a package being fed onto the spacing conveyor. A controller selectively actuates one or more actuators positioned along the length of the conveyor to move selected stops advancing with the conveyor from a retracted position to a blocking position to receive packages a variety of sizes and to control the gaps between consecutive packages. | 08-12-2010 |
20100219048 | BELT CONVEYORS WITH RETRACTABLE WALL SEGMENTS - A conveyor having a conveyor belt with wall segments that pivot between a retracted position below the conveying surface of the belt and an extended position above the conveying surface. When extended, the wall segments form a wall along the length of a portion of the belt to prevent conveyed articles from moving laterally past. The retractable wall segments are cam- or spring-actuated. Diverting conveyors using the retractable wall segments in an oblique-roller conveyor belt are useful as sorters or switches. | 09-02-2010 |
20110108396 | CONVEYOR WITH A GENTLE RETRACTABLE STOP - A conveyor having a retractable stop providing a nonsliding contact surface to the leading faces of conveyed articles to prevent damage to the faces of the articles. One version of such a stop has a contact surface defined by the peripheries of rollers that rotate on the accumulated articles as the stop moves from a blocking position accumulating articles on the conveyor to a retracted position releasing accumulated articles to advance downstream along the conveyor. | 05-12-2011 |
20140090961 | CONVEYOR BELT HAVING BIDIRECTIONAL STACKED ROLLERS - A conveyor belt and a belt module having multiple roller sets, each roller set including a bottom roller in contact with an axially elongated top roller. Driving the bottom roller in a first direction causes rotation of the top roller in an opposite angular direction. The bottom rollers in first longitudinal lanes are arranged to rotate obliquely toward one side of the belt, and the bottom rollers in second lanes are arranged to rotate toward the other side of the belt. Either the first lanes of roller sets or the second lanes can be selectively actuated to direct articles conveyed atop the top rollers rearward and toward one side of the belt or the other or to receive articles fed onto the belt from either side. | 04-03-2014 |
20140332343 | DIVERTING CONVEYOR WITH BIDIRECTIONAL ASSIST ROLLER - A sorting conveyor including a diverting conveyor and a bidirectional assist roller to help sort articles over the side of the diverting conveyor. The diverting conveyor includes, in one version, a conveyor belt with diverting rollers selectively actuated to push articles toward a side of the diverting conveyor. The bidirectional assist roller rotates on an axis parallel to the main conveying direction. As articles to be diverted reach the side of the diverting conveyor, the bidirectional roller rotates in a direction to assist articles over the side of the diverting conveyor and the bidirectional roller and onto an exit conveyor. When the diverting rollers are not actuated, the bidirectional roller rotates in the opposite direction to prevent articles from exiting the side of the diverting conveyor. In some instances, the bidirectional roller can be raised above the level of the diverting rollers to further block articles not selected for sorting from exiting over the side and onto the exit conveyor. | 11-13-2014 |
20150191311 | CONVEYOR SYSTEMS FOR DIVERTING OBJECTS - A conveyor system including a conveyor belt having a plurality of conveyor belt rollers configured to divert objects on the conveyor belt. A roller drive mechanism engages the conveyor belt rollers to actuate the conveyor belt rollers into rotation as the conveyor belt advances. The drive mechanism is adjustable to cause the conveyor belt rollers to rotate in a first angular direction and a second, opposite angular direction so that objects can be selectively diverted to either side of the conveyor belt at a desired diverting angle. The roller drive mechanism has drive rollers mounted in cartridges with pinion gears engaged by rack gears to adjust the orientation of the drive rollers relative to the belt rollers and the engagement of the belt rollers with the drive rollers as a function of the orientation by selective raising and lowering or laterally shifting the drive rollers. | 07-09-2015 |
20150259146 | ARTICLE DIVERTING CONVEYOR BELT - An article-diverting modular conveyor belt employs an article mover on a conveyor belt module for selectively moving a conveyed article towards a side of the module. The article mover may be a transversely-extending endless belt for carrying articles across the belt towards a side of the module. Rollers below the conveyor belt are selectively activated to induce movement of the article mover. | 09-17-2015 |
