Patent application number | Description | Published |
20090217854 | HINGE FOR FLOATING DOCK ASSEMBLY - In particular embodiments, a connection assembly for interconnecting two adjacent floats includes first and second hinge mounting members that are secured to respective floats, such as floating concrete dock sections, and a flexible hinge that is releasably connected at each end to the hinge mounting members so as to interconnect the two floats. The hinge mounting members can be, for example, rigid housings that are disposed in respective recesses formed in the concrete dock sections. The flexible hinge includes at least one layer of a flexible material, such as elastomeric belting material, and desirably includes several layers of flexible material, which can be placed in tension across the two floats. In certain embodiments, the hinge mounting members can be easily accessed from the side of the floats adjacent the joint in order to disconnect and remove the hinge for repair or replacement, without having to physically separate the floats. | 09-03-2009 |
20100124461 | CONCRETE FLOAT AND METHOD OF MANUFACTURE - A concrete floating dock can be formed using a form that has an inner and an outer form. Concrete sections can be cast such that they include a deck portion and two longitudinally extending side walls that extend downwardly from the deck portion. The concrete sections can be removed from the form and coupled together to form a concrete floating dock. One or more buoyancy elements can be positioned in the cavities of the fully cured concrete sections before or after the concrete sections are coupled to each other. | 05-20-2010 |
20100196098 | WAVE ATTENUATION SYSTEMS - Wave attenuation systems are disclosed. For example, a wave-attenuating panel can define a plane, a center-of buoyancy and a center-of-mass spaced from the center-of-buoyancy such that the panel is stably buoyant in a liquid with the plane oriented vertically. Wave attenuators are also disclosed. Such a wave attenuator can comprise a first row of support members extending vertically relative to a seabed and a second row of support members spaced from the first row. A vertically oriented, movable panel can be positioned between the first row and the second row, such that the panel is configured to rise and fall in a substantially vertical plane. Such wave attenuators can also comprise a second, fixed panel that remains submerged. | 08-05-2010 |
20130011197 | WAVE ATTENUATION SYSTEMS - Wave attenuation systems are disclosed. For example, a wave-attenuating panel can define a plane, a center-of buoyancy and a center-of-mass spaced from the center-of-buoyancy such that the panel is stably buoyant in a liquid with the plane oriented vertically. Wave attenuators are also disclosed. Such a wave attenuator can comprise a first row of support members extending vertically relative to a seabed and a second row of support members spaced from the first row. A vertically oriented, movable panel can be positioned between the first row and the second row, such that the panel is configured to rise and fall in a substantially vertical plane. Such wave attenuators can also comprise a second, fixed panel that remains submerged. | 01-10-2013 |
Patent application number | Description | Published |
20080226657 | MONOMETHYLVALINE COMPOUNDS CAPABLE OF CONJUGATION TO LIGANDS - Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo. | 09-18-2008 |
20080248051 | MONOMETHYLVALINE COMPOUNDS CAPABLE OF CONJUGATION TO LIGANDS - Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo. | 10-09-2008 |
20080248053 | MONOMETHYLVALINE COMPOUNDS CAPABLE OF CONJUGATION TO LIGANDS - Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo. | 10-09-2008 |
20090047296 | MONOMETHYLVALINE COMPOUNDS CAPABLE OF CONJUGATION TO LIGANDS - Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo. | 02-19-2009 |
20120003248 | MONOMETHYLVALINE COMPOUNDS CAPABLE OF CONJUGATION TO LIGANDS - Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo. | 01-05-2012 |
20120027783 | MONOMETHYLVALINE COMPOUNDS CAPABLE OF CONJUGATION TO LIGANDS - Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo. | 02-02-2012 |
20120027784 | MONOMETHYLVALINE COMPOUNDS CAPABLE OF CONJUGATION TO LIGANDS - Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo. | 02-02-2012 |
20120034246 | MONOMETHYLVALINE COMPOUNDS CAPABLE OF CONJUGATION TO LIGANDS - Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo. | 02-09-2012 |
20120034247 | MONOMETHYLVALINE COMPOUNDS CAPABLE OF CONJUGATION TO LIGANDS - Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo. | 02-09-2012 |
20120141508 | MONOMETHYLVALINE COMPOUNDS CAPABLE OF CONJUGATION TO LIGANDS - Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo. | 06-07-2012 |
20120141509 | MONOMETHYLVALINE COMPOUNDS CAPABLE OF CONJUGATION TO LIGANDS - Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo. | 06-07-2012 |
20120141510 | MONOMETHYLVALINE COMPOUNDS CAPABLE OF CONJUGATION TO LIGANDS - Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo. | 06-07-2012 |
