Patent application number | Description | Published |
20130059851 | Methods of Diagnosing and Treating Cancer in Patients Having or Developing Resistance to a First Cancer Therapy - A method of identifying a subject having cancer who is likely to benefit from treatment with a combination therapy with a RAF inhibitor and a second inhibitor is provided. A method of treating cancer in a subject in need thereof is also provided and includes administering to the subject an effective amount of a RAF inhibitor and an effective amount of a second inhibitor, wherein the second inhibitor is a MEK inhibitor, a CRAF inhibitor, a CrkL inhibitor or a TPL2/COT inhibitor. A method of identifying a kinase target that confers resistance to a first inhibitor is also provided. | 03-07-2013 |
20150141470 | DIAGNOSTIC AND TREATMENT METHODS IN PATIENTS HAVING OR AT RISK OF DEVELOPING RESISTANCE TO CANCER THERAPY - A method of identifying a subject having cancer who is likely to benefit from treatment with a combination therapy with a MAPK pathway inhibitor, such as a RAF inhibitor, MEK inhibitor, or ERK inhibitor, and a GEF or HDAC inhibitor is provided. A method of treating cancer in a subject in need thereof is also provided and includes administering to the subject an effective amount of a MAPK inhibitor, such as a RAF inhibitor, MEK inhibitor, or ERK inhibitor, and an effective amount of a GEF or HDAC inhibitor. A method of identifying targets that confers resistance to a MAPK pathway inhibitor is also provided. | 05-21-2015 |
20160024589 | METHODS OF IDENTIFYING RESPONSES TO MAP KINASE INHIBITION THERAPY - The invention provides methods and devices for determining molecular signatures in a cancer that predict response to a MARPK pathway inhibitor and methods of use of such signatures. | 01-28-2016 |
Patent application number | Description | Published |
20130038241 | Methods, Apparatus and Articles of Manufacture to Calibrate Lighting Units - A system and appertaining method calibrate a color LED light unit comprising at least first-, second-, and third-color LEDs, comprising: a) defining a target color on a color map to calibrate; b) selecting initial calibration coefficients associated with the target color; c) storing the initial or updated calibration coefficients in a non-volatile memory of the light unit; d) controlling the light unit to drive the LEDs to attempt to emit the target color, producing an attempted color, utilizing the calibration coefficients; e) measuring the attempted color to determine if it matches the target color within a predefined tolerance; f) if the attempted color matches the target color, then terminating the method; g) if the attempted color does not match the target color, then performing the following; h) selecting a color component; i) adapting at least one calibration coefficient associated with the selected color component; and j) performing (c)-(i) again. | 02-14-2013 |
20130162224 | Digitally-Controlled Power Factor Correction Circuits, Methods and Articles of Manufacture - Digitally-controlled power factor correction circuits, methods, and articles of manufacture are disclosed. A disclosed power supply comprises a power factor correction circuit including a switch, an inductor having a first terminal connected to an input voltage, and a second terminal connected to the switch, a storage capacitor and a load, a value of the inductor selected to operate the power factor correction circuit in discontinuous conduction mode, and a controller programmed to operate the switch to increase a power factor of the power supply. | 06-27-2013 |
20130249404 | Reduced-Size Modular LED Washlight Component - A light-emitting diode (LED) light module is provided, comprising: a single-piece printed circuit board (PCB) comprising the following integrated on the PCB: a plurality of LEDs in each of a plurality of LED groups; a power supply converter; a controller module comprising a processor, memory, operational program stored in the memory and executable by the processor; input/output (I/O) circuitry, and an LED driver that drives the LEDs; the module further comprising: a single metallic housing that contains the PCB; a heat sink that conducts heat from components on the PCB to the housing; and a lens for diffusing or directing lights from the LEDs. | 09-26-2013 |
20130342014 | Modular Power Inverter with Software Control - A power inverter is provided comprising: a control board comprising: a processor that generates an AC waveform from a pulse width modulation (PWM) signal according to instructions or data stored in a memory associated with the processor; and an output at which a signal having the AC waveform is provided; a power supply module that is connected to the control board, comprising: an input connected to the output of the control board at which the AC waveform signal is provided; and an output at which an AC power signal is provided on a channel of the power inverter. | 12-26-2013 |
