Patent application number | Description | Published |
20080279941 | METHOD OF TREATING JOINTS WITH HYDROGEL IMPLANTS - Implantable biomaterials, particularly hydrogel substrates with porous surfaces, and methods for enhancing the compatibility of biomaterials with living tissue, and for causing physical attachment between biomaterials and living tissues are provided. Also provided are implants suitable for load-bearing surfaces in hard tissue repair, replacement, or augmentation, and to methods of their use. One embodiment of the invention relates to an implantable spinal disc prosthesis. | 11-13-2008 |
20080279943 | METHOD OF MAKING HYDROGEL IMPLANTS - Implantable biomaterials, particularly hydrogel substrates with porous surfaces, and methods for enhancing the compatibility of biomaterials with living tissue, and for causing physical attachment between biomaterials and living tissues are provided. Also provided are implants suitable for load-bearing surfaces in hard tissue repair, replacement, or augmentation, and to methods of their use. One embodiment of the invention relates to an implantable spinal disc prosthesis. | 11-13-2008 |
20090263446 | METHOD OF MAKING LOAD BEARING HYDROGEL IMPLANTS - Implantable biomaterials, particularly hydrogel substrates with porous surfaces, and methods for enhancing the compatibility of biomaterials with living tissue, and for causing physical attachment between biomaterials and living tissues are provided. Also provided are implants suitable for load-bearing surfaces in hard tissue repair, replacement, or augmentation, and to methods of their use. One embodiment of the invention relates to an implantable spinal disc prosthesis. | 10-22-2009 |
20110172771 | HYDROGEL IMPLANT WITH SUPERFICIAL PORES - Implantable biomaterials, particularly hydrogel substrates with porous surfaces, and methods for enhancing the compatibility of biomaterials with living tissue, and for causing physical attachment between biomaterials and living tissues are provided. Also provided are implants suitable for load-bearing surfaces in hard tissue repair, replacement, or augmentation, and to methods of their use. One embodiment of the invention relates to an implantable spinal disc prosthesis. | 07-14-2011 |
20120142597 | BIOMOLECULAR COATING FOR IMPLANTS - Methods and compositions are provided for improving tissue growth and device integration in vivo. Substrates and devices coated with an α | 06-07-2012 |
20120185051 | ARTICULAR JOINT IMPLANT - Implantable biomaterials, particularly hydrogel substrates with porous surfaces, and methods for enhancing the compatibility of biomaterials with living tissue, and for causing physical attachment between biomaterials and living tissues are provided. Also provided are implants suitable for load-bearing surfaces in hard tissue repair, replacement, or augmentation, and to methods of their use. One embodiment of the invention relates to an implantable spinal disc prosthesis. | 07-19-2012 |
20130045360 | SURFACE MODIFICATION OF IMPLANT DEVICES - Provided according to embodiments of the invention are methods of manufacturing implant devices. In methods described herein, implant devices are exposed to a reactive gas that includes a reactive species, and optionally, an inert gas, at elevated temperatures, for a duration sufficient to generate a high density of nanoscale structures on the exposed surface of the device. Also provided are implant devices formed by methods described herein. | 02-21-2013 |
20130064861 | COMPOSITIONS AND METHODS FOR MODIFYING IN VIVO CALCIFICATION OF HYDROGELS - Provided herein according to some embodiments of the invention are methods of inhibiting or preventing calcification of hydrogels. Such methods may include combining the hydrogel with a buffer solution having a pH lower than 7.4; forming a hydrogel by crosslinking alginate in a solution comprising a bisphosphonate compound; and/or forming a hydrogel by crosslinking a polyanionic polymer with a polyvalent cation that is not Ca | 03-14-2013 |
20140171367 | Polymer Hydrogels For In Vivo Applications And Methods For Using And Preparing Same - Compositions and methods are described for a polymer hydrogel created by a cycloaddition reaction between an azide and an alkyne that proceeds rapidly without catalyst to produce the polymer hydrogel in less than ninety seconds. The polymer hydrogel can be used in in vivo applications for the localized delivery of therapeutic agent in aqueous solutions. An example of therapeutic delivery of a protein in a mouse model is demonstrated. | 06-19-2014 |
20140329052 | SURFACE MODIFICATION OF IMPLANT DEVICES - The present invention provides implant devices comprising nanoscale structures on the surface thereof and methods of manufacturing such implant devices. In some embodiments, methods of manufacturing an implant device comprise exposing a surface of the implant device to an oxidative hydrothermal environment for a duration sufficient to generate nanoscale structures on the exposed surface(s) of the implant device. | 11-06-2014 |
Patent application number | Description | Published |
20080222566 | Flexible-Date Travel Queries - Techniques for processing flexible-date queries are described. Techniques include a interface to enter a flexible date query including a description of a traveler's desired stay at a destination. A user receives a set of solutions that satisfy the flexible date query in the form of a calendar. The set of solutions can be stored in a database for eventual retrieval of a subset of the set of solutions to render to a user. | 09-11-2008 |
20110106574 | Query Widening for Query Caches for Travel Planning Systems - A query cache for travel planning includes a cache database that stores query results and a cache test mechanism that receives a travel planning query and uses the query to find a result in the cache database and if a result is found returns the result, the result including a set of answers each answer in the set having a flight and a fare useable with the flight. | 05-05-2011 |
20110125725 | Flexible-Date Travel Queries - Techniques for processing flexible-date queries are described. Techniques include a interface to enter a flexible date query including a description of a traveler's desired stay at a destination. A user receives a set of solutions that satisfy the flexible date query in the form of a calendar. The set of solutions can be stored in a database for eventual retrieval of a subset of the set of solutions to render to a user. | 05-26-2011 |
20110213833 | Multi-Passenger Multi-Route Travel Planning - Multiple passenger multiple route travel queries are solved using travel planning systems that receive multiple, individual queries to produce individual solutions that meet joint travel requirements. The multiple, individual sub-queries are merged to produce joint solutions for the passenger groups. | 09-01-2011 |
20120059679 | INCREMENTAL SEARCHING IN MULTI-PASSENGER MULTI-ROUTE TRAVEL PLANNING - A multiple routes for multiple passengers are produced by ordering passenger groups and for each passenger group, constructing an individual query and sending the individual query to a travel planning system. Solutions based on the individual query are received from the travel planning system and a single individual solution is selected from the response. Constraints are added to subsequent individual queries based on previously selected individual solutions and joint travel requirements or preferences. | 03-08-2012 |
20120059740 | BIAS OF QUERIES FOR MULTI-PASSENGER MULTI-ROUTE TRAVEL PLANNING - Determining multiple routes for multiple passenger groups, includes sending to a scheduler, multiple individual queries with a bias to produce individual solutions that meet joint travel requirements, merging results from the multiple individual queries to produce joint solutions for the passenger groups and returning the joint solutions. | 03-08-2012 |