Patent application number | Description | Published |
20080204009 | Method of Determining a Spatial Distribution of Magnetic Particles - The invention relates to a method of determining a spatial distribution of magnetic particles in an examination zone, in which method a first magnetic field is generated, which forms in the examination zone a first sub-zone having a relatively low magnetic field strength and a second sub-zone having a relatively high magnetic field strength. The position in space of the two sub-zones is then changed by a second magnetic field, whereby the magnetization in the examination zone is changed. Signals dependent on the change in magnetization are acquired and evaluated to extract information concerning the spatial distribution of the magnetic particles. The second magnetic field is generated so that the time derivative of the second magnetic field is substantially identical for each spatial component. | 08-28-2008 |
20080230715 | Optical Imaging - An optical imaging apparatus ( | 09-25-2008 |
20080231264 | System and Method for Magnetic Tracking of a Sensor for Interventional Device Localization - A system and method for determining the location of a remote object using a magnetic tracking sensor. The system and method include locating a magnetic core ( | 09-25-2008 |
20080278168 | Transmission Line for Use in Rf Fields - An electrically conductive link (connection lead) or transmission line ( | 11-13-2008 |
20080308746 | Optical Fluorescence Tomography - The invention relates to an optical fluorescence tomography system of biological targets. For increasing the resolution an the penetration depth of the impact radiation, in order to result a better depth signal, the biological target is supplied with a fluorescence dye (Material), bleachable by impact radiation, wherein a controllable dynamic tissue-wise bleaching-effect of the fluorescence dye is generated, so that by time dependant measuring of the maximum fluorescence response signal can be correlated to the actual selective bleaching front in depth. | 12-18-2008 |
20090240135 | METHOD OF DETERMINING A SPATIAL DISTRIBUTION OF MAGNETIC PARTICLES - The invention relates to a method of determining a spatial distribution of magnetic particles in an examination zone, in which a magnetic field is generated that has a first sub-zone of lower magnetic field strength and a second sub-zone of higher magnetic field strength. The positions of the two sub-zones are changed, as a result of which the magnetization in the examination zone changes. Measured values that depend on the change in magnetization are acquired. A reference response function by means of which measured values can be determined mathematically from a spatial distribution of magnetic particles is then determined by means of at least extensive magnetic specimen distribution. Finally, the spatial distribution of magnetic particles is reconstructed from the measured values by means of the reference response function. | 09-24-2009 |
20090251236 | TRANSMISSION PATH FOR USE IN RF FIELDS - A transmission path ( | 10-08-2009 |
20090281416 | ARRANGEMENT AND METHOD FOR DETERMINING THE SPATIAL DISTRIBUTION OF MAGNETIC PARTICLES - The invention relates to an arrangement and a method for determining the spatial distribution of magnetic particles in an examination area. Magnetic field means are used to generate a spatially inhomogeneous gradient magnetic field with at least one region with a low field strength, in which the magnetization of the particles is in a state of non- saturation, whereas they are in a state of saturation in the remaining region. By using change means to shift the area with a low field strength within the examination area, a change in the magnetization of the magnetic particles is brought about which can be detected from outside by detection means and contains information about the spatial distribution of the magnetic particles in the examination area. The magnetic field means or the change means or the detection means or a combination of these means are arranged at least partially on a medical instrument. | 11-12-2009 |
