Patent application number | Description | Published |
20090048430 | Site specific protein modification - The present invention relates, in general, to protein modifications and, in particular, to a method of effecting site-specific labeling of proteins with covalently coupled reporter groups. The invention further relates to a method of effecting orientation-specific immobilization of proteins on a solid surface. The invention also relates to products produced by such methods. | 02-19-2009 |
20100071083 | TEMPERATURE-DEPENDENT MEGANUCLEASE ACTIVITY - The invention relates to methods for the production of genetically modified plants using engineered meganucleases and elevated temperature and to genetically modified plants produced by such methods. | 03-18-2010 |
20100311817 | RATIONALLY-DESIGNED SINGLE-CHAIN MEGANUCLEASES WITH NON-PALINDROMIC RECOGNITION SEQUENCES - Disclosed are rationally-designed, non-naturally-occurring meganucleases in which a pair of enzyme subunits having specificity for different recognition sequence half-sites are joined into a single polypeptide to form a functional heterodimer with a non-palindromic recognition sequence. The invention also relates to methods of producing such meganucleases, and methods of producing recombinant nucleic acids and organisms using such meganucleases. | 12-09-2010 |
20110033935 | RATIONALLY-DESIGNED MEGANUCLEASES WITH RECOGNITION SEQUENCES FOUND IN DNASE HYPERSENSITIVE REGIONS OF THE HUMAN GENOME - Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research. | 02-10-2011 |
20110123509 | FUSION MOLECULES OF RATIONALLY-DESIGNED DNA-BINDING PROTEINS AND EFFECTOR DOMAINS - Targeted transcriptional effectors (transcription activators and transcription repressors) derived from meganucleases are described. Also described are nucleic acids encoding same, and methods of using same to regulate gene expression. The targeted transcriptional effectors can comprise (i) a meganuclease DNA-binding domain lacking endonuclease cleavage activity that binds to a target recognition site; and (ii) a transcription effector domain. | 05-26-2011 |
20110202479 | RECOGNITION SEQUENCES FOR I-CREI-DERIVED MEGANUCLEASES AND USES THEREOF - Methods of cleaving double-stranded DNA that can be recognized and cleaved by a rationally-designed, I-CreI-derived meganuclease are provided. Also provided are recombinant nucleic acids, cells, and organisms containing such recombinant nucleic acids, as well as cells and organisms produced using such meganucleases. Also provided are methods of conducting a custom-designed, I-CreI-derived meganuclease business. | 08-18-2011 |
20120015406 | RATIONALLY-DESIGNED MEGANUCLEASES WITH ALTERED SEQUENCE SPECIFICITY AND DNA-BINDING AFFINITY - Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research. | 01-19-2012 |
20120015421 | RATIONALLY-DESIGNED MEGANUCLEASES WITH ALTERED SEQUENCE SPECIFICITY AND DNA-BINDING AFFINITY - Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research. | 01-19-2012 |
20120021465 | RATIONALLY-DESIGNED MEGANUCLEASES WITH ALTERED SEQUENCE SPECIFICITY AND DNA-BINDING AFFINITY - Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research. | 01-26-2012 |
20120021520 | RATIONALLY-DESIGNED MEGANUCLEASES WITH ALTERED SEQUENCE SPECIFICITY AND DNA-BINDING AFFINITY - Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research. | 01-26-2012 |
20120021521 | RATIONALLY-DESIGNED MEGANUCLEASES WITH ALTERED SEQUENCE SPECIFICITY AND DNA-BINDING AFFINITY - Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research. | 01-26-2012 |
20120028314 | RATIONALLY-DESIGNED MEGANUCLEASES WITH ALTERED SEQUENCE SPECIFICITY AND DNA-BINDING AFFINITY - Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research. | 02-02-2012 |
20120028315 | RATIONALLY-DESIGNED MEGANUCLEASES WITH ALTERED SEQUENCE SPECIFICITY AND DNA-BINDING AFFINITY - Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research. | 02-02-2012 |
20120030783 | RATIONALLY DESIGNED MEGANUCLEASES WITH ALTERED SEQUENCE SPECIFICITY AND DNA-BINDING AFFINITY - Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research. | 02-02-2012 |
20120040405 | RATIONALLY-DESIGNED MEGANUCLEASES WITH ALTERED SEQUENCE SPECIFICITY AND DNA-BINDING AFFINITY - Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research. | 02-16-2012 |
20120040406 | RATIONALLY-DESIGNED MEGANUCLEASES WITH ALTERED SEQUENCE SPECIFICITY AND DNA-BINDING AFFINITY - Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research. | 02-16-2012 |
20120070877 | RATIONALLY DESIGNED MEGANUCLEASES WITH ALTERED SEQUENCE SPECIFICITY AND DNA-BINDING AFFINITY - Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research. | 03-22-2012 |
