Patent application number | Description | Published |
20100047257 | ANTAGONIST ANTIBODY FOR THE TREATMENT OF CANCER - Antibodies, humanized antibodies, resurfaced antibodies, antibody fragments, derivatized antibodies, and conjugates of same with cytotoxic agents, which specifically bind to, and inhibit A class of Eph receptors, antagonize the effects of growth factors on the growth and survival of tumor cells, and which have minimal agonistic activity or are preferentially devoid of agonist activity. Said antibodies and fragments thereof may be used in the treatment of tumors that express elevated levels of A class of Eph receptors, such as breast cancer, colon cancer, lung cancer, ovarian carcinoma, synovial sarcoma and pancreatic cancer, and said derivatized antibodies may be used in the diagnosis and imaging of tumors that express elevated levels of A class of Eph receptors. Also provided are cytotoxic conjugates comprising a cell binding agent and a cytotoxic agent, therapeutic compositions comprising the conjugate, methods for using the conjugates in the inhibition of cell growth and the treatment of disease, and a kit comprising the cytotoxic conjugate are disclosed are all embodiments of the invention. In particular, the cell binding agent is a monoclonal antibody, and epitope-binding fragments thereof, that recognizes and binds the A class of Eph receptors. | 02-25-2010 |
20130302316 | ANTAGONIST ANTIBODY FOR THE TREATMENT OF CANCER - Antibodies, humanized antibodies, resurfaced antibodies, antibody fragments, derivatized antibodies, and conjugates of same with cytotoxic agents, which specifically bind to, and inhibit A class of Eph receptors, antagonize the effects of growth factors on the growth and survival of tumor cells, and which have minimal agonistic activity or are preferentially devoid of agonist activity. Said antibodies and fragments thereof may be used in the treatment of tumors that express elevated levels of A class of Eph receptors, such as breast cancer, colon cancer, lung cancer, ovarian carcinoma, synovial sarcoma and pancreatic cancer, and said derivatized antibodies may be used in the diagnosis and imaging of tumors that express elevated levels of A class of Eph receptors. Also provided are cytotoxic conjugates comprising a cell binding agent and a cytotoxic agent, therapeutic compositions comprising the conjugate, methods for using the conjugates in the inhibition of cell growth and the treatment of disease, and a kit comprising the cytotoxic conjugate are disclosed are all embodiments of the invention. In particular, the cell binding agent is a monoclonal antibody, and epitope-binding fragments thereof, that recognizes and binds the A class of Eph receptors. | 11-14-2013 |
Patent application number | Description | Published |
20100158003 | SHARING OF NETWORK SECURITY AND SERVICES PROCESSING RESOURCES - Systems and methods are disclosed of routing traffic in a network that include classifying incoming data packets using the content of the incoming data packets that remains relatively consistent during a network session. These systems and methods also include ordering the incoming traffic according to at least one internet protocol address comprised within the incoming traffic, hashing the at least one internet protocol address and the destination port within the incoming traffic, and determining a destination service module for the incoming traffic. Through these systems and methods, data can be routed without the need for complete flow tables. | 06-24-2010 |
20100322253 | Method and Apparatus for Simulating IP Multinetting - IP Multinetting on a local area network is simulated by performing VLAN translation at a port connecting to the local area network. This allows IP addresses from multiple subnets to be associated with a single VLAN on the Local Area Network (LAN), while allowing the core switch to process the packets with a one-to-one correspondence between IP Subnet and VLAN. When a packet is received from the local area network at an IP multinetting port, the VLAN ID will be read to determine if the packet contains the IP Multinetting VLAN ID. The IP Subnet address will also be checked to see if the packet is associated with an IP Subnet that is part of the Multinetting. If so, the multinetting VLAN ID will be changed to an IP Subnet specific VLAN ID before the packet is processed by the core switch. In the reverse direction, IP subnet specific VLAN IDs will be translated to the IP Multinetting VLAN ID. | 12-23-2010 |
20120044937 | Method and Apparatus for Simulating IP Multinetting - IP Multinetting on a local area network is simulated by performing VLAN translation at a port connecting to the local area network. This allows IP addresses from multiple subnets to be associated with a single VLAN on the Local Area Network (LAN), while allowing the core switch to process the packets with a one-to-one correspondence between IP Subnet and VLAN. When a packet is received from the local area network at an IP multinetting port, the VLAN ID will be read to determine if the packet contains the IP Multinetting VLAN ID. The IP Subnet address will also be checked to see if the packet is associated with an IP Subnet that is part of the Multinetting. If so, the multinetting VLAN ID will be changed to an IP Subnet specific VLAN ID before the packet is processed by the core switch. | 02-23-2012 |
20120106320 | ROUTED SPLIT MULTI-LINK TRUNKING RESILIENCY FOR WIRELESS LOCAL AREA NETWORK SPLIT-PLANE ENVIRONMENTS - A method, apparatus and computer program product for performing Routed Split Multi-Link Trunking Resiliency for Wireless Local Area Network split-plane environments is presented. A first network switch learns first data associated with a second network switch and the first network switch terminates an Access Tunnel (AT). The said second network switch learns second data associated with said first network switch. The first and second data are synchronized between the first network switch and the second network switch. The first network switch and the second network load sharing tunnel data packets. The second network switch forwards tunnel control packets received by the second network switch to the first network. A failure relating to said first network switch is detected and a new AT is established with the second network switch. | 05-03-2012 |
20120106523 | PACKET FORWARDING FUNCTION OF A MOBILITY SWITCH DEPLOYED AS ROUTED SMLT (RSMLT) NODE - A method, apparatus and computer program product for providing Routed Split Multi Link Trunking (RSMLT) for Wireless Local Area Network (WLAN) tunnels is presented. A first and second network switch learn data associated with each other, wherein the first network switch and the second network switch operate concurrently. The first network switch terminates a WLAN Tunnel. The data is synchronized between the first network switch and the second network switch, wherein the data includes MAC Addresses, Internet Protocol (IP) interface addresses, Virtual Local Area Network (VLAN) associations, WLAN tunnel assignments and Network switch Internet Protocol (IP) addresses. Load sharing of tunnel data packets is performed by the first and the second network switch. Tunnel control packets received by the second network switch are forwarded to the first network switch over an Inter Switch Trunk (IST). | 05-03-2012 |
20120110393 | METHOD AND APPARATUS PROVIDING FAILOVER FOR A POINT TO POINT TUNNEL FOR WIRELESS LOCAL AREA NETWORK SPLIT-PLANE ENVIRONMENTS - A method, apparatus and computer program product for providing failover for a point to point tunnel for wireless local area network split-plane environments is presented. A second network switch learns first data associated with a third network switch and the second network switch terminates a tunnel. The third network switch learns second data associated with the second network switch. The first and second data are synchronized between the second network switch and the third network switch. The second network switch and the third network switch load sharing tunnel data packets. The third network switch forwards tunnel control packets received by the third network switch to the second network switch. A failure relating to the second network switch is detected and a new tunnel is established with the third network switch. | 05-03-2012 |
20120163162 | SPLIT MULTI-LINK TRUNKING (SMLT) HOLD-DOWN TIMER FOR INTERNET PROTOCOL (IP) MULTICAST - A method, apparatus and computer program product for providing mulitcast failover and recovery which minimizes lost packets is presented. A first network device returns to a fully active state and starts a multicast hold-down timer. A first message is sent to a second network device, the message indicating at least one Split Multi Link Trunk (SMLT) Virtual Local Area Network (VLAN) Identifier (ID) correlating to the multicast hold-down timer. The first network device receives an acknowledgment of said first message and Layer 2 forwards multicast data traffic to said second network device until the timer expires, whereupon the first device is capable of handling its own multicast data traffic, and then has Layer 2 bridging turned off and enables IP multicast routing. During the period of multicast hold-down timer, the second device will perform IP multicast forwarding on behalf of the first device. | 06-28-2012 |
20130242718 | METHOD AND APPARATUS PROVIDING NETWORK REDUNDANCY AND HIGH AVAILABILITY TO REMOTE NETWORK NODES - A method, apparatus and computer program product is presented. A first tunnel is provided across a layer 3 network from a first network device to a second network device. A first virtual interface (VI) is provided on the second network device, and assigned to the first tunnel. Information related to the first tunnel and the first VI is passed to a third network device, which is a member of a cluster with the second network device. A second tunnel is provided across the layer 3 network from the third device to the first network device, and a second virtual interface (VI) is provided on the third network device, and assigned to the second tunnel. Forwarding information is exchanged between the second network device and the third network device. The second network device and the third network device provide forwarding redundancy service to the first network device. | 09-19-2013 |
20140219282 | Method and Apparatus for Simulating IP Multinetting - IP Multinetting on a local area network is simulated by performing VLAN translation at a port connecting to the local area network. This allows IP addresses from multiple subnets to be associated with a single VLAN on the Local Area Network (LAN), while allowing the core switch to process the packets with a one-to-one correspondence between IP Subnet and VLAN. When a packet is received from the local area network at an IP multinetting port, the VLAN ID will be read to determine if the packet contains the IP Multinetting VLAN ID. The IP Subnet address will also be checked to see if the packet is associated with an IP Subnet that is part of the Multinetting. If so, the multinetting VLAN ID will be changed to an IP Subnet specific VLAN ID before the packet is processed by the core switch. | 08-07-2014 |
