Donahue, MA
Christine P. Donahue, Brighton, MA US
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20090075342 | Metabolic profile directed aptamer medicinal chemistry - The present invention provides materials and methods for enhancing aptamers. More specifically, the materials and methods of the present invention are directed toward the modification of aptamers by the identification of one or more cleavage sites, and introduction of a chemical substitution at a position proximal to the cleavage site(s). Such aptamers are useful for the treatment of disease, in diagnostic and detection applications, and/or research, e.g., target validation. | 03-19-2009 |
James Donahue, Raynham, MA US
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20120078308 | ROD REDUCTION INSTRUMENT AND METHODS OF ROD REDUCTION - An instrument for reducing a spinal rod includes a reduction member sized and shaped to be positioned about an anchor extension connected to a bone anchor, an actuator assembly connected to the reduction member and operable to move the reduction member distally relative to the anchor extension along a longitudinal axis of the anchor extension, and a connection mechanism for removable and replaceable connection of the actuator assembly to a proximal end of the anchor extension. The connection mechanism is adjustable between a first position in which the connection mechanism connects the actuator assembly to the proximal end of the anchor extension and a second position in which the connection mechanism and the actuator assembly are released from the anchor extension. | 03-29-2012 |
James R. Donahue, East Falmouth, MA US
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20110077689 | Methods and Devices for Manipulating a Vertebra - Methods and devices are provided for manipulating a vertebra. In one embodiment, a surgical device can include a frame configured to couple two or more surgical instruments attached to one or more vertebrae. Coupling the two or more surgical instruments together, the frame and/or at least one of the surgical instruments can be manipulated to move at least one of the surgical instruments, thereby effecting movement at least one of the vertebra or vertebrae to which the surgical instruments coupled to the frame are attached. In this way, the surgical device can be used to facilitate rotation of a vertebra relative to another vertebra to correct the angular relationship of the vertebrae. | 03-31-2011 |
20110282402 | INSTRUMENTS AND METHODS FOR MANIPULATING VERTEBRA - A method for manipulating a vertebra includes connecting a first bone anchor to a first vertebra, connecting a second bone anchor to a second bone anchor, positioning a spinal rod in a receiving member of the first bone anchor and in a receiving member of the second bone anchor, connecting a first instrument to the receiving member of the first bone anchor, and manipulating the first instrument to rotate first bone anchor and the first vertebra relative to the second vertebra. | 11-17-2011 |
20130060294 | Bone Implants - Various bone fixation devices and methods of using the same are provided. In one embodiment, a spinal implant assembly is provided having a generally U-shaped rod-receiving head or receiver member, and a bone-engaging member extending distally from the receiver member. The receiver member can have two side arms extending proximally from a distal end, and the arms can define a U-shaped channel therebetween for receiving a spinal fixation element. The side arms of the receiver can have various configurations and can include a number of features to facilitate mating with a spinal tool. | 03-07-2013 |
20140100618 | DEROTATION INSTRUMENT WITH REDUCTION FUNCTIONALITY - Instruments and methods are provided for manipulating a bone anchor and a spinal fixation element. The instruments and methods disclosed herein are particularly suited to facilitate rotation of a bone anchor relative to another bone to correct the angular rotation of the vertebrae attached to the bone anchor. The instrument does not require the spinal fixation element to be inserted into the bone anchor prior to manipulation. The instrument further may be used in the insertion of the spinal fixation element into the bone anchor. | 04-10-2014 |
20140188182 | INSTRUMENTS AND METHODS FOR MANIPULATING VERTEBRA - A method for manipulating a vertebra includes connecting a first bone anchor to a first vertebra, connecting a second bone anchor to a second bone anchor, positioning a spinal rod in a receiving member of the first bone anchor and in a receiving member of the second bone anchor, connecting a first instrument to the receiving member of the first bone anchor, and manipulating the first instrument to rotate first bone anchor and the first vertebra relative to the second vertebra. | 07-03-2014 |
Jason Donahue, Boston, MA US
