Patent application number | Description | Published |
20080275654 | APPARATUS AND METHOD FOR FULLY AUTOMATED CLOSED SYSTEM pH MEASUREMENT - The present invention provides an apparatus and method for a noninvasive optical determination of the pH of a substance in a compartment in a closed system comprising a compartment wherein a substance resides which is permeable to at least one wavelength of light, a light source and light detecting device configured to obtain spectral data for a substance for at least one wavelength, a processor adapted to determine the pH of the substance by correlating the spectral data with predetermined spectral data for a known substance at a known pH at the at least one wavelength, and wherein the processor is further configured to control the release of the substance from the compartment to its end use. | 11-06-2008 |
20080275659 | APPARATUS AND METHOD FOR FULLY AUTOMATED CLOSED SYSTEM QUALITY CONTROL OF A SUBSTANCE - The present invention provides an apparatus and method for automated quality control of a substance comprising a compartment wherein a substance is located, a monitoring device coupled to the compartment and configured to monitor at least one quality control parameter prior to an end-use of the substance, and a processor coupled to the monitoring device, wherein the monitoring device is configured to communicate data to the processor for comparing at least one quality control parameter to an end-use value, and wherein the processor is further configured to control the release of the substance from the compartment to its end-use. | 11-06-2008 |
20080275668 | APPARATUS AND METHOD FOR FULLY AUTOMATED CLOSED SYSTEM OPTICAL MEASUREMENT OF VOLUME - The present invention provides an apparatus and method for a noninvasive optical determination of the volume of a fluid in a compartment within a closed system comprising a compartment wherein a fluid resides which is permeable to at least one wavelength of light, a light source and light detecting device configured to obtain spectral data for a fluid for at least one wavelength, a processor adapted to determine the volume of the fluid by correlating the spectral data for a fluid at a known path length with the spectral data for the fluid at an unknown path length and wherein the processor is further configured to control the release of the substance from the compartment to its end use. | 11-06-2008 |
20080314836 | METHODS AND DEVICES FOR DYNAMIC FILTRATION OF PHARMACEUTICAL PRODUCTS - A device for dynamic filtration of a pharmaceutical product is provided. The device includes a resin configured to selectively retain one or more components from a mixture having the pharmaceutical product, where the resin is configured to be activated by a medium of the mixture. The device further includes at least one positioning material disposed adjacent to the resin, where the positioning material is configured to provide mechanical support to the resin to at least partially retain the resin in position. In certain embodiments, the device does not require conditioning immediately prior to filtration. | 12-25-2008 |
20090044603 | ARTICLE, DEVICE, AND METHOD - An article includes a substrate assembly for use in a detector system. The substrate assembly includes a substrate; a sample reception structure secured to the substrate; a test window extending through the substrate; and a fluid channel defined by a surface of the substrate and extending from the sample reception structure to the test window. | 02-19-2009 |
20090263325 | METHOD AND APPARATUS FOR THE DISSOLUTION AND FILTRATION OF A HYPERPOLARIZED AGENT WITH A NEUTRAL DISSOLUTION MEDIA - Methods and apparatuses that facilitate dissolving a hyperpolarized agent within a polarizer and transporting it to a receiver is provided. The methods include delivering water to a hyperpolarized agent contained within a polarizer, forming a hyperpolarized aqueous solution, transporting the aqueous solution through a fluid path system out of the polarizer, filtering the aqueous solution through a partical size exclusion filter to a receiver, and modifying the pH of the filtered hyperpolarized aquous solution with a dissolution medium contained in the receiver. Also disclosed herein are apparatuses for dissolving a hyperpolarized agent comprising a vial for containing a hyperpolarized imaging agent therein, a dissolution fluid path, a delivery fluid path, a particle size exclusion filter, and a receiver connected to the particle size exclusion filter and positioned to receive the filtered aqueous solution of the hyperpolarized imaging agent. | 10-22-2009 |
20100147481 | METHODS OF MANUFACTURING CASTED ARTICLES, AND SYSTEMS - A method for manufacturing a casted article is presented. The method includes steps of forming a casted article by a liquid metal cooled directional solidification process, removing a metallic material from a surface of the casted article and inspecting the surface of the casted article. The surface of the casted article is inspected for the presence of the metallic material by exposing the surface to a visualization reagent. A system for manufacturing the casted article is also presented. | 06-17-2010 |
