Patent application number | Description | Published |
20080296488 | IMAGING MASS SPECTROMETRY FOR SMALL MOLECULES IN TWO-DIMENSIONAL SAMPLES - The invention relates to spatially resolved mass spectrometric measurement and visualization of the distribution of small molecules in a mass range from approximately 150 to 500 Daltons, for example drugs and their metabolites, in thin sections or other two-dimensional samples, preferably with ionization of the molecules by matrix-assisted laser desorption. The invention includes the steps measuring a daughter ion produced by forced decomposition of the molecular ion instead of the ionized analyte molecule itself, the daughter ion having a much better signal-to-noise ratio. The daughter ions are detected in a relatively simple reflector time-of-flight mass spectrometer instead of using an expensive time-of-flight tandem mass spectrometers for the measurement of the daughter ions. Advantageously, substantially faster and less expensive scanning of the thousands of mass spectra which serve as the basis for visualizing the spatial distribution of the analyte molecule is achieved, while the mass resolution and sensitivity are at least equally good. | 12-04-2008 |
20090095903 | CLEANED DAUGHTER ION SPECTRA FROM MALDI IONIZATION - In a mass spectrometer having an ion source in which analyte substances are ionized by matrix assisted laser desorption and form an ion beam that travels to a parent ion selector for selecting ions to form daughter ions, the ion beam is reflected in at least one reflector prior to the parent ion selector so that only ions that have both the mass of the parent ions and their kinetic energy are allowed to pass to the parent ion selector. By taking this measure, the mass resolution in the daughter ion spectra is also increased; the improved mass resolution and improved signal-to-noise ratio produce higher sensitivity, even though fewer ions are admitted for analysis in the daughter ion spectrum. | 04-16-2009 |
20090101813 | MULTIPLEXING DAUGHTER ION SPECTRUM ACQUISITION FROM MALDI IONIZATION - The invention relates to the measurement of daughter ion spectra of analyte substances that are ionized by means of matrix-assisted laser desorption. The invention shows how to record several daughter ion spectra from several parent ions per single pulse of laser light, that is per desorption event, by spatially splitting the ion beams or by temporally sequencing the spectral measurement; the various parent ions are selected one after another by switching the parent ion selector several times. Summing up corresponding individual daughter ion spectra from many pulses of laser light leads to several sum spectra being recorded practically synchronously with the same series of laser light pulses, with correspondingly reduced sample consumption and shortened data acquisition time. | 04-23-2009 |
20090200457 | AUTOMATIC CLEANING OF MALDI ION SOURCES - In an ion source that generates ions by matrix-assisted laser desorption (MALDI), ion acceleration diaphragms having apertures though which ions are accelerated and which have become contaminated by matrix material, are cleaned by temporarily heating the diaphragms. During the cleaning process, the sample support plate is moved aside but remains in the ion source housing, and the heating is preferably limited to regions surrounding the apertures in the diaphragms. In one embodiment, the diaphragms are heated by irradiation generated by infrared laser diodes. | 08-13-2009 |
20090206247 | ADJUSTING THE DETECTOR AMPLIFICATION IN MASS SPECTROMETERS - The amplification of secondary-electron multipliers in mass spectrometers is automatically adjusted by generating mass spectra with single ion signals, determining the average value of the peak heights of these single ion signals, and setting the amplification so that the average peak height assumes a desired nominal value. The amplification may be set via the supply voltage of the secondary-electron multiplier and can be increased or decreased by a desired factor using the known characteristic of the secondary-electron multiplier. | 08-20-2009 |
20130056628 | LASER SPOT CONTROL IN MALDI MASS SPECTROMETERS - Mass spectrometers ionize samples by matrix-assisted laser desorption (MALDI). The samples are located on a moveable support plate, and irradiated by a pulsed laser. A fast positional control of laser spots is provided via a system of rotatable mirrors to relieve strain on a support plate motion drive. If the spot position is finely adjusted by the mirror system and follows the movement of the sample support plate, the intermittent movement of the sample support can be replaced with a continuous uniform motion. The fast positional control allows more uniform ablation of a sample area. Galvo mirrors with low inertia may be used between the beam generation and a Kepler telescope in the housing of the laser. The positional control can also provide a fully automatic adjustment of MALDI time-of-flight mass spectrometers, at least if the ion-optical elements are equipped with movement devices. | 03-07-2013 |
Patent application number | Description | Published |
20100109325 | Method and device for power regulation of an underwater power plant - The invention concerns a method for the operation of an underwater power plant with | 05-06-2010 |
20110101696 | WAVE POWER PLANT AND METHOD FOR OPERATING THE SAME - The invention concerns a method for operating a wave power station comrising
| 05-05-2011 |
20110316282 | UNDERWATER POWER PLANT HAVING REMOVABLE NACELLE - The invention relates to an underwater powerplant, comprising
| 12-29-2011 |
20120056424 | METHOD AND DEVICE FOR DECELERATING AN UNDERWATER POWER STATION - The invention concerns a method for the operation of an underwater powerplant comprising a water turbine for purposes of absorbing kinetic energy from a flow of water; an electrical generator with converter feed, whose generator rotor is connected in a torsionally rigid manner with the water turbine, wherein the invention is characterised in that in normal operation a first frequency converter is used for purposes of converter feed, and in the braking operation at least one second frequency converter, or one component of a second frequency converter, is connected into the circuit and synchronised with the first frequency converter, in order to execute with the latter in a combined manner a converter feed to the electrical generator, which generates a generator torque braking the water turbine. | 03-08-2012 |
20130214533 | Method for Power Regulation of an Underwater Power Plant - The invention concerns a method for the operation of an underwater power plant with
| 08-22-2013 |