Humphries
Bill Humphries, Victoria AU
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20080287747 | Flexible Electronic Device - According to the present invention there is provided a device that may be worn by a person, or fitted to an apparatus for monitoring, sensing or controlling one or more parameters such as, but by no means limited to, moisture, temperature, heart rate or respiration rate, or controlling various parameters of electronic functions. The device includes: | 11-20-2008 |
Cayley Humphries, Kelowna CA
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20110319160 | Systems and Methods for Creating and Delivering Skill-Enhancing Computer Applications - Systems and methods are disclosed for creating and delivering skill-enhancing applications based on pre-recorded media content without altering the prerecorded media content. | 12-29-2011 |
Deborah Marie Humphries, Calgary CA
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20130305470 | Cleaning System - A cleaning system for retaining a cleaning member such as a sponge or mop-head in a compressed and compacted state prior to use. The cleaning system generally includes one or more cleaning cartridges, each of which include a base, a cleaning member secured to the base, and an outer covering compressing the cleaning member. Upon removal of the outer covering, the cleaning member will expand and be ready for use. Also disclosed is a dispensing unit adapted to store, activate, use and dispose of the cleaning cartridges. The dispensing unit includes a nozzle which retains the outermost cleaning cartridge in a position partially extending through an outlet opening awaiting use. The dispensing unit may include a telescoping handle so that it may be converted for use as a mop. | 11-21-2013 |
Edward Humphries, Erskineville AU
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20140335325 | Polymer Composite Articles - The present disclosure pertains to resins/filler/matting composites that are formed via a resin infusion process. Certain embodiments are directed to methods and systems that may be used to produce a moulded composite article. For example, a unitary polymer composite article comprising: 50% to 90% by weight of particles; 10% to 50% by weight of resin; and at least one layer of matting integrally incorporated in the unitary polymer composite. | 11-13-2014 |
Edward Humphries, Erskineville, New South Wales AU
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20140203468 | Polymer Composites - The present disclosure pertains to resins/filler composites that are formed via a resin infusion process. Certain embodiments are directed to methods and systems that may be used to produce a moulded composite article. An exemplary method comprising: a) filling to a predetermined level a mould tool with particles; b) infusing a resin composition into the mould tool filled with the particles in order to form a composite; c) vibrating the mould tool for a portion of time at one or more of the following stages: during the filling with the particles, after the filling with particles, during the infusing of the resin composition and after the infusions of the resin composition; wherein the composite comprises between 10% to 50% by weight of the resin composition and between 50% to 90% by weight of the particles; and d) curing the composite to form a moulded composite article. | 07-24-2014 |
Gary W. Humphries, Dartmouth CA
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20100006630 | THERMAL CONTAINER - A thermal insulating liner for a container lid has a top sheet and a bottom sheet spaced by a core. The bottom sheet has an exterior metal foil layer. A side edge-to-side edge transverse cut line extends through the bottom sheet proximate each of two opposed ends of the liner. The liner has reduced thickness end margins extending between each said side edge-to-side edge transverse cut line and each of the opposed ends. A die to make the lid liner has a central well and, proximate each end of the die, an upward step to a land with an inside edge of the step having a ramp surface. A first cutting blade protrudes upwardly from the land and a second cutting blade protrudes upwardly above the land at each end of the die and above the level of the first cutting blade. | 01-14-2010 |
20120028775 | THERMAL CONTAINER - A thermal insulating liner for a container lid has a top sheet and a bottom sheet spaced by a core. The bottom sheet has an exterior metal foil layer. A side edge-to-side edge transverse cut line extends through the bottom sheet proximate each of two opposed ends of the liner. The liner has reduced thickness end margins extending between each said side edge-to-side edge transverse cut line and each of the opposed ends. A die to make the lid liner has a central well and, proximate each end of the die, an upward step to a land with an inside edge of the step having a ramp surface. A first cutting blade protrudes upwardly from the land and a second cutting blade protrudes upwardly above the land at each end of the die and above the level of the first cutting blade. | 02-02-2012 |
20120193365 | Thermal Container, Liner Therefor, and Liner Forming Dies - A thermal insulating liner for a container has a bottom panel, a pair of opposed end panels, a first side panel and an opposed second side panel. A first flap is hinged to the first side panel at a first hinge line and a second flap is hinged to the said second side panel at a second hinge line. The first flap and second flap are sized so that they are moveable between an open position whereat the first flap is spaced from said second flap and a folded position whereat a side margin of the first flap which extends along a side edge of the first flap opposite the first hinge line overlaps with a side margin of the second flap which extends along a side edge of the second flap opposite the second hinge line. Each flap comprises an outer sheet and an inner sheet spaced by a core with an innermost layer of the inner sheet comprising a metal foil layer. Each flap has a first thickness outside its side margin and a second, reduced, thickness, within its side margin. A thermal container may contain such a thermal insulating liner. A pair of dies can form a liner for a thermal container. A bottom a bottom die half has a bottom die pair of raised rectangular blocks and a top die half has a top die pair of raised rectangular blocks sized and positioned so as to register with the bottom die pair of rectangular blocks when the dies are brought together in use. The bottom die half has two spaced creasing rules between the bottom die pair of raised rectangular blocks and the top die half has two spaced creasing rules between the top die pair of raised rectangular blocks. The top spaced creasing rules are positioned so as to register with the bottom die spaced creasing rules when the dies are brought together in use. | 08-02-2012 |