20090299176 | MARKER FOR POSITION DETERMINATION WITH A MAGNETIC METHOD - The invention relates to an arrangement and a method for determining the spatial distribution of magnetic particles in an examination area. Magnetic field means are used to generate a spatially inhomogeneous gradient magnetic field with at least one region with a low field strength, in which the magnetization of the particles is in a state of non-saturation, whereas they are in a state of saturation in the remaining region. By using change means to shift the area with a low field strength within the examination area, a change in the magnetization of the magnetic particles is brought about which can be detected from outside by detection means and contains information about the spatial distribution of the magnetic particles in the examination area The magnetic field means or the change means or the detection means or a combination of these means are arranged at least partially on a medical instrument. | 12-03-2009 |
20100004528 | INTERVENTIONAL DEVICE FOR RF ABLATION FOR USE IN RF FIELDS - A interventional device for RF ablation for use in a RF electrical and/or magnetic field especially of a MR imaging system is disclosed, comprising an ablation catheter which is preferably trackable or can be guided or visualized in the image generated by the MR imaging system by means of a MR micro-coil ( | 01-07-2010 |
20100033171 | ARRANGEMENT AND METHOD FOR INFLUENCING AND/OR DETECTING MAGNETIC PARTICLES IN A REGION OF ACTION - An arrangement and a method for influencing and/or detecting magnetic particles in a region of action is disclosed, which arrangement comprises:—selection means for generating a magnetic selection field having a pattern in space of its magnetic field strength such that a first sub-zone having a low magnetic field strength and a second sub-zone having a higher magnetic field strength are formed in the region of action,—drive means for changing the position in space of the two sub-zones in the region of action by means of a magnetic drive field so that the magnetization of the magnetic particles changes locally, wherein the selection means comprises at least one permanent magnet wherein the permanent magnet is at least partially shielded by an electrically high conductive shielding means. | 02-11-2010 |
20100033172 | ARRANGEMENT AND METHOD FOR INFLUENCING AND/OR DETECTING AND/OR LOCATING MAGNETIC PARTICLES IN A REGION OF ACTION - An arrangement and a method for influencing and/or detecting and/or locating magnetic particles in a region of action is disclosed, which arrangement comprises: —drive means for generating a magnetic drive field so that the magnetization of the magnetic particles changes, wherein the magnetic particles comprise at least a first and a second magnetic particle, —the receiving means comprising at least a first receiving probe providing a first signal ( | 02-11-2010 |
20100033174 | ARRANGEMENT AND METHOD FOR INFLUENCING AND/OR DETECTING MAGNETIC PARTICLES IN A REGION OF ACTION - An arrangement for influencing and/or detecting magnetic particles, a method for calibrating such an arrangement and a method for influencing and/or detecting magnetic particles in a region of action is disclosed, which arrangement comprises selection means for generating a magnetic selection field having a pattern in space of its magnetic field strength such that a first sub-zone having a low magnetic field strength and a second sub-zone having a higher magnetic field strength are formed in the region of action, drive means for changing the position in space of the two sub-zones in the region of action by means of a magnetic drive field so that the magnetization of the magnetic particles changes locally, the arrangement comprising a drive signal chain, receiving means for acquiring detection signals, which detection signals depend on the magnetization in the region of action, which magnetization is influenced by the change in the position in space of the first and second sub-zone, the arrangement comprising a detection signal chain, wherein the arrangement comprises a compensation controller providing a compensation signal to the drive signal chain and/or to the detection signal chain by means of a coupling means. | 02-11-2010 |
20100041977 | CATHETER AND MEDICAL ASSEMBLY - The present invention relates to a catheter ( | 02-18-2010 |
20100045280 | ARRANGEMENT AND METHOD FOR INFLUENCING AND/OR DETECTING MAGNETIC PARTICLES IN A REGION OF ACTION, COIL ARRANGEMENT - An arrangement and a method for influencing and/or detecting magnetic particles in a region of action is disclosed, which arrangement comprises: selection means for generating a magnetic selection field having a pattern in space of its magnetic field strength such that a first sub-zone having a low magnetic field strength and a second sub-zone having a higher magnetic field strength are formed in the region of action, drive means for changing the position in space of the two sub-zones in the region of action by means of a magnetic drive field so that the magnetization of the magnetic particles changes locally, receiving means for acquiring signals, which signals depend on the magnetization in the region of action, which magnetization is influenced by the change in the position in space of the first and second sub-zone, wherein the arrangement comprises a coil arrangement comprising a surrounding coil and a magnetic field generator such that the surrounding coil almost completely surrounds the magnetic field generator. | 02-25-2010 |
