Patent application number | Description | Published |
20120220494 | COMPOSITIONS AND METHODS FOR MOLECULAR LABELING - The invention provides barcode libraries and methods of making and using them including obtaining a plurality of nucleic acid constructs in which each construct comprises a unique N-mer and a functional N-mer and segregating the constructs into a fluid compartments such that each compartment contains one or more copies of a unique construct. The invention further provides methods for digital PCR and for use of barcode libraries in digital PCR. | 08-30-2012 |
20130210638 | METHODS FOR SEQUENCING NUCLEIC ACID - The invention generally relates to methods for sequencing a nucleic acid template from both a 5′ and a 3′ end in a single sequencing reaction. In certain embodiments, methods of the invention involve amplifying a nucleic acid template to produce a plurality of amplicons, splitting the amplicons into first and second portions, attaching a first oligonucleotide including a first universal primer site to a 5′ end of the amplicons in the first portion, and attaching a second oligonucleotide including a second universal primer site to a 3′ end of the amplicons in the second portion. The first and second primer sites may be the same or may be different. The method additionally involves pooling the first and second portions, and sequencing the pooled amplicons, thereby sequencing a nucleic acid template from both a 5′ and a 3′ end in a single sequencing reaction. | 08-15-2013 |
20130210659 | MOLECULAR DIAGNOSTIC SCREENING ASSAY - The invention generally relates to method for screening for a condition in a subject. In certain embodiments, methods of the invention involve obtaining a pool of nucleic acids from a sample, incubating the nucleic acids with first and second sets of binders, in which the first set binds uniquely to different regions of a target nucleic acid in the pool, the second set binds uniquely to different regions of a reference nucleic acid in the pool, and the first and second sets include different detectable labels, removing unbound binders, detecting the labels, and screening for a condition based upon results of the detecting step. | 08-15-2013 |
20130225418 | LABELING AND SAMPLE PREPARATION FOR SEQUENCING - The invention provides methods for sequencing and sample preparation for sequencing and amplification. | 08-29-2013 |
20130295567 | DIGITAL ANALYTE ANALYSIS - The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons. | 11-07-2013 |
20150126400 | MOLECULAR DIAGNOSTIC SCREENING ASSAY - The invention generally relates to method for screening for a condition in a subject. In certain embodiments, methods of the invention involve obtaining a pool of nucleic acids from a sample, incubating the nucleic acids with first and second sets of binders, in which the first set binds uniquely to different regions of a target nucleic acid in the pool, the second set binds uniquely to different regions of a reference nucleic acid in the pool, and the first and second sets include different detectable labels, removing unbound binders, detecting the labels, and screening for a condition based upon results of the detecting step. | 05-07-2015 |
Patent application number | Description | Published |
20100209467 | TDF-RELATED COMPOUNDS AND ANALOGS THEREOF, ANALOGS AND BIOACTIVE FRAGMENTS - The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules, which act as functional modulators of TDF-like receptors. The invention further relates to methods of detecting, preventing, and treating TDF-associated disorders. | 08-19-2010 |
20130231294 | TDF-RELATED COMPOUNDS AND ANALOGS THEREOF, ANALOGS AND BIOACTIVE FRAGMENTS - The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules, which act as functional modulators of TDF-like receptors. The invention further relates to methods of detecting, preventing, and treating TDF-associated disorders. | 09-05-2013 |
20150126451 | TDF-RELATED COMPOUNDS AND ANALOGS THEREOF, ANALOGS AND BIOACTIVE FRAGMENTS - The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules, which act as functional modulators of TDF-like receptors. The invention further relates to methods of detecting, preventing, and treating TDF-associated disorders. | 05-07-2015 |
Patent application number | Description | Published |
20090240218 | Wound Therapy System - A portable system for subatmospheric pressure therapy in connection with healing a surgical wound includes a wound dressing dimensioned for positioning relative to a wound bed of a subject and a portable subatmospheric pressure mechanism dimensioned to be carried or worn by the subject. The subatmospheric pressure mechanism includes a housing having a control unit, a collection canister, and means for releasably connecting the housing and the canister. The collection canister collects exudates from the wound bed which has been removed under subatmospheric pressure supplied by the control unit. The connection means between the housing and the canister permits the removal of the canister for emptying thereof or replacement with a new collection canister. | 09-24-2009 |
20100036334 | Wound Dressing of Continuous Fibers - A method for treating a wound that includes incorporating a wound dressing comprising a plurality of fibers, each fiber having a length of at least two (2) inches, into a wound to cause the walls of the wound to remain apart and allow the wound to heal from the inside to the outside, and removing the wound exudate. | 02-11-2010 |
20100191197 | Flanged Connector for Wound Therapy - A wound dressing for use in negative wound pressure therapy includes a cover layer for positioning over a wound to define a reservoir over the wound in which a reduced pressure may be maintained. At least one vacuum port is affixed to the cover layer and includes a conduit receiving portion configured to receive a fluid conduit to provide fluid communication between the fluid conduit and the reservoir. The at least one vacuum port is configured to receive the fluid conduit from a plurality of directions relative to the cover layer. | 07-29-2010 |
