Melnick, US
Andrew Melnick, Los Gatos, CA US
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20110258027 | POINT-OF-SALE PROMOTIONS - A method and a system to publish a promotion at a point-of-sale are provided. For example, a preliminary selection associated with a purchase from a user may be received. A promotion may be published to the user at a point-of-sale associated with the purchase after the user makes the preliminary selection and before the user finalizes the purchase. The promotion may be based on at least one attribute of past transactions and the preliminary selection. | 10-20-2011 |
20140032566 | SYSTEMS AND METHODS TO BUILD AND UTILIZE A SEARCH INFRASTRUCTURE - Methods and systems to build and utilize a search infrastructure are described. The system generates index information components in real-time based on a database that is time-stamped. The system updates index information at a plurality of query node servers based on the index information components. A query engine receives a search query from a client machine and identifies search results based on the query and the index information. The system communicates the search results, over the network, to the client machine. | 01-30-2014 |
Andrew John Melnick, Los Gatos, CA US
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20130246196 | SYSTEM AND METHOD TO PROMOTE A PUBLICATION - A method and a system to promote a publication are provided. In example embodiments, data is received from a user that is used to create a publication for placement on a networked-based system. An indication to promote the publication on the networked-based system is received. A user interface through which the user selects an option to promote the publication on the network-based system is presented. The publication is published on the network-based system, whereby the publication is promoted based on the option selected to promote the publication. | 09-19-2013 |
Ari Melnick, New York, NJ US
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20150297570 | SMALL MOLECULE INHIBITORS OF MALT1 - MALT1 cleavage activity is linked to the pathogenesis of activated B-cell-like diffuse large B-cell lymphoma (ABC-DLBCL), a chemo-resistant form of DLBCL. We developed a MALT1 activity assay and identified chemically diverse MALT1 inhibitors. A selected lead compound MI-2 featured direct binding to MALT1 and suppression of its protease function. MI-2 concentrated within human ABC-DLBCL cells and irreversibly inhibited cleavage of MALT1 substrates. This was accompanied by suppression of NF- | 10-22-2015 |
Ari M. Melnick, New York, NY US
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20090018083 | Methods and compositions for inhibition of bcl6 repression - Provided are peptides or mimetics that block corepressor binding to a BCL6 lateral groove. Also provided are methods of blocking corepressor binding to the BCL6 lateral groove. Additionally, methods of inhibiting BCL6 repression in a mammalian, cell, and methods of treating a mammal with cancer are provided. | 01-15-2009 |
20110152200 | METHODS AND COMPOSITIONS FOR INHIBITION OF BCL6 REPRESSION - The invention is directed to a compound that binds to a BCL6 lateral groove and prevents binding of a corepressor to the lateral groove. The present invention is further directed to methods for blocking corepressor binding to a BCL6 lateral groove, methods for inhibiting BCL6 repression in a mammalian cell, and methods for treating a mammal with cancer, wherein the cancer requires BCL6 repression. The present invention is further directed to polypeptides comprising a portion of the corepressor binding site for BCL6 and related polynucleotides and vectors. | 06-23-2011 |
20110286928 | Methods and compositions for inhibition of BCL6 repression - Provided are peptides or mimetics that block corepressor binding to a BCL6 lateral groove. Also provided are methods or blocking corepressor binding to the BCL6 lateral groove. Additionally, methods of inhibiting BCL6 repression in a mammalian cell, and methods of treating a mammal with cancer are provided. | 11-24-2011 |
Ari Matthew Melnick, New York, NY US
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20100130564 | SMALL MOLECULE INHIBITORS OF BCL6 - Provided are methods of inhibiting BCL6 repression in a mammalian cell. Also provided are methods of treating cancer in a mammal. | 05-27-2010 |
Benedetta Delorenzo Melnick, Rome, NY US
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20080294171 | Device and method for lumbar interbody fusion - A method for performing percutaneous interbody fusion is disclosed. The method includes the steps of inserting a guide needle posteriorly to the disc space, inserting a dilator having an inner diameter slightly larger than the outer diameter of the guide needle over the guide needle to the disc space to enlarge the disc space, and successively passing a series of dilators, each having an inner diameter slightly larger than the outer diameter of the previous dilator, over the previous dilator to the disc space the gradually and incrementally increase the height of the disc space. Once the desired disc height is achieved, the guide needle and all the dilators, with the exception of the outermost dilator, are removed. An expandable intervertebral disc spacer is then passed through the remaining dilator and positioned in the disc space. The disc spacer is expanded to the required disc height, and then a bone matrix is passed through the dilator to fill the disc space. The dilator is then removed. An expandable intervertebral disc spacer is also disclosed, having a tapered bore that causes greater expansion of one end of the spacer with respect to the other. A kit for performing the percutaneous interbody fusion procedure is also disclosed. | 11-27-2008 |
