Doemling
Alexander Doemling, Pittsburgh, PA US
Patent application number | Description | Published |
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20080280769 | SELECTIVE AND DUAL-ACTION P53/MDM2/MDM4 ANTAGONISTS - A fragment-based strategy, involving “multicomponent reaction chemistry” (MCR), can identify novel chemotypes that disrupt the p53/MDM2 or p53/MDM4 complex employs. This approach uses high resolution structural information to delineate the region of a first protein or a ligand that is nestled within the binding pocket of a second target protein. The identified region is imported into a database containing MCR scaffolds to generate a virtual library of compounds, which subsequently are docked into the binding pocket of the target protein. Results from docking then are used to select compounds for synthesis and screening. A complementary, NMR-based methodology allows for screening the ability of compounds, selected using MCR, to disrupt the p53/MDM2 or p53/MDM4 complex. | 11-13-2008 |
20100022520 | MALONYL-COA ACETYLTRANSFERASE INHIBITORS AGAINST ANTIBIOTIC RESISTANT BACTERTIA - Compounds characterized by thiolactone or thiomorpholino cores display useful antibiotic and radioprotective properties. The latter properties are believed to arise from an ability of the compounds to inhibit proteins involved in apoptosis. | 01-28-2010 |
20110313167 | Substituted Heterocycles as Therapeutic agents for treating cancer - MDM2 and MDM4 proteins prevent apoptosis of cancer cells by negatively regulating the transcription factor p53. Compounds according to Formula I | 12-22-2011 |
20130211079 | SUBSTITUTED HETEROCYCLES AS THERAPEUTIC AGENTS FOR TREATING CANCER - MDM2 and MDM4 proteins prevent apoptosis of cancer cells by negatively regulating the transcription factor p53. Compounds according to Formula I | 08-15-2013 |
Alexander Doemling, Solinger DE
Patent application number | Description | Published |
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20140005386 | p53-Mdm2 ANTAGONISTS | 01-02-2014 |
Marcus Doemling, Saratoga, CA US
Patent application number | Description | Published |
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20100082441 | DECOMPILATION USED TO GENERATE DYNAMIC DATA DRIVEN ADVERTISEMENTS - A dynamic advertisement creative is generated from a static advertisement creative. An advertisement creative is received. The advertisement creative is decompiled into a plurality of static elements. A user is enabled to select a static element of the plurality of static elements to be converted into a dynamic element. A dynamic version of the received advertisement creative is generated that includes a placeholder corresponding to the selected static element. The placeholder is configured to be dynamically populated with data. The data populating the placeholder may be dynamically selected each time the dynamic advertisement creative is displayed. | 04-01-2010 |