Patent application number | Description | Published |
20080300220 | Linkable Lewis X Analogs - Disclosed herein is a class of linkable tetrasaccharide compounds that includes the amino phenyl glycoside of sialyl Lewis X (SLe | 12-04-2008 |
20090131636 | TARGETING VECTOR-PHOSPHOLIPID CONJUGATES - Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA. | 05-21-2009 |
20100003195 | KDR AND VEGF/KDR BINDING PEPTIDES AND THEIR USE IN DIAGNOSIS AND THERAPY - The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a K | 01-07-2010 |
20100233090 | TARGETING VECTOR-PHOSPHOLIPID CONJUGATES - Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA. | 09-16-2010 |
20110229409 | LINKABLE LEWIS X ANALOGS - Disclosed herein is a class of linkable tetrasaccharide compounds that includes the amino phenyl glycoside of sialyl Lewis X (SLe | 09-22-2011 |
20120258043 | Linkable Lewis X Analogs - Disclosed herein is a class of linkable tetrasaccharide compounds that includes the amino phenyl glycoside of sialyl Lewis X (SLe | 10-11-2012 |
20120315220 | Compounds for Targeting Endothelial Cells, Compositions Containing the Same and Methods for Their Use - The present invention provides compounds for targeting endothelial cells, tumor cells or other cells that express the NP-1 receptor, compositions containing the same and methods for their use. Additionally, the present invention includes diagnostic, therapeutic and radiotherapeutic compositions useful for visualization, therapy or radiotherapy. | 12-13-2012 |
20140107041 | KDR AND VEGF/KDR BINDING PEPTIDES AND THEIR USE IN DIAGNOSIS AND THERAPY - The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a K | 04-17-2014 |
Patent application number | Description | Published |
20110070165 | MULTIVALENT CONSTRUCTS FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS - The invention provides compositions and methods for therapeutic and diagnostic applications. | 03-24-2011 |
20110097275 | KDR AND VEGF/KDR BINDING PEPTIDES AND THEIR USE IN DIAGNOSIS AND THERAPY - The present invention provides polypeptides, peptide dimers, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a K | 04-28-2011 |
20110262366 | COMPOUNDS FOR TARGETING ENDOTHELIAL CELLS, COMPOSITIONS CONTAINING THE SAME AND METHODS FOR THEIR USE - The present invention provides compounds for targeting endothelial cells, tumor cells or other cells that express the NP-1 receptor, compositions containing the same and methods for their use. Additionally, the present invention includes diagnostic, therapeutic and radiotherapeutic compositions useful for visualization, therapy or radiotherapy. | 10-27-2011 |
20110286929 | MULTIVALENT CONSTRUCTS FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS - The invention provides compositions and methods for therapeutic and diagnostic applications. | 11-24-2011 |
20110286936 | TARGETING VECTOR-PHOSPHOLIPID CONJUGATES - Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA. | 11-24-2011 |
20130266519 | TARGETING VECTOR-PHOSPHOLIPID CONJUGATES - Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA. | 10-10-2013 |
20140031520 | TARGETING VECTOR-PHOSPHOLIPID CONJUGATES - Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA. | 01-30-2014 |
20140161732 | KDR AND VEGF/KDR BINDING PEPTIDES AND THEIR USE IN DIAGNOSIS AND THERAPY - The present invention provides polypeptides, peptide dimers, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a K | 06-12-2014 |
20140205545 | MULTIVALENT CONSTRUCTS FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS - The invention provides compositions and methods for therapeutic and diagnostic applications. | 07-24-2014 |
20140206837 | TARGETING VECTOR-PHOSPHOLIPID CONJUGATES - Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA. | 07-24-2014 |
20140286864 | KDR AND VEGF/KDR BINDING PEPTIDES AND THEIR USE IN DIAGNOSIS AND THERAPY - The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a K | 09-25-2014 |
Patent application number | Description | Published |
20090148391 | SYNERGISTIC ACTIVE PREPARATIONS COMPRISING DIPHENYLMETHANE DERIVATIVES AND FURTHER SKIN AND/OR HAIR LIGHTENING AND/OR SENILE KERATOSIS REDUCING COMPOUNDS - The present invention relates to specific synergistic active skin- and/or hair-lightening and/or senile keratosis-reducing (cosmetic or pharmaceutical) preparations comprising a mixture comprising or consisting of
| 06-11-2009 |
20090297468 | Mixtures Comprising Anthranilic Acid Amides and Cooling Agents as Cosmetic and Pharmaceutical Compositions for Alleviating Itching - The invention relates to a mixture comprising or consisting of:
| 12-03-2009 |
20090306154 | SYNERGISTIC ANTI-MICROBIAL MIXTURES OF TROPOLONE (DERIVATIVES) AND SELECTED COMPOUNDS - The present invention relates to the antimicrobial mixture comprising or consisting of:
| 12-10-2009 |
20100196504 | SYNERGISTIC ACTIVE PREPARATIONS COMPRISING 1,2-DECANEDIOL AND FURTHER ANTIMICROBIAL ACTIVE COMPOUNDS - The present invention relates to specific synergistic active antimicrobial compositions for hygiene disinfectant products like antimicrobial liquid or solid soaps, disinfectant cleansing solutions and disinfectant emulsions for the treatment of skin surface, specifically for the treatment of hand surface and/or for the treatment of technical surfaces like e.g. surgery equipment comprising a mixture comprising or consisting of