Bennett Melnick, Chicago, IL US
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20100048483 | POLYMERIC BENZYL CARBONATE-DERIVATIVES - The present invention relates to polymeric derivatives, which can be conjugated to an amino-containing drug to improve its in vivo properties. The polymeric derivative can subsequently be released to yield the drug in its native form. Methods of preparing and using these polymeric derivatives and drug conjugates are described. | 02-25-2010 |
20140128445 | POLYMERIC BENZYL CARBONATE-DERIVATIVES - The present invention relates to polymeric derivatives, which can be conjugated to an amino-containing drug to improve its in vivo properties. The polymeric derivative can subsequently be released to yield the drug in its native form. Methods of preparing and using these polymeric derivatives and drug conjugates are described. | 05-08-2014 |
Christopher Nathan Melnick, St. Charles, MO US
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20150199763 | SYSTEMS AND METHODS FOR MANAGING PORTFOLIO-RELEVANT NEWS CONTENT - A computer-implemented method for managing portfolio-relevant content is implemented by a content management computer system coupled to a memory. The method includes receiving a set of assets associated with an investor account, transmitting an investment content request for an investment content associated with at least one asset of the set of assets, receiving the investment content including a plurality of investment content items, determining a plurality of content indicators associated with each investment content item, determining a set of relevant investment content including a plurality of display parameters based at least partially on at least a portion of the investment content and at least a portion of the set of assets, and providing the set of relevant investment content for display on a user device based on at least a portion of the display parameters. | 07-16-2015 |
David Melnick, Madison, WI US
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20100249734 | OSTOMY POUCH CONTAINING AND SUPPORTING DEVICE AND SYSTEM - The present invention provides a device for containing, positioning, holding, and/or supporting an ostomy pouching system. In particular, the present invention provides a bag comprising one or more shoulder support straps for containing, positioning, holding, and supporting an ostomy pouch over a surgical stoma. | 09-30-2010 |
David Alan Melnick, Wilmington, DE US
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20120035219 | Compound for the Treatment of Tuberculosis - (5R)-3-[4-[1-[(2S)-2,3-dihydroxypropanoyl]-3,6-dihydro-2H-pyridin-4-yl]-3,5-difluoro-phenyl]-5-(isoxazol-3-yloxymethyl)oxazolidin-2-one, or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, for use in the treatment of | 02-09-2012 |
Joel Melnick, Waltham, VT US
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20120307512 | Multi-Wavelength Multi-Lamp Radiation Sources and Systems and Apparatuses Incorporating Same - Systems for providing high-intensity and high-quality illumination and other electromagnetic radiation (EMR) to target regions. The systems each include multiple EMR sources and a radiation combiner for combining the output radiation of the multiple sources. In some examples, the EMR sources are visible light sources, such as light-emitting diodes and laser diodes. In some of those examples, the light sources are of differing colors that are combined to form output illumination having user-selected qualities, such as color and intensity. The output of the radiation combiner can be directed into an optical fiber or bundle of optical fibers for remote delivery of the output to a target, such as in endoscopy and remote-illumination microscopy. Systems disclosed can also include additional EMR beams, such as visible light beams used for pointing/targeting and non-visible beams used, for example, for heating and fluoroscopic excitation of dyes/stains, among other things. | 12-06-2012 |
Joel Z. Melnick, Wilmette, IL US
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20110052567 | Methods Compositions, Uses, and Kits Useful for Vitamin D Deficiency and Related Disorders - Methods for diagnosing, treating, and preventing catabolism-related vitamin D deficiency and related disorders; related compositions, apparatus and kits, are disclosed. A method involves measuring CYP24 expression and/or activity, or a proxy thereof such as FGF23 level, in a patient and correlating abnormally elevated CYP24 expression and/or activity with catabolism-related vitamin D deficiency or with susceptibility for catabolism-related vitamin D deficiency. In response to abnormally elevated CYP24 expression and/or activity, the method further includes administering a CYP24 inhibitor to the vitamin D deficient or at-risk patient, and preferably avoiding activation of the vitamin D binding receptor, such as by avoiding administration of active vitamin D compounds to such patients. Optionally, a vitamin D prohormone or prohormone can be administered. | 03-03-2011 |
