Patent application number | Description | Published |
20090304814 | FIBRILLATION RESISTANT PROTEINS - Protection of proteins against fibrillation may be afforded by introduction of certain histidine substitutions into the protein, such that a pair of histidines are present with sufficient spacing as to allow the histidines to coordinate with zinc. In the case of insulin, introduction of histidine residue substitutions at residues A4 and A8 together or a histidine residue substitution at residue B1, provides increased resistance to fibrillation while maintaining at least a majority of the activity of the insulin analogue. Introduction of a histidine residue substitution at residue A8 restores at least a portion of fibrillation resistance that may have been harmed by substitutions present on the B-chain such as those present in fast-acting insulins. Proteins protected by such histidine substitutions may be used to provide a pharmaceutical composition. A method of treating a patient includes administering a physiologically effective amount of the pharmaceutical composition to the patient. | 12-10-2009 |
20100099601 | FIBRILLATION-RESISTANT INSULIN AND INSULIN ANALOGUES - A fibrillation-resistant insulin analogue may be a single-chain insulin analogue or a physiologically acceptable salt thereof, containing an insulin A chain sequence or an analogue thereof and an insulin B chain sequence or an analogue thereof connected by a polypeptide of 4-10 amino acids. The fibrillation-resistant insulin analogue preferably displays less than 1 percent fibrillation with incubation at 37° C. for at least 21 days. A single-chain insulin analogue displays greater in vitro insulin receptor binding than normal insulin while displaying less than or equal binding to IGFR than normal insulin. The fibrillation-resistant insulin may be used to treat a patient using an implantable or external insulin pump, due to its greater fibrillation resistance. | 04-22-2010 |
20110059887 | MEAL-TIME INSULIN ANALOGUES OF ENHANCED STABILITY - A method treating a patient includes administering a physiologically effective amount of a fibrillation-resistant insulin analogue or a physiologically acceptable salt thereof to the patient. The fibrillation-resistant insulin analogue or a physiologically acceptable salt thereof, contains an insulin A-chain sequence modified at position A8 and an insulin B-chain sequence or an analogue thereof. The fibrillation-resistant insulin analogue may exhibit thermodynamic stability similar to or exceeding that of wild-type human insulin and displays a susceptibility to fibrillation similar to or exceeding that of wild-type human insulin. An insulin analogue may display greater in vitro insulin receptor binding than normal insulin while displaying binding to IGFR less than twice that of normal insulin and less than that of fast-acting insulin analogs. The fibrillation-resistant insulin may be used to treat a patient by subcutaneous injection or by using an implantable or external insulin pump, due to its fibrillation resistance. | 03-10-2011 |
20110166064 | HALOGEN-STABILIZED INSULIN - An insulin analogue comprises a B-chain polypeptide incorporating a halogenated phenylalanine at position B24, B25 or B26. The halogenated phenylalanine may be ortho-monofluoro-phenylalanine, ortho-monobromo-phenylalanine, ortho-monochloro-phenylalanine, or para-monochloro-phenylalanine. The analogue may be of a mammalian insulin, such as human insulin. A nucleic acid encodes such an insulin analogue. The halogenated insulin analogues retain significant activity. A method of treating a patient comprises administering a physiologically effective amount of the insulin analogue or a physiologically acceptable salt thereof to a patient. Halogen substitution-based stabilization of insulin may enhance the treatment of diabetes mellitus in regions of the developing world lacking refrigeration. | 07-07-2011 |
20110195896 | ISOFORM-SPECIFIC INSULIN ANALOGUES - A method treating a mammal by administering a physiologically effective amount of an insulin analogue or a physiologically acceptable salt thereof where the insulin analogue displays more than twofold greater binding affinity to insulin receptor isoform A (IR-A) than insulin receptor isoform B (IR-B). The insulin analogue may be a single-chain insulin analogue or a physiologically acceptable salt thereof, containing an insulin A-chain sequence or an analogue thereof and an insulin B-chain sequence or an analogue thereof connected by a polypeptide of 4-13 amino acids. A single-chain insulin analogue may display greater in vitro insulin receptor binding to IR-A but lower binding to IR-B than normal insulin while displaying less than or equal binding to IGFR than normal insulin. | 08-11-2011 |