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20100099954 | Data-driven sleep coaching system - System and method for a user to monitor and/or modify his or her sleep. In one embodiment, the sleep coaching system comprises a sensor for sensing a physiological signal of a sleeping user such as an EEG, computer memory databases for storing user and sleep-related data and advice, and a processor that generates a set of advice to improve user sleep satisfaction based on the user and sleep-related data. The advice to improve user sleep satisfaction, which may be communicated to the user, may comprise a sleep coaching plan, which may include one or more sleep coaching workshops that the user may undertake. | 04-22-2010 |
20130344465 | DATA-DRIVEN SLEEP COACHING SYSTEM - System and method for a user to monitor and/or modify his or her sleep. In one embodiment, the sleep coaching system comprises a sensor for sensing a physiological signal of a sleeping user such as an EEG, computer memory databases for storing user and sleep-related data and advice, and a processor that generates a set of advice to improve user sleep satisfaction based on the user and sleep-related data. The advice to improve user sleep satisfaction, which may be communicated to the user, may comprise a sleep coaching plan, which may include one or more sleep coaching workshops that the user may undertake. | 12-26-2013 |
Jeffrey G. Donahue, Hopkinton, MA US
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20090061535 | Method of adjusting the working range of multi-analyte assay - The invention features a method of adjusting the concentration of at least one but not all of a plurality of analytes in a fluid sample to match a known working range of detection of an analyte assay system, where each of the plurality of analytes may or may not be present within an expected initial concentration range having a high end and a low end, and at least one analyte has a high end expected concentration range that exceeds the high end of the working range of the assay system. The expected concentration of the high concentration analyte is adjusted by a proportional scaling constant, α, so that the high end of the adjusted expected concentration range is less than or equal to the high end of the working range, without adjusting the expected concentration range of at least one other of the plurality of analytes. Adjustment is preferably accomplished by adding to the solution phase of the assay one or more scaling agents, each scaling agent binding with specificity to an analyte and thereby preventing it from being detected by the assay system, e.g., by competing with binding to immobilized capture agent. This scaling method contrasts with prior methods, in which a concentration of available analyte is offset by a fixed amount to adjust the detectable threshold of the assay. Here, the amount of scaling agent is proportional to a scaling coefficient, and the scaling agent is present in the solution phase of the assay at high concentrations relative to analyte. Due to the equilibrium conditions established by the laws of mass transfer, the amount of free analyte remaining in solution in the presence of scaling agent is predictable and finite, and can be measured as a quantitative indicator of the initial concentration of the analyte in the sample. | 03-05-2009 |
Kevin Donahue, Harvard, MA US
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20080295405 | Method for controlling syngas production in a system with multiple feed materials - Two or more feed materials that possess differing syngas generation potentials are mixed in a mixer and fed as a composite feed stream into a gasifier to produce syngas. By controlling the feed rate of the mixture into the gasifier as well as the feed rates of one or more of the individual feed materials into the mixer, the syngas is produced at a target production rate, with target energy content (BTU). Potential feed materials include, but are not limited to, construction and demolition (C&D) debris, municipal solid waste (MSW), other sewage-related solids, waste tires, and other substances that contain varying levels of organic compounds capable of producing a syngas. | 12-04-2008 |
20110289845 | METHOD FOR CONTROLLING SYNGAS PRODUCTION IN A SYSTEM WITH MULTIPLE FEED MATERIALS USING A MOLTEN METAL BATH - Processes and apparatus for treating organic and inorganic materials in a metal bath contained in a high temperature reactor to produce synthesis gas are provided. Two or more feed materials that possess differing syngas generation potentials are mixed in a mixer and fed as a composite feed stream into a gasifier to produce syngas. The feed materials are prepared and analyzed for heat value prior to injection and the composition of materials in and exiting the reactor are monitored. By controlling the feed rate of the mixture into the gasifier as well as the feed rates of one or more of the individual feed materials into the mixer, the syngas is produced at a target production rate, with target energy content (BTU). Based upon the results of the analysis and monitoring, oxygen, steam, and/or other feed materials are also injected into the reactor, to control processing and synthesis gas quality. Potential feed materials include, but are not limited to, construction and demolition (C&D) debris, municipal solid waste (MSW), other sewage-related solids, waste tires, and other substances that contain varying levels of organic compounds capable of producing a syngas. | 12-01-2011 |