20140028189 | Architectures for LED Lighting Assemblies - A modular light emitting diode (LED), remote phosphor, and other lighting technologies lighting assembly includes a plurality of lighting subassemblies and a power supply electrically coupled with the plurality of lighting subassemblies in parallel such that each of the plurality of lighting subassemblies receives electrical power from the power supply in parallel with the other of the plurality of lighting subassemblies. | 01-30-2014 |
20150230315 | Methods, Apparatus and Articles of Manufacture to Calibrate Lighting Units - A system and appertaining method calibrate a color LED light unit comprising at least first-, second-, and third-color LEDs, comprising: a) defining a target color on a color map to calibrate; b) selecting initial calibration coefficients associated with the target color; c) storing the initial or updated calibration coefficients in a non-volatile memory of the light unit; d) controlling the light unit to drive the LEDs to attempt to emit the target color, producing an attempted color, utilizing the calibration coefficients; e) measuring the attempted color to determine if it matches the target color within a predefined tolerance; f) if the attempted color matches the target color, then terminating the method; g) if the attempted color does not match the target color, then performing the following; h) selecting a color component; i) adapting at least one calibration coefficient associated with the selected color component; and j) performing (c)-(i) again. | 08-13-2015 |
Patent application number | Description | Published |
20080253122 | LED LIGHTING SYSTEM FOR RETROFITTING AN AIRCRAFT CABIN FLUORESCENT LIGHTING SYSTEM - A system and method are provided for retrofitting a fluorescent lighting system, for example a passenger cabin fluorescent lighting system on a vehicle such as an aircraft. The present system may include at least one LED lighting unit for replacing, in situ, at least one fluorescent light of the fluorescent lighting system, and a control module for replacing, in situ, at least one ballast-type unit of the fluorescent lighting system that illuminates the at least one fluorescent light. The present system may further include a master control module, which may replace, in situ, an inverter of the fluorescent lighting system. The present method may include steps of: replacing at least one fluorescent light, in situ, with at least one LED lighting unit; and replacing at least one ballast-type unit, in situ, with at least one control module configured to control illumination of the LED lighting unit. | 10-16-2008 |
20100128472 | LED LIGHTING SYSTEM - A lighting apparatus comprising a white LED and a RGB LED disposed on a mounting and at least partially enclosed by a housing. The RGB LED produces red, green and blue components of light. A white LED driver controls current to the white LED and a RGB LED driver controls current to the RGB LED. A lighting system including the lighting apparatus and a system controller having a memory in which preset lighting programs are stored. A method for method for providing wash lighting comprising the steps of emitting a current color and intensity from a white LED and from a RGB LED, receiving data representing a change of color and intensity from the current color and intensity for at least the RGB LED and emitting white light that is on the Planckian locus in the CIE 1931 chromaticity diagram. | 05-27-2010 |
Patent application number | Description | Published |
20130056221 | FLOW CONTROL DEVICE AND FLOW CONTROL METHOD - A method and apparatus is disclosed for controlling the flow of fluid in oil and/or gas production, involving a control device or an autonomous valve ( | 03-07-2013 |
20130321165 | SIGNAL AND POWER TRANSMISSION IN HYDROCARBON WELLS - One aspect relates to a method of installing a transmission system in a hydrocarbon production well. The transmission system is operable for transmitting power and/or control signals down the well or for transmitting data signals back up the well. The well comprises a main well bore, a production tubing inside the main well bore and a branch off the production tubing. The branch comprises a side track tubing. The method includes: providing a sensor and/or load assembly in the branch; installing a first inductive coupler of an induced current transmission arrangement around the production tubing in the main well bore, and connecting the sensor/load assembly to the first inductive coupler via a communication link. Another aspect relates to a hydrocarbon production well installation. | 12-05-2013 |