Keith Humphries, Vancouver CA
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20080300187 | MUTATED HOXB4 PROTEINS WITH IMPROVED STABILITY, AND METHODS OF USE THEREOF - A polypeptide, the amino acid sequence of which comprises a sequence as set forth in SEQ ID NO:2, including at least one mutation within the degron domain of the polypeptide encompassed between positions 1 and 35 of the sequence, wherein said at least one mutation reduces the susceptibility of the polypeptide to ubiquitin-proteasome degradation. | 12-04-2008 |
Marian Humphries, Dublin IE
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20110229439 | COMPLEMENT PROTEINS - The present invention relates to classical pathway complement proteins and their use in the prognosis and prevention of diseases involving cone photoreceptor degeneration. Specifically, the present invention is directed to the use of one or more classical pathway complement proteins, preferably involved in the recognition phase, in the maintenance of cone photoreceptor cell viability in a degenerating retina. The invention is also directed to a method for determining the susceptibility, risk of development and/or progression of diseases involving cone photoreceptor degeneration in a subject. | 09-22-2011 |
20140234252 | Composition and Methods for the Treatment of Degenerative Retinal Conditions - The present invention is directed to compositions and methods for the treatment of degenerative retinal conditions. According to a general aspect, the present invention is directed to inflammatory mediators, preferably components or substrates of the NLRP | 08-21-2014 |
Peter Humphries, Co Dublin IE
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20100190841 | GENETIC SUPPRESSION AND REPLACEMENT - The invention relates to gene suppression and replacement. In particular, the invention relates to enhanced expression of suppression agents for suppressing gene expression in a cell and in vivo and replacement nucleic acids that are not inhibited by the suppression agent. Regulatory elements are included in expression vectors to optimize expression of the suppression agent and/or replacement nucleic acid. | 07-29-2010 |
20120278912 | GENETIC SUPPRESSION AND REPLACEMENT - The invention relates to gene suppression and replacement. In particular, the invention relates to enhanced expression of suppression agents for suppressing gene expression in a cell and in vivo and replacement nucleic acids that are not inhibited by the suppression agent. Regulatory elements are included in expression vectors to optimize expression of the suppression agent and/or replacement nucleic acid. | 11-01-2012 |
Peter Humphries, Cabinteeley IE
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20110190371 | GENETIC SUPPRESSION AND REPLACEMENT - Methods and agents for suppressing expression of a mutant allele of a gene and providing a replacement nucleic acid are provided. The methods of the invention provide suppression effectors such as, for example, antisense nucleic acids, ribozymes, or RNAi, that bind to the gene or its RNA. The invention further provides for the introduction of a replacement nucleic acid with modified sequences such that the replacement nucleic acid is protected from suppression by the suppression effector. The replacement nucleic acid is modified at degenerate wobble positions in the target region of the suppression effector and thereby is not suppressed by the suppression effector. In addition, by altering wobble positions, the replacement nucleic acid can still encode a wild type gene product. The invention has the advantage that the same suppression strategy could be used to suppress, in principle, many mutations in a gene. Also disclosed is a transgenic mouse that expresses human rhodopsin (modified replacement gene) and a transgenic mouse that expresses a suppression effector targeting rhodopsin. Also disclosed in intraocular administration of siRNA. | 08-04-2011 |
Peter Humphries, Cabinteeley D18 IE
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20090197336 | SUPPRESSION OF POLYMORPHIC ALLELES - Methods and agents for suppressing expression of a mutant allele of a gene having a polymorphism are provided. The methods of the invention provide suppression effectors such as antisense nucleic acids or ribozymes, that bind to nucleic acid regions having a polymorphism within a gene such that one allele of a gene is exclusively or preferentially suppressed. The method also provides the administration of a replacement nucleic acid, if required. The invention has the advantage that the same suppression strategy, when directed to polymorphisms, could be used to suppress, in principle, many mutations in a polymorphic gene. This is particularly relevant when large numbers of mutations within a single gene cause disease pathology. | 08-06-2009 |
20090233368 | ALLELE SUPPRESSION - A strategy for suppressing expression of one allele of an endogenous gene is provided comprising providing suppression effectors such as antisense nucleic acids able to bind to polymorphisms within or adjacent to a gene such that one allele of a gene is exclusively or preferentially suppressed and if required of a replacement gene can be introduced. | 09-17-2009 |
Peter Humphries, Dublin IE