20120148608 | MONOMETHYLVALINE COMPOUNDS CAPABLE OF CONJUGATION TO LIGANDS - Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo. | 06-14-2012 |
20120148610 | MONOMETHYLVALINE COMPOUNDS CAPABLE OF CONJUGATION TO LIGANDS - Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo. | 06-14-2012 |
20140127197 | Anti-CD22 Antibodies and Immunoconjugates and Methods of Use - Anti-CD22 antibodies and immunoconjugates thereof are provided. Methods of using anti-CD22 antibodies and immunoconjugates thereof are provided. | 05-08-2014 |
20150098900 | ANTI-FCRH5 ANTIBODIES - The invention provides anti-FcRH5 antibodies and immunoconjugates and methods of using the same. | 04-09-2015 |
Patent application number | Description | Published |
20100305800 | METHOD AND APPARATUS FOR DETECTING ENGINE FIRING IN A HYBRID POWERTRAIN SYSTEM - A method for controlling a hybrid powertrain system includes commanding engine operation to transition from an engine-off state to an engine-on state. A control scheme detects engine firing based upon input speed, input torque and a change in the input torque. | 12-02-2010 |
20110066359 | METHOD AND APPARATUS FOR OPTIMIZING ENGINE ON/OFF CYCLING IN A VEHICLE - A method is provided for optimizing the cycling frequency between engine on/off states in a vehicle having a controller and auto start/auto stop functionality. The method includes detecting an engine state cycling event, measuring a plurality of vehicle operating values, and using the controller to optimize the cycling frequency via at least one of: automatically adjusting an interval between an auto start event and an auto stop event when each of a first set of the vehicle operating values exceeds a corresponding threshold, and temporarily inhibiting the auto start/auto stop functionality when any value in a second set of the vehicle operating values falls outside of a hysteresis band created around the second set. A vehicle includes an engine and a controller having an algorithm for optimizing the cycling frequency between engine on/off states as set forth above. | 03-17-2011 |
20120065023 | SYSTEM AND METHOD FOR CONTROLLING AMOUNT OF TIME NEEDED TO COMMENCE TRANSMITTING ENGINE TORQUE IN A VEHICLE - A method controls an amount of time required to commence transmitting torque of an internal combustion engine equipped with a stop/start feature to a transmission configured to transmit the torque of the engine to drive-wheels in a vehicle. The method includes determining whether a start of the engine is likely. The method also includes pre-filling with fluid a hydraulically-actuated clutch that is configured to connect the engine to the transmission when the start of the engine is likely. Accordingly, the amount of time required to commence transmitting torque of the engine to the transmission is reduced. A system employs the method for controlling an amount of time required to commence transmitting torque of the engine. | 03-15-2012 |
20120323461 | METHOD AND APPARATUS FOR CONTROLLING HYBRID POWERTRAIN SYSTEM IN RESPONSE TO ENGINE TEMPERATURE - A method for controlling a hybrid powertrain system including an internal combustion engine includes controlling operation of the hybrid powertrain system in response to a preferred minimum coolant temperature trajectory for the internal combustion engine. | 12-20-2012 |
20130225363 | METHOD TO REDUCE POWERTRAIN NOISE AND VIBRATION DURING ENGINE START IN HYBRID VEHICLE - A method of controlling a powertrain system of a hybrid vehicle includes detecting a request to start an engine, incrementally applying torque to the powertrain system, and biasing the torque against a static member of the powertrain system, such as a parking pawl of a transmission when the transmission is disposed in a parking position, to remove lash from the powertrain system prior to starting the engine. | 08-29-2013 |
20130316872 | METHOD AND APPARATUS FOR CONTROLLING A HYDRAULIC PUMP FOR A MULTIMODE TRANSMISSION OF A POWERTRAIN SYSTEM - A powertrain system includes an internal combustion engine configured to execute autostop and autostart operations, and a multi-mode transmission with an electrically-powered hydraulic pump configured to provide pressurized hydraulic fluid to a hydraulic circuit. A Method for controlling operation of the hydraulic pump includes operating the hydraulic pump in a low power mode only when the engine is in an engine-off state, operator inputs to a brake pedal, an accelerator pedal, and a transmission range selector are within allowable states, temperatures of select transmission components are within respective predetermined temperature ranges, and transmission output torque is less than a threshold torque request. | 11-28-2013 |
20140031171 | METHOD AND APPARATUS FOR EXECUTING A CLUTCH-DRIVEN ENGINE AUTOSTART OPERATION - A powertrain system includes an internal combustion engine, a multi-mode transmission and a driveline. A method for controlling the powertrain system in response to a command to execute an engine autostart operation during vehicle operation includes executing a clutch-driven engine autostart operation to start the engine upon determining that a present transmission output speed is greater than a minimum output speed for engine operation and upon determining that a selected clutch configured to effect a mechanical coupling between the engine and the driveline is activatable. | 01-30-2014 |
