Patent application number | Description | Published |
20080203502 | SELF-ADDRESSABLE SELF-ASSEMBLING MICROELECTRONIC SYSTEMS AND DEVICES FOR MOLECULAR BIOLOGICAL ANALYSIS AND DIAGNOSTICS - A self-addressable, self-assembling microelectronic device is designed and fabricated to actively carry out and control multi-step and multiplex molecular biological reactions in microscopic formats. These reactions include nucleic acid hybridization, antibody/antigen reaction, diagnostics, and biopolymer synthesis. The device can be fabricated using both microlithographic and micro-machining techniques. The device can electronically control the transport and attachment of specific binding entities to specific micro-locations. The specific binding entities include molecular biological molecules such as nucleic acids and polypeptides. The device can subsequently control the transport and reaction of analytes or reactants at the addressed specific micro-locations. The device is able to concentrate analytes and reactants, remove non-specifically bound molecules, provide stringency control for DNA hybridization reactions, and improve the detection of analytes. The device can be electronically replicated. | 08-28-2008 |
20080261295 | Cell Sorting System and Methods - Apparatus and Methods are provided for a microfabricated fluorescence activated cell sorter based on a switch for rapid, active control of cell routing through a microfluidic channel network. This sorter enables low-stress, highly efficient sorting of populations of small numbers of cells (i.e., 1000-100,000 cells). The invention includes packaging of the microfluidic channel network in a self-contained plastic cartridge that enables microfluidic channel network to macro-scale instrument interconnect, in a sterile, disposable format. Optical and/or fluidic switching forces are used alone or in combination to effect switching. | 10-23-2008 |
20080262240 | Separation And Manipulation Of A Chiral Object - Among other things, to cause directional motion of chiral objects in a mixture in a chamber, a field is rotated relative, to a chamber to cause rotation of the chiral objects. The rotation of the objects causes them to move directionally based on their chirality. | 10-23-2008 |
20080274555 | Separation and Manipulation of a Chiral Object - Among other things, for use in directional motion of chiral objects in a mixture, a field is applied across the chamber and is rotating relative to the chamber to cause rotation of the chiral objects. The rotation of the objects causes them to move directionally based on their chirality. The method applies to sugars, proteins, and peptides, among other things, and can be used in a wide variety of applications. | 11-06-2008 |
20090148828 | VIRAL DETECTION LIPOSOMES AND METHOD - A method of generating pathogen detecting liposomes includes a step of providing molecular beacons with fluorescing components. The molecular beacons include either strands of RNA or DNA and the fluorescing components include an emitter and a quencher. The method further uses nanodroplet technology to encapsulate the molecular beacons within a lipid membrane. Subsequently, receptors are assembled in association with the membrane. | 06-11-2009 |
20090180967 | ULTRSONICALLY ACTIVE MICROPARTICLES AND METHOD OF USE - An ultrasonically active microparticle is taught that includes a porous interior particle having hydrophobic pores, a gas in the hydrophobic pores and a hydrophilic exterior shell surrounding the interior particle forming an ultrasonically active microparticle and allowing the microparticle to be suspended in an aqueous solution. | 07-16-2009 |
20090188800 | ENHANCING PHORETIC SEPARATION - Among other things, a force is applied, at a first location in a medium and at a first time, to cause an object to move in a direction along the medium. At a later, second time, a force is applied at a second location, which is farther along the direction in which the object is moving, to cause the object to move an additional distance in the medium, when the force is no longer being applied at the first location. Both the distance traveled by the object and how long the object is subject to the force depend on a property of the object. At least one of the times and locations of applying the force is selected based on the property of the object. | 07-30-2009 |
20090239281 | Moving A Small Object in A Direction - For directional motion of a small object, a combination of at least two different properties is imparted to the object. At least one of the properties being responsive to an external influence to produce a force or torque acting on the object. At least another of the properties is responsive to the force or torque to cause a directional motion of the object. | 09-24-2009 |
20100047901 | SYSTEM AND METHOD FOR ELECTRONIC SENSING OF BIOMOLECULES - A nanoelectronic device is combined with a cellular membrane component to provide a sensor for biomolecules or to provide information about the structure of the membrane. The nanoelectronic device may comprise a network of randomly-oriented nanotubes, or other nanostructure, arranged on a substrate with adjacent electrodes so as to operate as a field-effect transistor sensor or as a capacitive sensor. A cellular membrane is disposed over the nanostructure element. | 02-25-2010 |