20120184488 | INSULIN ANALOGUES OF ENHANCED RECEPTOR-BINDING SPECIFICITY - A method of treating a patient includes administering a physiologically effective amount of an insulin analogue or a physiologically acceptable salt thereof to the patient. The insulin analogue or physiologically acceptable salt thereof contains an insulin A-chain sequence modified at positions selected from the group consisting of A0, A1, A4, A8, and A21. The insulin analogue may exhibit decreased affinity for the IGF receptor in comparison to wild type insulin of the same species and at least 20% of the affinity of wild-type insulin for the insulin receptor of the same species. Position A0 may be arginine. Position A1 may be D-alanine, D-aspartic acid, or D-leucine. Position A8 may be histidine, lysine, or arginine. Optionally, an insulin B-chain analogue sequence comprises a histidine at position B1. A nucleic acid may encode such an insulin polypeptide. | 07-19-2012 |
20120277148 | INSULIN ANALOGUES WITH CHLORINATED AMINO ACIDS - An insulin analogue comprises a B-chain polypeptide incorporating a chlorinated phenylalanine. The chlorinated phenylalanine may be located at position B24. The chlorinated phenylalanine may be para-monochloro-phenylalanine. The analogue may be of a mammalian insulin, such as human insulin. A nucleic acid encodes such an insulin analogue. The chlorinated insulin analogues retain significant activity. A method of treating a patient comprises administering a physiologically effective amount of the insulin analogue or a physiologically acceptable salt thereof to a patient. Chlorine substitution-based stabilization of insulin may reduce fibrillation and thereby enhance the treatment of diabetes mellitus in regions of the developing world lacking refrigeration. | 11-01-2012 |
20120316107 | FIBRILLATION-RESISTANT INSULIN AND INSULIN ANALOGUES - A fibrillation-resistant insulin analogue may be a single-chain insulin analogue or a physiologically acceptable salt thereof, containing an insulin A chain sequence or an analogue thereof and an insulin B chain sequence or an analogue thereof connected by a polypeptide of 4-10 amino acids. The fibrillation-resistant insulin analogue preferably displays less than 1 percent fibrillation with incubation at 37° C. for at least 21 days. A single-chain insulin analogue displays greater in vitro insulin receptor binding than normal insulin while displaying less than or equal binding to IGFR than normal insulin. The fibrillation-resistant insulin may be used to treat a patient using an implantable or external insulin pump, due to its greater fibrillation resistance. | 12-13-2012 |
20130085101 | LONG-ACTING INSULIN ANALOGUE PREPARATIONS IN SOLUBLE AND CRYSTALLINE FORMS - A pharmaceutical formulation comprises an insulin analogue or a physiologically acceptable salt thereof, wherein the insulin analogue or a physiologically acceptable salt thereof contains an insulin A-chain sequence that contains paired Histidine substitutions at A4 and A8, and optionally a substitution at A21. The formulation further contains a pharmaceutically acceptable buffer containing at least about 4 zinc ions per 6 insulin analogue molecules. The formulation forms a long-acting zinc-dependent subcutaneous depot upon subcutaneous injection. In a zinc-free formulation, the insulin analogue monomer exhibits decreased affinity for the Insulin-like Growth Factor receptor and at least 20% of the affinity for the insulin receptor of the same species, in comparison to an otherwise identical insulin or insulin analogue that does not contain the His | 04-04-2013 |
20140128319 | INSULIN ANALOGUES CONTAINING PENTA-FLUORO-PHENYLALANINE AT POSITION B24 - An insulin analogue comprises a B-chain polypeptide incorporating a halogenated phenylalanine at position B24, B25 or B26. The halogenated phenylalanine may be ortho-monofluoro-phenylalanine, ortho-monobromo-phenylalanine, ortho-monochloro-phenylalanine, or para-monochloro-phenylalanine or penta-fluoro-Phenylalanine at position B24 alone or in combination with an acidic substitution (Aspartic Acid or Glutamic Acid) at position B10. The analogue may be of a mammalian insulin, such as human insulin. A nucleic acid encodes such an insulin analogue. The halogenated insulin analogues retain significant activity. A method of treating a patient comprises administering a physiologically effective amount of the insulin analogue or a physiologically acceptable salt thereof to a patient. Halogen substitution-based stabilization of insulin may enhance the treatment of diabetes mellitus in regions of the developing world lacking refrigeration. | 05-08-2014 |
