Patent application number | Description | Published |
20100331295 | MODULATORS OF LXR - Compounds of the invention, such as compounds of Formulae Ia, Ib, Ic, or Id and pharmaceutically acceptable salts, isomers, and prodrugs thereof, which are useful as modulators of the activity of liver X receptors, where R1, R2, R21, R3, and G are defined herein. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed. | 12-30-2010 |
20130331397 | COMPOUNDS AND COMPOSITIONS AS TRK INHIBITORS - The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated TRK kinase activity. | 12-12-2013 |
Patent application number | Description | Published |
20080234270 | Pyrrole Derivatives As Pharmaceutical Agents - Compounds, compositions and methods for modulating the activity of receptors are provided. In particular compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors. | 09-25-2008 |
20090203577 | Azepinoindole Derivatives As Pharmaceutical Agents - The present invention relates to compounds of formula I, which exhibit affinity for the farnesoid X receptor. | 08-13-2009 |
20090247515 | 11 Beta-HSD1 Modulators - A compound according to Formula A: | 10-01-2009 |
20090326218 | Azepinoindole and Pyridoindole Derivatives as Pharmaceutical Agents - Compounds, compositions and methods for modulating the activity of receptors are provided. In particular compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors. | 12-31-2009 |
20100075964 | IMIDAZOLE BASED LXR MODULATORS - Compounds of the invention, such as compounds of Formulae IIa, IIb, IIc or IId, and pharmaceutically acceptable salts, isomers, and prodrugs thereof, are useful as modulators of the activity of liver X receptors, where R | 03-25-2010 |
20100173824 | Azepinoindole Derivatives As Pharmaceutical Agents - Compounds, compositions and methods for modulating the activity of receptors are provided. In particular, compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors. | 07-08-2010 |
20110144128 | Heterocyclic Carboxamide Compounds as Steroid Nuclear Receptors Ligands - Heterocyclic carboxamide compounds are described herein as being useful in modulating the activity of steroid nuclear receptors. Pharmaceutical compositions containing the compounds, methods of using the compounds and processes for making the compounds are also described. | 06-16-2011 |
20110301128 | Pyrrole Derivatives As Pharmaceutical Agents - Compounds, compositions and methods for modulating the activity of receptors are provided. In particular compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors. | 12-08-2011 |
20120040985 | TRIAZOLE AND IMIDAZOLE DERIVATIVES FOR USE AS TGR5 AGONISTS IN THE TREATMENT OF DIABETES AND OBESITY - The present invention comprises TGR5 agonists of structural formula I, | 02-16-2012 |
20120064025 | Quinazolinone Modulators Of Nuclear Receptors - Compounds, pharmaceutical compositions and methods for modulating the activity of nuclear receptors are provided. In particular, quinazolinones are provided for modulating the activity of farnesoid X receptor (FXR) and/or orphan nuclear receptors. | 03-15-2012 |
20120065184 | COMPOUNDS AND COMPOSITIONS AS TRK INHIBITORS - The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated TRK kinase activity. | 03-15-2012 |
20130303505 | TGR5 AGONISTS - TGR5 agonists of structural formula VIII(Q), wherein X, R | 11-14-2013 |
20140038964 | IMIDAZOLE BASED LXR MODULATORS - Methods of using compounds of the invention, such as compounds of Formulae IIa, IIb, IIc, or IId | 02-06-2014 |
Patent application number | Description | Published |
20080203221 | JAM TOLERANT ELECTROMECHANICAL ACTUATION SYSTEMS AND METHODS OF OPERATION - In a vehicle, having a fixed supporting structure and a load movable relative thereto, a jam tolerant actuating system, a method for controlling this system including: Locating a physical coupling/decoupling mechanism between the load and an actuator assembly as close a practicable to the load; constructing the coupling/uncoupling mechanism to be reversible, and hence testable; and controlling the connection/disconnection via decision making electronics which will detect any system failure by monitoring, at a minimum: actuator main motor load and speed, and actuator output load. Also set forth are specific embodiments of pivotable rotary geared actuators as well as linear ball screw type actuators embodying the coupling/uncoupling mechanisms of this invention. | 08-28-2008 |
20090108129 | JAM TOLERANT ELECTROMECHANICAL ACTUATION SYSTEMS AND METHODS OF OPERATION - In a vehicle, having a fixed supporting structure and a load movable relative thereto, a jam tolerant actuating system, a method for controlling this system including: Locating a physical coupling/decoupling mechanism between the load and an actuator assembly as close a practicable to the load; constructing the coupling/uncoupling mechanism to be reversible, and hence testable; and controlling the connection/disconnection via decision making electronics which will detect any system failure by monitoring, at a minimum: actuator main motor load and speed, and actuator output load. Also set forth are specific embodiments of pivotable rotary geared actuators as well as linear ball screw type actuators embodying the coupling/uncoupling mechanisms of this invention. | 04-30-2009 |
20090108130 | JAM TOLERANT ELECTROMECHANICAL ACTUATION SYSTEMS AND METHODS OF OPERATION - In a vehicle, having a fixed supporting structure and a load movable relative thereto, a jam tolerant actuating system, a method for controlling this system including: Locating a physical coupling/decoupling mechanism between the load and an actuator assembly as close a practicable to the load; constructing the coupling/uncoupling mechanism to be reversible, and hence testable; and controlling the connection/disconnection via decision making electronics which will detect any system failure by monitoring, at a minimum: actuator main motor load and speed, and actuator output load. Also set forth are specific embodiments of pivotable rotary geared actuators as well as linear ball screw type actuators embodying the coupling/uncoupling mechanisms of this invention. | 04-30-2009 |
20100213311 | ELECTROMECHANICAL ACTUATING ASSEMBLY - An electromechanical actuating assembly ( | 08-26-2010 |