Patent application number | Description | Published |
20080279822 | Crystalline Polymorphs of a CXC-Chemokine Receptor Ligand - The present invention relates to four distinct crystalline polymorphs of a monohydrate of Compound A having the following chemical structure: | 11-13-2008 |
20090048458 | SYNTHESIS OF 2-HYDROXY-N,N-DIMETHYL-3-[[2-[[1(R)-(5-METHYL-2-FURANYL)PROPYL]AMINO]-3,4- -DIOXO-1-CYCLOBUTEN-1-YL]AMINO]BENZAMIDE - Disclosed is a process for making the compound of formula I: | 02-19-2009 |
20090203925 | SYNTHESIS OF HIMBACINE ANALOGS - The present invention relates to an improved process for preparing himbacine analogs. The compounds are useful as thrombin receptor antagonists. The improved process may allow for at least one of easier purification by crystallization, easier scalability, and improved process yield on the desired enantiomer. | 08-13-2009 |
20100137597 | SYNTHESIS Of DIETHYLPHOSPHONATE - This application discloses a novel process for the preparation of phosphonate esters useful as intermediates in the preparation of himbacine analogs, themselves useful as thrombin receptor antagonists. The chemistry taught herein can be exemplified by the following scheme: | 06-03-2010 |
20100249411 | Stereoselective Alkylation of Chiral 2-Methly-4 Protected Piperazines - In an illustrative embodiment, the present invention describes the synthesis of the following compound and similar compounds, in high stereochemical purity by a novel stereoselective alkylation process: | 09-30-2010 |
20110144327 | PROCESS FOR THE SYNTHESIS OF AZETIDINONES - A process is provided for preparing azetidinones useful as intermediates in the synthesis of penems and as hypocholesterolemic agents, comprising reacting a β-(substituted-amino)amide, a β-(substituted-amino)acid ester, or a β-(substituted-amino)thiolcarbonic acid ester with a silylating agent and a cyclizing agent selected from the group consisting of alkali metal carboxylates, quaternary ammonium carboxylates, quaternary ammonium hydroxides, quaternary ammonium alkoxides, quaternary ammonium aryloxides and hydrates thereof, or the reaction product of: (i) at least one quaternary ammonium halide and at least one alkali metal carboxylate; or (ii) at least one quaternary ammonium chloride, quaternary ammonium bromide, or quaternary ammonium iodide and at least one alkali metal fluoride, wherein a quaternary ammonium moiety of the cyclizing agent is unsubstituted or substituted by one to four groups independently selected from the group consisting of alkyl, arylalkyl and arylalkyl-alkyl. | 06-16-2011 |
20110160469 | PROCESS AND INTERMEDIATES FOR THE SYNTHESIS OF 1,2-SUBSTITUTED 3,4-DIOXO-1-CYCLOBUTENE COMPOUNDS - This application discloses a novel process for the preparation of 1,2-substituted 3,4-dioxo-1-cyclobutene compounds, which have utility, for example, in the treatment of CXC chemokine-mediated diseases, and intermediates useful in the synthesis thereof. | 06-30-2011 |
20120083601 | PROCESS FOR THE SYNTHESIS OF AZETIDINONES - A process is provided for preparing azetidinones useful as intermediates in the synthesis of penems and as hypocholesterolemic agents, comprising reacting a β-(substituted-amino)amide, a β-(substituted-amino)acid ester, or a β-(substituted-amino)thiolcarbonic acid ester with a silylating agent and a cyclizing agent selected from the group consisting of alkali metal carboxylates, quaternary ammonium carboxylates, quaternary ammonium hydroxides, quaternary ammonium alkoxides, quaternary ammonium aryloxides and hydrates thereof, or the reaction product of: (i) at least one quaternary ammonium halide and at least one alkali metal carboxylate; or (ii) at least one quaternary ammonium chloride, quaternary ammonium bromide, or quaternary ammonium iodide and at least one alkali metal fluoride, wherein a quaternary ammonium moiety of the cyclizing agent is unsubstituted or substituted by one to four groups independently selected from the group consisting of alkyl, arylalkyl and arylalkyl-alkyl. | 04-05-2012 |
20140031549 | Process and Intermediates for the Synthesis of 8-[-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one Compounds - This application discloses a novel process to synthesize 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds, which may be used, for example, as NK-1 inhibitor compounds in pharmaceutical preparations, intermediates useful in said process, and processes for preparing said intermediates; also disclosed is a process for removal of metals from N-heterocyclic carbine metal complexes. | 01-30-2014 |
Patent application number | Description | Published |
20100218540 | REFRIGERATION SYSTEM FOR REFRIGERATION APPLIANCE - Provided is a refrigeration appliance including a fresh food compartment for storing food items in a refrigerated environment having a target temperature above zero degrees Centigrade. A freezer compartment is disposed at an elevation vertically below the fresh food compartment for storing food items in a sub-freezing environment having a target temperature below zero degrees Centigrade. The refrigeration appliance also includes one or more of a hand-removable insulated cover, a cool air duct for introducing cooled air adjacent an ice bin, and a rearward-sloped catch pan positioned to catch dripping water in said ice maker and direct the dripping water into a drain. | 09-02-2010 |