| 08-05-2010 |
20100216892 | Use of synergistically active 1,2-alkanediol mixtures as skin moisture-regulating compositions - Synergistically active mixtures of straight-chain 1,2-alkanediols having 5 to 10 C atoms and their use as skin moisture-regulating compositions are described. Binary and ternary mixtures of 1,2-pentanediol, 1,2-hexanediol and 1,2-octanediol have proved to be particularly active here. Cosmetic or pharmaceutical formulations and ready-to-use cosmetic or pharmaceutical products comprising particularly synergistically active mixtures of the 1,2-alkanediols mentioned and the use of these formulations and products are furthermore described. | 08-26-2010 |
20130136709 | SYNERGISTICALLY ACTING TERNARY ANTIMICROBIAL MIXTURES - The invention relates to synergistically effective ternary antimicrobial mixtures. | 05-30-2013 |
Patent application number | Description | Published |
20120308489 | ORAL CARE COMPOSITIONS - Disclosed herein are methods of enhancing the solubility and delivery of one or more active ingredients found in magnolia extract, or a synthetic analogue thereof, in an oral composition. | 12-06-2012 |
20130202536 | FLUOROPHORE CHELATED LANTHANIDE LUMINESCENT PROBES WITH IMPROVED QUANTUM EFFICIENCY - The invention relates to novel luminescent compositions of matter containing a fluorophore, synthetic methods for making the compositions, macromolecular conjugates of the compositions, and the use of the compositions in various methods of detection. The invention also provides kits containing the compositions and their conjugates for use in the methods of detection. | 08-08-2013 |
20130249159 | Apparatus for Conducting Oral Care Experiments and Method of Forming and Using the Same - An apparatus for conducting oral care experiments with enamel block substrates ( | 09-26-2013 |
20130315844 | Oral Care Compositions - Described herein are compositions comprising an active compound from an extract of magnolia, or a derivative thereof; and a non-surfactant electrolyte in an amount effective to stabilize the composition, and methods of making and using the same. | 11-28-2013 |
20140242001 | TOOTH FILM FORMULATIONS - The invention provides novel dental film-forming compositions, comprising i. an acrylate/octylacrylamide copolymer, ii. one or more alkyl cellulose ethers, and iii. a solvent, and optionally further comprising whitening materials and/or active agents, together with method for using the same. | 08-28-2014 |
Patent application number | Description | Published |
20090132433 | MATCHED FILTER APPROACH TO PORTFOLIO OPTIMIZATION - Given a fixed amount of capital, how to invest it optimally by distributing it among a set of stocks and securities so as to maximize the return while minimizing the overall risk is addressed here. Given that one has full freedom in selecting the type of stocks, a new strategy is outlined here by maximizing the ratio of the gain to risk—rather than minimizing the risk alone—to determine the fraction of capital that must go to each stock. An optimum gain versus variance plot can be used to determine the type of stocks to be selected in addition to their relative quantity for maximum yield over the duration of interest. By modifying the definition of risk to include a function of the covariance matrix of secondary stocks that are sympathetic to the primary stocks of interest, an alternate investment strategy is also developed here. If short selling of stocks and securities is not allowed in a portfolio, then stock selection becomes important so as to maintain the desired fractions to be positive. In this context, a new iterative method that incrementally increases the diagonal loading of the covariance matrix of the primary returns so as to achieve positive weight factors is also developed. | 05-21-2009 |
20090147625 | EFFICIENT METHODS FOR WIDEBAND CIRCULAR AND LINEAR ARRAY PROCESSING - The objective of this patent is to develop new signal processing algorithms for a wide-band circular electronically scanned array (CESA) or a wideband linear electronically scanned array (LESA) for use in surveillance and communications applications, where a sequence of pulses are transmitted and their returns are collected by the array for further processing. Instead of partitioning the entire wideband frequency into various subbands and then processing them separately using narrowband schemes, a frequency focusing method is proposed here to compensate and focus the wideband spatio-temporal data into a single narrow frequency band. This is made possible by operating with a pre-computed frequency focusing matrix that transforms the data from various frequency slots that are spread across the entire wideband region into a common narrowband frequency for the array outputs. Finally the focused narrowband data can be processed using conventional space-time adaptive processing methods to suppress the clutter/noise returns and detect any targets present. | 06-11-2009 |
