Patent application number | Description | Published |
20080278663 | ANAMORPHIC MICROLENS ARRAY - An LC display comprises in order (a) a light source, (b) a transparent polymeric film bearing on the light exit surface of the film an array of close-packed convex microlenses having a distribution of sizes and oriented in one direction, whereby the light output is preferentially spread in a desired direction, and (c) an LC panel. A related process and film are also disclosed. | 11-13-2008 |
20080310186 | LIGHT EMITTING DEVICE WITH MICROLENS ARRAY - A method of manufacturing a micro-lens array and light-emitting device, comprising forming a first structured polymer film with close packed surface cavities having a mean diameter of less than 20 micrometers and a relatively lower surface energy surface, forming a transparent second structured film with an array of microlenses formed thereon corresponding to the cavities of the first structured film, wherein the second structured film comprises a relatively high surface energy material and has a refractive index greater than 1.45, and wherein the microlenses are randomly distributed, separating the second structured film with the micro-lens array from the first structured polymer film, and attaching the second structured film to a transparent substrate or cover of a light-emitting device through which light is emitted. Use of microlens arrays formed from relatively high surface energy materials enables matching refractive index of microlens array to that of light-emitting devices substrate or cover through which light is emitted and relatively high elastic modulus providing good scratch resistance. | 12-18-2008 |
20090316417 | Light-redirecting article - A method for forming a light-redirecting article is provided wherein a surface of a substrate is conditioned by applying a layer of an embedment material. A close-packed layer of microspheres is assembled using drying-assisted self-assembly and applied to the conditioned surface. Microspheres are then embedded halfway into the surface of the layer of the embedment material. | 12-24-2009 |
20100224313 | LIGHT EMITTING DEVICE WITH MICROLENS ARRAY - A method of manufacturing a micro-lens array and light-emitting device, comprising forming a first structured polymer film with close packed surface cavities having a mean diameter of less than 20 micrometers and a relatively lower surface energy surface, forming a transparent second structured film with an array of microlenses formed thereon corresponding to the cavities of the first structured film, wherein the second structured film comprises a relatively high surface energy material and has a refractive index greater than 1.45, and wherein the microlenses are randomly distributed, separating the second structured film with the micro-lens array from the first structured polymer film, and attaching the second structured film to a transparent substrate or cover of a light-emitting device through which light is emitted. Use of microlens arrays formed from relatively high surface energy materials enables matching refractive index of microlens array to that of light-emitting devices substrate or cover through which light is emitted and relatively high elastic modulus providing good scratch resistance. | 09-09-2010 |
Patent application number | Description | Published |
20120134024 | ANTI-GLARE SURFACE TREATMENT METHOD AND ARTICLES THEREOF - A glass article including: at least one anti-glare surface having haze, distinctness-of-image, surface roughness, and uniformity properties, as defined herein. A method of making the glass article includes, for example: depositing deformable particles on at least a portion of a glass surface of the article; causing the deposited deformable particles on the surface to deform and adhere to the surface; and contacting the surface having the adhered particles with an etchant to form the anti-glare surface. A display system that incorporates the glass article, as defined herein, is also disclosed. | 05-31-2012 |
20130082213 | HYDROCHLORIC ACID WASHING OF CARBON AND GRAPHITE FOR MAKING CONDUCTIVE INK FOR ULTRACAPACITORS - Water-based conductive ink compositions may include acid-washed graphite particles, carbon black particles, at least one polymeric dispersant, at least one acrylic binder, at least one polyvinylpyrrolidone binder, at least one defoamer, and an aqueous carrier. At least 90 wt. % of the acid-washed graphite particles and the carbon black particles, based on the combined weight of the acid-washed graphite particles and the carbon black particles, may have particle sizes less than 10 μm. The water-based conductive ink composition may have a total elemental contaminant level of less than 100 ppm, based on the total weight of the water-based conductive ink composition. Methods for preparing the water-based conductive ink compositions may include preparing a letdown phase from a first premix containing carbon black and a second premix containing acid-washed graphite. The methods may include washing graphite particles in an strong acid such as hydrochloric acid, nitric acid, sulfuric acid, or mixtures thereof. | 04-04-2013 |