Patent application number | Description | Published |
20090196909 | CARBON NANOTUBE CONTAINING MATERIAL FOR THE CAPTURE AND REMOVAL OF CONTAMINANTS FROM A SURFACE - There is disclosed an article and method of making an article for removing at least one contaminant from a solid surface. In one embodiment, the article comprises carbon nanotubes attached to a support media, such as a nonwoven mixture of PET and cotton. There is also disclosed a method of removing at least one contaminant from a solid surface, such as areas where microbial, particle, or static contamination is undesirable, including hospitals, clean rooms, kitchens, baths, or human hands. | 08-06-2009 |
20090282802 | CARBON NANOTUBE YARN, THREAD, ROPE, FABRIC AND COMPOSITE AND METHODS OF MAKING THE SAME - There is disclosed a material comprising an assembly of at least one spun yarn substantially comprising carbon nanotubes, a majority of which are longer than one millimeter, such as longer than one centimeter, chemically interlinked one to another, and arranged in the morphology of spiral configurations. The disclosed materials may take the form of a yarn, thread, rope, or fabric. There are also disclosed composite materials constructed from the disclosed materials. | 11-19-2009 |
20120251432 | METHODS FOR THE PRODUCTION OF ALIGNED CARBON NANOTUBES AND NANOSTRUCTURED MATERIAL CONTAINING THE SAME - Disclosed herein is a scaled method for producing substantially aligned carbon nanotubes by depositing onto a continuously moving substrate, (1) a catalyst to initiate and maintain the growth of carbon nanotubes, and (2) a carbon-bearing precursor. Products made from the disclosed method, such as monolayers of substantially aligned carbon nanotubes, and methods of using them are also disclosed. | 10-04-2012 |
20140186550 | METHODS FOR THE PRODUCTION OF ALIGNED CARBON NANOTUBES AND NANOSTRUCTURED MATERIAL CONTAINING THE SAME - Disclosed herein is a scaled method for producing substantially aligned carbon nanotubes by depositing onto a continuously moving substrate, (1) a catalyst to initiate and maintain the growth of carbon nanotubes, and (2) a carbon-bearing precursor. Products made from the disclosed method, such as monolayers of substantially aligned carbon nanotubes, and methods of using them are also disclosed. | 07-03-2014 |
20140377410 | SYSTEMS, COMPOSITIONS AND METHODS FOR PROVIDING SAFE AND HEALTHY WATER AND WATER-BASED PRODUCTS - A method for providing a safe and healthy water and water-based product, comprising: testing pretreated reverse osmosis water to determine whether it meets a first set of pre-defined specifications; introducing a pre-defined nutrient composition into the water, wherein the predefined nutrient composition comprising one or more of mineral nutrients, trace elements and nutritional supplements; testing the water to determine whether it meets a second set of pre-defined specifications; and disinfecting the water along with its container by UV irradiation from a UV light source to obtain a water product. | 12-25-2014 |
Patent application number | Description | Published |
20100113367 | PEPTIDE-CYTOTOXIC CONJUGATES - The invention features targeted cytotoxic compounds and methods relating to their therapeutic use for the treatment of neoplasia and other conditions. | 05-06-2010 |
20110065632 | PHARMACEUTICAL COMPOSITIONS OF SOMATOSTATIN-DOPAMINE CONJUGATES - The present invention is directed to improvements in compositions containing a somatostatin-dopamine conjugate which retains both somatostatin and dopamine activity in vivo, methods for preparing such compositions, and method of using such compositions to treat mammals. In particular, the present invention relates to a pharmaceutical composition comprising Dop2-DLys(Dop2)-cyclo[Cys-Tyr-DTrp-Lys-Abu-Cys]-Thr-NH | 03-17-2011 |
20120190616 | Analogues of Insulin-Like Growth Factor-1 (IGF-1) Having Amino Acid Substitution at Position 59 - The present invention relates to novel analogues of insulin-like growth factor-1 (IGF-1), pharmaceutical compositions containing said analogues, and the use of said analogues for treatment of IGF-1-receptor mediated conditions, such as short stature, diabetes therapy, neurodegenerative disease treatment, and cartilage repair. More particularly, the present invention relates to novel analogues of IGF-1 having an amino acid substitution at position 59, e.g., (Asn | 07-26-2012 |
20120225816 | Pharmaceutical Compositions of Melanocortin Receptor Ligands - The present invention relates to improvements in compositions containing peptides that are ligands of one or more of the melanocortin receptors (MC-R), or pharmaceutically acceptable salts thereof, methods for preparing such compositions, and method of using such compositions to treat mammals. In particular, the present invention relates to a pharmaceutical composition comprising a pamoate salt of Ac-Arg-cyclo(Cys-D-Ala-His-D-Phe-Arg-Trp-Cys)-NH | 09-06-2012 |
20130210751 | Pharmaceutical Compositions of Growth Hormone Secretagogue Receptor Ligands - The present invention relates to improvements in compositions containing peptides that are ligands of the GHS receptor, or pharmaceutically acceptable salts thereof, methods for preparing such compositions, and methods of using such compositions to treat mammals. In particular, the present invention relates to a pharmaceutical composition comprising a pamoate salt of H-Inp-D-Bal-D-Trp-Phe-Apc-NH2, which is a ligand of the GHS receptor and in which, after subcutaneous or intramuscular administration to a subject, the peptide forms an in situ depot at physiological pH that is slowly dissolved and released into the body fluid and bloodstream. The present invention may further comprise an organic component such as dimethylacetamide (DMA) or polyethylene glycol with an average molecular weight of lower than 1000. | 08-15-2013 |
Patent application number | Description | Published |
20100130510 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES - The invention relates to certain compounds, or pharmaceutically acceptable salts, solvates, clathrates, or prodrugs thereof, that are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders. | 05-27-2010 |
20100130522 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES - The invention relates to certain compounds according to Formula (I): | 05-27-2010 |
20100273751 | SUBSTITUTED BENZOIMIDAZOLYL-PYRAZINE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES - This invention relates to certain biologically active chemical compounds, namely benzoimidazolyl-pyrazine derivatives or pharmaceutically acceptable salts, solvates, clathrates, or prodrugs thereof. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders. | 10-28-2010 |
20120190853 | BENZOIMIDAZOLYL-PYRAZINE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES - The invention relates to compounds of structural formula (I) or (III): | 07-26-2012 |
20120196838 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES - The invention relates to certain compounds according to Formula (I): | 08-02-2012 |
20120283272 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES - The invention relates to certain compounds, or pharmaceutically acceptable salts, solvates, clathrates, or prodrugs thereof, that are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders. | 11-08-2012 |
20130165451 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES - The invention relates to certain compounds, or pharmaceutically acceptable salts, solvates, clathrates, or prodrugs thereof, that are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders. | 06-27-2013 |
20140039009 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES - The invention relates to compounds of structural formulas (I), (VII) and (XI): | 02-06-2014 |
20140045861 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES - The invention relates to certain compounds according to Formula (I): | 02-13-2014 |
20140107132 | SUBSTITUTED PYRIDINE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES - The invention relates to certain compounds of Formula (I): | 04-17-2014 |
20140187586 | PYRIDYLPHENYL COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES - The invention relates to compounds of structural formula (I): | 07-03-2014 |
20140242099 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES - The invention relates to certain compounds or pharmaceutically acceptable salts, solvates, clathrates, or prodrugs thereof, that are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders. | 08-28-2014 |
Patent application number | Description | Published |
20090029376 | High Fidelity Restriction Endonucleases - Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions include restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor. | 01-29-2009 |
20120301881 | Compositions, Methods and Related Uses for Cleaving Modified DNA - Compositions, methods and a kit are described relating to a novel family of enzymes which preferentially bind to a hydroxymethylated cytosine or a glucosylated hydroxymethylated cytosine and cleave double-stranded DNA at a defined distance 3′ of the recognition site to produce a cleavage fragment with a 1-3 base overhang. | 11-29-2012 |
20130115676 | High Fidelity Restriction Endonucleases - Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor. | 05-09-2013 |
20130115677 | High Fidelity Restriction Endonucleases - Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor. | 05-09-2013 |
20130115678 | High Fidelity Restriction Endonucleases - Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor. | 05-09-2013 |
20130115679 | High Fidelity Restriction Endonucleases - Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor. | 05-09-2013 |
20130115680 | High Fidelity Restriction Endonucleases - Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor. | 05-09-2013 |
20130115681 | High Fidelity Restriction Endonucleases - Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor. | 05-09-2013 |
20130122568 | High Fidelity Restriction Endonucleases - Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor. | 05-16-2013 |
20130130935 | High Fidelity Restriction Endonucleases - Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor. | 05-23-2013 |
20130190209 | High Fidelity Restriction Endonucleases - Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor. | 07-25-2013 |
Patent application number | Description | Published |
20100088081 | Computer Simulation of Physical Processes - Simulating a physical process includes storing, in a computer-accessible memory, state vectors for voxels, where the state vectors correspond to a model and include entries that correspond to particular momentum states of possible momentum states at a voxel. Interaction operations are performed on the state vectors. The interaction operations model interactions between elements of different momentum states according to the model. Move operations performed on the state vectors reflect movement of elements to new voxels according to the model. The model is adapted to simulate a high-Knudsen number flow that has a Knudsen number greater than 0.1. | 04-08-2010 |