20150274803 | LONG-ACTING SINGLE-CHAIN INSULIN ANALOGUES - A single-chain insulin analogue containing a basic side chain at position A8 (Arginine, Histidine, Lysine, or Ornithine), a basic side chain at position B29 (Arginine, Histidine, Lysine, or Ornithine), and a foreshortened C-domain of length 6-11 residues is provided. Residues C1 and C2 of the C-domain have a net negative charge of −1 or −2; C3 is chosen from a group consisting of Gly, Ala, Pro, or Ser; and the remaining C-domain segment is successively derived from the C-domain of IGF-II (RRSR, SRRSR, VSRRSR, RVSRRSR, or SRVSRRSR; SEQ ID NO: 13). A method of treating a patient with diabetes mellitus or obesity comprises administering a physiologically effective amount of the insulin analogue or a physiologically acceptable salt thereof to a patient. | 10-01-2015 |
20150299287 | O-LINKED CARBOHYDRATE-MODIFIED INSULIN ANALOGUES - An insulin analogue comprises an insulin B-chain polypeptide modified with an O-linked monosaccaride pyranoside adduct at the side chain of residue B27 or an O-linked monosaccaride pyranoside adduct at the side chain of residue B30, or both, where the positions are recited relative to human insulin. The monosaccaride may be a manopyranoside, an N-acetyl-galactopyranoside, or a glucopyranoside. The insulin analogue may additionally comprise containing a foreshortened B-chain polypeptide lacking residues B1-B3, an extension of 1 or 2 Glu residues on the carboxy terminal end of the B-chain polypeptide, an extension of ornithine at the carboxy-terminal end of the B-chain, the substitutions Lys at position B28 and Pro at position B29, an ornithine substitution at position B29, or combinations thereof. The analogue may be an analogue of a mammalian insulin, such as human insulin. A method of treating a patient comprises administering a physiologically effective amount of the insulin analogue. | 10-22-2015 |
20150361153 | INSULIN ANALOGUES WITH CHLORINATED AMINO ACIDS AND NUCLEIC ACIDS ENCODING THE SAME - An insulin analogue comprises a B-chain polypeptide incorporating a chlorinated phenylalanine. The chlorinated phenylalanine may be located at position B24. The chlorinated phenylalanine may be para-monochloro-phenylalanine. The analogue may be of a mammalian insulin, such as human insulin. A nucleic acid encodes such an insulin analogue. The chlorinated insulin analogues retain significant activity. A method of treating a patient comprises administering a physiologically effective amount of the insulin analogue or a physiologically acceptable salt thereof to a patient. Chlorine substitution-based stabilization of insulin may reduce fibrillation and thereby enhance the treatment of diabetes mellitus in regions of the developing world lacking refrigeration. | 12-17-2015 |
Patent application number | Description | Published |
20080290080 | Flat Heating Element - This invention relates to a flat heating element ( | 11-27-2008 |
20100044075 | ELECTRIC CONDUCTOR - This invention relates to an electrical conductor ( | 02-25-2010 |
20100187214 | FLAT HEATING ELEMENT - The present invention relates to a heating element for heating at least one surface contacted at times by a user, with a plurality of heating conductors or heating conductor sections that are directly or indirectly connected electrically to one another, at least in part by mutual contact, with at least one heating conductor or heating conductor section which, upon exceeding a permissible maximum temperature, at least temporarily loses its electrical conductivity at least in part. It is provided that the electrical resistance of at least two heating conductors or heating conductor sections is dependent at least in part on its mechanical strain, that these heating conductors or heating conductor sections are electrically connected to one another in parallel, and that they are separated from one another at least in sections by a spacing zone in order to prevent electrical connection between them in spacing zone. | 07-29-2010 |
20120013433 | ELECTRIC LINE - The present invention concerns an electric line ( | 01-19-2012 |