20130137663 | METHODS AND COMPOSITIONS FOR REDUCING PARATHYROID LEVELS - Methods and compositions for reducing serum parathyroid levels in, for example, chronic kidney disease patients are disclosed. In these methods, an effective amount of a modified release formulation of 25-hydroxy vitamin D is orally administered to a patient suffering from secondary hyperparathyroidism to lower the patient's serum intact parathyroid hormone (iPTH) level, while avoiding a surge in serum total 25-hydroxy vitamin D. | 05-30-2013 |
20150141385 | Methods Useful for Vitamin D Deficiency and Related Disorders - Methods for diagnosing, treating, and preventing catabolism-related vitamin D deficiency and related disorders, related compositions, apparatus and kits, are disclosed. A method involves measuring CYP24 expression and/or activity, or a proxy thereof such as FGF23 level, in a patient and correlating abnormally elevated CYP24 expression and/or activity with catabolism-related vitamin D deficiency or with susceptibility for catabolism-related vitamin D deficiency. In response to abnormally elevated CYP24 expression and/or activity, the method further includes administering a CYP24 inhibitor to the vitamin D deficient or at-risk patient, and preferably avoiding activation of the vitamin D binding receptor, such as by avoiding administration of active vitamin D compounds to such patients. Optionally, a vitamin D prohormone or prohormone can be administered. | 05-21-2015 |
Laurence Melnick, Watertown, MA US
Marina Melnick, Orlando, FL US
Mark Melnick, Orlando, FL US
Michael Melnick, Portage, MI US
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20120232083 | FLUORO-PYRIDINONE DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS - The present invention is directed to a new class of hydroxamic acid derivatives, their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections. | 09-13-2012 |
Michael Melnick, San Francisco, CA US
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20120184004 | METHODS AND COMPOSITIONS FOR THE PRODUCTION OF FATTY ACIDS IN PHOTOSYNTHETIC PROKARYOTIC MICROORGANISMS - Provided herein are methods and compositions for the production of renewable fatty acids from photosynthetic prokaryotic microorganisms, such as a blue green algae, any specie of the phylum Cyanophyta, a chloroplast of a green algae and/or a Cyanobacterium. Engineered or natural strains of these organisms or organelles can be used to produce both saturated and unsaturated fatty acids with variable chain length specificity from 8-18 carbons. The fatty acids can then be secreted into the culture medium, allowing for rapid, continuous and efficient separation of fatty acid product without harvesting of cell mass. | 07-19-2012 |
Michael J. Melnick, Portage, MI US
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20120058989 | ANTIBACTERIAL FLUOROQUINOLONE ANALOGS - Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): | 03-08-2012 |
20150225389 | THERAPEUTIC COMPOUNDS AND COMPOSITIONS - The present invention provides compounds and compositions that inhibit Factor XIa or kallikrein and methods of using these compounds and composition. | 08-13-2015 |
Michael Joesph Melnick, Portage, MI US
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20140343031 | N-Link Hydroxamic Acid Derivatives Useful As Antibacterial Agents - The present invention is directed to a new class of hydroxamic acid derivatives, their use as LpxC inhibitors, and more specifically their use to treat bacterial infections. | 11-20-2014 |
20150182513 | N-Link Hydroxamic Acid Derivatives Useful As Antibacterial Agents - The present invention is directed to a new class of hydroxamic acid derivatives, their use as LpxC inhibitors, and more specifically their use to treat bacterial infections. | 07-02-2015 |
Michael Joseph Melnick, Portage, MI US
Patent application number | Description | Published |
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20120202777 | C-Linked Hydroxamic Acid Derivatives Useful As Antibacterial Agents - The present invention is directed to a new class of hydroxamic acid derivatives of Formula I, | 08-09-2012 |
20120258948 | N-Linked Hydroxamic Acid Derivatives Useful As Antibacterial Agents - The present invention is directed to a new class of hydroxamic acid derivatives of formula I, | 10-11-2012 |
20140024690 | Isoxazole Derivatives Useful As Antibacterial Agents - The present invention is directed to a new class of hydroxamic acid derivatives, their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections. | 01-23-2014 |
20140038975 | Imidazole, Pyrazole, and Triazole Derivatives Useful As Antibacterial Agents - The present invention is directed to a new class of hydroxamic acid derivatives, their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections. | 02-06-2014 |
20140057919 | FLUORO-PYRIDINONE DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS - The present invention is directed to a new class of hydroxamic acid derivatives, their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections. | 02-27-2014 |