20120265511 | Computer Simulation of Physical Processes - Simulating a physical process includes storing, in a computer-accessible memory, state vectors for voxels, where the state vectors correspond to a model and include entries that correspond to particular momentum states of possible momentum states at a voxel. Interaction operations are performed on the state vectors. The interaction operations model interactions between elements of different momentum states according to the model. Move operations performed on the state vectors reflect movement of elements to new voxels according to the model. The model is adapted to simulate a high-Knudsen number flow that has a Knudsen number greater than 0.1. | 10-18-2012 |
20130116997 | COMPUTER SIMULATION OF PHYSICAL PROCESSES - A computer-implemented method for simulating flow and acoustic interaction of a fluid with a porous medium includes simulating activity of a fluid in a first volume adjoining a second volume occupied by a porous medium, the activity of the fluid in the first volume being simulated so as to model movement of elements within the first volume and using a first model having a first set of parameters, simulating activity of the fluid in the second volume occupied by the porous medium, the activity in the second volume being simulated so as to model movement of elements within the second volume and using a second model having a second set of parameters and differing from the first model in a way that accounts for flow and acoustic properties of the porous medium, and simulating movement of elements between the first volume and the second volume at an interface between the first volume and the second volume. | 05-09-2013 |
20130151221 | COMPUTER SIMULATION OF PHYSICAL PROCESSES - A computer-implemented method for simulating fluid flow using a lattice Boltzmann (LB) approach and for solving scalar transport equations is described herein. In addition to the lattice Boltzmann functions for fluid flow, a second set of distribution functions is introduced for transport scalars. | 06-13-2013 |
20130317794 | Cascaded Eddy Simulation - A fluid flow is simulated by causing a computer to perform operations on data stored in the memory to compute at least one eddy of a fluid flow at a first scale and perform operations to compute at least one eddy of the fluid flow at both the first scale and a second scale. The second scale is a finer scale than the first scale, and the computation of the at least one eddy of the fluid flow at the second scale is constrained by results of the computation of the at least one eddy of the fluid flow at the first scale. | 11-28-2013 |
20140136159 | COMPUTER SIMULATION OF PHYSICAL PROCESSES INCLUDING MODELING OF LAMINAR-TO-TURBULENT TRANSITION - A computer-implemented method for simulating fluid flow using a lattice Boltzmann (LB) approach that includes assigning values for the wall shear stress on a per-facet (e.g., per-surfel) basis based on whether the fluid flow is laminar or turbulent is described herein. | 05-15-2014 |
20140343858 | MASS EXCHANGE MODEL FOR RELATIVE PERMEABILITY SIMULATION - This description relates to computer simulation of physical processes, such as computer simulation of multi-species flow through porous media including the determination/estimation of relative permeabilities for the multi-species flow through the porous media. | 11-20-2014 |
Patent application number | Description | Published |
20090069547 | STABILIZATION OF MAMMALIAN MEMBRANE PROTEINS BY SHORT SURFACTANT PEPTIDES - The present invention provides for a method and kits for stabilizing mammalian membrane protein using short surfactant peptides. The mammalian membrane protein can be a G protein-coupled receptor. | 03-12-2009 |
20090111734 | COMPOSITIONS AND METHODS FOR PROMOTING HEMOSTASIS AND OTHER PHYSIOLOGICAL ACTIVITIES - Compositions that include nanoscale structured materials or precursors thereof (e.g., self-assembling peptides) are described. The compositions can include other substances (e.g., a vasoconstrictor). Also described are methods for using the compositions to promote hemostasis, to protect the skin or wounds from contamination, to decontaiminate a site upon removal of previously applied compositions that provided a protective coating, and to inhibit the movement of bodily substances other than blood. The compositions are also useful in isolating tissue, removing tissue, preserving tissue (for, e.g., subsequent transplantation or reattachment), and as bulking, stabilizing or hydrating agents. Medical devices that include the compositions (e.g., a stent or catheter), bandages or other wound dressings, sutures, and kits that include the compositions are also described. | 04-30-2009 |
20090156427 | Bio-Sensing Nanodevice - The invention provides a bio-sensing nanodevice comprising: a stabilized biologically-derived G-protein coupled receptor—the olfactory receptor—on a support, a real time receptor-ligand binding detection method, an odorant delivery system and an odorant recognition program. The biologically-derived G-protein coupled receptor can be stabilized on nanotechnology using surfactant peptide. The said nanodevice provides a greater surface area for better precision and sensitivity to odorant detection. The invention further provides a microfluidic chip containing a stabilized biologically-derived G-protein coupled receptor—the olfactory receptor—immobilized on a support, and arranged in at least two dimensional microarray system. The invention also provides a method of delivering odorant comprising the step of manipulating the bubbles in complex microfluidic networks wherein the bubbles travel in a microfluidic channel carrying a variety of gas samples to a precise location on a chip. The invention further provides method of fabricating hOR17-4 olfactory receptor. | 06-18-2009 |
20090162437 | Modified self-assembling peptides - The present invention provides a self-assembling peptide comprising: (a) a first amino acid domain that mediates self-assembly, wherein the domain comprises alternating hydrophobic and hydrophilic amino acids that are complementary and structurally compatible and self-assemble into a macroscopic structure when present in unmodified form; and (b) a second amino acid domain that does not mediate self-assembly in isolated form, wherein the second amino acid domain comprises at least one minimal biologically active sequence. Such self-assembling peptides are described herein as “modified self-assembling peptides.” The present invention also provides pharmaceutical compositions, kits and matrices comprising a modified self-assembling peptide, and methods of using and making such compositions, kits and matrices. | 06-25-2009 |
20100311640 | SELF-ASSEMBLING PEPTIDE INCORPORATING MODIFICATIONS AND METHODS OF USE THEREOF - The invention provides a self-assembling peptide comprising (a) a first amino acid domain that mediates self-assembly, wherein the domain comprises alternating hydrophobic and hydrophilic amino acids that are complementary and structurally compatible and self-assemble into a macroscopic structure when present in unmodified form; and (b) a second amino acid domain that does not self-assemble in isolated form. In certain embodiments of the invention the second amino acid domain comprises a biologically active peptide motif, e.g., a peptide motif found in a naturally occurring protein, or a target site for an interaction with a biomolecule. In certain embodiments of the invention the naturally occurring protein is a component of the extracellular matrix, e.g., a component of the basement membrane. The invention further provides scaffolds comprising the self-assembling peptides and methods of using the scaffolds including for cell culture, tissue engineering, and tissue repair. | 12-09-2010 |
20110200560 | NON-IONIC SELF-ASSEMBLING PEPTIDES AND USES THEREOF - The invention relates to a novel class of non-ionic, self-assembling peptides, compositions thereof, methods for the preparation thereof and methods of use thereof. | 08-18-2011 |
20120010140 | SELF-ASSEMBLING PEPTIDES FOR REGENERATION AND REPAIR OF NEURAL TISSUE - The present invention provides methods and compositions for enhancing regeneration and/or repair of neural tissue. One method include providing a nanoscale structured material at the site of injury, wherein the nanoscale structured material provides an environment that is permissive for regeneration of neural tissue and allows axon growth from a location on one side of a site of injury or barrier to a location on the other side of the site of injury or barrier. A second method includes introducing a composition comprising self-assembling peptides into the subject at the site of injury, wherein the peptides are amphiphilic peptides that comprise substantially equal proportions of hydrophobic and hydrophilic amino acids and are complementary and structurally compatible. A variety of compositions comprising a nanoscale structured material or precursor thereof, and an additional substance such as a regeneration promoting factor, are also provided. In certain embodiments of the invention the nanoscale structured material or precursor thereof comprises self-assembling peptides. The invention further provides compositions and methods for repair of an intervertebral disc, including nucleus pulpusos repair. | 01-12-2012 |
20120014925 | Self-Assembling Peptides Incorporating Modifications and Methods of Use Thereof - The invention relates to a novel class of self-assembling peptides, compositions thereof, methods for the preparation thereof and methods of use thereof. The invention also encompasses methods for tissue regeneration, increasing the production of extracellular matrix proteins, and methods of treatment comprising administering self-assembling peptides. | 01-19-2012 |
20120021932 | Multiplexed Olfactory Receptor-Based Microsurface Plasmon Polariton Detector - The invention provides a bio-sensing nanodevice comprising: a stabilized G-protein coupled receptor on a support, a real time receptor-ligand binding detection method, a test composition delivery system and a test composition recognition program. The G-protein coupled receptor can be stabilized using surfactant peptide. The nanodevice provides a greater surface area for better precision and sensitivity to odorant detection. The invention further provides a microfluidic chip containing a stabilized G-protein coupled receptor immobilized on a support, and arranged in at least two dimensional microarray system. The invention also provides a method of delivering odorant comprising the step of manipulating the bubbles in complex microfluidic networks wherein the bubbles travel in a microfluidic channel carrying a variety of gas samples to a precise location on a chip. The invention further provides method of fabricating hOR17-4 olfactory receptor. | 01-26-2012 |
20120252719 | WATER SOLUBLE MEMBRANE PROTEINS AND METHODS FOR THE PREPARATION AND USE THEREOF - The present invention is directed to water-soluble membrane proteins, methods for the preparation thereof and methods of use thereof. | 10-04-2012 |
20140161753 | Self-Assembling Peptide and Peptide Gel with High Strength - Provide are a peptide gel with practically sufficient mechanical strength and a self-assembling peptide capable of forming the peptide gel. The self-assembling peptide is formed of the following amino acid sequence: a | 06-12-2014 |