20140195080 | HYBRID POWERTRAIN INPUT TORQUE MANAGEMENT - A method for controlling a hybrid powertrain includes monitoring input torque of an input member and may include determining an oscillation torque. The method monitors critical vehicle characteristics, including at least a transmission operating mode and an input speed, and operates the powertrain at the input torque. The method compares input torque to a minimum threshold or oscillation torque to a fatigue threshold and identifies a first critical event, which occurs when input torque exceeds the minimum threshold or oscillation torque exceeds the fatigue threshold. The method identifies a first peak with the on-board controller during the first critical event. Peak events occur when the monitored input torque or oscillation torque changes between positive and negative slope. The method identifies a first CVC set occurring with the first peak and may record the first CVC set and the first peak in a look-up table. | 07-10-2014 |
Patent application number | Description | Published |
20140277761 | CONTROLLING AN HVAC SYSTEM IN ASSOCIATION WITH A DEMAND-RESPONSE EVENT - Apparatus, systems, methods, and related computer program products for carrying out a demand response (DR) event via an intelligent, network-connected thermostat associated with a structure. The systems disclosed include an energy management system in operation with an intelligent, network-connected thermostat located at a structure. The thermostat is operable to control an HVAC system. Control during a DR event period may be performed based on an optimal control trajectory of the HVAC system, where the control trajectory is optimal in that it minimizes a cost function comprising a combination of a first factor representative of a total energy consumption during the DR event period, a second factor representative of a metric of occupant discomfort, and a third factor representative of deviations of a rate of energy consumption over the DR event period. | 09-18-2014 |
20140312128 | GENERATING AND IMPLEMENTING THERMODYNAMIC MODELS OF A STRUCTURE - Apparatus, systems, methods, and related computer program products for generating and implementing thermodynamic models of a structure. Thermostats disclosed herein are operable to control an HVAC system. In controlling the HVAC system, a need to determine an expected indoor temperature profile for a particular schedule of setpoint temperatures may arise. To make such a determination, a thermodynamic model of the structure may be used. The thermodynamic model may be generated by fitting weighting factors of a set of basis functions to a variety of historical data including time information, temperature information, and HVAC actuation state information. The set of basis functions characterize an indoor temperature trajectory of the structure in response to a change in HVAC actuation state, and include an inertial carryover component that characterizes a carryover of a rate of indoor temperature change that was occurring immediately prior to the change in actuation state. | 10-23-2014 |
Patent application number | Description | Published |
20140022452 | SYSTEM AND METHOD FOR ARTIFACT REMOVAL - A method and apparatus provide for improving signal quality. The method includes receiving a first media signal, such as a video signal, in a first format, such as 1080p. The provided video signal is one that is created by upsampling a video signal recorded in a format having a lower sampling rate. The method also includes obtaining a second signal indicative of error within the first media signal. The second signal is in a second format, such as the format having a lower sampling rage in which the video signal was recorded. The signal is processed to place the second signal in the format of the first signal. Then, the estimated error signal is combined with the original signal to arrive at an error corrected output. | 01-23-2014 |
20140211854 | APPARATUS AND METHOD FOR VIDEO PROCESSING - Methods and apparatus for facilitating motion estimation in video processing are provided. In one embodiment, search block is defined within one frame. A relative location of a corresponding block in another frame with respect to the search block is determined based on comparative searching at a predetermined granularity to produce a motion vector for the search block with a first precision. Correlation values are determined with respect to the search block for the corresponding block and for one block or more blocks defined at relative locations of less than the predetermined granularity with respect to the corresponding block in different directions. A refined motion vector for the search block with a second higher precision is determined based on the relative location of the block having a selected correlation value that is selected from among the determined correlation values. | 07-31-2014 |