20160101957 | MISSORT PREVENTION SYSTEM IN A CONVEYING SYSTEM - A missort prevention system prevents missorts in a sortation conveying system. The missort prevention system includes a sensor for detecting the presence of an unexpected article on a chute transitioning articles off of a conveyor and a missort preventer for blocking the further passage of the unexpected article on the chute. | 04-14-2016 |
Mark Anthony Costanzo, Richmond, VA US
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20100230477 | CONFIDENTIAL POSTCARDS - Confidential postcards are described herein. An example postcard mailer includes a substrate having a first panel and a second panel adjacent the first panel, wherein each of the first panel and the second panel includes a first face and a second face. The example mailer also includes a first line of weakness separating the first panel and the second panel and a first fastener pattern included on at least one of the first face of the first panel or the first face of the second panel to releasably adhere a first portion of the first face of the first panel to a first portion the first face of the second panel when the substrate is folded about the first line of weakness. In addition, the example mailer includes a second fastener pattern included on at least one of the first face of the first panel or the first face of the second panel to releasably adhere a second portion of the first face of the first panel to a second portion of the first face of the second panel. The second fastener pattern and at least a portion of the first fastener pattern define an area that is not visible when the first face of the first panel is releasably adhered to the first face of the second panel and a third portion of the first face of the first panel and a third portion of the second face of the second panel are separated from each other. | 09-16-2010 |
Michael A. Costanzo, Rocky River, OH US
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20140262257 | SMALL SUPERCRITICAL ONCE-THRU STEAM GENERATOR - A small supercritical once-through steam generator (OTSG) includes a radiant section with a furnace coil, and a convection section downstream of the radiant section that includes a superheater which is fluidically connected to the furnace coil. Optionally, the OTSG is devoid of a steam separator. An economizer can also be included downstream of the superheater. Supercritical steam can be generated using the OTSG, for use, among other things, in enhanced oil recovery applications. | 09-18-2014 |
Michael J. Costanzo, Ivyland, PA US
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20080306044 | SPIROBENZOAZEPANES AS VASOPRESSIN ANTAGONISTS - The present invention is directed to a compound of Formula (I) or a form thereof: | 12-11-2008 |
20090163527 | Spiropiperidines for use as tryptase inhibitors - The present invention is directed to a compound of Formula (I): | 06-25-2009 |
20110082306 | BIRCH REDUCTION OF STEROID SUBSTRATES VIA ALKALI METAL - SILICA GEL MATERIALS - Steroids are well known, medicinal relevant, chemical entities. There are numerous steroids which have fully or partially reduced ‘A’ rings. These fully or partially reduced ‘A’ rings have been reduced in the past through Birch and other dissolving metal reductions. Novel reducing conditions for steroid substrates are described which utilizes stabilized alkali metal-silica gel materials. The invention relates to a method for reducing a double bond within a steroid by contacting an unsaturated steroid having a phenyl ring with a Stage 0 or Stage I alkali metal-silica gel material in the presence of a proton source under reaction conditions sufficient to form a reduced steroid having a diene structure. | 04-07-2011 |
20120165327 | SPIROPIPERIDINES FOR USE AS TRYPTASE INHIBITORS - The present invention is directed to a compound of Formula (I): | 06-28-2012 |
20140308317 | Polymeric Compounds And Methods Of Making And Using The Same - The present disclosure provides compounds, or pharmaceutically acceptable salts thereof, for inhibiting the growth of a microbe; treating a mammal having a microbial infection, malaria, mucositis, an ophthalmic infection, an otic infection, a cancer, or a | 10-16-2014 |
Michael J. Costanzo, Radnor, PA US
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20110178104 | Anti-Heparin Compounds - The present invention provides compounds and methods for antagonizing the anticoagulant effect of an anticoagulant agent that is selected from UFH, LMWH, and a heparin/LMWH derivative in a patient comprising administering to the patient a compound of the invention or a salt thereof, or a composition comprising the same. | 07-21-2011 |