20130107370 | METHOD FOR SPARKLE CONTROL AND ARTICLES THEREOF | 05-02-2013 |
20150055275 | CERAMIC SEPARATOR FOR ULTRACAPACITORS - A separator such as for an electrochemical double layer capacitor includes acicular inorganic particles that are dried to form a porous membrane. Example inorganic particles are calcium silicate particles. A deposition method implementing slurry that includes the acicular inorganic particles and a dispersing medium along with a binder material can be used to form the separator layer directly on electrode materials. | 02-26-2015 |
20150198752 | ANTI-GLARE SURFACE TREATMENT METHOD AND ARTICLES THEREOF - A glass article including: at least one anti-glare surface having haze, distinctness-of-image, surface roughness, and uniformity properties, as defined herein. A method of making the glass article includes, for example: depositing deformable particles on at least a portion of a glass surface of the article; causing the deposited deformable particles on the surface to deform and adhere to the surface; and contacting the surface having the adhered particles with an etchant to form the anti-glare surface. A display system that incorporates the glass article, as defined herein, is also disclosed. | 07-16-2015 |
Patent application number | Description | Published |
20110288036 | Methods for Treating or Preventing Vascular Graft Failure - The described invention provides pharmaceutical compositions and methods for treating or preventing vascular graft failure in a subject in need of such treatment, the method comprising administering a therapeutically effective amount of a composition comprising a polypeptide of amino acid sequence YARAAARQARAKALARQLGVAA (SEQ ID NO: 1) or a functional equivalent thereof, and a pharmaceutically acceptable carrier. The methods also are clinically useful for treating a pre-atherosclerotic intimal hyperplasia condition. | 11-24-2011 |
20120263680 | Compositions And Methods For Preventing Or Treating Diseases, Conditions, Or Processes Characterized By Aberrant Fibroblast Proliferation And Extracellular Matrix Deposition - The described invention provides compositions and methods for preventing or treating a disease, condition, or pathologic process characterized by aberrant fibroblast proliferation and extracellular matrix deposition in a tissue of a subject. The method includes administering a therapeutic amount of a pharmaceutical composition comprising a polypeptide having the amino acid sequence YARAAARQARAKALARQLGVAA (SEQ ID NO: 1) or functional equivalent thereof, and a pharmaceutically acceptable carrier. | 10-18-2012 |
20140072613 | Compositions and Methods for Treating Cutaneous Scarring - The described invention provides compositions, dressings and methods for treating a cutaneous scar in a subject. The compositions of the derived invention contains a pharmaceutical composition comprising a therapeutic amount of a Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MK2) inhibitor comprising an MK2 polypeptide inhibitor or a functional equivalent thereof, and a pharmaceutically acceptable carrier. | 03-13-2014 |
20150064134 | COMPOSITIONS AND METHODS FOR PREVENTING OR TREATING DISEASES, CONDITIONS, OR PROCESSES CHARACTERIZED BY ABERRANT FIBROBLAST PROLIFERATION AND EXTRACELLULAR MATRIX DEPOSITION - The described invention provides compositions and methods for treating asthma, a disease, condition or pathologic process whose progression is characterized by one or more of aberrant fibroblast proliferation and extracellular matrix deposition producing constriction in an airway, airway remodeling, and airway obstruction in lung tissue. The method includes administering a pharmaceutical composition comprising a therapeutic amount of a polypeptide having the amino acid sequence YARAAARQARAKALARQLGVAA (SEQ ID NO: 1) or functional equivalent thereof, and a pharmaceutically acceptable carrier, wherein the therapeutic amount of the polypeptide is effective to reduce the constriction of small airway dimensions and airway obstruction, treat airway remodeling, or a combination thereof. | 03-05-2015 |