Kevin G. Donahue, Harvard, MA US
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20090268483 | ILLUMINABLE MARKING DEVICE - An illuminable marking device includes a light guide panel overlaid with an illuminable pressure-sensitive film. Light is injected into the light guide panel at an angle of incidence sufficient to establish total internal reflection of the light between the surfaces of the light guide panel. When pressure is applied at selected points on the illuminable pressure-sensitive film, contact points on the film then interface with the light guide panel. The total internal reflection of light at that contact point is frustrated, allowing light to be extracted from the light guide panel and transmitted into the illuminable pressure-sensitive film. The viewer then sees illumination at the selected points. The illuminable marking device can be toy where children can create illuminated markings and drawings. | 10-29-2009 |
20100061115 | ONE-WAY SEE-THROUGH ILLUMINATION SYSTEM - A one-way see-through illumination system is constructed from a light guide panel, a front-illuminable image film, and a light injector. The light injector injects light into the light guide panel at a suitable angle for total internal reflection of the injected light at the surfaces of the light guide panel. The image film includes a half-toned front-illuminable image pattern that extracts light from the light guide panel. When active, light from the light guide panel front illuminates the image pattern for viewing by a front-side view, while a back-side viewer can see through the image pattern. | 03-11-2010 |
20120134172 | One-way see-through illumination system - A one-way see-through illumination system is constructed from a light guide panel, a front-illumination image film, and a light injector. The light injector injects light into the light guide panel at a suitable angle for total internal reflection of the injected light at the surfaces of the light guide panel. The image film includes a half-toned front-illuminable image pattern that extracts light from the light guide panel. When active, light from the light guide panel front illuminates the image pattern for viewing by a front-side view, while a back-side viewer can see through the image pattern. | 05-31-2012 |
20140104813 | METHOD AND DEVICE FOR EMITTING AN ILLUMINATED LIQUID STREAM - Method and device for emitting an illuminated water stream. According to one embodiment, the device includes a liquid stream generator for emitting at least one continuous liquid stream and an illumination device for emitting light. The liquid stream generator and the illumination device are arranged relative to one another so that light emitted from the illumination device is directed into at least one of the at least one continuous liquid stream at an angle such that at least one of the at least one continuous liquid stream is illuminated under the principle of total internal reflection. The liquid used to make the at least one continuous liquid stream may include water and at least one additive, such as a viscosity thickener and a light-diffusing agent. | 04-17-2014 |
Nancy C. Donahue, Lowell, MA US
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20090204061 | METHOD AND APPARATUS FOR TREATING CELLULITE - A device and a method for treating cellulite is disclosed. An oscillation therapy device includes a body, a motor, a drive shaft powered by the motor, and a contact surface coupled to the drive shaft, which may be substantially enclosed in a covering adapted to frictionally engage human skin. The motor and drive shaft drive the contact surface to impart an oscillating motion to the contact surface and to skin in contact with the surface. | 08-13-2009 |
Stephen R. Donahue, Lexington, MA US
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20100204286 | METHOD FOR REDUCING GASTROINTESTINAL ADVERSE EFFECTS OF CYTOTOXIC AGENTS - A method for moderating a gastrointestinal adverse effect induced by at least one cytotoxic agent, for example ionizing radiation and/or at least one chemotherapeutic agent, in a subject comprises administering to the subject a therapeutically effective amount of an ACE2 inhibitor or a compound selected from (S,S)-2-[1-carboxy-2-[3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl]-ethylaminol-4-methylpentanoic acid (ORE1001), pharmaceutically acceptable salts thereof and prodrugs thereof. A method for treating a cancerous condition in a subject comprises administering to the subject (a) at least one cytotoxic anticancer agent, for example ionizing radiation and/or at least one chemotherapeutic agent; and (b) an ACE2 inhibitor or a compound selected from ORE1001, pharmaceutically acceptable salts thereof and prodrugs thereof in an amount effective to moderate a gastrointestinal adverse effect induced by the anticancer agent. | 08-12-2010 |