20100072984 | INFLUENCING AND/OR DETECTING MAGNETIC PARTICLES IN A REGION OF ACTION OF AN EXAMINATION OBJECT - A method and an arrangement for influencing and/or detecting magnetic particles in a region of action of an examination object is disclosed, which method comprises the steps of: generating a magnetic selection field by means of selection means, the magnetic selection field having a pattern in space of its magnetic field strength such that a first sub-zone having a low magnetic field strength and a second sub-zone having a higher magnetic field strength are formed in the region of action, changing the position in space of the two sub-zones in the region of action by means of a magnetic drive field generated by drive means so that the magnetization of the magnetic particles change locally, acquiring signals by means of receiving means, which signals depend on the magnetization in the region of action, which magnetization is influenced by the change in the position in space of the first and second sub-zone, wherein the selection means and/or the drive means and/or the receiving means are provided at least partly movable relative to the examination object during the acquisition and/or the change in the position in space of the two sub-zones in the region of action. | 03-25-2010 |
20100072991 | METHOD AND ARRANGEMENT FOR LOCATING MAGNETIC MARKERS IN A REGION OF ACTION - A method and an arrangement for influencing and/or detecting and/or locating magnetic markers in a region of action is disclosed, which method comprises the steps of: generating a magnetic drive field so that the magnetization of the magnetic marker changes, generating a magnetic selection field having a pattern in space of its magnetic field strength providing a magnetic field gradient in the region of action, acquiring a first signal by means of a first receiving probe and acquiring a second signal by means of a second receiving probe, the first receiving probe and the second receiving probe being located at different locations relative to the region of action, the first signal and the second signal depending on the magnetization of the magnetic marker in the drive field and in the selection field and further depending on the location of the magnetic marker, the magnetic selection field having a first magnetic field strength configuration, repeating at least once the acquisition of the first signal and of the second signal in the presence of the selection field having a second magnetic field strength configuration, computing an estimation of the location of the magnetic marker by means of the acquired signals. | 03-25-2010 |
20100243574 | SEPARATOR COLUMN, SEPARATOR SYSTEM, METHOD OF FRACTIONATING MAGNETIC PARTICLES, METHOD OF MANUFACTURING A SEPARATOR COLUMN AND USE OF A SEPARATOR COLUMN - A separator system with a separator column and a method of fractionating magnetic particles, preferably using field-flow fractionation is proposed, which allows for more effective fractionation of magnetic particles with respect to their dynamic magnetic response in a wide frequency and amplitude range of an applied magnetic field, in particular relevant for magnetic particle imaging (MPI). | 09-30-2010 |
20100249578 | ARRANGEMENT AND METHOD FOR DETERMINING THE SPATIAL DISTRIBUTION OF MAGNETIC PARTICLES - The invention relates to an arrangement and a method for determining the spatial distribution of magnetic particles in an examination area. Magnetic field means are used to generate a spatially inhomogeneous gradient magnetic field with at least one region with a low field strength, in which the magnetization of the particles is in a state of non-saturation, whereas they are in a state of saturation in the remaining region. By using change means to shift the area with a low field strength within the examination area, a change in the magnetization of the magnetic particles is brought about which can be detected from outside by detection means and contains information about the spatial distribution of the magnetic particles in the examination area. The magnetic field means or the change means or the detection means or a combination of these means are arranged at least partially on a medical instrument. | 09-30-2010 |