20150094294 | COMPOUNDS AND METHODS FOR TREATING MALARIA - The present disclosure provides compounds, specifically pyrimidin-4,6-dicarboxylic acid amide derivatives, or pharmaceutically acceptable salts thereof and pharmaceutical compositions containing said compounds. Also provided are methods for treating a mammal having malaria, or killing or inhibiting the growth of a | 04-02-2015 |
Nicholas Costanzo, Greenville, SC US
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20160023372 | MORTISING TOOL - A mortising tool or mortiser including a handle having a first longitudinal axis and a head having a second longitudinal axis. The mortiser includes an interchangeable scorer holder that has a first side and a second side. A first scorer is fixedly attached to the first side, and a second scorer different from the first scorer is fixedly attached to the second side. The interchangeable scorer holder is positionable in a first orientation substantially within a chamber to expose the first scorer and positionable in a second orientation substantially within the chamber to expose the second scorer. A guide is received by the mortiser and orients one of the first scorer and the second scorer at a desired distance from a face of a door. The guide is positionable in two orientations to orient one of the scorers at either a first or second distance from the face of the door. | 01-28-2016 |
Philip J. Costanzo, Silver Spring, MD US
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20080226995 | Thermally controlled particulate core migration within polymer matrix - A composition is provided that includes a polymer matrix. A core having a core surface is embedded within the polymer matrix. A polymeric ligand passivates the core surface and has a moiety Y, where Y is a Diels-Alder group of a diene or dienophile. A polymeric linker has a complementary Diels-Alder group diene or dienophile to moiety Y and forms a Diels-Alder bond with the moiety Y. A composition is also provided that includes polymer matrix having a matrix surface. A core having a core surface is present on the matrix surface. A polymeric ligand passivates the core surface and has a moiety Y, where Y is Diels-Alder group of a diene or dienophile. The polymer matrix and polymeric ligand together define a matrix-ligand Flory-Huggins binary interaction function greater than 0. | 09-18-2008 |
Richard M. Costanzo, Crozier, VA US
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20160051815 | OLFACTORY IMPLANT SYSTEM - The system includes five components: (1) a sensor array, (2) a processor, (3) a transmitter, (4) a receiver-stimulator, and (5) an implantable electrode array. The olfactory implant system generates odor fingerprints by detecting odors with an array of chemical sensors and then transmitting variable spatio-temporal stimulation patterns for an electrode array with electrode stimulating points positioned at different locations in the olfactory cortex (e.g., stimulating the olfactory bulb). Different patterns of activity in the olfactory cortex are thereby generated which mimic the sense of smell in a subject. Once trained the system should be usable by a subject to detect or correctly identify one or more odors. | 02-25-2016 |
Robert Costanzo US
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20150202502 | BALL RETRIEVING RETRACTABLE CLAW - An apparatus for retrieving an object: more than two claws mounted to a plunger that is movably housed within a cup, the claws extending through a lid of the cup. With the plunger at the bottom of the cup, each claw is retracted into the lid; with the plunger at the top of the cup, each claw extends beyond the lid to a ball-grasping position. At least one claw is bent and resilient. On pressing the tips of the claws against an object, the at least one claw bends apart from the other claws to admit the object between the claws, and on passing beyond a diameter of the object, the tip of the at least one claw springs back toward the other claws to capture the object between the claws. | 07-23-2015 |
Robert Costanzo, Newington, CT US
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20150202502 | BALL RETRIEVING RETRACTABLE CLAW - An apparatus for retrieving an object: more than two claws mounted to a plunger that is movably housed within a cup, the claws extending through a lid of the cup. With the plunger at the bottom of the cup, each claw is retracted into the lid; with the plunger at the top of the cup, each claw extends beyond the lid to a ball-grasping position. At least one claw is bent and resilient. On pressing the tips of the claws against an object, the at least one claw bends apart from the other claws to admit the object between the claws, and on passing beyond a diameter of the object, the tip of the at least one claw springs back toward the other claws to capture the object between the claws. | 07-23-2015 |