20120264189 | Rationally-Designed Meganucleases With Altered Sequence Specificity and DNA-Binding Affinity - Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research. | 10-18-2012 |
20120266266 | METHODS OF PRODUCING GENETICALLY-MODIFIED EUKARYOTIC CELLS WITH RATIONALLY-DESIGNED MEGANUCLEASES - Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research. | 10-18-2012 |
Patent application number | Description | Published |
20090064004 | Dynamically configurable portlet - An improved solution for portlets is provided. In an embodiment of the invention, a method of automatically configuring a portlet includes: receiving a portlet; searching content of the portlet for a contextual aspect; and automatically applying attribute information to a portlet window object based on a discovered contextual aspect. | 03-05-2009 |
20090064033 | DYNAMICALLY CONFIGURABLE PORTLET - An improved solution for portlets is provided. In an embodiment of the invention, a system for automatically configuring a portlet includes: a module for receiving a portlet; a module for searching content of the portlet for a contextual aspect; and a module for automatically applying attribute information to a portlet window object based on a discovered contextual aspect. | 03-05-2009 |
20090204887 | MANAGING WHITE SPACE IN A PORTAL WEB PAGE - Embodiments of the present invention address deficiencies of the art in respect to web page layout and provide a novel and non-obvious system for managing white space in a web page. In one embodiment of the invention, a method for managing white space in a web page includes detecting white space adjacent to a non-rectangular shaped portlet rendered on the web page. The method further includes measuring a non-rectangular shape of the white space and selecting a graphic having a shape congruent with the shape of the white space. The method further includes rendering the graphic that was selected into the white space. | 08-13-2009 |
20110157219 | AUTOMATIC TARGETING OF BROWSER CONTENT TO OPTIMAL RENDERING ENGINE - Embodiments of the present invention provide a method, system and computer program product for content driven selection of a rendering engine. In an embodiment of the invention, a method for or content driven selection of a rendering engine can include retrieving content for display in a content browser executing in memory by a processor of a host computer, mapping at least one directive embedded in the retrieved content to a target rendering engine, selecting the target rendering engine for rendering the content, and passing the content to the selected target rendering engine. In this regard, in an aspect of the embodiment, multiple directives embedded in the retrieved content can be mapped, each to one of a selection of different target rendering engines, and a most often mapped one of the target rendering engines can be selected for rendering the content. | 06-30-2011 |
20130191891 | AUTOMATIC PROVISIONING OF RESOURCES FOR MEETING COLLABORATION - A method may comprise maintaining by a computer system connected to a network an indication of availability dates and times of one or more output devices connected to the network. The computer system may receive an output device invitation indicating an output device to reserve for a meeting conducted over a conferencing system and determine whether the output device is available for reservation during a date and time period of the meeting. The computer system may be communicating over the network to the output device activation information indicating that the output device is to become active at a predetermined date and time related to the date and time period of the meeting and login information including a credential for the output device to use for logging into the conferencing system for the meeting. | 07-25-2013 |
20130191896 | AUTOMATIC PROVISIONING OF RESOURCES FOR MEETING COLLABORATION - A system for provisioning an output device, may include a processor; a memory; and a records display program. The records display program may be executed by the processor to maintain an indication of availability dates and times of one or more output devices connected to the network; to receive an output device invitation indicating a first output device to reserve at a meeting conducted over a conferencing system; to determine whether the first output device is available for reservation during a date and time period of the meeting; and to communicate to the first output device activation information indicating that the first output device is to become active at a first predetermined date and time related to the date and time period of the meeting and login information including a first credential for the first output device to use for logging into the conferencing system for the meeting. | 07-25-2013 |