Patent application number | Description | Published |
20080287399 | Substituted Aminopyridines and Uses Thereof | 11-20-2008 |
20080306054 | Pharmaceutical Compounds - The invention provides a compound for use as an inhibitor of Hsp90, the compound having the formula (I): | 12-11-2008 |
20090062282 | Substituted Amino-Pyrimidones and Uses Thereof - This invention relates to novel compounds having the structural formula Ia or formula Ib below: (Ia, Ib), and their pharmaceutically acceptable salts, tautomers or in vivo hydrolysable precursors, compositions and methods of use thereof. These novel compounds provide a treatment or prophylaxis of Aβ related pathologies such as cognitive impairment, Alzheimer Disease, neurodegeneration and dementia. | 03-05-2009 |
20090215772 | Hydroxybenzamide derivatives and their use as inhibitors of HSP90 - The invention provides compounds of the formula (I): | 08-27-2009 |
20090221579 | Substituted Amino-Compounds and Uses Thereof - This invention relates to novel compounds having the structural formula Ia or formula Ib: Ia Ib and their pharmaceutically acceptable salts, tautomers or in vivo hydrolysable precursors, compositions and methods of use thereof. These novel compounds provide a treatment or prophylaxis of Aβ related pathologies such as cognitive impairment, Alzheimer Disease, neurodegeneration and dementia. | 09-03-2009 |
20100093748 | SUBSTITUTED PIPERIDINES HAVING PROTEIN KINASE INHIBITING ACTIVITY - The invention provides PKA and PKB kinase-inhibiting compounds of the formula (I): | 04-15-2010 |
20100113551 | COMPOSITIONS COMPRISING (S)-2-AMINO-1-(4-CHLOROPHENYL)-1-[4-(1H-PYRAZOL-4-YL)-PHENYL]-ETHANOL AS MODULATOR OF PROTEIN KINASES - The invention provides a composition comprising (S) 2-amino-1-(4-chloro-phenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol, wherein the composition is either substantially free of (R) 2-amino-1-(4-chloro-phenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol or the composition contains a mixture of the (S) and (R) enantiomers in which the (S) enantiomer predominates. Also provided are processes for the preparation of the (S) 2-amino-1-(4-chloro-phenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol, novel process intermediates and methods for making the novel process intermediates. | 05-06-2010 |
20100152184 | PHARMACEUTICAL COMPOUNDS - The invention provides a compound for use in medicine, the compound being a compound of the formula (VI | 06-17-2010 |
20100216782 | HYDROXYBENZAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF HSP90 - This invention provides methods for treating, alleviating or reducing the incidence of a disease or condition comprising or arising from abnormal cell growth in a mammal, which comprise administering to the mammal a compound, salt, hydrate, tautomer or N-oxide according to formula (I): | 08-26-2010 |
20100286167 | DIHYDROXYPHENYL ISOINDOLYLMETHANONES - This invention provides methods for treating cancer, particularly hematopoietic tumors of lymphoid or myeloid lineage, prostate cancer, lung cancer, gastrointestinal stromal tumor, breast cancer and melanoma, which comprise administering to the mammal a compound, salt, hydrate, tautomer or N-oxide according to formula (I): | 11-11-2010 |
20110046155 | HYDROBENZAMIDE DERIVATIVES AS INHIBITORS OF HSP90 - The invention provides an acid addition salt of a compound of the formula (1) Also provided by the invention are processes for preparing the compound of formula (1) and alkyl analogues thereof, novel intermediates for use in the process and methods for preparing the intermediates. The invention also provides new medical uses of compounds of the formula (1) and its ethyl analogue. | 02-24-2011 |
20110098290 | PHARMACEUTICAL COMPOUNDS - The invention provides a compound of the formula (1): | 04-28-2011 |
20110269808 | COMPOSITIONS COMPRISING (S)-2-AMINO-1-(4-CHLOROPHENYL)-1-[4-(1H-PYRAZOL-4-YL)-PHENYL]-ETHANOL AS MODULATOR OF PROTEIN KINASES - The invention provides a composition comprising (S) 2-amino-1-(4-chloro-phenyl)-1-[4-( | 11-03-2011 |
20120208791 | IMIDAZOPYRIDINE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSINE KINASES - The invention relates to new bicyclic heterocyclic derivative compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer. | 08-16-2012 |
20120251545 | Therapeutic Combinations Of Hydroxybenzamide Derivatives As Inhibitors Of HSP90 - The invention provides a combination comprising an Hsp90 inhibitor compound of the formula (VII): | 10-04-2012 |
20130210820 | Pharmaceutical Compounds - The invention provides a compound of the formula (1): | 08-15-2013 |
20140179666 | BICYCLIC HETEROCYCLE COMPOUNDS AND THEIR USES IN THERAPY - The invention relates to bicyclic heterocycle compounds of formula (I): or tautomeric or stereochemically isomeric forms, N-oxides, pharmaceutically acceptable salts or the solvates thereof; wherein R | 06-26-2014 |
20140221394 | HYDROBENZAMIDE DERIVATIVES AS INHIBITORS OF HSP90 - The invention provides an acid addition salt of a compound of the formula ( | 08-07-2014 |
20150045362 | Hydroxybenzamide Derivatives And Their Use As Inhibitors Of HSP90 - The invention provides compounds of the formula (I): | 02-12-2015 |