20120018414 | FLAT HEATING ELEMENT - This invention relates to a flat heating element ( | 01-26-2012 |
20120091112 | ELECTRICAL CONDUCTOR - The present invention relates to an electrical conductor, which is formed at least in part of an electrically conductive material, and is at least in part coated with a protective layer that at least locally has a lower electrical conductivity than the electrically conductive material of the conductor. | 04-19-2012 |
20150329136 | TEMPERATURE CONTROL DEVICE FOR A STEERING DEVICE - A temperature control device for temperature control of a steering device, characterized in that the temperature control device has at least one heat-conducting device, at least one thermoelectric device, and at least one fluid transport apparatus. | 11-19-2015 |
Patent application number | Description | Published |
20100051303 | HAND-HELD POWER TOOL - The invention relates to a hand-held power tool, in particular a hammer drill which has a hammer drive, a rotary drive, a switching device, and a main output element. The switching device has a slide mechanism, which is designed for switching between different operating modes. According to the invention, the slide mechanism has at least one coupling element, which in at least one operating mode is directly coupled to a coupling element, the latter being rotationally fixed to the main output element. | 03-04-2010 |
20120279741 | VARIATION OF THE NATURAL FREQUENCY OF VIBRATORY MEANS IN ELECTRIC TOOLS - An electric tool includes a vibratory means which is configured to impart a counteracting vibration which counteracts a housing vibration of the electric tool. A vibration-relevant characteristic of the vibratory means can be adapted during the operation of the electric tool in such a way that the amplitude, the phase position and/or the frequency of the counteracting vibration varies with a change in the vibration-relevant characteristic. The vibratory means of the electric tool has a natural frequency which can be varied by variation means of the electric tool. A method for compensating housing vibrations, in particular of the electric tool, includes imparting a counteracting vibration by a vibratory means which counteracts a housing vibration of the electric tool. The amplitude, the phase position and/or the frequency of the counteracting vibration is varied during the operation of the electric tool. | 11-08-2012 |
20150040341 | Hand-Held Power Tool Suction Extractor Apparatus - A hand-held power tool suction extractor apparatus comprises at least one fastening unit configured to mount on a hand-held power tool. The at least one fastening unit includes at least one holding element configured to be positioned on the hand-held power tool and at least one fastening element configured to exert a holding force on the at least one holding element. The at least one fastening unit also includes at least one movably mounted position fixing element configured to fix the at least one fastening element. | 02-12-2015 |
20150306719 | Power-Tool Cooling Apparatus - A power-tool cooling apparatus for a portable power tool comprises at least one cooling unit configured to generate a cooling fluid flow to cool a drive unit of the portable power tool, and at least one further cooling unit configured to generate a further cooling fluid flow. The at least one further cooling unit is designed to differ from the at least one cooling unit. | 10-29-2015 |
20160129540 | Hand-Held Power-Tool Device - A hand-held power-tool device includes at least one coupling device, which has at least one contact receiving region, and which is configured to couple an optional additional module to at least one energy supply unit, in at least one operating state. The at least one contact receiving region has (i) at least one receiving opening configured to receive a corresponding contact element of the optional additional module, and (ii) at least one dirt removal opening. | 05-12-2016 |
Patent application number | Description | Published |
20090158723 | Exhaust Manifold - The present invention relates to an exhaust manifold for an internal combustion engine, in particular in a motor vehicle, comprising a housing from which a plurality of inlet pipes emanate, which, in the built-in state, lead to cylinders of the internal combustion engine, and comprising a flange, which is welded to the inlet pipes and which, in the built-in state, is screwed to the cylinder head of the internal combustion engine by means of a screw connection. The fatigue strength of the exhaust manifold can be improved by subdividing the flange into at least two partial flanges in a longitudinal direction of the exhaust manifold. | 06-25-2009 |