20140211855 | APPARATUS AND METHOD FOR VIDEO DATA PROCESSING - Methods and apparatus for facilitating processing a reference frame to produce an output frame. Motion vector data for a block of reference frame pels estimates the displacement of the reference frame pels from corresponding pels in a prior input frame. Comparison metrics are produced for a pel of the reference frame with respect to that pel and a plurality of neighboring reference frame pels A first comparison metric is based on a comparison with corresponding pels of a prior output frame that corresponds to the prior input frame as previously processed. A second comparison metric is based on a comparison with corresponding pels of a motion compensated prior output frame derived from applying motion vector data to the pels of the prior output frame. A pel of the output frame that corresponds to the reference frame pel is determined using the first and second comparison metrics. | 07-31-2014 |
Patent application number | Description | Published |
20100004676 | Low-Cost Disposable Tourniquet Cuff - A low-cost disposable tourniquet cuff includes: a first sheet formed of flexible material that is impermeable to gas; a second sheet facing the first sheet and formed of flexible material impermeable to gas; a bladder seal joining the first sheet to the second sheet around a perimeter to form an inflatable bladder within the perimeter; port means communicating pneumatically with the bladder and releasably connectable to a tourniquet instrument; stiffener means contained within the inflatable bladder and formed of gas-impermeable material less flexible than the first sheet, wherein the stiffener means has a stiffener width dimension less than the bladder width dimension and is joined to the first sheet to form a non-inflatable portion of the first sheet; and securing means attached to the non-inflatable portion of the first sheet and adapted to allow a surgical user to releasably secure the cuff around the limb at the desired location so that the bladder overlaps upon itself. | 01-07-2010 |
20100268267 | Low-Cost Contour Cuff For Surgical Tourniquet Systems - A low-cost contour cuff for surgical tourniquet systems comprises: a sheath containing an inflatable bladder, the sheath having an arcuate shape, an outer surface and a centerline equidistant between first and second side edges; a securing strap non-releasably attached to the outer surface and formed of substantially inextensible material having a shape that is predetermined and substantially flat, wherein the strap includes a bending portion near a first strap end and a fastening portion near a second strap end, and wherein the bending portion is adapted to allow twisting of the bending portion out of the substantially flat shape to facilitate positioning of the fastening portion into any of a plurality of positions in the substantially flat shape; and fastening means for releasably attaching the fastening portion of the securing strap to the outer surface whenever the sheath is curved into a position for surrounding a limb. | 10-21-2010 |
20120203267 | Disposable Tourniquet Cuff - A disposable tourniquet cuff for encircling a patient's limb includes first and second sheets; a gas-tight peripheral seal joining the first sheet to the second sheet around a perimeter of those sheets to form an inflatable bladder within the perimeter. A stiffener fits inside the bladder and is sized to extend substantially the length of the bladder and to fit completely within the peripheral seal. The stiffener is separate from the second sheet and the stiffener surface is welded to the first sheet at a location within the bladder and away from the peripheral seal. A tubular port is provided for directing gas into the bladder from a tourniquet instrument to which the port may be connected. The port defines a passageway therethrough and includes a flange made of a thermoplastic polymer that is compatible for welding the flange to the first sheet. | 08-09-2012 |
20130289612 | Tourniquet Cuff for Various Non-Cylindrical Limb Shapes - A low-cost contour cuff for surgical tourniquet systems comprises: a sheath containing an inflatable bladder, the sheath having an arcuate shape, an outer surface and a centerline equidistant between first and second side edges; a securing strap non-releasably attached to the outer surface and formed of substantially inextensible material having a shape that is predetermined and substantially flat, wherein the strap includes a bending portion near a first strap end and a fastening portion near a second strap end, and wherein the bending portion is adapted to allow twisting of the bending portion out of the substantially flat shape to facilitate positioning of the fastening portion into any of a plurality of positions in the substantially flat shape; and fastening means for releasably attaching the fastening portion of the securing strap to the outer surface whenever the sheath is curved into a position for surrounding a limb. | 10-31-2013 |