Robert P. Costanzo, New York, NY US
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20090307002 | System and Method for Communicating Targeted Health Related Data - The present invention provides a system and a method for communicating targeted health related data. The method includes targeting the consumers with an advertisement content and registering the consumers upon the selection of the advertisement. The registering includes capturing and storing the personal profile and health related data of the consumer and/or member(s) of this household. The method further includes processing the stored data to provide the consumer with the targeted content relevant to the consumer. The method further includes retrieving additional healthographic profiling of the consumer and the activity of the consumer to and further processing with the stored data to provide the consumer with an advertisement content targeted to the consumer and/or member(s) of his/her household. | 12-10-2009 |
20140214550 | System and Method for Communicating Targeted Health Related Data - The present invention provides a system and a method for communicating targeted health related data. The method includes targeting the consumers with an advertisement content and registering the consumers upon the selection of the advertisement. The registering includes capturing and storing the personal profile and health related data of the consumer and/or member(s) of this household. The method further includes processing the stored data to provide the consumer with the targeted content relevant to the consumer. The method further includes retrieving additional healthographic profiling of the consumer and the activity of the consumer to and further processing with the stored data to provide the consumer with an advertisement content targeted to the consumer and/or member(s) of his/her household. | 07-31-2014 |
Sherene Costanzo, Parkland, FL US
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20110062252 | NON-REUSABLE DISPOSABLE SPRAY CONTAINER - A disposable spray assembly is disclosed. The disposable spray assembly includes a container for holding a liquid, the container having a neck portion, a ring coupled to an exterior surface of the neck portion, the ring having an increasing outer diameter in a downwards direction, a spray mechanism for expelling the liquid, the spray mechanism coupled with the neck portion and having a hilt that rests upon a top of the neck portion and a collar element for placement around the neck portion under the ring, wherein an inner diameter of the collar element is equal to or larger than an exterior diameter of a top portion of the ring but smaller than an exterior diameter of a bottom portion of the ring such that upon placement of the inner diameter of the collar element around the neck portion underneath the ring, the collar element cannot be removed from the neck portion. | 03-17-2011 |
Thomas F. Costanzo, Elmhurst, IL US
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20110207530 | WAGERING GAME MACHINES WITH UNIVERSAL MOUNTING BASE FOR LIGHT AND MARQUEE ASSEMBLIES - Wagering game systems, gaming machines, and methods of changing the appearance of a gaming machine are presented herein. In one embodiment, a gaming machine for playing a wagering game is presented. The gaming machine includes a display for displaying the outcomes of the wagering game, and an input device for receiving wagers from players. The gaming machine also includes a cabinet with a mounting base integrated to the top of the cabinet. The mounting base is configured to support any of a plurality of different top-box mounted fixtures, such as tower lights, marquees, and other signage. In some embodiments, the gaming machine also includes at least one electrical connector that is accessible from the exterior of the cabinet. The electrical connector is configured to electrically couple the selected top-box mounted fixture to the cabinet. | 08-25-2011 |
Timothy Costanzo, Emporium, PA US
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20120132160 | ADHESIVE JOINING FOR POWDER METAL COMPONENTS - A method of joining multiple powder metal components to form a powder metal component assembly using an adhesive is disclosed. By machining at least one of the powder metal components prior to the adhesive joining, otherwise difficult to machine features can be more easily machined for less cost and at higher production rates. Unlike high temperature joining techniques, the adhesive joins the powder metal components at room temperature. This room temperature adhesive joining eliminates the thermal distortions in pre-joined machined features common to high temperature joining techniques such as brazing or welding that bring these features out of specification during joining. | 05-31-2012 |