20090200795 | Component Connection - The present invention pertains to a connection between two annular sections of two components that are arranged coaxial to one another, particularly of an exhaust system of an internal combustion engine that is installed, in particular, in a motor vehicle. The connection comprises an annular connecting element that features a first ring section, as well as a second ring section that is arranged concentric to the first ring section. The ring sections are axially connected to one another in a rigid fashion on the face side by means of a connecting region. The first ring section is rigidly connected to the annular section of the first component by means of a first connecting region that is spaced apart from the connecting region while the second ring section is rigidly connected to the annular section of the second component by means of a second connecting region that is spaced apart from the connecting region. The connection is characterized by a high fatigue strength under thermal stress. | 08-13-2009 |
20120266588 | Exhaust Manifold - The present invention relates to an exhaust manifold for an internal combustion engine, in particular in a motor vehicle, comprising a housing from which a plurality of inlet pipes emanate, which, in the built-in state, lead to cylinders of the internal combustion engine, and comprising a flange, which is welded to the inlet pipes and which, in the built-in state, is screwed to the cylinder head of the internal combustion engine by means of a screw connection. The fatigue strength of the exhaust manifold can be improved by subdividing the flange into at least two partial flanges in a longitudinal direction of the exhaust manifold. | 10-25-2012 |
Patent application number | Description | Published |
20130081583 | REGULATABLE COOLANT PUMP HAVING INTEGRATED PRESSURE CHAMBER - A regulatable coolant pump of an internal combustion engine having a pump housing in which a pump shaft with an associated impeller is rotatably mounted. The impeller conveys a coolant via an intake connection into a pressure channel of the coolant pump, a volume flow of the coolant pump being adjustable by a guide plate that externally surrounds the impeller at least in some regions and is displaceable by a pressure medium. The guide plate is connected in rotationally fixed fashion to the impeller and is continuously axially displaceable between two end positions and guided with a cylindrical bushing, with play at both sides, in an annular groove of the impeller or of an insert enclosed by the impeller. The guide plate, the pump shaft, the insert part, and/or the impeller together delimit a pressure chamber that is charged by the pressure medium in order to displace the guide plate. | 04-04-2013 |
20130343877 | REGULATABLE COOLANT PUMP - The invention relates to a regulatable coolant pump for a cooling circuit of an internal combustion engine, comprising a hollow bearing shaft ( | 12-26-2013 |
20140037432 | CONTROLLABLE COOLANT PUMP - A coolant pump for a coolant circuit of an internal combustion engine, the coolant pump having a pump housing in which is mounted a drivable shaft, to one end of which is attached an impeller-which has vanes extending into a suction chamber and is connected to a cover plate. Fluid can be drawn into the suction chamber through an intake port of the pump housing by joint rotation of the impeller and the cover plate and can be conveyed by the vanes into the pump housing. A guide plate, which is axially displaceable by an actuation unit, is disposed between the impeller and the cover plate. The guide plate has a contour corresponding to the impeller and a collar oriented toward the impeller. The coolant pump is characterized in that the guide plate has at least one opening. | 02-06-2014 |
20140147304 | COOLANT PUMP FOR A COLLANT CIRCUIT OF AN INTERNAL COMBUSTION ENGINE - A coolant pump for a coolant circuit of an internal combustion engine, including a drive wheel which is connected to an impeller via a drive shaft rotatably mounted in a pump housing has at least one coolant outlet provided radially with respect to the impeller. A blocking ring is movable in an axial direction and serves to change or block a cross-sectional area of the coolant outlet and is displaced by a pressure-medium-operated actuator. The actuator is arranged concentrically with the drive shaft in the region of the end thereof facing the impeller is secured on the end of the drive shaft, and is connected to a pressure medium supply via at least one longitudinal bore provided in the drive shaft. | 05-29-2014 |