20100106442 | GENERATION OF CONSTANT ENVELOPE OR NEARLY-CONSTANT ENVELOPE SIGNALS SATISFYING A GIVEN FOURIER TRANSFORM MAGNITUDE - One or more embodiments of the present invention relates to an iterative method for generating an almost-constant, nearly constant, or substantially-constant envelope time signal with prescribed Fourier transform magnitude in the frequency domain, and a constant envelope time signal whose Fourier transform magnitude closely matches the prescribed Fourier transform magnitude in the frequency domain. Different starting points for the iterative algorithm give rise to different solutions and their accuracy can be adjusted using a monotonic error criterion presented here. | 04-29-2010 |
20100164806 | TARGET AND CLUTTER ADAPTIVE ON-OFF TYPE TRANSMIT PULSING SCHEMES - One or more embodiments of the present invention relates to the design an adaptive transmit non-periodic ON-OFF pulse width modulated (PWM) signal sequence over a radar dwell time that is matched to the target and clutter characteristics so as to maximize the target response adaptively. In this context, in the first step, some optimality criterion such as maximizing the ratio of the target output signal power to the mean clutter power at the receiver input is used to design a pre-transmit waveform. In the second step, a Pulse Width Modulation method is used to convert the pre-transmit waveform so designed to a non-periodic ON-OFF pulse width modulated (PWM) waveform signal without destroying the target and clutter matching characteristics of the pre-transmit signal. This allows maximum response from the target and minimum response from the clutter and the environment when the target and its surroundings are interrogated with the non-periodic ON-OFF pulse width modulated (PWM) signal waveform. | 07-01-2010 |
20110183625 | MULTICHANNEL CONSTANT ENVELOPE ORTHOGONAL WAVEFORMS USING RECEIVER DESIGN - An radar apparatus including a first transmitter, a second transmitter, a first receiver, a second receiver, and a control device. The control device is programmed to use both the characteristics of a first transmit signal from the first transmitter and a second transmit signal from the second transmitter to determine a first control signal for applying to the first receiver to determine its impulse response characteristics, and to determine a second control signal for applying to the second receiver to determine its impulse response characteristics which differ from the first receiver. These control signals have the ability to separate out the first transmit signal and the second transmit signal from their combined sum that appears at the input of the receiver. The procedure can be generalized to include any number of transmit signals and a corresponding number of control signals to separate out the transmit signals from their combined form. | 07-28-2011 |
20130173114 | METHOD AND APPARATUS FOR AUTOMOBILE ACCIDENT REDUCTION USING LOCALIZED DYNAMIC SWARMING - A method, system, and apparatus to detect when one or more moving vehicles are close to a first vehicle, and to take necessary actions to maintain a minimum distance between vehicles in a dynamic environment by automatic navigation. A computer method and apparatus for automobile accident reduction by maintaining a minimum distance with respect to all nearby vehicles on the road. In addition, methods to synchronously move a group of vehicles on a highway through a swarming action where each vehicle keeps a region immediately around it free of other vehicles while maintaining the speed of the vehicle immediately in front or nearby is also disclosed. | 07-04-2013 |
20130289858 | METHOD FOR CONTROLLING AND COMMUNICATING WITH A SWARM OF AUTONOMOUS VEHICLES USING ONE-TOUCH OR ONE-CLICK GESTURES FROM A MOBILE PLATFORM - A method for controlling a swarm of autonomous vehicles to perform a multitude of tasks using either a one touch or a single gesture/action command. These commands may include sending the swarm on an escort mission, protecting a convoy, distributed surveillance, search and rescue, returning to a base, or general travel to a point as a swarm. A gesture to initiate a command may include a simple touch of a button, drawing a shape on the screen, a voice command, shaking the unit, or pressing a physical button on or attached to the mobile platform. | 10-31-2013 |
20140191900 | METHOD AND APPARATUS FOR SIMULTANEOUS MULTI-MODE PROCESSING PERFORMING TARGET DETECTION AND TRACKING USING ALONG TRACK INTERFEROMETRY (ATI) AND SPACE-TIME ADAPTIVE PROCESSING (STAP) - The present invention discloses one or more methods to perform multimode processing using a single set of measured data in a multi-sensor fusion framework. In this context, various data processing methodologies are combined in parallel in a suitable manner to simultaneously image, detect, identify and track moving targets over clutter such as stationary background using data obtained from a single set of measurements. Traditionally multiple sets of data would be required to perform these tasks, furthermore the disparate datum would be processed independently of one another. By using a common data source and interconnected processors the information content of the measured data can be fully exploited and leveraged to provide actionable intelligence and aid logistics. | 07-10-2014 |