20140243277 | Water Soluble Membrane Proteins and Methods for the Preparation and Use Thereof - The present invention is directed to water-soluble membrane proteins, methods for the preparation thereof and methods of use thereof. | 08-28-2014 |
20140302144 | MULTI-LAYERED INJECTABLE SELF-ASSEMBLING PEPTIDE SCAFFOLD HYDROGELS FOR LONG-TERM SUSTAINED RELEASE OF HUMAN ANTIBODIES - The invention relates to a pharmaceutical formulation for sustained delivery of a therapeutic agent, preferably a protein, polypeptide, an antibody or an antibody fragment, comprising one or more gel forming peptides wherein the formulation exhibits sustained delivery for at least two weeks, three weeks, four weeks, five weeks, six weeks, seven weeks, eight weeks, nine weeks, ten weeks, eleven weeks, twelve weeks or more. In one embodiment, the invention relates to a formulation comprising self-assembling peptides that undergo sol-gel transition in the presence of an electrolyte solution such as biological fluids and salts. The formulation can provide sustained release of antibody and antibody fragments, in particular, IgG. Antibody diffusivities can be decreased with increasing hydrogel nanofiber density, providing a means to control the release kinetics. | 10-09-2014 |
20140322279 | Self-Assembling Peptides Incorporating Modifications and Methods of Use Thereof - The invention relates to a novel class of self-assembling peptides, compositions thereof, methods for the preparation thereof and methods of use thereof. The invention also encompasses methods for tissue regeneration, increasing the production of extracellular matrix proteins, and methods of treatment comprising administering self-assembling peptides. | 10-30-2014 |
20140364330 | Multiplexed Olfactory Receptor-Based Microsurface Plasmon Polariton Detector - The invention provides a bio-sensing nanodevice comprising: a stabilized G-protein coupled receptor on a support, a real time receptor-ligand binding detection method, a test composition delivery system and a test composition recognition program. The G-protein coupled receptor can be stabilized using surfactant peptide. The nanodevice provides a greater surface area for better precision and sensitivity to odorant detection. The invention further provides a microfluidic chip containing a stabilized G-protein coupled receptor immobilized on a support, and arranged in at least two dimensional microarray system. The invention also provides a method of delivering odorant comprising the step of manipulating the bubbles in complex microfluidic networks wherein the bubbles travel in a microfluidic channel carrying a variety of gas samples to a precise location on a chip. The invention further provides method of fabricating hOR17-4 olfactory receptor. | 12-11-2014 |
Patent application number | Description | Published |
20080231370 | Apparatus and methods for amplifiers - Circuits and methods for reducing distortion in an amplified signal are disclosed. The circuits and methods may use multiple single-ended gain stages to produce multiple amplified signals. The amplified signals may be processed in combination to produce a resulting output signal having little, or no, distortion. The circuits may be implemented on a single chip as integrated circuits. | 09-25-2008 |
20090184785 | Attenuator - A π-type voltage-controlled variable attenuator is disclosed. The variable attenuator may include variably resistive components in the series and shunt arms. The variably resistive components may be implemented as field effect transistors. The shunt arms may be coupled to the series arm, and the variable attenuator may lack capacitors between the series arm and shunt arms. The series arm and shunt arms may display variable resistances which, in combination, operate to provide a variable level of attenuation of an input signal. The variable attenuator may provide any level of attenuation of an input signal over a wide frequency range. The variable attenuator may be implemented as an integrated circuit. | 07-23-2009 |
20130234209 | SWITCHING DEVICE FOR HETEROJUNCTION INTEGRATED CIRCUITS AND METHODS OF FORMING THE SAME - A switching device for heterojunction integrated circuits is disclosed. According to one aspect, the switching device is configured to protect a circuit from an electro-static discharge (ESD) event. The switching device includes a second base contact region that is configured to be electrically floating, a first base contact region and a collector contact region that are coupled to a first input terminal of the switching device, and an emitter contact region that is coupled to a second input terminal of the switching device. Due in part to capacitive coupling between the first base contact region and the second base contact region, the switching device exhibits a low transient trigger voltage and a fast response to ESD events. Further, the switching device exhibits a high DC trigger voltage (for example, greater than 20V), while maintaining relatively low leakage current during operation (for example, less than about 0.5 μA at 20V DC. | 09-12-2013 |
20140084331 | HETEROJUNCTION COMPOUND SEMICONDUCTOR PROTECTION CLAMPS AND METHODS OF FORMING THE SAME - A protection clamp is provided between a first terminal and a second terminal, and includes a multi-gate high electron mobility transistor (HEMT), a current limiting circuit, and a forward trigger control circuit. The multi-gate HEMT includes a drain/source, a source/drain, a first depletion-mode (D-mode) gate, a second D-mode gate, and an enhancement-mode (E-mode) gate disposed between the first and second D-mode gates. The drain/source and the first D-mode gate are connected to the first terminal and the source/drain and the second D-mode gate are connected to the second terminal. The forward trigger control and the current limiting circuits are coupled between the E-mode gate and the first and second terminals, respectively. The forward trigger control circuit provides an activation voltage to the E-mode gate when a voltage of the first terminal exceeds a voltage of the second terminal by a forward trigger voltage. | 03-27-2014 |
20140084347 | BIDIRECTIONAL HETEROJUNCTION COMPOUND SEMICONDUCTOR PROTECTION DEVICES AND METHODS OF FORMING THE SAME - A protection circuit including a multi-gate high electron mobility transistor (HEMT), a forward conduction control block, and a reverse conduction control block is provided between a first terminal and a second terminal. The multi-gate HEMT includes an explicit drain/source, a first depletion-mode (D-mode) gate, a first enhancement-mode (E-mode) gate, a second E-mode gate, a second D-mode gate, and an explicit source/drain. The drain/source and the first D-mode gate are connected to the first terminal and the source/drain and the second D-mode gate are connected to the second terminal. The forward conduction control block turns on the second E-mode gate when a voltage difference between the first and second terminals is greater than a forward conduction trigger voltage, and the reverse conduction control block turns on the first E-mode gate when the voltage difference is more negative than a reverse conduction trigger voltage. | 03-27-2014 |
20140110825 | Compound Semiconductor Lateral PNP Bipolar Transistors - Compound semiconductor lateral PNP bipolar transistors are fabricated based on processes traditionally used for formation of compound semiconductor NPN heterojunction bipolar transistors and hence such PNP bipolar transistors can be fabricated inexpensively using existing fabrication technologies. In particular, GaAs-based lateral PNP bipolar transistors are fabricated using GaAs-based NPN heterojunction bipolar transistor fabrication processes. | 04-24-2014 |
Patent application number | Description | Published |
20090262603 | Method for characterizing a geological formation traversed by a borehole - Methods for characterizing a geological formation, the methods include retrieving measured data provided by a measuring tool along one or more logged borehole length for a borehole, another borehole or both in order to produce a borehole imaging log. Selecting depth-defined intervals of the borehole imaging log as training images for inputting in a multi-point geostatistical model. Determining pattern based simulations for each training image using a pixel-based template of the multi-point geostatistical model so as to obtain training image patterns. Using the pattern based simulation of each training image to assign to each of the training image a corresponding training image pattern. Constructing from the training image patterns one or more fullbore image log of a borehole wall of the borehole. Repeat the second to fourth steps through the one or more logged borehole length in order to construct fullbore images from successive, adjacent training images. | 10-22-2009 |
20110004447 | Method to build 3D digital models of porous media using transmitted laser scanning confocal mircoscopy and multi-point statistics - Methods for characterizing a three-dimensional (3D) sample of porous media using at least one measuring tool that retrieves two or more set of transmitted measured data at two or more depths of the sample, such that the retrieved two or more set of transmitted measured data is communicated to a processor and computed in at least one multi-point statistical (MPS) model. | 01-06-2011 |
20110004448 | Method to quantify discrete pore shapes, volumes, and surface areas using confocal profilometry - Methods for characterizing a sample of porous media using a measuring device along with a multipoint statistical (MPS) model. Retrieving a set of reflected measured data provided by the measuring device of a surface of the sample in order to produce a sample imaging log, wherein the retrieved set of measured data is communicated to a processor. Selecting depth-defined surface portions of the sample from the sample imaging log as a training image for inputting in the MPS model. Determining pattern based simulations from the training image using one of a pixel-based template which is applied to the training image. Constructing from the pattern based simulations a complete-sampling image log of surface portions of the sample. Repeat the above steps in order to construct three dimensional (3D) sample images from stacked successive pattern based simulations so as to construct at least one 3D model of the sample. | 01-06-2011 |
20110231164 | GENERATING FACIES PROBABLITY CUBES - A method for generating one or more geological models for oil field exploration. The method includes receiving one or more well facies logs, a vertical facies proportion curve, a lateral proportion map, a variogram model and a global target histogram. The method then includes generating a facies probability cube using a modified Sequential Gaussian Simulation (SGSIM) algorithm, the well facies logs, the vertical facies proportion curve, the lateral proportion map and the variogram model. After generating the facies probability cube, the method includes matching the facies probability cube to the global histogram and generating the geological models based on the matched facies probability cube. | 09-22-2011 |