20140128363 | N-Link Hydroxamic Acid Derivatives Useful As Antibacterial Agents - The present invention is directed to a new class of hydroxamic acid derivatives, their use as LpxC inhibitors, and more specifically their use to treat bacterial infections. | 05-08-2014 |
20140364398 | C-Linked Hydroxamic Acid Derivatives Useful As Antibacterial Agents - The present invention is directed to a new class of hydroxamic acid derivatives, their use as LpxC inhibitors, and more specifically their use to treat bacterial infections. | 12-11-2014 |
Nikkol Melnick, Brasclton, GA US
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20110195075 | USE OF A PNEUMOCOCCAL P4 PEPTIDE FOR ENHANCING OPSONOPHAGOCYTOSIS IN RESPONSE TO A PATHOGEN - Methods for enhancing opsonophagocytosis of a pathogen of interest are disclosed. The disclosed methods include administering to a subject an isolated P4 peptide, which including the amino acid sequence set forth as SEQ ID NO: 1 and optionally an isolated opsonic antibody or a fragment thereof that specifically binds to an antigen present of the surface of the pathogen of interest. In some examples isolated complement protein or a fragment thereof (for example, a C3a, C3b, iC3b, C3d, C4b, or C5a fragment of a complement protein) is also administering. Compositions contain isolated P4 peptide and one or more isolated opsonic antibodies or a fragment thereof that specifically binds to an antigen present of the surface of a pathogen of interest are also disclosed. In some examples, the compositions also isolated complement protein or fragment thereof, such as one or more of C3a, C3b, iC3b, C3d, C4b, or C5a. | 08-11-2011 |
Nikkol Melnick, Braselton, GA US
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20130195893 | USE OF A PNEUMOCOCCAL P4 PEPTIDE FOR ENHANCING OPSONOPHAGOCYTOSIS IN RESPONSE TO A PATHOGEN - Methods for enhancing opsonophagocytosis of a pathogen of interest are disclosed. The disclosed methods include administering to a subject an isolated P4 peptide, which includes the amino acid sequence set forth as SEQ ID NO: 1 and optionally an isolated opsonic antibody or a fragment thereof that specifically binds to an antigen present on the surface of the pathogen of interest. In some examples isolated complement protein or a fragment thereof (for example, a C3a, C3b, iC3b, C3d, C4b, or C5a fragment of a complement protein) is also administered. Compositions containing isolated P4 peptide and one or more isolated opsonic antibodies or a fragment thereof that specifically binds to an antigen present on the surface of a pathogen of interest are also disclosed. In some examples, the compositions also include isolated complement protein or fragment thereof, such as one or more of C3a, C3b, iC3b, C3d, C4b, or C5a. | 08-01-2013 |
Scott Melnick, Atlanta, GA US
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20130310140 | THREE-DIMENSIONAL REELS FOR AN ELECTRONIC GAMING DEVICE - Examples disclosed herein relate to systems and methods for delivering game play, which may include providing wagering game options that may include a two-dimensional option, a three-dimensional option, and/or a combination of both. | 11-21-2013 |
Scott Melnick, Decatur, GA US
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20140179394 | ELECTRONIC GAMING DEVICE WITH CARD TOURNAMENT FUNCTIONALITY - Examples disclosed herein relate to systems and methods, which may receive wagers on one or more paylines. The systems and methods may utilize one or more tournament game structures. The systems and methods may utilize one or more power-up cards in the one or more tournament game structures. | 06-26-2014 |
20140179395 | ELECTRONIC GAMING DEVICE WITH CARD TOURNAMENT FUNCTIONALITY - Examples disclosed herein relate to systems and methods, which may receive wagers on one or more paylines. The systems and methods may utilize one or more tournament game structures. The systems and methods may utilize one or more power-up cards in the one or more tournament game structures. | 06-26-2014 |
20150072752 | ELECTRONIC GAMING SYSTEM WITH UNIVERSAL PLAYER TRACKING - Examples disclosed herein relate to systems and methods for utilizing one or more universal player tracking systems. The electronic gaming device may include a memory, a processor, and a plurality of reels. The plurality of reels may include one or more areas. The memory may include a universal player tracking module. The processor may generate one or more symbols to be located in the one or more areas and to validate one or more universal player tracking numbers based on data received from an external device. | 03-12-2015 |
20150141113 | ELECTRONIC GAMING DEVICE WITH AMBIENT LIGHTING FUNCTIONALITY - Examples disclosed herein relate to systems and methods for utilizing one or more presentations and one or more ambient light shows. The electronic gaming device may include a plurality of reels. The plurality of reels may include one or more areas. The electronic gaming device may include a memory and one or more processors. The memory may include one or more ambient lighting modules, one or more presentation modules, and/or one or more synchronization modules. The electronic gaming device may include one or more ambient light sensors and/or one or more light emitters. Further, the one or more processors may display one or more presentations and initiate one or more ambient light shows. | 05-21-2015 |