20130328692 | ELECTRO-MAGNETIC ANTENNA FOR WIRELESS COMMUNICATION AND INTER-WELL ELECTRO-MAGNETIC CHARACTERIZATION IN HYDROCARBON PRODUCTION WELLS - Methods, a system and antennas are provided for transmitting or receiving signals from a hydrocarbon production well. The well comprises a well bore formed in a formation, a production liner/tubing extending axially along the well bore, and an inductive coupling disposed around the liner/tubing. The liner tubing is electrically coupled to the formation at two axially separated locations and is electrically isolated from the formation between the locations. For transmitting, an alternating current signal to the inductive coupling to induce a current in the liner/tubing, the liner tubing forming a dipole antenna that generates an electromagnetic radiation signal propagating through the formation. For receiving, the dipole antenna is exposed to an electromagnetic radiation signal propagated through the formation which induces an alternating current signal in the tubing and the current signal is detected at the inductive coupling. | 12-12-2013 |
20140163889 | METHOD OF ACOUSTIC SURVEYING - The invention relates to the use of distributed optical fibre sensors for distributed acoustic sensing, and in particular, modal analysis of distributed acoustic data obtained in-well to monitoring well integrity. By determining one or more acoustic modes corresponding to distributed speed of sound measurements within the wellbore, and analysing variations in the distributed speed of sound measurement it is possible to derive information relating to a formation and/or fluid in the wellbore. | 06-12-2014 |
Patent application number | Description | Published |
20130233719 | MASKING PROCESS - Methods and systems for masking interior surfaces of a part from exposure to a subsequent process. In some embodiments the interior surfaces are threaded. Methods include forming a plugged insert by overmolding a masking plug material into an opening in the insert, the plug being substantially impervious to exposure to a subsequent process. The plugged insert can then be assembled in the part and the part is exposed to the process. Processes can include anodizing, cleaning, machining and laser etch processes. After the process is complete, the plug is removed from the insert, leaving the insert in the part without the plug. The described embodiments describe methods for optimizing masking methods in a production setting. More specifically, embodiments describe methods for automatic insertion and removal of plugs in a part before and after exposure of the part to a process such as anodization. | 09-12-2013 |
20130318766 | COMPONENTS OF AN ELECTRONIC DEVICE AND METHODS FOR THEIR ASSEMBLY - Various components of an electronic device housing and methods for their assembly are disclosed. The housing can be formed by assembling and connecting two or more different sections together. The sections of the housing may be coupled together using one or more coupling members. The coupling members may be formed using a two-shot molding process in which the first shot forms a structural portion of the coupling members, and the second shot forms cosmetic portions of the coupling members. | 12-05-2013 |
20130319865 | DOUBLE ANODIZING PROCESSES - Methods and structures for forming anodization layers that protect and cosmetically enhance metal surfaces are described. In some embodiments, methods involve forming an anodization layer on an underlying metal that permits an underlying metal surface to be viewable. In some embodiments, methods involve forming a first anodization layer and an adjacent second anodization layer on an angled surface, the interface between the two anodization layers being regular and uniform. Described are photomasking techniques and tools for providing sharply defined corners on anodized and texturized patterns on metal surfaces. Also described are techniques and tools for providing anodizing resistant components in the manufacture of electronic devices. | 12-05-2013 |
20140030443 | Sapphire Window - Methods for creating sapphire windows are provided herein. In particular, one embodiment may take the form of a method of manufacturing sapphire windows. The method includes obtaining a polished sapphire wafer and applying decoration to the sapphire wafer. The method also includes cutting the sapphire wafer into discrete windows. In some embodiments, the cutting step comprises laser ablation of the sapphire. | 01-30-2014 |
Patent application number | Description | Published |
20110081828 | EDGE BREAK DETAILS AND PROCESSING - A method and an apparatus for shaping an edge at a juncture of two adjoining surfaces of a part. A first surface and a second surface of the part are abraded by contacting a polishing surface of a polishing wheel to the first surface and to the second surface. The polishing surface spins in opposite rotational directions about an axis parallel to the edge when contacting the first and second surfaces respectively. The polishing surface moves at different translational speeds and the polishing wheel spins at different rotational speeds along straight segments and along curved segments of the edge. The shaped edge has a visually smooth and geometrically uniform appearance. | 04-07-2011 |