20120221306 | MULTISCALE DIGITAL ROCK MODELING FOR RESERVOIR SIMULATION - Methods for upscaling digital rock modeling data are described. Core-plug samples for pore-scale modeling are strategically chosen using whole-core minipermeability grids and conventional CT (Computed Tomography) scans. Pore models or pore-network models are used for flow modeling. Computed numerical SCAL (Special Core AnaLysis) properties are validated using laboratory-derived data, then they are used to populate borehole-scale models. Borehole-scale models use MPS (Multi-Point Statistics) to combine minipermeability grids and conventional CTscans of whole core with electrical borehole images to create 3D numerical pseudocores for each RRT (Reservoir Rock Type). SCAL properties determined from pore-scale models are distributed for each petrophysical facies in numerical pseudocores. Effective SCAL properties computed from various MPS borehole-scale realizations or models are used to populate interwell-scale models for each RRT. At the interwell scale, seismic attributes and variogram statistics from LWD (logging while drilling) data are used to populate digital rock models. Effective properties computed from flow simulations for interwell volumes are used to populate full-field scale models. At the full-field scale, outcrop analogs, sequence stratigraphy, forward stratigraphic models, diagenetic models, and basin-scale models are combined using MPS to improve flow simulations. At every stage, REVs (representative element volumes) are computed to be certain rock heterogeneities have been captured. | 08-30-2012 |
20120277996 | METHOD TO DETERMINE REPRESENTATIVE ELEMENT AREAS AND VOLUMES IN POROUS MEDIA - The subject disclosure relates to methods for determining representative element areas and volumes in porous media. Representative element area (REA) is the smallest area that can be modeled to yield consistent results, within acceptable limits of variance of the modeled property. Porosity and permeability are examples of such properties. In 3D, the appropriate term is representative element volume (REV). REV is the smallest volume of a porous media that is representative of the measured parameter. | 11-01-2012 |
20120281883 | METHODS TO BUILD 3D DIGITAL MODELS OF POROUS MEDIA USING A COMBINATION OF HIGH- AND LOW-RESOLUTION DATA AND MULTI-POINT STATISTICS - This subject disclosure describes methods to build and/or enhance 3D digital models of porous media by combining high- and low-resolution data to capture large and small pores in single models. High-resolution data includes laser scanning fluorescence microscopy (LSFM), nano computed tomography (CT) scans, and focused ion beam-scanning electron microscopy (FIB-SEM). Low-resolution data includes conventional CT scans, micro computed tomography scans, and synchrotron computed tomography scans. | 11-08-2012 |
20130338978 | GENERATING FACIES PROBABLITY CUBES - A method for generating one or more geological models for oil field exploration. The method includes receiving one or more well facies logs, a vertical facies proportion curve, a lateral proportion map, a variogram model and a global target histogram. The method then includes generating a facies probability cube using a modified Sequential Gaussian Simulation (SGSIM) algorithm, the well facies logs, the vertical facies proportion curve, the lateral proportion map and the variogram model. After generating the facies probability cube, the method includes matching the facies probability cube to the global histogram and generating the geological models based on the matched facies probability cube. | 12-19-2013 |
Patent application number | Description | Published |
20090124214 | REMOTE FRONT-END FOR A MULTI-ANTENNA STATION - A multi-antenna station has multiple remote front-ends coupled to multiple antennas. Each remote front-end includes a power amplifier (PA), a low noise amplifier (LNA), and first and second coupling units. On the transmit path, a first RF signal is received via a first port, routed by the first coupling unit to the power amplifier, amplified to obtain the desired output power level, and routed by the second coupling unit to a second port for transmission via the antenna. On the receive path, a second RF signal is received via the second port, routed by the second coupling unit to the LNA, amplified to obtain a higher signal level, and routed by the first coupling unit to the first port for transmission to the transceiver. | 05-14-2009 |
20090175398 | I/Q IMBALANCE ESTIMATION AND CORRECTION IN A COMMUNICATION SYSTEM - Certain aspects and embodiments provide for accurate measurement and estimation of imbalances between in-phase (I) and quadrature (Q) components of a complex baseband signal. The accuracy of I/Q phase imbalance estimates may be enhanced by conducting them on a transmitter and a receiver that are connected via a local, loopback connection and by removing cross-spectrum interference in transferred packets. Once these accurate I/Q phase imbalances are determined, they may be used to adjust a signal processed by the transmitter or the receiver to increase the performance and data throughput of communications using the signal. | 07-09-2009 |
20090238313 | STEPPED GAIN MIXER - An amplified stepped gain mixer portion improves the signal-to-noise ratio of a receiver by using multiple gain states to improve linearity. The mixer portion includes an amplifier, a switch and two transistors. The amplifier output is coupled to the sources of the two transistors. An oscillating signal is present on the transistor gates. The transistor drains are coupled to one another through the switch when the switch is closed. The mixer portion operates in two modes. In a 1/2 mode, the mixer portion output current flows only through the first transistor and not through the second transistor because the switch is open. In a 2/2 mode, the mixer portion output current flows through both transistors. The mixer portion is configured such that the switch is closed when a switching signal is asserted. The switching signal is asserted when a bit of a mixer control register is written to. | 09-24-2009 |
20110013724 | I/Q IMBALANCE ESTIMATION AND COMPENSATION FOR A TRANSMITTER AND A RECEIVER - Techniques for performing inphase/quadrature (I/Q) imbalance estimation and compensation are described. In one exemplary design, I/Q imbalances in a receiver may be estimated by (i) applying a continuous wave signal at different frequencies to the receiver and (ii) processing I and Q input samples from the receiver to determine I/Q imbalances at different frequencies. In another exemplary design, I/Q imbalances may be estimated by (i) downconverting an input RF signal with an LO signal that is offset in frequency from the input RF signal, (ii) transforming I and Q input samples from the receiver to the frequency domain to obtain I and Q symbols, and (iii) determining I/Q imbalances based on the I and Q symbols. In one exemplary design, I/Q imbalances may be corrected by compensating for frequency-dependent and frequency-independent I/Q imbalances separately. I/Q imbalances in a transmitter may also be estimated and compensated. | 01-20-2011 |
20130063223 | IMPEDANCE MATCHING CIRCUITS WITH MULTIPLE CONFIGURATIONS - Reconfigurable impedance matching circuits with multiple configurations are disclosed. A reconfigurable impedance matching circuit may be implemented with a set of reactive elements (e.g., inductors and/or capacitors) and a set of switches. Different configurations may be obtained with different settings of the switches and may be associated with different impedance tuning curves. This may enable the reconfigurable impedance matching circuit to provide better impedance matching for a load circuit (e.g., an antenna). In an exemplary design, the reconfigurable impedance matching circuit includes at least one variable reactive element configured to tune the impedance of the reconfigurable impedance matching circuit in order to provide better impedance matching. In an exemplary design, the reconfigurable impedance matching circuit may include at least one reconfigurable reactive element, each of which can be connected as a series element or a shunt element. | 03-14-2013 |
20130069737 | ADAPTIVE TUNING OF AN IMPEDANCE MATCHING CIRCUIT IN A WIRELESS DEVICE - Techniques for adaptively tuning an impedance matching circuit are disclosed. In an aspect, the impedance matching circuit is pre-characterized. The performance of the impedance matching circuit is determined for multiple settings of the impedance matching circuit, stored in memory, and used to tune the impedance matching circuit. In another aspect, the impedance matching circuit is tuned based on measurements for one or more parameters such as delivered power, return loss, power amplifier current, antenna/load impedance, etc. In an exemplary design, an apparatus includes a memory and a control unit. The memory stores information for multiple settings of an impedance matching circuit. The control unit selects one of the multiple settings of the impedance matching circuit based on the information for the multiple settings and measurements for the impedance matching circuit. The impedance matching circuit performs impedance matching for a load circuit (e.g., an antenna) based on the selected setting. | 03-21-2013 |
20130322562 | METHOD AND APPARATUS FOR ANTENNA TUNING AND TRANSMIT PATH SELECTION - Certain aspects of the present disclosure propose a method and an apparatus for antenna tuning and transmit path selection in an RF system. A method may include antenna diversity path selection by (optionally) diagnosing damaged antennas, tuning antennas, and selecting an antenna with better performance. Embodiments can be used in wireless radio-frequency (RF) front-ends. Other aspects, embodiments, and features are also claimed and described. | 12-05-2013 |
20130324057 | DETERMINING A DELIVERED POWER ESTIMATE AND A LOAD IMPEDANCE ESTIMATE USING A DIRECTIONAL COUPLER - A wireless device configured for optimizing a delivered power is described. The wireless device includes a filter duplexer or switch coupled to a transmitter and a receiver. The wireless device also includes a power/impedance detector coupled to the filter duplexer or switch. The power/impedance detector includes a directional coupler. An antenna is coupled to the power/impedance detector. Other aspects, embodiments and features are also claimed and described. | 12-05-2013 |
20130324062 | POWER DETECTOR WITH TEMPERATURE COMPENSTATION - Power detectors with temperature compensation and having improved accuracy over temperature are disclosed. In an aspect of the disclosure, variations of a power detector gain over temperature is reduced by varying both the gate and drain voltages of MOS transistors within a power detector. In an exemplary design, an apparatus includes at least one MOS transistor, which receives an input signal, detects the power of the input signal based on a power detection gain, and provides an output signal indicative of the power of the input signal. The at least one MOS transistor is applied a variable gate bias voltage and a variable drain bias voltage in order to reduce variations of the power detection gain over temperature. At least one additional MOS transistor may receive a second variable gate bias voltage and provide the variable drain bias voltage for the at least one MOS transistor. | 12-05-2013 |