Valentino Costanzo, Chittenango, NY US
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20100179462 | Stabilizing Brace For Use By Individuals Having Neuromuscular Disorders - A brace for supporting the arms or wrists of a user afflicted with a muscular disorder is provided. The brace generally includes a yoke section having first and second terminal ends and being adapted for positioning over the shoulders and behind the neck of the user, and a pair of opposed arm/wrist supports that extend outwardly from respective ones of the first and second terminal ends of the yoke portion and being adapted to support the arms/wrists of the user. | 07-15-2010 |
Wendi Ann Costanzo, Webster, NY US
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20130273659 | NANOPARTICLES OF CERIUM AND AMINO ACIDS - A process for making nanoparticles of biocompatible materials is described, wherein an aqueous reaction mixture comprising cerous ion, an α-amino acid, an oxidant and water is provided along with temperature conditions to effectively form nanoparticles. These biocompatible nanoparticles may be further conjugated to biologically active agents, such as plasmid DNA, siRNA or proteins, such that a cell transfection agent is formed. | 10-17-2013 |
20130337083 | NANOCERIA FOR THE TREATMENT OF OXIDATIVE STRESS - A process for making nanoparticles of biocompatible materials is described, wherein an aqueous reaction mixture comprising cerous ion, citric acid and ethylenediaminetetraacetic acid in a predetermined ratio, an oxidant, and water is provided along with temperature conditions to directly form, without isolation, a stable dispersion of cerium oxide nanoparticles. These biocompatible cerium oxide nanoparticles may be used to prevent and/or treat oxidative stress related diseases, such as stroke, relapse/remitting multiple sclerosis, chronic-progressive multiple sclerosis, amyotrophic lateral sclerosis, and ischemic reperfusion injury. | 12-19-2013 |
20130337084 | NANOCERIA WITH CITRIC ACID ADDITIVE - A process for making nanoparticles of biocompatible materials is described, wherein an aqueous reaction mixture comprising cerous ion, citric acid, an oxidant, and water, is adjusted to a predetermined range of pH, held at temperature conditions to directly form, without isolation, a stable dispersion of cerium oxide nanoparticles. Dispersions of these biocompatible cerium oxide nanoparticles exhibit self-life well in excess of one year, and may be used to prevent and/or treat disease or injury, such as oxidative stress related diseases and events. | 12-19-2013 |
20150045450 | NANOPARTICLES OF A METAL AND A NUCLEOBASE - A process for making nanoparticles of biocompatible materials is described, wherein an aqueous reaction mixture comprising a metal ion, a nucleobase, an oxidant, and water, is provided along with temperature conditions to directly form within the reaction mixture, a stable dispersion of nanoparticles. Biocompatible nanoparticles comprised of cerium or iron as the metal ion, and a purine and/or a pyrimidine as the nucleobase, are described. | 02-12-2015 |
20150196510 | NANOPARTICLES OF A METAL AND A BIGUANIDE - A process for making nanoparticles of biocompatible materials is described, wherein an aqueous reaction mixture comprising a metal ion, a biguanide, an oxidant, and water; optionally further comprising an alpha-amino acid or a nucleobase; is provided along with temperature conditions to directly form within the reaction mixture, a stable dispersion of metal-containing nanoparticles. Biocompatible nanoparticles comprised of cerium and a biguanide, and optionally containing an alpha-amino acid or a nucleobase, are also described. The use of metal oxide nanoparticles comprising a biguanide as a nanoparticle core/corona in the preparation of nanoscale ionic (liquid) material compositions is disclosed. | 07-16-2015 |
20150231174 | NANOCERIA FOR THE TREATMENT OF OXIDATIVE STRESS - A process for making nanoparticles of biocompatible materials is described, wherein an aqueous reaction mixture comprising cerous ion, citric acid and ethylenediaminetetraacetic acid in a predetermined ratio, an oxidant, and water is provided along with temperature conditions to directly form, without isolation, a stable dispersion of cerium oxide nanoparticles. These biocompatible cerium oxide nanoparticles may be used to prevent and/or treat oxidative stress related diseases, such as stroke, relapse/remitting multiple sclerosis, chronic-progressive multiple sclerosis, amyotrophic lateral sclerosis, and ischemic reperfusion injury. | 08-20-2015 |