20100062040 | WATER SOLUBLE DRUGS AND SUPPLEMENTS - A method of forming water soluble microparticles is disclosed that includes the steps of providing a water insoluble food supplement, mixing the food supplement in a water miscible polar solvent, heating the mixture to increase the solubility and dissolve the food supplement into the solvent to form a saturated solution, and streaming the solution into water to form a solvent-water mix such that microparticles of the food supplement are produced | 03-11-2010 |
20100104630 | WATER SOLUBLE STATIN MICROSTRUCTURES AND METHOD OF PREPARATION - A method of preparing a water soluble microstructure includes the steps of providing a saturated solution of a payload with poor water solubility, providing a solution of helper molecules, and combining the saturated solution of the payload with the solution of helper molecules. The combined saturated solution of the payload with the solution of helper molecules is mixed with an aqueous solution to form a water soluble microstructure. The water soluble microstructure includes the helper molecules forming an outside portion of the microstructure, and the payload having poor water solubility contained within the outside portion and forming an inside portion of the microstructure. | 04-29-2010 |
20100108577 | METHODS AND APPARATUS FOR USE OF OPTICAL FORCES FOR IDENTIFICATION, CHARACTERIZATION AND/OR SORTING OF PARTICLES - Apparatus and methods are provided for interacting light with particles, including but not limited to biological matter such as cells, in unique and highly useful ways. Optophoresis consists of subjecting particles to various optical forces, especially optical gradient forces, and more particularly moving optical gradient forces, so as to obtain useful results. In biology, this technology represents a practical approach to probing the inner workings of a living cell, preferably without any dyes, labels or other markers. In one aspect, a particle may be characterized by determining its optophoretic constant or signature. For example, a diseased cell has a different optophoretic constant from a healthy cell, thereby providing information, or the basis for sorting. In the event of physical sorting, various forces may be used for separation, including fluidic forces, such as through the use of laminar flow, or optical forces, or mechanical forces, such as through adhesion. Various techniques for measuring the dielectric constant of particles are provided. | 05-06-2010 |
20100120087 | Enzymatic or Organic Catalytic Chemical Reactions - In an aspect, a perturbation is applied to a system comprising an enzymatic chemical reaction and/or an organic catalytic chemical reaction with the perturbation being non-directional (average of the force applied by the perturbation being zero) with respect to a variable of the system. A directional effect is caused with respect to the said enzymatic or organic catalytic chemical reaction as a result of the perturbation and an asymmetry of the perturbed system. The present invention also embodies an apparatus comprising a site for an enzymatic or organic catalytic chemical reaction and a device controlled to perturb a system that includes the enzymatic or organic catalytic chemical reaction, the average of the force applied by the perturbation being zero, a directional effect being caused with respect to the chemical reaction as a result of the perturbation and an asymmetry of the perturbed system. | 05-13-2010 |
20100173792 | Self-addressable self-assembling microelectronic systems and devices for molecular biological analysis and diagnostics - A method for analyzing nucleic acid obtained from a cell sample on a platform is described. A platform having a cell selector, a nucleic acid selector, and an array of microlocations, wherein at least one microlocation has an associated capture sequence, is provided. The cell selector is contacted with a cell sample, wherein a portion of the cells remain associated with the cell selector. At least a portion of cells associated with the cell selector are lysed to release a nucleic acid sample. The nucleic acid selector is then contacted with the nucleic acid sample, such that a portion of the nucleic acid sample remains associated with the nucleic acid selector. The associated nucleic acid sample is then released from the nucleic acid selector and then is contacted with the array of microlocations, such that at least a portion of the released nucleic acid sample hybridizes with the capture sequence. | 07-08-2010 |
20100190198 | ASYMMETRIC SYSTEMS - Among other things, a combination comprises interaction with a system that has a perturbation. In such perturbed system, a non-directional input is applied to a first variable of the system. Based on an asymmetry of the perturbed system, a directional effect is achieved in a second variable of the system, the first and second variables comprising a conjugate pair of variables. At least one of the following pertains: the interaction occurs other than by an apparatus and other than in a way that actually achieves the directional effect, or the conjugate pair is other than position and momentum, or the input or the asymmetry are in a dimension other than spatial coordinates, or the directional effect is other than translational motion and other than rotary motion. | 07-29-2010 |