20130331042 | CONTROL OF TRANSMIT POWER AND ADJUSTMENT OF ANTENNA TUNING NETWORK OF A WIRELESS DEVICE - Techniques for controlling transmit power and adjusting an antenna tuning network of a wireless device are disclosed. In an exemplary design, an apparatus (e.g., a wireless device or a circuit module) includes a directional coupler and at least one detector. The directional coupler receives an input radio frequency (RF) signal at a first port, provides an output RF signal at a second port, and provides a coupled RF signal at a third port. The detector(s) receive at least one RF signal on at least one port of the directional coupler, measure the at least one RF signal, and provide measurements that are used to control the transmit power of the wireless device and adjust an antenna tuning network. For example, the measurements may be used to determine incident power, reflected power, delivered power, etc., which may be used to control the transmit power and/or adjust the antenna tuning network. | 12-12-2013 |
20140197902 | DIPLEXER DESIGN USING THROUGH GLASS VIA TECHNOLOGY - A diplexer includes a substrate having a set of through substrate vias. The diplexer also includes a first set of traces on a first surface of the substrate. The first traces are coupled to the through substrate vias. The diplexer further includes a second set of traces on a second surface of the substrate that is opposite the first surface. The second traces are coupled to opposite ends of the set of through substrate vias. The through substrate vias and the traces also operate as a 3D inductor. The diplexer also includes a capacitor supported by the substrate. | 07-17-2014 |
20140266518 | Step Attenuator with Constant Input Capacitance - A step attenuator with constant input capacitance and having good performance is disclosed. In an exemplary design, an apparatus includes a step attenuator having a constant input capacitance for different amounts of attenuation. The step attenuator receives an input signal, provides a variable amount of attenuation for the input signal, and provides an output signal. The step attenuator may include a plurality of attenuator sections coupled in series. Each attenuator section may include a plurality of capacitors and may have the constant input capacitance. At least one of the plurality of attenuator sections may be selected or unselected to obtain a selected amount of attenuation for the step attenuator. An attenuator section may provide a predetermined amount of attenuation or a variable amount of attenuation when selected. The apparatus may further include a power detector that receives and determines the power of the output signal from the step attenuator. | 09-18-2014 |
20140327496 | TUNABLE DIPLEXERS IN THREE-DIMENSIONAL (3D) INTEGRATED CIRCUITS (IC) (3DIC) AND RELATED COMPONENTS AND METHODS - Tunable diplexers in three-dimensional (3D) integrated circuits (IC) (3DIC) are disclosed. In one embodiment, the tunable diplexer may be formed by providing one of either a varactor or a variable inductor in the diplexer. The variable nature of the varactor or the variable inductor allows a notch in the diplexer to be tuned so as to select a band stop to eliminate harmonics at a desired frequency as well as control the cutoff frequency of the pass band. By stacking the elements of the diplexer into three dimensions, space is conserved and a variety of varactors and inductors are able to be used. | 11-06-2014 |
20150022024 | SWITCH LINEARIZER - Exemplary embodiments are related to switch linearizer. A device may include at least one switch. The device may further include a linearizer coupled to the at least one switch and configured to cancel at least a portion of distortion generated by the at least one switch in an off-state. | 01-22-2015 |
20150042399 | ANALOG SWITCH FOR RF FRONT END - Techniques for improving the linearity of radio-frequency (RF) front-end switches. In an aspect, open-loop techniques are disclosed for superimposing the output voltage of one or more negative rectifiers on a negative substrate bias voltage to reduce the non-linearities associated with voltage-dependent substrate leakage current. In another aspect, closed-loop techniques are further disclosed for maintaining the substrate bias voltage close to a reference voltage. Exemplary embodiments of the circuit blocks are further described. | 02-12-2015 |
20150061813 | VARYING THICKNESS INDUCTOR - A particular device includes a substrate and a spiral inductor coupled to the substrate. The spiral inductor includes a first conductive spiral and a second conductive spiral overlaying the first conductive spiral. A first portion of an innermost turn of the spiral inductor has a first thickness in a direction perpendicular to the substrate. The first portion of the innermost turn includes a first portion of the first conductive spiral and does not include the second conductive spiral. A second portion of the innermost turn includes a first portion of the second conductive spiral. A portion of an outermost turn of the spiral inductor has a second thickness in the direction perpendicular to the substrate that is greater than the first thickness. A portion of the outermost turn includes a second portion of the first conductive spiral and a second portion of the second conductive spiral. | 03-05-2015 |
Patent application number | Description | Published |
20100131109 | SYSTEM AND METHOD FOR ASSESSING AND MANAGING DATA CENTER AIRFLOW AND ENERGY USAGE - A system and method for providing energy assessment and optimization in a data center that includes at least one cooling provider, and at least one cooling consumer, the at least one cooling consumer having cooling requirements. The method according to one aspect includes receiving data regarding cooling availability and power consumption for the at least one cooling consumer, cooling capacity of the at least one cooling provider, and a physical relationship between the at least one cooling consumer and the at least one cooling provider in the data center, storing the received data, determining airflow distribution effectiveness between the at least one cooling consumer and the at least one cooling provider, and displaying at least one value representative of the effectiveness of the distribution of airflow in the data center between the at least one cooling consumer and the at least one cooling provider. | 05-27-2010 |
20100286956 | SYSTEM AND METHOD FOR PREDICTING COOLING PERFORMANCE OF ARRANGEMENTS OF EQUIPMENT IN A DATA CENTER - A system and method for evaluating equipment in an improper cluster in a data center, the equipment including a plurality of equipment racks, and at least one cooling provider. In one aspect, the method includes receiving data regarding each of the plurality of equipment racks and the at least one cooling provider, the data including a layout of the improper cluster of equipment racks and the at least one cooling provider, storing the received data, identifying at least one gap in the layout, determining cooling performance of at least one of the plurality of equipment racks based, at least in part, on characteristics of the at least one gap, and displaying the layout of the data center, wherein the layout includes an indication of the cooling performance of the at least one of the plurality of equipment racks. | 11-11-2010 |
20110077795 | DATA CENTER CONTROL - Systems and methods for data center control are provided. The data center includes a plurality of racks and at least one cooling unit. The racks including at least one server. Information regarding the at least one cooling unit, the at least one server, the plurality of racks, and at least one application is received. A rack based cooling metric threshold is also received. The systems and methods can determine a layout of the data center that minimizes total power consumption of the plurality of racks and the cooling unit while maintaining cooling performance at an acceptable level based on the threshold. | 03-31-2011 |
20110301911 | SYSTEM AND METHOD FOR PREDICTING TEMPERATURE VALUES IN A DATA CENTER - A system and method for evaluating equipment in a data center, the equipment including a plurality of equipment racks, and at least one cooling provider. In one aspect, a method includes receiving data regarding each of the plurality of equipment racks and the at least one cooling provider, the data including a layout of the equipment racks and the at least one cooling provider, and a power draw value for each of the equipment racks, storing the received data, determining air flow between the at least one cooling provider and each of the equipment racks, determining inlet and exit air temperature for the at least one cooling provider based on the layout, the power draw and the airflow, for each equipment rack, determining inlet and exit air temperature based on the layout, the power draw and the airflow, and displaying an indication of the inlet and exit temperature for each of the plurality of equipment racks and the at least one cooler. In the method, determining the inlet and exit temperature of each of the equipment racks and the at least one cooling provider includes establishing a set of S coupled equations, with S equal to a number of temperature values to be determined, and solving the S coupled equations. | 12-08-2011 |
20120041569 | SYSTEM AND METHOD FOR PREDICTING TRANSIENT COOLING PERFORMANCE FOR A DATA CENTER - A system and method is provided for evaluating the transient cooling performance of a data center. In one version, the method includes receiving input data from a storage device, the input data including data center architecture information and operating data, displaying a model of the data center, performing real-time transient cooling performance calculations for the data center using the input data, and displaying results of the real-time transient cooling performance calculations, wherein the results include a maximum predicted temperature of the data center following a power outage of the data center. | 02-16-2012 |
20120059628 | SYSTEM AND METHOD FOR EVALUATING EQUIPMENT RACK COOLING PERFORMANCE - Aspects of the invention are directed to systems and methods for designing and analyzing data centers. One aspect is directed to a method of determining cooling characteristics of a data center. The method includes receiving data related to a configuration of equipment in the data center, identifying rack clusters in the configuration of equipment, and determining a capture index for at least one equipment rack of at least one rack cluster. | 03-08-2012 |