20150258192 | COMPOSITIONS AND METHODS FOR PREVENTING OR TREATING CHRONIC LUNG ALLOGRAFT DYSFUNCTION (CLAD) AND IDIOPATHIC PULMONARY FIBROSIS (IPF) - The described invention provides compositions and methods for reducing lung allograft dysfunction after lung transplant and for treating a severe pulmonary fibrosis characterized by aberrant fibroblast proliferation and extracellular matrix deposition in a tissue of a subject. The methods comprise administering to a subject in need thereof a composition comprising an antibody component comprising a therapeutic amount of an anti-CD44 antibody; and an MK2 inhibitor component comprising a therapeutic amount of an MK2 inhibitor (MK2i) polypeptide of amino acid sequence YARAAARQARAKALARQLGVAA (SEQ ID NO: 1) or at least one peptide functionally equivalent to the therapeutic domain thereof selected from a polypeptide of amino acid sequence KALARQLAVA (SEQ ID NO: 8), a polypeptide of amino acid sequence KALARQLGVA (SEQ ID NO: 9) and a polypeptide of aminoacid sequence KALARQLGVAA (SEQ ID NO: 2), or a functional equivalent thereof, and a pharmaceutically acceptable carrier. | 09-17-2015 |
20150299264 | INHIBITION OF CARDIAC FIBROSIS IN MYOCARDIAL INFARCTION - The described invention provides a method for treating myocardial infarction (MI) in a subject comprising administering to the subject a therapeutic amount of a pharmaceutical composition comprising a polypeptide of amino sequence YARAAARQARAKALARQLGVAA (SEQ ID NO: 1) or a functional equivalent thereof made from a fusion between a first polypeptide that is a cell permeable protein (CPP) selected from the group consisting of a polypeptide of amino acid sequence YARAAARQARA (SEQ ID NO: 2), WLRRIKAWLRRIKA (SEQ ID NO: 21), WLRRIKA (SEQ ID NO: 22), YGRKKRRQRRR (SEQ ID NO: 23), FAKLAARLYR (SEQ ID NO: 25), and KAFAKLAARLYR (SEQ ID NO: 26), and a second polypeptide that is a therapeutic domain (TD), and a pharmaceutically acceptable carrier. The described invention also provides a kit comprising a composition comprising at least one MK2 inhibitor peptide; a means for administering the composition; and a packaging material. | 10-22-2015 |
Patent application number | Description | Published |
20080233575 | Methods for increasing accuracy of nucleic scid sequencing - The invention provides methods for improving the fidelity of a sequencing-by-synthesis reaction by resequencing at least a portion of a nucleic acid template. | 09-25-2008 |
20090075252 | Methods for increasing accuracy of nucleic acid sequencing - The invention provides methods for improving the fidelity of a sequencing-by-synthesis reaction by resequencing at least a portion of a nucleic acid template. | 03-19-2009 |
20100029498 | SELECTION OF NUCLEIC ACIDS BY SOLUTION HYBRIDIZATION TO OLIGONUCLEOTIDE BAITS - Methods of selection of nucleic acids using solution hybridization, methods of sequencing nucleic acids including such selection methods, and products for use in the methods are disclosed. | 02-04-2010 |
20110191868 | METHODS FOR IDENTIFICATION AND USE OF AGENTS TARGETING CANCER STEM CELLS - The invention relates to methods for identifying compounds and compositions that target cancer stem cells. In some aspects, the invention relates to treatment methods that use compounds and compositions that specifically target cancer stem cells for inhibiting the growth and/or survival of cancer stem cells in a subject in need thereof. Other aspects of the invention relate to the use of cancer stem cell biomarkers in the selection of a treatment for inhibiting the growth and/or survival of cancer stem cells in a subject in need thereof. | 08-04-2011 |
20130171124 | Compositions And Methods Of Treating Head And Neck Cancer - The present invention provides methods related to the treatment of head and neck squamous cell carcinoma (HNSCC) and its associated premalignant lesions. In particular, the invention features methods which may specifically target HNSCC-associated genes and alter gene expression to treat or alleviate a symptom of HNSCC, or its related premalignant lesions. These methods may involve decreasing the function of an HNSCC-associated gene with aberrant gain-of-function; or increasing the function of an HNSCC-associated gene with aberrant loss-of-function. | 07-04-2013 |
20130260376 | Prediction of and Monitoring Cancer Therapy Response Based on Gene Expression Profiling - The invention utilizes gene expression profiles in methods of predicting the likelihood that a patient's cancer will respond to standard-of-care therapy. Also provided are methods of identifying therapeutic agents that target cancer stem cells or epithelial cancers that have undergone an epithelial to mesenchymal transition using such gene expression profiles. | 10-03-2013 |