20120083712 | Monitoring Compliance Using Venous Refill Detection - Monitoring patient compliance with a compression therapy regimen. Venous Refill Time (VRT) is monitored via a pressure sensor in a bladder of a compression system. A controller of the compression system correlates the monitored VRT to a predetermined threshold to determine whether the patient is using the compression system. | 04-05-2012 |
20130144229 | Flanged Connector for Wound Therapy - A wound dressing for use in negative wound pressure therapy includes a cover layer for positioning over a wound to define a reservoir over the wound in which a reduced pressure may be maintained. At least one vacuum port is affixed to the cover layer and includes a conduit receiving portion configured to receive a fluid conduit to provide fluid communication between the fluid conduit and the reservoir. The at least one vacuum port is configured to receive the fluid conduit from a plurality of directions relative to the cover layer. | 06-06-2013 |
20130204213 | Wound Dressing of Continuous Fibers - A method for treating a wound that includes incorporating a wound dressing comprising a plurality of fibers, each fiber having a length of at least two (2) inches, into a wound to cause the walls of the wound to remain apart and allow the wound to heal from the inside to the outside, and removing the wound exudate. | 08-08-2013 |
20130310720 | Venous Augmentation System - A method for augmenting blood flow in a limb that is wrapped with a sleeve having at least one chamber for applying compression to the limb in a region generally underlying the chamber includes pressurizing the chamber to a first compression pressure and then reducing the pressure to a refill pressure. Pressure in the chamber is then sensed to determine a first venous refill time. The preceding steps are repeated a second and other times using second and other compression pressures that are different from the first compression pressure and from each other to determine second and other venous refill times. A customized compression pressure is determined by locating the compression pressure at which blood flow out of the region generally underlying the chamber is maximized by finding compression pressure at a maximum venous refill time. A compression device employing such a method is also disclosed. | 11-21-2013 |
20140323997 | WOUND DRESSING OF CONTINUOUS FIBERS - A method for treating a wound that includes incorporating a wound dressing comprising a plurality of fibers, each fiber having a length of at least two (2) inches, into a wound to cause the walls of the wound to remain apart and allow the wound to heal from the inside to the outside, and removing the wound exudate. | 10-30-2014 |
20150094628 | COMPRESSION GARMENT VENTILATION - A compression garment includes fluid-impermeable bladder layers defining an inflatable bladder. A ventilator is at least partially disposed on an inward side of the inflatable bladder. The ventilator at least partially defines at least one passage between the wearer's skin and the inward side of the bladder and in fluid communication with atmospheric air at a location outside of the compression garment when the compression garment is worn on the wearer's body part. The ventilator is flexible to collapse the at least one passage under the force of inflation of the bladder and to resiliently expand the at least one passage upon deflation of the bladder. The collapse of the at least one passage expels air from the at least one passage to the atmospheric air and the expansion of the at least one passage draws the atmospheric air into the at least one passage. | 04-02-2015 |
Patent application number | Description | Published |
20090237511 | MULTI-WINDOW/MULTI-TARGET TRACKING (MW/MT TRACKING) FOR POINT SOURCE OBJECTS - A sensor is used to detect and track a plurality of objects by using a separate track window for each object. Such sensors may be electro optical or infrared. Each object of interest (potential target) in the sensor FOV has a unique track window assigned. This allows independent control of video frame summing for each object to maintain a constant (optimized) signal to noise ratio (SNR) over an extremely large signal dynamic range and reduces track jitter by the simultaneous tracking of multiple objects. | 09-24-2009 |
20100123951 | LOW BACKGROUND FLUX TELESCOPE - A telescope design is disclosed that has at least some of its interior facing surfaces configured with corner reflectors, so that a detector operatively coupled to the telescope views itself, instead of those surfaces. The corner reflectors may be on, for example, interior facing surfaces of a conventional baffle appended to the telescope and/or minor supports or other structures inside the telescope housing that are within the detector's FOV. Likewise, the corner reflectors may be on interior facing surfaces of a baffle that is integrated into the telescope housing. In some such cases, the integrated baffle can be configured as both a baffle and a mirror support. The integrated baffle can be shaped to the F-cone between minors of a given telescope design, and/or configured to minimize or otherwise reduce the total obscuration of the baffle to improve the optical throughput. | 05-20-2010 |
20110176205 | INTEGRATED TELESCOPE BAFFLE AND MIRROR SUPPORT - A telescope design having an integrated baffle is disclosed herein. The integrated baffle is configured as both a baffle and a mirror support. The integrated baffle can be shaped to the F-cone between the primary and secondary mirrors of a given telescope design. The baffle design can be adjusted to minimize or otherwise reduce the total obscuration of the baffle to improve the optical throughput. The interior facing surfaces of the integrated baffle can be configured with corner reflectors, so that the detector views itself, instead of the baffle. | 07-21-2011 |