Scott Andrew Melnick, Atlanta, GA US
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20130310135 | Three-Dimensional Reels For An Electronic Gaming Device - Examples disclosed herein relate to systems and methods for delivering game play, which may include providing wagering game options that may include a two-dimensional option, a three-dimensional option, and/or a combination of both. | 11-21-2013 |
Scott Andrew Melnick, Decatur, GA US
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20140045570 | ELECTRONIC GAMING DEVICE - Examples disclosed herein relate to systems and methods, which may receive wagers on one or more repeat paylines. The systems and methods may receive one or more secondary wagers on one or more repeat paylines. The repeat paylines may be based on data received from a player. The systems and methods may determine a repeat paylines payout based on the one or more repeat paylines. | 02-13-2014 |
Steve Melnick, St. Louis, MO US
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20130103602 | SYSTEM AND METHOD FOR BENEFIT PLAN COST ESTIMATION - A computer-based method and system to enable a benefit plan sponsor to design a plurality of benefit plans to be offered to a given participant population and for determining the cost of sponsoring the plans for the participant population by predicting utilization for each of the plans based upon historical utilization data for the population, projected plan selections based upon presumed participant objectives, and/or survey or historical data from a sample of the given population or from preexisting statistical samples exhibiting analogous demographic characteristics to the given participant population relating to expected benefit utilization and plan preference criteria. | 04-25-2013 |
Steven J. Melnick, Miami, FL US
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20090203634 | Compositions and Uses of Amooranin Compounds - Amooranin (AMR) has been found to cause tumor cell death through G | 08-13-2009 |
Susan Marie Melnick, Parsippany, NJ US
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20100331332 | METHODS FOR TREATING DRUG ADDICTION AND IMPROVING ADDICTION-RELATED BEHAVIOR - The invention is directed to a method of treating addiction to drugs of abuse in a subject, comprising administering a therapeutically effective amount of a cabamoyl compound, or pharmaceutically acceptable salt or ester thereof. | 12-30-2010 |
20120004300 | METHODS FOR TREATING BIPOLAR DISORDER - The invention is directed to a method of treating bipolar disorder in a subject, comprising administering a therapeutically effective amount of a carbamate compound, or pharmaceutically acceptable salt or amide thereof. | 01-05-2012 |
20120004301 | METHODS FOR TREATING RESTLESS LEGS SYNDROME - The invention is directed to a method of treating restless legs syndrome in a subject, comprising administering a therapeutically effective amount of a carbamate compound, or pharmaceutically acceptable salt or amide thereof. | 01-05-2012 |
20120142769 | METHODS FOR TREATING OR PREVENTING FATIGUE - The present invention relates to the use of compounds of the invention for treatment and/or prevention of fatigue, including fatigue associated with diseases or treatments. | 06-07-2012 |
20120245226 | METHODS FOR TREATING ATTENTION-DEFICIT/HYPERACTIVITY DISORDER - The invention is directed to a method of treating attention-deficit/hyperactivity disorder (ADHD) in a subject, comprising administering a therapeutically effective amount of a carbamoyl compound, or pharmaceutically acceptable salt thereof. | 09-27-2012 |
20120252892 | METHODS FOR TREATING FIBROMYALGIA SYNDROME - The invention is directed to a method of treating fibromyalgia syndrome in a subject, comprising administering a therapeutically effective amount of a carbamoyl compound, or pharmaceutically acceptable salt thereof. | 10-04-2012 |
20140243406 | Methods for Treating or Preventing Fatigue - The present invention relates to the use of compounds of the invention for treatment and/or prevention of fatigue, including fatigue associated with diseases or treatments. | 08-28-2014 |
20150025137 | METHODS FOR TREATING ATTENTION-DEFICIT/HYPERACTIVITY DISORDER - The invention is directed to a method of treating attention-deficit/hyperactivity disorder (ADHD) in a subject, comprising administering a therapeutically effective amount of a carbamoyl compound, or pharmaceutically acceptable salt thereof. | 01-22-2015 |
Warren Melnick, Huntington Station, NY US
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20110010535 | MULTI-MEDIA DIGITAL CARTRIDGE STORAGE AND PLAYBACK UNITS BACKGROUND OF THE INVENTION - A method and apparatus for playing back a digital media file. The invention comprises defining a plurality of predetermined media types based upon an advertising scheme associated therewith, and valuing each of the plurality of predetermined media types in accordance with the advertising scheme. Then, one of the plurality of media types is selected and played back, thus invoking the associated advertising scheme. | 01-13-2011 |