20140200163 | MULTIPLEXED GENETIC REPORTER ASSAYS AND COMPOSITIONS - The invention provides methods for determining the activity of a plurality of nucleic acid regulatory elements. These methods may facilitate, e.g., the systematic reverse engineering, and optimization of mammalian cis-regulatory elements at high resolution and at a large scale. The method may include integration of multiplexed DNA synthesis and sequencing technologies to generate and quantify the transcriptional regulatory activity of e.g., thousands of arbitrary DNA sequences in parallel in cell-based as says (e.g., mammalian cell based assays). | 07-17-2014 |
20140294729 | METHODS FOR IDENTIFICATION AND USE OF AGENTS TARGETING CANCER STEM CELLS - The invention relates to methods for identifying compounds and compositions that target cancer stem cells. In some aspects, the invention relates to treatment methods that use compounds and compositions that specifically target cancer stem cells for inhibiting the growth and/or survival of cancer stem cells in a subject in need thereof. Other aspects of the invention relate to the use of cancer stem cell biomarkers in the selection of a treatment for inhibiting the growth and/or survival of cancer stem cells in a subject in need thereof. | 10-02-2014 |
20150126377 | SELECTION OF NUCLEIC ACIDS BY SOLUTION HYBRIDIZATION TO OLIGONUCLEOTIDE BAITS - Methods of selection of nucleic acids using solution hybridization, methods of sequencing nucleic acids including such selection methods, and products for use in the methods are disclosed. | 05-07-2015 |
20150159210 | Methods for Increasing Accuracy of Nucleic Acid Sequencing - The invention provides methods for improving the fidelity of a sequencing-by-synthesis reaction by resequencing at least a portion of a nucleic acid template. | 06-11-2015 |
20160024572 | Massively Multiplexed RNA Sequencing - A method for parallel sequencing target RNA from samples from multiple sources while maintaining source identification is provided. The method includes providing samples of RNA comprising target RNA from two or more sources; labeling, at the 3′ end, the RNA from the two or more sources with a first nucleic acid adaptor that comprises a nucleic acid sequence that differentiates between the RNA from the two or more sources; reverse transcribing the two or more sources to create a single stranded DNA comprising the nucleic acid sequence that differentiates between the RNA from the two or more sources; amplifying the single stranded DNA to create DNA amplification products that comprise the nucleic acid sequence that differentiates between the RNA from the two or more sources; sequencing the DNA amplification products thereby parallel sequencing target RNA from samples from multiple sources while maintaining source identification. | 01-28-2016 |
20160040212 | Methods for the Detection of DNA-RNA Proximity in Vivo - Disclosed is a method for detecting spatial proximity relationships between RNA and DNA molecules in a cell. The method includes: providing a sample of RNA and DNA wherein the RNA and fDNA have ends capable of joining to other DNA and RNA, respectively; joining at least one end of the fragmented RNA to the end of at least one fragmented DNA, to create at least one joined RNA-DNA hybrid molecule, wherein the join encodes the information about the proximity of the RNA and DNA in the cell; reverse transcribing the at least one joined rRNA-DNA hybrid molecule to create least one target join DNA molecule that retains the information of the join, and determining the sequence of the target join thereby detecting spatial proximity relationships between RNA and DNA molecules in a cell. | 02-11-2016 |
20160040218 | Selective Purification of RNA and RNA-Bound Molecular Complexes - Disclosed are methods for isolating a target nucleic molecule of interest from a sample. The methods include contacting a sample comprising a target nucleic molecule of interest with at least one single stranded nucleic acid targeting probe comprising a nucleic acid sequence between about 30 nucleotide and the length of the target nucleic acid length that hybridizes to the target nucleic molecule of interest under highly stringent hybridization conditions. The probe comprises a capture moiety covalently linked to one or more nucleotide bases in the probe. The targeting probes can be captured with a specific binding agent that specifically binds the capture moiety, thereby isolating the target nucleic molecule of interest. In some embodiments, the sample is further contacted with a crosslinking agent before contacting the sample with a targeting probe. Thus, complexes formed with the target nucleic acid can also be isolated. | 02-11-2016 |