20100194574 | PARTICLE DETECTION SYSTEM AND METHOD OF DETECTING PARTICLES - A method for detecting an aerosol plume includes emitting a light beam from a light source, the light beam having at least one light pulse, wherein the light pulse having a pulse width of between about 10 picoseconds (ps) and about 75 nanoseconds (ns), detecting backscattered light produced by the at least one light pulse interacting with particles in the aerosol plume, determining a presence of the aerosol plume based on the detected backscattered light, and outputting a signal indicating the presence of the aerosol plume. | 08-05-2010 |
20100251732 | APPARATUS AND METHOD FOR INTRODUCTION OF A MATERIAL INTO A CRYOGENIC SYSTEM - Provided is an apparatus and method for introducing a sample into a cryogenic system comprising, an airlock chamber, a sample path having a first end connected to the airlock chamber and a second end connected to a cryogenic helium bath, an equilibrator, inserted into the sample path and positioned between the airlock and the cryogenic bath and which allows for passage of a sample to the cryogenic helium bath, and a cooling unit to coupled to the equilibration to control the temperature of the equilibrator. A machine-readable medium, comprising instructions which when executed by a controller causes a sample to be positioned within the cryogenic system, is also provided. | 10-07-2010 |
20110180482 | METHODS AND DEVICES FOR DYNAMIC FILTRATION OF PHARMACEUTICAL PRODUCTS - A device for dynamic filtration of a pharmaceutical product is provided. The device includes a resin configured to selectively retain one or more components from a mixture having the pharmaceutical product, where the resin is configured to be activated by a medium of the mixture. The device further includes at least one positioning material disposed adjacent to the resin, where the positioning material is configured to provide mechanical support to the resin to at least partially retain the resin in position. In certain embodiments, the device does not require conditioning immediately prior to filtration. | 07-28-2011 |
20120117985 | FLUID PATH SYSTEM FOR DISSOLUTION AND TRANSPORT OF A HYPERPOLARIZED MATERIAL - A fluid path system includes a vial containing a pharmaceutical product therein. A dissolution fluid path is also included in the fluid path system, the dissolution fluid path having an output end in fluid communication with the vial and an input end attached to a pressure vessel containing a dissolution medium. A delivery fluid path is also included in the system having a first end hermetically attached to the vial to transport therefrom a mixture of dissolved pharmaceutical product and dissolution medium and a second end connected to a receiving vessel to receive the mixture. A dissolution fluid path valve is positioned between the pressure vessel and the dissolution fluid path to control flow of the dissolution medium, and a delivery fluid path valve is also included in the fluid path system to control flow of the mixture from the delivery fluid path to the receiving vessel. | 05-17-2012 |
20130029411 | SYSTEMS, METHODS AND CONTROL LAWS FOR CELL HARVESTING - The methods of harvesting cells are provided, wherein the methods comprise introducing a processing material and a source material into a processing loop. The processing loop comprises a processing chamber and a filtering device. The processing material and the source material are circulating through the processing chamber and the filtering device, wherein the processing chamber has a mass; balancing an influx of the processing material into the processing chamber with a permeate flux of the filtering device to maintain the mass of the processing chamber at a constant value; and collecting the cells in a collection chamber. Cell harvesting devices are also provided for processing and harvesting cells using a control law to balance the mass of the processing chamber through the entire process. | 01-31-2013 |
20130047633 | APPARATUS AND METHOD FOR INTRODUCTION OF A MATERIAL INTO A CRYOGENIC SYSTEM - Provided is an apparatus and method comprising, an airlock chamber; a cryogenic chamber; an equilibrator positioned between the airlock chamber and the cryogenic chamber that is configured to allow for the passage of a sample along to the cryogenic chamber; and a cooling unit that is thermally coupled to the equilibrator. Collectively, the airlock chamber, equilibrator, and the cryogenic chamber define a travel path. A machine-readable medium, comprising instructions which when executed by a controller causes a sample to be cooled, is also provided. | 02-28-2013 |