20120071992 | SYSTEM AND METHOD FOR PREDICTING PERFORATED TILE AIRFLOW IN A DATA CENTER - Systems and methods provide determinations of airflow from a raised floor plenum. In one aspect, a computer-implemented method is provided for predicting airflow from a plurality of openings in a plenum. The method includes (A) receiving input data from a storage device, the input data including data related to the plenum (B) determining an average air pressure in the plenum, (C) determining an airflow value for each of the openings based on the average air pressure, (D) dividing the plenum into a plurality of grid cells, (E) using a first iterative method, determine a value for airflow velocity for each of the grid cells, (F) determining an air pressure value at each of the openings based on the airflow velocity, (G) using a second iterative method, determine a new airflow value for each one of the plurality of openings based on the air pressure value at the one of the openings, (H) determining whether a difference between the new airflow values and previous airflow values is greater than a threshold, and (I) repeating acts (E) through (H) until the difference is not greater than the threshold, and then storing the new airflow value for each one of the plurality of openings as a final airflow value. | 03-22-2012 |
20120158387 | SYSTEM AND METHODS FOR RACK COOLING ANALYSIS - According to at least one embodiment, a computer-implemented method for modeling cooling performance is provided. The method includes acts of receiving, by a computer, input data from a storage device, the input data including data related to physical structures within at least one equipment rack, selecting, based on the data related to physical structures, at least one first equation of a plurality of predetermined equations that describe pressure values in a plurality of spaces within the at least one equipment rack, determining pressure values in identified spaces of the plurality of spaces by solving the at least one first equation using the input data, determining airflow values between identified spaces by calculating a difference between the pressure values and storing, on the storage device, the airflow values as equipment rack airflow values within the at least one equipment rack. | 06-21-2012 |
20120170205 | SYSTEM AND METHOD FOR SEQUENTIAL PLACEMENT OF COOLING RESOURCES WITHIN DATA CENTER LAYOUTS - A computer-implemented method for sequential placement of cooling resources in a data center comprises: defining a weighted, higher-order cooling metric, | 07-05-2012 |
20130006426 | SYSTEM AND METHOD FOR MEASUREMENT AIDED PREDICTION OF TEMPERATURE AND AIRFLOW VALUES IN A DATA CENTER - A system and method for evaluating cooling performance of equipment in a data center, the equipment including a plurality of equipment racks and at least one cooling provider. In one aspect, a method includes receiving a plurality of measured inlet and exhaust air temperature values for the at least one cooling provider and a subset of the plurality of equipment racks, implementing a cooling model, the model including an ambient air temperature value, a plurality of inlet and exhaust air temperature values for the plurality of equipment racks and the at least one cooling provider, and a plurality of airflow values for the plurality of equipment racks and the at least one cooling provider, adjusting at least one of the ambient air temperature value and each of the plurality of airflow values in the cooling model, adjusting the cooling model to compensate for the adjusted at least one of the ambient air temperature value and each of the plurality of airflow values in the cooling model, substituting a first subset of the plurality of inlet and exhaust air temperature values in the cooling model with the plurality of measured inlet and exhaust air temperature values, and predicting a second subset of the plurality of inlet and exhaust air temperature values for the plurality of equipment racks and the at least one cooling provider in the cooling model. | 01-03-2013 |
20130030585 | SYSTEM AND METHOD FOR ASSESSING AND MANAGING DATA CENTER AIRFLOW AND ENERGY USAGE - A system and method for providing energy assessment and optimization in a data center that includes at least one cooling provider, and at least one cooling consumer, the at least one cooling consumer having cooling requirements. The method according to one aspect includes receiving data regarding cooling availability and power consumption for the at least one cooling consumer, cooling capacity of the at least one cooling provider, and a physical relationship between the at least one cooling consumer and the at least one cooling provider in the data center, storing the received data, determining airflow distribution effectiveness between the at least one cooling consumer and the at least one cooling provider, and displaying at least one value representative of the effectiveness of the distribution of airflow in the data center between the at least one cooling consumer and the at least one cooling provider. | 01-31-2013 |
20130073258 | SYSTEM AND METHOD FOR PREDICTING COOLING PERFORMANCE OF ARRANGEMENTS OF EQUIPMENT IN A DATA CENTER - A system and method for evaluating equipment in an improper cluster in a data center, the equipment including a plurality of equipment racks, and at least one cooling provider. In one aspect, the method includes receiving data regarding each of the plurality of equipment racks and the at least one cooling provider, the data including a layout of the improper cluster of equipment racks and the at least one cooling provider, storing the received data, identifying at least one gap in the layout, determining cooling performance of at least one of the plurality of equipment racks based, at least in part, on characteristics of the at least one gap, and displaying the layout of the data center, wherein the layout includes an indication of the cooling performance of the at least one of the plurality of equipment racks. | 03-21-2013 |
20140039852 | SYSTEM AND METHOD FOR PREDICTING TRANSIENT COOLING PERFORMANCE FOR DATA CENTER - A system and method is provided for evaluating the transient cooling performance of a data center. In one version, the method includes receiving input data from a storage device, the input data including data center architecture information and operating data, performing transient cooling performance calculations for the data center using the input data, and displaying results of the transient cooling performance calculations, wherein the results include at least one of a cooling runtime and a maximum predicted temperature of the data center following a power outage of the data center. | 02-06-2014 |
20140122033 | SYSTEM AND METHOD FOR FLUID DYNAMICS PREDICTION WITH AN ENHANCED POTENTIAL FLOW MODEL - A system and method for modeling airflow and temperature are disclosed. In one example, the method includes receiving input data related to a physical layout of a facility, dividing, by a computer, a representation of the facility into a plurality of grid cells, identifying where effects of at least one of jet airflow, thermal plumes and buoyancy forces are present in the facility based on the physical layout, specifying a velocity value, using a velocity correction method, for a first set of the plurality of grid cells if the effects of at least one of jet airflow and thermal plumes are present within the first set of the plurality of grid cells, calculating, by the computer, an airflow velocity value for each of a second set of the plurality of grid cells, the second set being different from the first set, modifying the determined airflow velocity value for any of the second set of the plurality of grid cells where the effects of buoyancy forces are present, and storing, on a storage device, the modified airflow values. | 05-01-2014 |
20140330447 | DROPPED CEILING SYSTEM COOLING PREDICTION - In one embodiment, there is provided a computer-implemented method for evaluating ceiling plenum airflow patterns and cooling performance of equipment in a data center. The method includes receiving data related to equipment in the data center, receiving data related to the ceiling plenum, determining first parameters related to airflow and to pressure in the ceiling plenum using a first airflow model, determining second parameters related to airflow through a plurality of equipment racks and to pressure across the plurality of equipment racks using a second airflow model distinct from the first airflow model, determining a coupling relationship between airflow through the equipment racks and airflow into the ceiling plenum, adjusting the first parameters based on at least the second parameters and the coupling relationship, determining a sufficiency of airflow through the equipment racks, and storing, on a storage device, an indication of the sufficiency of airflow through the equipment racks. | 11-06-2014 |
20140358471 | ANALYSIS OF EFFECT OF TRANSIENT EVENTS ON TEMPERATURE IN A DATA CENTER - A computer-implemented method for evaluating cooling performance of equipment in a data center. In one aspect, the method comprises receiving data related to equipment in the data center, determining first parameters related to airflow and temperature in the data center at a first period in time, receiving a description of a transient event affecting one of airflow and temperature in the data center at a second time, breaking a second time period subsequent to the second time into a plurality of time intervals, determining second parameters related to airflow in the data center during one of the time intervals, determining the parameters related to temperature in the data center at each of the time intervals based on the second parameters related to airflow, and storing, on a storage device, a representation of the parameters related to temperature in the data center during the second time period. | 12-04-2014 |
Patent application number | Description | Published |
20100142078 | Systems and Methods for Memory Efficient Repeatable Run Out Processing - Various embodiments of the present invention provide systems and methods for low overhead disk wobble compensation. As an example, a method for performing synchronous wobble compensation processing is disclosed. The method includes providing a medium that includes a servo data region and a user data region. The servo data region includes a clock recovery pattern and a location pattern. A detectable pattern is written to the user data region a known number of bit periods from the location pattern. The detectable pattern is read back, and a fractional processing delay is calculated. Based at least on the fractional processing delay and a known number of bit periods from the location pattern to the end of the servo data region, a wobble compensation pattern is written an integral number of bit periods from the location pattern. | 06-10-2010 |
20120026620 | METHODS AND APPARATUS FOR GAIN ESTIMATION USING SERVO DATA WITH IMPROVED BIAS CORRECTION - Methods and apparatus are provided for gain estimation using servo data with improved bias correction. The gain is estimated using a preamble in a servo sector by obtaining a first gain estimate using a first gain estimation algorithm (such as a Zero Gain Start Algorithm) and a first portion of the preamble; storing the first portion of the preamble in a memory buffer; obtaining a second gain estimate using a second gain estimation algorithm (such as a Zero Forcing algorithm) and the first portion of the preamble; and processing Servo Address Mark (SAM) and Gray data in the servo sector using the first gain estimate substantially simultaneous to the step of obtaining the second gain estimate. A gain error can be obtained by calculating a difference between the first gain estimate and the second gain estimate. The gain error can be used in burst processing of the servo data. | 02-02-2012 |