Patent application number | Description | Published |
20130098120 | Hinge Arrangement for a Garment Washing Device - A bra-washing device includes a shell with an interior, the shell includes two shell portions, each with a rim. A latch holds the two shell portions closed and the latch may be opened to access the interior of the shell. A hinge pivotally couples the two shell portions to each other. The hinge includes at least one hinge knuckle extending from the rim of each shell portion, the hinge knuckles of the two shell portions in axial alignment, an internal bore extending into the hinge knuckles on each shell portion, a hinge pin inserted into the internal bore of the hinge knuckles, and a fastener extending at least partially through the internal bore near one end of the hinge pin to block the hinge pin from sliding out of the internal bore. | 04-25-2013 |
20150335139 | Tablet Support Accessory - A tablet support accessory is revealed that holds electronic tablets, iPads, notebooks, game players, e-readers, smart-phones, or other interactive electronic devices or viewing devices, on the thigh of a sitting, supine, or semi-supine person. Because interactivity at times involves the tapping on the face of the device, the tablet support accessory is stabilized by coupling a thigh brace and platform assembly, on which the device is held, to a support in the wearer's knee-shin region by means of an adjustable strap. | 11-26-2015 |
Patent application number | Description | Published |
20140279258 | SYSTEMS AND METHODS FOR DETERMINING COST OF VEHICLE OWNERSHIP - Systems and methods for estimating the cost of vehicle ownership wherein, in one embodiment, a system includes a computer processor that is coupled to a network interface, a data storage device and an output device, the processor being configured to receive information identifying a user-specified vehicle of interest and interval of interest. The processor uses this information to identify and retrieve pre-calculated data items that are stored in the data storage device, and to request external data items from an external data source and receive the requested external data items via the network interface. The processor computes cost-of-vehicle-ownership (COVO) components for the vehicle of interest, sums the components to determine an overall COVO, and outputs the components and overall COVO to a user via the output device. The user may provide further input to modify the COVO calculation. | 09-18-2014 |
20140279708 | SYSTEMS AND METHODS FOR DETERMINING THE TIME TO BUY OR SELL A VEHICLE - Systems and methods for assisting a vehicle owner in making decisions regarding when to replace a vehicle by determining a vehicle owner's satisfaction with the vehicle relative to the cost of owning the vehicle. In one embodiment, a system is configured to provide a model for owner satisfaction which is based on historical vehicle replacement information, but is tailored to a particular owner according to user input. An owner satisfaction curve is produced from this model and is compared to a cost-of-ownership curve that is tailored to the vehicle and possibly also the user. The owner satisfaction curve is compared to the cost-of-ownership curve to enable the user to determine where the cost of ownership exceeds the owner's satisfaction, and the vehicle should be replaced. | 09-18-2014 |
20140279709 | SYSTEMS AND METHODS FOR DETERMINING COSTS OF VEHICLE REPAIRS AND TIMES TO MAJOR REPAIRS - Systems, methods and computer program products for determining costs of vehicle repairs and times to major repairs. In one embodiment, a system includes a computer processor, a data storage device, and an output device. The processor receives information from a user identifying a vehicle of interest. The processor retrieves repair data items that have characteristics common to the vehicle of interest from a database stored in the data storage device. The processor determines repairs that are expected to be necessary for the vehicle of interest based on the retrieved repair data items, and determines the costs associated with the identified expected repairs. The processor provides output to the user indicating the repair costs and/or the times at which the repairs are likely to be necessary. The output may be in graphical and/or numerical form. | 09-18-2014 |