20140241862 | CONTROLLABLE COOLANT PUMP - A controllable coolant pump for a coolant circuit of an internal combustion engine. The coolant pump has a hollow bearing shaft which is supported in a bearing sleeve, carries a drive wheel at one end, and is permanently connected to an impeller at its opposite end, the impeller having a stop surface at the end face thereof. The space between the stop surface and the impeller forms the pumping cross section for a coolant. A piston that can be axially displaced by an actuation unit is disposed in the hollow bearing shaft and provided at its outer end with a guide plate having a collar facing the impeller for completely or partially closing the pumping cross section in accordance with the position of the piston. The coolant pump has a second actuation unit, and the piston can be displaced by the first or second actuation unit. | 08-28-2014 |
20140241864 | CONTROLLABLE COOLANT PUMP - A controllable coolant pump for a coolant circuit of an internal combustion engine, the coolant pump including a hollow bearing shaft which is supported in a bearing sleeve, carries a drive wheel at one end, and is permanently connected at its opposite end to an impeller, the impeller having a stop surface at the end face thereof; the space between the stop surface and the impeller forming the pumping cross section for a coolant, and a piston that can be axially displaced by an actuation unit being disposed in the hollow bearing shaft and provided at its outer end with a guide plate having a collar facing the impeller for completely or partially closing the pumping cross section in accordance with the position of the piston. The actuation unit has a release lever which can be pivoted by an electromechanical actuating element about an axis of rotation, thus allowing axial positioning of the piston. | 08-28-2014 |
20140243139 | ASSEMBLY HAVING A BELT-PULLEY DRIVE - Assembly having a belt-pulley drive, having a pulley wheel which can be driven by a belt and is configured for transmitting a torque to a drive shaft of the assembly. The assembly has a switchable gear mechanism which makes a transmission ratio possible between the rotational speed of the pulley wheel and the rotational speed of the drive shaft. | 08-28-2014 |
20140271267 | CONTROLLABLE COOLANT PUMP HAVING A FLUIDIC ACTUATOR - A controllable coolant pump for a cooling circuit of an internal combustion engine having a pump housing with an inner bore, a shaft drivable via a pulley mounted rotatably via a first bearing and a second bearing, wherein the shaft is configured at least partially as a hollow shaft and has a longitudinal axis, wherein a rotor is fastened to one end of the shaft, which rotor has an idler pulley and vanes which project into a suction chamber to suck water via a suction connector of the pump housing into the suction chamber to an annular channel of the pump housing, wherein the idler pulley can be displaced axially via a push rod connected to an actuator. The fluidic actuator has a first pressure chamber and a second pressure chamber. The weight and the installation space requirement of the controllable coolant pump can be reduced. | 09-18-2014 |
20140299439 | ACTUATOR DEVICE FOR ACTUATING A COUPLING MECHANISM - An actuator device for actuating a coupling mechanism or a transmission in a drive wheel in a belt drive or chain drive, includes a shaft, releasably connectable to the drive wheel and at least partially hollow, a push rod connected to the coupling mechanism or transmission and displaceable coaxially to the longitudinal axis of the shaft, a housing having an internal bore for at least partially receiving the shaft, and at least one first bearing disposed in the internal bore of the housing for rotatably supporting the shaft. The actuator device constitutes a fluidic actuator having at least one first pressure chamber capable of being pressurized with a fluid. | 10-09-2014 |
20150219003 | DIRT TRAP AS A FUNCTIONAL MODULE IN THE IMPELLER OF A COOLANT PUMP - A coolant pump ( | 08-06-2015 |
20150300505 | SEAL ARRANGEMENT FOR A CONTROL VALVE - A seal arrangement for a control valve ( | 10-22-2015 |