20120033323 | Systems and Methods for Servo Data Based Harmonics Calculation - Various embodiments of the present invention provide systems and methods for servo data based harmonics calculation. For example, a circuit for determining harmonics is disclosed that includes an analog to digital conversion circuit that provides a series of digital samples corresponding to a pattern within a servo data region of a storage medium, and a harmonic calculation circuit. The harmonic calculation circuit is operable to calculate a first harmonic value for the series of digital samples, calculate a second harmonic value for the series of digital samples, and calculate a ratio of the first harmonic value to the second harmonic value. | 02-09-2012 |
20120182643 | Systems and Methods for Reduced Format Data Processing - Various embodiments of the present invention provide systems and methods for data processing. For example, some embodiments of the present invention provide data processing circuits that include a variable gain amplifier circuit, an analog to digital conversion circuit, a cosine component calculation circuit, a sine calculation circuit, and a zero gain start calculation circuit. The variable gain amplifier circuit is operable to apply a gain to a data input corresponding to a gain feedback value and providing an amplified output. The analog to digital conversion circuit is operable to convert the amplified output to a corresponding series of digital samples. The cosine component calculation circuit is operable to calculate a cosine component from the series of digital samples, and the sine component calculation circuit operable to calculate a sine component from the series of digital samples. The zero gain start calculation circuit is operable to calculate a raw gain error value based on the cosine component and the sine component, where the gain feedback value is derived from the raw gain error value. | 07-19-2012 |
20120281305 | Systems and Methods for Servo Data Detection - Various embodiments of the present invention provide systems and methods for data processing. As an example, a data processing circuit is disclosed that includes a codeword detector circuit operable to apply a codeword based data detection algorithm to a data input corresponding to an encoded servo data region to yield a detected output, and a servo address mark processing circuit operable to identify a pre-defined pattern in the detected output. | 11-08-2012 |
20120303327 | Systems and Methods for Pattern Detection - Various embodiments of the present invention provide systems and methods related to pattern detection. As an example, a system for sample selection is disclosed that includes a difference calculation circuit, a comparator circuit, and an output selector circuit. The difference calculation circuit is operable to calculate a first difference between a first value corresponding to a first digital sample and a second value corresponding to a second digital sample, and to calculate a second difference between a third value corresponding to a third digital sample and a fourth value corresponding to a fourth digital sample. The comparator circuit is operable to compare the first difference with the second difference to yield a comparison output. The output selector circuit is operable to select one of the second value and the fourth value as an output based at least upon the comparison output. | 11-29-2012 |
20130107687 | METHODS AND APPARATUS FOR VALIDATING DETECTION OF RRO ADDRESS MARKS | 05-02-2013 |
20130329312 | Multi-Zone Servo Processor - The present inventions are related to systems and methods for transferring information to and from a storage medium, and more particularly to systems and methods for positioning a sensor in relation to a storage medium. For example, an apparatus for determining a sensor position is disclosed that includes a data stream processor operable to generate a number of data streams at different frequencies based on an input data stream, a number of servo preamble detectors each operable to process a different one of the data streams to detect a servo preamble, a selector operable to output one of the data streams in which the servo preamble was detected as a winning data stream, and a pattern detector operable to detect a pattern in the winning data stream. | 12-12-2013 |
20130329313 | Servo Zone Detector - The present inventions are related to systems and methods for transferring information to and from a storage medium, and more particularly to systems and methods for positioning a sensor in relation to a storage medium. For example, an apparatus for determining a sensor position is disclosed that includes discrete Fourier transform calculators operable to process input data to yield a magnitude response of the input data at each of a number of candidate frequencies, a comparator operable to compare the magnitude responses to yield a winning candidate frequency, a servo controller operable to process at least one servo field in the input data to identify a position of a sensor based on the at least one servo field, and a servo frequency synthesizer operable to establish a frequency of operation in the servo controller based at least in part on the winning candidate frequency. | 12-12-2013 |
20140139939 | ADAPTIVE SERVO ADDRESS MARK DETECTION - Various embodiments of the present inventions provide systems and methods for adaptive servo address mark detection. | 05-22-2014 |
20140146413 | Systems and Methods for Enhanced Servo Data Processing - Systems and method relating generally to detecting information, and more particularly without limitation to systems and methods for synchronizing to a data stream. | 05-29-2014 |
20140233128 | Systems and Methods For Burst Demodulation - A data processing circuit with flaw robust burst field demodulation includes a burst integration circuit operable to calculate burst integration results for a servo data burst field, a comparison circuit operable to determine whether an absolute value of the burst integration results falls outside a window, and an error indicating circuit operable to indicate that a media flaw has been detected when the absolute value of the burst integration results fall outside the window. | 08-21-2014 |
20140268397 | Hardware Support of Servo Format with Two Preamble Fields - A hard disk drive uses a second, reference burst field in a preamble to estimate burst phase and burst magnitude. Such estimations are used for position error signal integration and repeatable runout correction. Gain error is also derived from such estimations. Information contained in a preamble field is used in conjunction with the reference burst phase estimation to synchronize servo address marks. | 09-18-2014 |
20140331108 | Systems and Methods for Detecting Media Flaws - An apparatus for detecting media flaws includes a branch metric selection circuit operable to select a first branch metric and a second branch metric, a subtraction circuit operable to subtract the second branch metric from the first branch metric to yield a difference, and a comparator operable to compare the difference with a threshold value and to indicate a presence of a potential flaw in a storage medium when the difference is less than the threshold value. | 11-06-2014 |
20140340780 | Method and System for Sliding-Window Based Phase, Gain, Frequency and DC Offset Estimation for Servo Channel - Sliding-window based data processing includes receiving an analog signal, converting the analog signal to a series of digital samples synchronous to a sampling clock, performing a first discrete Fourier transform on a first portion of the series of digital samples, performing a second discrete Fourier transform on a second portion of the series of digital samples, performing a third discrete Fourier transform on a third portion of the series of digital samples, generating a first series of zero phase start values by calculating a zero phase start value based on the first discrete Fourier transform in a sliding-window at a series of time increments across the servo preamble, storing the zero phase start values, and averaging the stored zero phase start values at the end of the servo preamble. | 11-20-2014 |
Patent application number | Description | Published |
20100324035 | Carboxamide Compounds and Their Use - Chemokine receptor antagonists, in particular, compounds of Formula (I-A) that act as antagonists of the chemokine CCR2 receptor, including pharmaceutical compositions and uses thereof to treat or prevent diseases associated with monocyte accumulation, lymphocyte accumulation or leukocyte accumulation are described herein. | 12-23-2010 |
20100331298 | Carboxamide Compounds and Their Use - Chemokine receptor antagonists, in particular, compounds of Formula (I) that act as antagonists of the chemokine CCR2 receptor, including pharmaceutical compositions and uses thereof to treat or prevent diseases associated with monocyte accumulation, lymphocyte accumulation or leukocyte accumulation are described herein. | 12-30-2010 |
20110212940 | S1P Receptor Modulating Compounds and Use Thereof - The present invention relates to compounds of the general formula (I) that have activity as S1P receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate S1P receptor activity. The compounds may be used as immunomodulators, e.g., for treating or preventing diseases such as autoimmune and related immune disorders including systemic lupus erythematosus, inflammatory bowel diseases such as Crohn's disease and ulcerative colitis, type I diabetes, uveitis, psoriasis, myasthenia gravis, rheumatoid arthritis, non-glomerular nephrosis, hepatitis, Behçet's disease, glomerulonephritis, chronic thrombocytopenic purpura, hemolytic anemia, hepatitis and Wegner's granuloma; and for treating other conditions. | 09-01-2011 |
20110237529 | Adenosine Analogs and Their Use - The invention provides adenosine analog compounds that act at P2Y receptors, e.g., the P2Y | 09-29-2011 |
20120114557 | Methods for Collagen Imaging - Diagnostic compositions and methods for imaging and/or assessing collagen are described. The diagnostic compositions can include collagen binding peptides. | 05-10-2012 |
20120129828 | S1P1 RECEPTOR AGONISTS AND USE THEREOF - The present invention relates to compounds of Formula (I) that are have activity as S1P1 receptor modulating agents, more specifically to specifically compounds that are S1P1 receptor agonists. The invention also related to the use of such compounds to treat diseases associated with inappropriate S1P1 receptor activity such as autoimmune diseases. | 05-24-2012 |
20140038912 | ADENOSINE ANALOGS AND THEIR USE - Provided are adenosine analog compounds of the general formula that act as P2Y receptors, e.g., the P2Y | 02-06-2014 |