20110203305 | ICE AND WATER SYSTEM IN REFRIGERATOR WITH STIRRING FAN IN ICE CHAMBER - A refrigerator includes a freezer compartment and a fresh food compartment which includes an ice chamber. The ice chamber includes an ice maker which includes a first heat exchanger for producing ice. The ice chamber further includes an ice container, a second heat exchanger, an air moving apparatus, and an enclosed loop passageway. The ice container is for storing ice produced by the ice maker and includes an exterior surface. The second heat exchanger is for controlling temperature at the ice container. The passageway forms an air flow path such that air travels in thermal contact with the second heat exchanger. The air moving apparatus is positioned to move air through the passageway. | 08-25-2011 |
20120082550 | APPARATUS AND METHODS FOR COOLING PLATFORM REGIONS OF TURBINE ROTOR BLADES - A platform cooling configuration in a turbine rotor blade that includes platform slot formed through at least one of the pressure side slashface and the suction side slashface; a removably-engaged impingement insert that separates the platform into two radially stacked plenums, a first plenum that resides inboard of a second plenum; a high-pressure connector that connects the first plenum to the high-pressure coolant region of the interior cooling passage; a low-pressure connector that connects the second plenum to the low-pressure coolant region of the interior cooling passage. | 04-05-2012 |
20120082565 | APPARATUS AND METHODS FOR COOLING PLATFORM REGIONS OF TURBINE ROTOR BLADES - In a turbine rotor blade having a platform at an interface between an airfoil and a root, wherein the airfoil and the root include an interior cooling passage formed therein, wherein, in operation, the interior cooling passage comprises at least a high-pressure coolant region and a low-pressure coolant region, platform cooling arrangement that includes: a platform slot extending circumferentially from a mouth formed through the pressure side slashface; a high-pressure connector that connects the platform slot to the high-pressure coolant region of the interior cooling passage; a low-pressure connector that connects the platform slot to the low-pressure coolant region of the interior cooling passage; and a platform cooling cartridge removably engaged within the platform slot, the platform cooling cartridge comprising one or more cartridge cooling channels. | 04-05-2012 |
20120107134 | APPARATUS AND METHODS FOR COOLING PLATFORM REGIONS OF TURBINE ROTOR BLADES - A platform cooling arrangement in a turbine rotor blade having a platform at an interface between an airfoil and a root, wherein the rotor blade includes an interior cooling passage that extends from a connection at the root to the approximate radial height of the platform, wherein, the interior cooling passage comprises a high-pressure coolant region and a low-pressure coolant region, and wherein a pressure side of the platform comprises a topside extending circumferentially from the airfoil to a pressure side slashface. The platform cooling arrangement may include: a platform cavity formed within the pressure side of the platform, a high-pressure connector that connects the platform cavity to the high-pressure coolant region of the interior cooling passage; a low-pressure connector that connects the platform cavity to the low-pressure coolant region of the interior cooling passage; and a pin bank formed within the platform cavity that includes radial pins. | 05-03-2012 |
20120156055 | APPARATUS AND METHODS FOR COOLING PLATFORM REGIONS OF TURBINE ROTOR BLADES - A configuration of cooling channels through the interior of a turbine rotor blade, the turbine rotor blade including a platform at an interface between an airfoil and a root. In one embodiment, the configuration of cooling channels includes: an interior cooling passage that is configured to extend from a connection with a coolant source in the root to the interior of the airfoil; a platform cooling channel that traverses at least a portion of the platform; a turndown extension that includes a first section, which comprises a connection with the platform cooling channel, and a second section, which comprises a radially oriented cooling channel; and a connector that extends from a connector opening formed through an outer face of the root to a connection with the interior cooling passage and, therebetween, bisects the second section of the turndown extension. | 06-21-2012 |
20130136610 | TURBINE BUCKET AIRFOIL PROFILE - A turbine bucket is provided including a bucket airfoil having an airfoil shape, the bucket airfoil having a nominal profile substantially in accordance with Cartesian coordinate values of X, Y and Z set forth in Table 1 wherein the Cartesian coordinate values of X, Y and Z are non-dimensional values from 0% to 100% convertible to dimensional distances in inches by multiplying the Cartesian coordinate values of X, Y and Z by a height of the airfoil in inches, and wherein X and Y are distances in inches which, when connected by smooth continuing arcs, define airfoil profile sections at each distance Z, the airfoil profile sections at Z distances being joined smoothly with one another to form a complete airfoil shape. | 05-30-2013 |
20140069110 | TURBINE BUCKET INTERNAL CORE PROFILE - Turbine bucket nominal internal core profiles and core insert external profiles are provided. In one embodiment, a turbine bucket includes an airfoil, platform, shank and dovetail. The bucket has a nominal internal core profile substantially in accordance with Cartesian coordinate values of X, Y and Z set forth in Table 1 wherein the Z values are non-dimensional values from 0 to 1 convertible to Z distances in inches by multiplying the Z values by a height of the bucket in inches, and wherein X and Y are non-dimensional values which, when connected by smooth continuing arcs, define internal core profile sections at each distance Z along the bucket, the profile sections at the Z distances being joined smoothly with one another to form said bucket internal core profile. | 03-13-2014 |