Buber
M.n. Tulu Buber, Newtown, PA US
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20080306030 | Use of a TRPM5 Inhibitor to Regulate Insulin and GLP-1 Release - The present invention is directed to methods of enhancing insulin release, GLP-1 release, and insulin sensitivity, methods of increasing insulin gene expression, methods of decreasing gastric secretion and emptying and glucagons secretion, and methods of inhibiting food intake, and methods of treating diabetes mellitus, insulin resistance syndrome, hyperglycemia, and obesity comprising administering to a subject an effective amount of a TRPM5 inhibitor. | 12-11-2008 |
20100248988 | High Throughput Screening Assay for the TRPM5 Ion Channel - There exists a need in the art for high throughput screening assays that can identify compounds that specifically modulate the activity of fast-acting ion channels, such as TRPM5. Current methods suffer from a lack of sensitivity, low throughput, and are labor intensive. The claimed methods provide fluorescent assays with an optical readout that gives rapid readout of the results, has a high signal to noise background ratio, are easy to use, can be modified for automation and miniaturization, and provide verification that a compound specifically modulates TRPM5. | 09-30-2010 |
M.n. Tulu Buber, Newton, PA US
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20090136975 | Non-desensitizing mutant of the transient receptor potential TRPM5 ion channel - There exists a need in the art for high throughput screening assays that can identify compounds that specifically modulate the activity of fast-acting ion channels, such as TRPM5. Current methods, especially electrophysiological, suffer from a lack of sensitivity, rapid signal loss, low throughput, and are labor intensive. The claimed methods and compositions provide electrophysiology methods that allow prolonged sample testing and fluorescent assays with an optical readout that gives rapid readout of the results, has a high signal to noise background ratio, are easy to use, can be modified for automation and miniaturization, and provide verification that a compound specifically modulates TRPM5. | 05-28-2009 |
M. Tekamul Buber, Delta CA
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20110308695 | SYSTEMS AND METHODS FOR MANUFACTURING COMPOSITE WOOD PRODUCTS TO REDUCE BOWING - The present disclosure includes systems and methods for manufacturing a composite wood product. In some embodiments, the method includes the steps of forming a mat from a plurality of wood elements and an adhesive, the mat having a width W measured substantially perpendicular to a longitudinal axis of the mat and an initial thickness T | 12-22-2011 |
Tekamul M. Buber, Delta CA
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20130199731 | SYSTEMS AND METHODS FOR MANUFACTURING COMPOSITE WOOD PRODUCTS TO REDUCE BOWING - The present disclosure includes systems and methods for manufacturing a composite wood product. In some embodiments, the method includes the steps of forming a mat from a plurality of wood elements and an adhesive, the mat having a width W measured substantially perpendicular to a longitudinal axis of the mat and an initial thickness T | 08-08-2013 |
Tulu Buber, Newton, PA US
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20100248987 | Screening Assay for Inhibitors of TRPA1 Activation by a Lower Alkyl Phenol - The invention relates an assay useful for screening and identifying compounds as modulators of lower alkyl phenol activation of TRPA1. Thymol, a lower alkyl phenol anti-infective and the active ingredient in, e.g., mouthwashes, is stringent and has an objectionable burning taste sensation. Thymol activates the transient receptor potential like ion channel TRPA1. The assay described and claimed herein involves measurement of activation of TRPA1 and enables the screening of compounds that inhibit lower alkyl phenol, or thymol activation of TRPA1. Inhibitors of thymol activation of TRPA1 can be used to prevent the objectionable taste of thymol in medical uses where taste limits acceptance. | 09-30-2010 |
Tulu Buber, Newtown, PA US
Patent application number | Description | Published |
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20090175848 | Modulation of the Cooperativity Between the Ion Channels TRPM5 and TRPA1 - The present invention is related to modulating TRPA1 ion channel activity by targeting the ion channel TRPM5. The cooperativity between the ion channels can be used to modulate pain, mechanosensation and taste responses triggered through TRPA1 by modulating the activity of TRPM5 | 07-09-2009 |