20110081837 | COMPLEX GEOGRAPHICAL EDGE POLISHING - A complex geographical edge finishing system includes a fixture that holds an external part having a complex three-dimensional edge, a track disposed around the fixture and surrounding the edge of the part held in the fixture, and one or more finishing apparatuses that can sand, polish, buff, paint and/or apply coatings to the complex three-dimensional edge. The finishing apparatuses move about the track such that the three-dimensional edge of the part can be polished. The path of the track can substantially match, mimic or otherwise correspond to the path of the three-dimensional edge, such that special requirements for the finishing apparatuses are not required. | 04-07-2011 |
20110081839 | METHOD AND APPARATUS FOR POLISHING A CURVED EDGE - A method and an apparatus for polishing a curved edge of a molded part. A surface of the curved edge is abraded by contacting a polishing surface of a first polishing wheel to the curved edge repeatedly in a first direction concurrent with a rotational spinning direction of the first polishing wheel. The abraded surface of the curved edge is polished by contacting a polishing surface of a second polishing wheel to the curved edge in the first direction and in a second direction opposite to the first direction. The polishing surfaces of the first and second polishing wheels are shaped to conform to a portion of the surface of the curved edge of the molded part. The polishing wheel is maintained at a constant rotational speed by a controller when contacting the curved edge. The polished surface of the curved edge is visually smoothly uniform in reflective appearance. | 04-07-2011 |
20120011690 | REMOVABLE FIXTURE FOR MANUFACTURING DEVICE - A CNC system can include a cylinder adapted to rotate about, travel along, and deliver a force in an axial direction, an extension coupled to a distal end of and extending outward from the elongated component in a direction perpendicular to the axial direction, and a removable fixture adapted to receive the axial force and to be moved and positioned thereby along a plane (i.e., two directions) substantially perpendicular to the axial direction. The fixture has a central opening along the first direction adapted to receive the elongated component, and includes external features adapted to guide manufacturing operations for other manufacturing components. Chamfers on both the extension and removable fixture convert the downward axial force into a plurality of lateral forces that move the fixture against a receiver base. Datums located at guide holes in the fixture stop such lateral movement when the movement causes them to contact guide pins coupled to the receiver base. | 01-19-2012 |
20150315715 | METHODS FOR FORMING DEFECT-FREE ANODIZED PARTS - Manufacturing methods related to anodizing of metal parts are described. In particular, pre-anodizing and post-anodizing methods for forming a consistent and defect-free interface between metal and non-metal sections of a part are described. Methods involve preventing residues from various manufacturing processes from entering a gap or space at the interface between the metal and non-metal section of the part and that can disrupt subsequent anodizing and anodic film dyeing processes. In particular embodiments, methods involve forming a barrier layer or filler layer between the metal and non-metal sections. Portions of the barrier layer or filler layer can be removed prior to anodizing. The resultant part has a well-defined and uniform space between the metal and non-metal sections that is free from visual defects. | 11-05-2015 |
20160089834 | ASSEMBLED INTEGRAL PLASTIC ELEMENTS ON AN ANODIZED MOBILE DEVICE ENCLOSURE - Methods and systems for manufacturing composite parts that include anodizable portions and non-anodizable portions such that an interface between the anodizable portions and non-anodizable portions are free of visible defects are described. The non-anodizable portions can be made of anodizable metals such as aluminum or aluminum alloy. The non-anodizable portions are made of material that do not generally form an anodic film, such as plastic, ceramic or glass materials. In particular, the methods described relate to manufacturing methods that are compatible with anodizing processes and avoid defects related to anodizing processes. In particular embodiments, the methods involve avoiding trapping of anodizing chemicals within a gap between an anodizable portion and a non-anodizable portion, which prevents the anodizing chemicals from disrupting the uptake of dye in a post-anodizing dyeing process. | 03-31-2016 |