20110237928 | ARRANGEMENT AND METHOD FOR DETECTING AND/OR LOCATING A MAGNETIC MATERIAL IN A REGION OF ACTION - In Magnetic Particle Imaging (MPI) the reconstruction requires the knowledge of a so called system function. This function describes the relation between spatial position and frequency response. For reasonable resolutions and field of views the system function becomes quite large, resulting in large acquisition times for the system function and high memory demand during reconstruction. The present invention proposes to reduce the size of the system function matrix by making use of structural properties of the matrix. Such properties are, for instance, spatial symmetries reducing the number of columns and identical responses at different frequencies reducing the number of rows. In other embodiments the matrix can be transformed to a sparse representation using appropriate base functions. | 09-29-2011 |
20110246103 | ARRANGEMENT AND METHOD FOR DETECTING AND/OR LOCATING A MAGNETIC MATERIAL IN A REGION OF ACTION - In Magnetic Particle Imaging (MPI) the reconstruction requires the knowledge of a so called system function. This function describes the relation between spatial position and frequency response and is currently measured once for a scanner set-up and a tracer material. For reasonable resolutions and fields of view the system function becomes quite large, resulting in large acquisition times to obtain reasonable signal-to-noise. However, the system function has a number of properties which can be used to improve signal-to-noise. According to the present invention use is made of the spatial symmetry and/or identical responses at different frequencies for this purpose. | 10-06-2011 |
20110251476 | ARRANGEMENT AND METHOD FOR MEASURING THE LOCAL VELOCITY OF A LIQUID - The present invention relates to an arrangement ( | 10-13-2011 |
20110273175 | PERMANENT MAGNETIC ASSEMBLY FOR - The present invention relates to an arrangement ( | 11-10-2011 |
20120035456 | ARRANGEMENT FOR IMAGING AN OBJECT INCLUDING A VESSEL USING MAGNETIC PARTICLE IMAGING - An arrangement ( | 02-09-2012 |
20120065491 | ARRANGEMENT AND METHOD FOR INFLUENCING AND/OR DETECTING MAGNETIC PARTICLES - The present invention relates to an arrangement and a method for influencing and/or detecting magnetic particles in a region of action, in particular for monitoring of intra-cerebral or intra-cranial bleeding using Magnetic Particle Imaging (MPI). A common coupling unit per coil of a coil array is provided for coupling all signals for generating the magnetic fields to the set of common coils. Further, the same coils are used for acquiring detection signals. In this way a small scanner can be built that can be left permanently or can be provided periodically to the patient, in particular for bleeding monitoring. | 03-15-2012 |
20120119739 | ARRANGEMENT AND METHOD FOR INFLUENCING AND/OR DETECTING MAGNETIC PARTICLES AND FOR MAGNETIC RESONANCE IMAGING - Magnetic particle imaging allows the imaging of fast tracer dynamics, but there is no native tissue contrast. A combination with MRI solves this issue. However, coil geometries in MPI and MRI differ significantly, making direct use impractical. According to one aspect of the present invention it is proposed to use pre-polarized MRI to overcome these difficulties. Further, methods and arrangements are proposed to achieve MRI imaging with minimal additional hardware. | 05-17-2012 |
20120146632 | APPARATUS AND METHOD FOR INFLUENCING AND/OR DETECTING MAGNETIC PARTICLES - The present invention relates to an apparatus and a method for void size determination of voids within an object into which an aerosol containing magnetic particles has been introduced, in particular for determining the size of a patient's pulmonary alveoli, said patient having inhaled an aerosol containing magnetic particles To review information concerning the lung structure, it is proposed to use magnetic particle imaging. First and second detection signals are acquired subsequently at different moments in time after introduction of the aerosol containing the magnetic particles into the object, in particular after inhalation of the aerosol by the patient. These detection signals are exploited, in particular the drop in intensity and/or the signal decay time, to get information about the diffusion of the magnetic particles within the voids, in particular alveoli, and to retrieve information therefrom about the size of the voids, in particular alveoli. | 06-14-2012 |