Stephen Richard Donahue, Lexington, MA US
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20100035848 | THERAPY FOR DISORDERS OF THE PROXIMAL DIGESTIVE TRACT - A method for managing or treating an inflammatory, erosive, dyspeptic or reflux disorder of the proximal digestive tract of a subject comprises administering to the subject a therapeutically effective amount of an ACE2 inhibitor. A therapeutic combination, useful to treat any disease or condition in which an NSAID is indicated, comprises an NSAID in an anti-inflammatory, analgesic or antipyretic effective amount and a gastroprotective agent that comprises an ACE2 inhibitor in an amount effective to protect mucosal surfaces of the proximal digestive tract from erosion or ulceration induced by the NSAID. | 02-11-2010 |
Timothy P. Donahue, Natick, MA US
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20120027015 | Application of Services in a Packet Switching Device - A service is applied in a packet switching device to both directions of a flow of packets through the packet switching device, with the application of this Layer-4 to layer-7 service to one direction requiring state information shared from the application of the service to packets traversing in the other direction. The service (e.g. firewall, network address translation) can be applied by different processing complexes which do not share memory; thus, state information is communicated between the processing complexes. When the service is applied by a single processing complex, packets can be directed explicitly to the single processing complex. The inline application of services in a packet switching system typically eliminates the need to change a packet's path through the packet switching system to that through a dedicated application server, and may eliminate the need for a dedicated services card or blade server. | 02-02-2012 |
Timothy Patrick Donahue, Natick, MA US
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20110019677 | Limiting of Network Device Resources Responsive to IPv6 Originating Entity Identification - Methods, apparatus, computer-storage media, mechanisms, and means associated therewith are used to limit network device resources based on the identification of the Internet Protocol version 6 (IPv6) originating entity (e.g., subscriber of a network carrier). As an IPv6 originating entity will typically be assigned 264 or more valid IPv6 addresses, the originating entity may send packets with a source address of any of these valid IPv6 addresses and still be compliant with Internet standards and/or other specifications (e.g., RFCs). By determining the originating entity and controlling the allocation of network device resources based on the originating entity (in contrast to on a per valid IPv6 address basis), a network service provider can manage its network device resources, such as in a manner to prevent a depletion of resources caused by an originating entity using a plethora valid IPv6 addresses, or a malicious denial-of-service attack. | 01-27-2011 |
William Donahue, Quincy, MA US
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20090317875 | NUCLEIC ACID CLONING - The present invention provides an improved system for linking nucleic acids to one another. In particular, the present invention provides techniques for producing DNA product molecules that may be easily and directly ligated to recipient molecules. The product molecules need not be cleaved with restriction enzymes in order to undergo such ligation. In preferred embodiments of the invention, the DNA product molecules are produced through iterative DNA synthesis reactions, so that the product molecules are amplified products. The invention further provides methods for directed ligation of product molecules (i.e., for selective ligation of certain molecules within a collection of molecules), and also for methods of exon shuffling, in which multiple different product molecules are produced in a single ligation reaction. Preferred embodiments of the invention involve ligation of product molecules encoding functional protein domains, particularly domains naturally found in conserved gene families. The inventive DNA manipulation system is readily integrated with other nucleic acid manipulation systems, such as ribozyme-mediated systems, and also is susceptible to automation. | 12-24-2009 |
William F. Donahue, Quincy, MA US
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20090176281 | MODULAR VECTOR SYSTEMS - The present invention provides improved techniques and reagents for producing nucleic acid molecules. In certain preferred embodiments, the nucleic acid molecules are modular vectors. In certain preferred embodiments, the nucleic acid molecules are produced in polymerase chain reactions employing terminator primer residues. | 07-09-2009 |