20100304429 | METHODS AND APPARATUS FOR SORTING CELLS USING AN OPTICAL SWITCH IN A MICROFLUIDIC CHANNEL NETWORK - Apparatus and Methods are provided for a microfabricated fluorescence activated cell sorter based on an optical switch for rapid, active control of cell routing through a microfluidic channel network. This sorter enables low-stress, highly efficient sorting of populations of small numbers of cells (i.e., 1000-100,000 cells). The invention includes packaging of the microfluidic channel network in a self-contained plastic cartridge that enables microfluidic channel network to macro-scale instrument interconnect, in a sterile, disposable format. | 12-02-2010 |
20110033840 | VIRAL DETECTION LIPOSOMES AND METHOD - A method of generating pathogen detecting liposomes includes a step of providing molecular beacons with fluorescing components. The molecular beacons include either strands of RNA or DNA and the fluorescing components include an emitter and a quencher. The method further uses nanodroplet technology to encapsulate the molecular beacons within a lipid membrane. Subsequently, receptors are assembled in association with the membrane. | 02-10-2011 |
20110132812 | Separation and Manipulation of a Chiral Object - Among other things, to cause directional motion of chiral objects in a mixture in a chamber, a field is rotated relative to a chamber to cause rotation of the chiral objects. The rotation of the objects causes them to move directionally based on their chirality. | 06-09-2011 |
20120077191 | GENOTYPING DNA - Described herein are compositions and methods useful for the detection of nucleic acid variations. Ligation within a probe or between probes is used to distinguish between probes perfectly complementary to a target and those containing a mismatch. Nucleotide fill-in/extension steps are optionally applied according to the type of assay performed. A circularization and relinearization step can be applied to create a template for further amplification and detection. In certain aspects, portions of a target sequence or its complement are not amplified. | 03-29-2012 |
20120263828 | Stabilization of Oil in Water Microparticles Using Natural Polymeric Polyphenols - A method of stabilizing nutritional drinks, and the stabilized drink, including the steps of forming edible oil microparticles, dissolving polyphenol concentrate in a liquid, and associating the polyphenol from the concentrate with the microparticles in the liquid to prevent free radicals from reaching the surface of the microparticles. | 10-18-2012 |
20130075794 | NANO-ELECTRONIC SENSORS FOR CHEMICAL AND BIOLOGICAL ANALYTES, INCLUDING CAPACITANCE AND BIO-MEMBRANE DEVICES - Embodiments of nanoelectronic sensors are described, including sensors for detecting analytes inorganic gases, organic vapors, biomolecules, viruses and the like. A number of embodiments of capacitive sensors having alternative architectures are described. Particular examples include integrated cell membranes and membrane-like structures in nanoelectronic sensors. | 03-28-2013 |
20130273640 | NUCLEIC ACID SAMPLE PREPARATION - The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples. | 10-17-2013 |
20130306491 | ELECTROCHEMICAL NANOSENSORS FOR BIOMOLECULE DETECTION - Sensor devices, methods and kits for detection of biomolecules are provided. According to various embodiments, the devices, methods and kits provide enhanced sensitivity through the measurement of electrochemical impedance and related properties. Certain embodiments employ nanostructured electrode elements including nanotubes, nanoparticles, nanowires, and nanocones. In a particular embodiment, single walled carbon nanotubes disposed in interconnected networks are used as electrodes. The device, methods and kits described herein have application for detection and measurement of biomolecular species including polynucleotides, proteins, polysaccharides and the like. | 11-21-2013 |
20140127697 | NUCLEIC ACID SAMPLE PREPARATION - The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples. | 05-08-2014 |
20140174931 | NUCLEIC ACID SAMPLE PREPARATION - The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples. | 06-26-2014 |
20140183042 | NUCLEIC ACID SAMPLE PREPARATION - The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples. | 07-03-2014 |
20140183043 | NUCLEIC ACID SAMPLE PREPARATION - The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples. | 07-03-2014 |
20140209464 | Separation and Manipulation of a Chiral Object - Among other things, for use in directional motion of chiral objects in a mixture, a field is applied across the chamber and is rotating relative to the chamber to cause rotation of the chiral objects. The rotation of the objects causes them to move directionally based on their chirality. The method applies to sugars, proteins, and peptides, among other things, and can be used in a wide variety of applications. | 07-31-2014 |
20140238860 | NUCLEIC ACID SAMPLE PREPARATION - The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples. | 08-28-2014 |
20140248627 | NUCLEIC ACID SAMPLE PREPARATION - The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples. | 09-04-2014 |
20140356877 | NUCLEIC ACID SAMPLE PREPARATION - The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples. | 12-04-2014 |
20150024476 | CELL SORTING SYSTEM AND METHODS - Apparatus and Methods are provided for a microfabricated fluorescence activated cell sorter based on a switch for rapid, active control of cell routing through a microfluidic channel network. This sorter enables low-stress, highly efficient sorting of populations of small numbers of cells (i.e., | 01-22-2015 |
20150083595 | NUCLEIC ACID SAMPLE PREPARATION - The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples. | 03-26-2015 |