Kohrt
Holbrook Kohrt, Santa Clara, CA US
Patent application number | Description | Published |
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20120321646 | Methods for Enhancing Anti-Tumor Antibody Therapy - Methods of enhancing the efficacy of antibody-directed cellular cytotoxicity (ADCC) for therapy directed to killing of tumor cells are disclosed. Cancer specific cell surface antigens are bound by monoclonal antibodies, thereby stimulating a cytotoxic T cell response characterized by an upregulation of cell surface expression of costimulatory molecules on the T cell. The ADCC response is augmented by the subsequent administration of a second antibody that is an agonist of the costimulatory molecule. | 12-20-2012 |
Holbrook Kohrt, San Francisco, CA US
Patent application number | Description | Published |
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20150118222 | TREATMENT USING BRUTON'S TYROSINE KINASE INHIBITORS AND IMMUNOTHERAPY - Combinations of Bruton's tyrosine kinase (Btk) inhibitors, e.g., 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one, with immunotherapy are provided. Also provided are methods of treating cancers, and autoimmune disorders by administering combinations of Bruton's tyrosine kinase (Btk) inhibitors, e.g., 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one, and an immune checkpoint inhibitor. | 04-30-2015 |
Holbrook E. Kohrt, San Francisco, CA US
Patent application number | Description | Published |
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20160032398 | METHODS FOR TREATING CANCER - The disclosure features a method of treating cancer by lowering a patient's two gene score (TGS), particularly by increasing the number of tumor-infiltrating leukocytes. In addition, a TGS animal model and uses thereof are provided. | 02-04-2016 |
Jeff Kohrt, Mystic, CT US
Patent application number | Description | Published |
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20080287479 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE - This invention provides compounds of the formula: | 11-20-2008 |