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20110064792 | Method for Opening Tight Junctions - The present invention is directed to a method and use of RNA interference (RNAi) for the transient, reversible and controlled opening of the tight junctions of the blood brain barrier and/or the blood retinal barrier. This method may be used in the treatment of many diseases and disorders which require the opening of the blood brain barrier and/or blood retinal barrier. Such methods generally involve the use of an RNAi-inducing agent, such as siRNA, miRNA, shRNA or an RNAi-inducing vector whose presence within a cell results in production of an siRNA or shRNA, targeting tight junction proteins to open the blood brain barrier and/or blood retinal barrier. | 03-17-2011 |
20110229439 | COMPLEMENT PROTEINS - The present invention relates to classical pathway complement proteins and their use in the prognosis and prevention of diseases involving cone photoreceptor degeneration. Specifically, the present invention is directed to the use of one or more classical pathway complement proteins, preferably involved in the recognition phase, in the maintenance of cone photoreceptor cell viability in a degenerating retina. The invention is also directed to a method for determining the susceptibility, risk of development and/or progression of diseases involving cone photoreceptor degeneration in a subject. | 09-22-2011 |
20140234252 | Composition and Methods for the Treatment of Degenerative Retinal Conditions - The present invention is directed to compositions and methods for the treatment of degenerative retinal conditions. According to a general aspect, the present invention is directed to inflammatory mediators, preferably components or substrates of the NLRP | 08-21-2014 |
Richard Keith Humphries, Vancouver CA
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20100080778 | STEM CELL EXPANSION ENHANCING FACTOR AND METHOD OF USE - The present invention relates to a stem cell expansion factor, and to a method for enhancing hematopoietic stem cell expansion by direct delivery of a protein in the cell and which protein is able to cross cell membrane. The method comprises directly delivering in a HSC an amino acid sequence having the activity of a peptide encoded by a Hoxb4 nucleotide sequence. Once delivered, the amino acid sequence is functionally active in the hematopoietic stem cell and enhances expansion thereof. The amino acid sequence may is a HOXB4 or HOXA4 protein. | 04-01-2010 |
20110244024 | MICRORNA COMPOSITIONS AND METHODS FOR THE TREATMENT OF MYELOGENOUS LEUKEMIA - The invention provides methods, uses, kits and compositions comprising a therapeutically effective amount of the microRNA miR-223 for treating myelogenous leukemia in a subject in need of such treatment. The invention further comprises methods encompassing the use of miR-223 for promoting the differentiation of a leukemia stem cell that is resistant to a differentiating agent, and a method of screening for candidate compounds capable of treating a myeloid leukemia by comparison of the therapeutic activity of the candidate compound with the therapeutic activity of miR-233. | 10-06-2011 |
20110281786 | STEM CELL EXPANSION ENHANCING FACTOR AND METHOD OF USE - The present invention relates to a stem cell expansion factor, and to a method for enhancing hematopoietic stem cell expansion by direct delivery of a protein in the cell and which protein is able to cross cell membrane. The method comprises directly delivering in a HSC an amino acid sequence having the activity of a peptide encoded by a Hoxb4 nucleotide sequence. Once delivered, the amino acid sequence is functionally active in the hematopoietic stem cell and enhances expansion thereof. The amino acid sequence may is a HOXB4 or HOXA4 protein. | 11-17-2011 |
R. Keith Humphries, Vancouver CA
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20080299095 | Nup98-Hox Fusions for Expansion of Hemopoietic Stem Cells - Nucleic acid constructs encoding homeobox-nucleoporin fusions are disclosed, compositions comprising same, and methods which provide enhanced expansion of stem cells. In particular, an isolated nucleic acid construct encoding a NUP98-HOX fusion is provided, which when introduced into hemopoietic stem cells provides enhanced expansion of these cells. Methods of expanding stem cells in vivo or ex vivo and methods of treatment using the stem cells are also described. | 12-04-2008 |
Tony Humphries, Wellington NZ
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20120192744 | REMOTE INITIATOR BREACHING SYSTEM - A remote initiator breaching system for initiating breaching charges over a short range requiring no physical link between the breacher and the demolition charge. The remote initiator breaching system has at least one transmitter, at least one receiver, at least one shock tube connectable to a breaching charge and a power source for each of the transmitter and receiver. The transmitter is able to generate and transmit a coded signal. The transmitter has an input for inputting operational commands into the transmitter for generating the coded signal, The transmitter has a plurality of channels representing different frequency bands, and multiple addresses for each channel such that transmission of the coded signal from the transmitter to the receiver is possible per individual addresses or all addresses simultaneously. | 08-02-2012 |
Tony Humphries, Lower Hutt NZ
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20100170411 | REMOTE INITIATOR FOR THE REMOTE INITIATION OF EXPLOSIVE CHARGES - A remote initiator for the remote initiation of explosive charges. The remote initiator having: (i) a transmitter with means for generating and transmitting a coded signal and input means for inputting operational commands into the transmitter for generating the coded signal, (ii) at least one receiver adapted to be connected with the explosive charges, the receiver having means for receiving the coded signal from the transmitter and input means for inputting operational commands into the receiver for generating an output signal for the remote initiation of explosive charges upon receipt of a valid transmitted coded signal, (iii) a power source for each of the transmitter and receiver, and dual processing means that are independent of each other are adapted to provide independent control of a firing circuit and adapted to synchronize with each processing means before initiation can occur so as to enhance safety and reliability of the transmitter and receiver and the initiation of the remote initiator. | 07-08-2010 |