20120152262 | APPARATUS AND METHOD FOR MOVING AND ACTIVATING AN ACTIVE AGENT - The present invention relates to an apparatus ( | 06-21-2012 |
20120153948 | APPARATUS AND METHOD FOR INFLUENCING AND/OR DETECTING MAGNETIC PARTICLES IN A FIELD OF VIEW - The present invention relates to an apparatus ( | 06-21-2012 |
20120157823 | APPARATUS AND METHOD FOR CONTROLLING THE MOVEMENT AND FOR LOCALIZATION OF A CATHETER - The present invention relates to apparatus ( | 06-21-2012 |
20120165649 | APPARATUS AND METHOD FOR MEASURING THE INTERNAL PRESSURE OF AN EXAMINATION OBJECT - The present invention relates to an apparatus ( | 06-28-2012 |
20120172738 | APPARATUS AND METHOD FOR NON-INVASIVE INTRACARDIAC ELECTROCARDIOGRAPHY USING MPI - The present invention relates to an apparatus and a corresponding method for non-invasive intracardiac electrocardiography (ECG) by use of a magnetic and electrically conducting interference device ( | 07-05-2012 |
20120183197 | DEVICE AND METHOD FOR GENERATING SOFT TISSUE CONTRAST IMAGES - The present invention relates to a device for generating soft tissue contrast images of an area of interest of an examination object ( | 07-19-2012 |
20130225979 | COLON SCREENING BY USING MAGNETIC PARTICLE IMAGING - The present invention relates to a method for colon screening by using Magnetic Particle Imaging comprising the steps of: (a) generating an imaging magnetic field with a spatial distribution of the magnetic field strength such that the area of examination in the colon consists of a first sub-area of the colon with lower magnetic field strength, where the magnetization of a magnetic particle which was pre-delivered to the colon is not saturated, and a second sub-area of the colon with a higher magnetic field strength, where the magnetization of said magnetic particle is saturated; (b) changing the spatial location of both sub-areas in the area of examination so that the magnetization of said particles changes locally; (c) acquiring signals that depend on the magnetization in the area of examination influenced by this change; and (d) evaluating said signals to obtain information about the spatial distribution of the signals in the area of examination. The area of examination in the colon preferably comprises a portion or segment of the colon and steps (a) to (c) may be carried out during an entire peristaltic cycle in said colon portion or segment. The present invention further relates to a corresponding method for collecting data, the use of a magnetic particle for colon screening via Magnetic Particle Imaging, a food stuff or liquid for in vivo diagnostic use comprising a magnetic particle, and a method for preparing a patient for colon screening by using Magnetic Particle Imaging. | 08-29-2013 |
20130253304 | APPARATUS AND METHOD FOR INFLUENCING AND/OR DETECTING MAGNETIC PARTICLES - The present invention relates to an apparatus and a method for influencing and/or detecting magnetic particles in a field of view ( | 09-26-2013 |
20130338481 | DEVICE AND METHOD FOR EXAMINATION AND USE OF AN ELECTRICAL FIELD IN AN OBJECT UNDER EXAMINATION CONTAINING MAGNETIC PARTICLES - Aspects of the present invention relate to a device and method for examining and using an electrical field in a magnetic gradient field, containing magnetic particles in an examination area of an object under examination, including introducing magnetic particles into at least part of the examination area of the object under examination; generating an electrical field at least in part of the examination area; generating a magnetic field having a spatial magnetic field strength profile with a first sub-zone with a low magnetic field strength and a second sub-zone with a higher magnetic field strength in the examination area; varying a spatial position of the two sub-zones in the examination area such that a magnetization of the particles changes locally; detecting signals which depend on the magnetization in the examination area influenced by this variation; evaluating the signals to obtain information about the spatial distribution of the magnetic particles in the examination area; and determining a conductivity in the examination area as a function of a magnetization status of the magnetic particles. | 12-19-2013 |
20140306698 | APPARATUS AND METHOD FOR INFLUENCING AND/OR DETECTING MAGNETIC PARTICLES HAVING A LARGE FIELD OF VIEW - The present invention relates to an apparatus and a method for influencing and/or detecting magnetic particles in a field of view ( | 10-16-2014 |