Patent application number | Description | Published |
20080290289 | MASS SPECTROSCOPIC REACTION-MONITORING METHOD - A mass spectroscopic reaction-monitoring method including: forcing charge-laden liquid drops to move along a traveling path; exposing to a laser beam a region to be formed of a liquid sample surface, the laser beam having an irradiation energy sufficient to cause analytes present behind the liquid sample surface to be desorbed to fly along a flying path; introducing to the region at successive points of time a liquid sample containing one reactant that undergoes an ongoing chemical reaction as a first analyte to form one product as a second analyte, and positioning the liquid sample surface relative to the laser beam at each point of time such that the flying path intersects the traveling path for enabling occlusion of at least one of the first and second analytes in at least one charge-laden liquid drop to thereby form at least a corresponding one of first and second ionized analytes. | 11-27-2008 |
20080308722 | ELECTROSPRAY-ASSISTED LASER-INDUCED ACOUSTIC DESORPTION IONIZATION MASS SPECTROMETER AND A METHOD FOR MASS SPECTROMETRY - A mass spectrometer includes: an electrospray unit for forming liquid drops of an electrospray medium; a voltage supplying member disposed to allow the liquid drops to be laden with a plurality of charges for heading toward a receiving unit along a traveling path; a substrate having a sample surface for placement of a sample and an irradiated surface opposite to the sample surface; and a laser transmission mechanism for irradiating the irradiated surface. The substrate permits propagation of laser energy therethrough such that laser energy is passed on to at least one analyte in the sample via the substrate so that the analyte is desorbed to fly along a flying path intersecting the traveling path to enable occlusion of the analyte in the liquid drops. As a result of dwindling in size of the liquid drops, charges will pass on to the analyte to form a corresponding ionized analyte. | 12-18-2008 |
20090212206 | MASS SPECTROMETRIC METHOD AND MASS SPECTROMETER FOR ANALYZING A VAPORIZED SAMPLE - A mass spectrometric method for analyzing a vaporized sample, comprising the steps of: forcing sequentially generated charge-laden liquid drops to move towards a receiving unit of a mass spectrometer along a traveling path; establishing a concentration gradient for a target analyte so as to permit diffusion of the vaporized sample which contains at least one of the target analyte therein along a plurality of diffusing paths; and introducing the target-analyte containing vaporized sample through an inlet such that at least one of said diffusing paths intersects said traveling path so as to enable said at least one target analyte to be occluded in at least one of said charge-laden liquid drops to thereby form at least one corresponding ionized analyte for analysis by the mass spectrometer. | 08-27-2009 |
20110220787 | CYCLING ELECTROSPRAY IONIZATION DEVICE - A cycling electrospray ionization device includes a driving mechanism and a nozzle. The nozzle is configured to sequentially form liquid droplets of an electrospray medium thereat, and is adapted to establish a traveling path with a receiving unit of a mass spectrometer such that when a potential difference is applied between the nozzle and the receiving unit to lade the liquid droplets with a plurality of electric charges for ionizing analytes to form ionized analytes, the charged droplets are forced to move toward the receiving unit along the traveling path. The nozzle defines a nozzle axis, and is driven by the driving mechanism to proceed with a cycling route about a cycling axis such that the nozzle axis tracks along the cycling route, and such that immediately after leaving the nozzle, the liquid droplets cooperate to form a substantially columnar plume with a cross section substantially surrounded by the cycling route. | 09-15-2011 |
20140312244 | MULTIMODE IONIZATION DEVICE - A multimode ionization device includes an electrospray unit, a charge generating unit, and a plasma supplying unit. The electrospray unit is configured to form an electrospray plume which travels along a traveling path. The charge generating unit is configured to permit a liquid electrospray medium to leave the electrospray unit as the electrospray plume. The plasma supplying unit can generate and guide a plasma plume to mix with the electrospray plume so as to obtain a plume combination in a confluent zone, and is oriented to permit at least one of analytes carried in the plume combination to travel to the receiving unit along a linearly-extending end zone of the traveling path. | 10-23-2014 |