Patent application number | Description | Published |
20090060969 | Porous biodegradable polymeric materials for cell transplantation - Polymeric materials are used to make a pliable, non-toxic, injectable porous template for vascular ingrowth. The pore size, usually between approximately 100 and 300 microns, allows vascular and connective tissue ingrowth throughout approximately 10 to 90% of the matrix following implantation, and the injection of cells uniformly throughout the implanted matrix without damage to the cells or patient. The introduced cells attach to the connective tissue within the matrix and are fed by the blood vessels. The preferred material for forming the matrix or support structure is a biocompatible synthetic polymer which degrades in a controlled manner by hydrolysis into harmless metabolites, for example, polyglycolic acid, polylactic acid, polyorthoester, polyanhydride, or copolymers thereof. The rate of tissue ingrowth increases as the porosity and/or the pore size of the implanted devices increases. The time required for the tissue to fill the device depends on the polymer crystallinity and is less for amorphous polymers versus semicrystalline polymers. The vascularity of the advancing tissue is consistent with time and independent of the biomaterial composition and morphology. | 03-05-2009 |
20090111928 | Novel Macromonomers and Hydrogels - Macromonomers capable of both physical crosslinking and chemical crosslinking. The combination of chemical crosslinking and physical crosslinking provides the ability to generate rapidly gelling hydrogels for many different applications. Moreover, the macromonomers may incorporate functional groups that allow for two different gelation mechanisms—thermal gelation and ionic gelation—further improving mechanical stability of hydrogels formed from the disclosed macromonomers. | 04-30-2009 |
20100075420 | Novel Gene Delivery Vectors for Human Mesenchymal Stem Cells - Novel gene delivery vector compositions that interact with human mesenchymal stem cells are provided, as well as methods of synthesizing and using such compositions. Such compositions may comprise a plurality of hyaluronic acid hexamers covalently attached to a branched polyethylenimine. Such methods of synthesis may comprise providing a plurality of hyaluronic acid hexamers and a branched polyethylenimine, and allowing a hexamer of hyaluronic acid to covalently attach to a branched polyethylenimine to form a conjugate. Such methods of use may comprise providing a conjugate comprising a plurality of hyaluronic acid hexamers covalently attached to a branched polyethylenimine, and administering the conjugate to a cell. | 03-25-2010 |
20120141543 | Carbon Nanotube Based Nanocomposites - Novel methods and compositions of nanocomposites are provided. One exemplary composition comprises a biocompatible polymer, such as polypropylene fumarate, and a carbon nanotube, such as a single walled carbon nanotube, an ultra-short carbon nanotube, or a substituted ultra-short carbon nanotube. An exemplary method comprises providing a biocompatible polymer and a carbon nanotube and combining a biocompatible polymer and a carbon nanotube to form a nanocomposite. Another exemplary method comprises providing a nanocomposite comprising a biocompatible polymer and a carbon nanotube and administering the composition to a subject. | 06-07-2012 |
20130173014 | Combined Space Maintenance and Bone Regeneration System for the Reconstruction of Large Osseous Defects - Systems, methods and compositions useful for treatment of traumatic bone injuries are provided. In one embodiment, a bone reconstruction system comprising a space maintaining composition comprising porous polymethylmethacrylate; and an osseous generating construct comprising a polymethylmethacrylate chamber that comprises one or more osseous generating materials is provided. Associated compositions and methods are also provided. | 07-04-2013 |
20130304233 | CONTINUOUS DIGITAL LIGHT PROCESSING ADDITIVE MANUFACTURING OF IMPLANTS - A process for additive manufacturing of a resorbable implant to be implanted into a patient includes providing a biocompatible resin including a liquid light-polymerizable material that is resorbable after polymerization and an initiator. The process further includes actuating an additive manufacturing apparatus to expose an amount of the biocompatible resin to light to at least partially cure the exposed amount of biocompatible resin to form a layer of the resorbable implant and actuating the additive manufacturing apparatus to expose at least some additional amount of biocompatible resin to light to at least partially cure the exposed additional amount of biocompatible resin to form an additional layer of the resorbable implant and to at least partially overcure previously cured layers to cause at least some interlayer binding between the previously cured layers and the additional layer. | 11-14-2013 |
20150079020 | INJECTABLE HYDROGELS - The present disclosure generally relates to injectable compositions. More particularly, the present disclosure relates to injectable, thermogelling hydrogels and associated methods. In one embodiment, the present disclosure provides for a composition comprising a poly(N-isopropylacrylamide)-based macromer and a polyamidoamine-based macromer. | 03-19-2015 |
20150081034 | COMBINED SPACE MAINTENANCE AND BONE REGENERATION SYSTEM FOR THE RECONSTRUCTION OF LARGE OSSEOUS DEFECTS - Systems, methods and compositions useful for treatment of traumatic bone injuries are provided. In one embodiment, a bone reconstruction system comprising a space maintaining composition comprising porous polymethylmethacrylate; and an osseous generating construct comprising a polymethylmethacrylate chamber that comprises one or more osseous generating materials is provided. Associated compositions and methods are also provided. | 03-19-2015 |
Patent application number | Description | Published |
20100219195 | SLEEVE FOR A CONTAINER - An adjustable sleeve is disclosed that employs a pivot region which allows rotation of the first end of the sleeve relative to the second end of the sleeve. Rotation about the pivot region allows the sleeve size to adapt to many different sizes and tapers of containers. Rotation results in increasing a diameter of the top of the sleeve and decreasing a diameter of the bottom of the sleeve, and vice versa. | 09-02-2010 |
20100243719 | CARTON WITH TAMPER EVIDENT PRIZE INFORMATION FEATURE - A carton including a top and bottom portion adapted to secure an item within the top and bottom portion in a closed configuration. The carton also includes an information tab defined in a first surface of the top portion. The information tab is defined via series of perforated edges. An information tab cover on the carton is defined by a series of perforated edges that enable at least partial separation of the information tab from the carton. When the carton is in an unassembled configuration, a surface of the information tab is exposed to enable placement of information on the information tab. When the carton is in an assembled configuration the information tab cover covers the surface of the information tab so that the information placed on the information tab is not visible. | 09-30-2010 |
20120125987 | FLATBREAD CONTAINER - A container is disclosed for packaging flatbread, a flatbread sandwich or other food item. The container is made from a single, flat piece of paperboard having four sides and a pair of perforated lines formed therein running between two first sides and generally in the middle of the paperboard. The perforated lines come together at end portions thereof to meet at edges of the first sides to facilitate folding the flat paperboard in half along the perforated lines to close the container around a food item placed therein. Scored lines are formed spaced from the first and second sides to facilitate folding to form end and top portions of the container. Diagonal slots may be formed in corners of the flat paperboard that define hook structures capable of mutual engagement for securing closed the second sides around the food item. | 05-24-2012 |
20140332584 | CLAMSHELL CARTON WITH TEAR STRIP - A carton includes a top portion and a bottom portion. Each portion includes a front wall, a rear wall, and opposing side walls extending therebetween. The top portion and bottom portion include respective top and bottom surfaces. The rear walls of the top and bottom portions are hingedly connected to another along respective outer edges. When closed, the top portion and bottom portion define a cavity for storing an item. The carton also includes a separation region defined on the top and bottom portions that extends from an outside edge of the front wall of the top portion, around the top portion and the bottom portion, to an outside edge of the front wall of the bottom portion. The separation region is configured to facilitate controlled separation of the carton into first and second side portions and to prevent liquid flow through separation region. | 11-13-2014 |