Patent application number | Description | Published |
20080275546 | Inhibitory cell adhesion surfaces - Textured nanostructured surfaces are described which are highly resistant to cell adhesion. Such surfaces on medical implants inhibit fibroblast adhesion particularly on titanium treated silicone. The surfaces can also be engineered so that other cell types, such as endothelial and osteoblast cells, show little if any tendency to attach to the surface in vivo. | 11-06-2008 |
20090035722 | Hydroxyapatite coated nanostructured titanium surfaces - Nanotubular structured titanium (Ti) substrates have been coated with nanoparticulate hydroxyapatite (nano-HA). The nano-HA surface is highly adherent to the nanotubular Ti surface and is free of microparticles. The nano-HA coated nanotubular Ti surface promotes osteoblast cell adhesion and is particularly suitable for orthopedic and dental implants where deposition of osteoblasts and other proteins is important in bone formation. | 02-05-2009 |
20090186068 | Atomic plasma deposited coatings for drug release - Nanophase single or multiple layer time release coatings over drugs attached to metal surfaces are described. The coatings are deposited over a drug attached to a porous metal substrate using an atomic plasma deposition procedure. Porosity of the substrate and the number of APD deposited layers controls drug release when the attached drug is exposed to an aqueous medium. | 07-23-2009 |
20090287302 | Polymer coated spinulose metal surfaces - Spinulose surfaces such as titanium and zirconium can be coated with a range of polymers used to form thin, adherent polymer surface films. Selected polymer coatings are useful for use as biocompatible surfaces on implants, catheters, guidewires, stents and a variety of medical devices for in vivo applications. The polymer coatings can also be used to protect metal surfaces nanostructured with spinulose titanium or zirconium. | 11-19-2009 |
20100028387 | Biocompatible Coated Nanostructured Titanium Surfaces - Bioactive molecules have been coated on nanotubular structured titanium substrates by molecular plasma deposition. The coatings promote cell adhesion and are particularly suited for orthopedic implants that provide improved bone cell adhesion and new tissue growth. Nanodimensional features on titanium substrates are engineered using electrochemical anodization techniques. The nanostructured surfaces provide superior support for a wide selection of polypeptide coatings. | 02-04-2010 |
20100057179 | Conductive metal thin coatings for implantable medical sensing devices - Thin conductive metal coatings suitable for flexible nonmetal fine wires and leads are described. Polymer clad silica fiber cores are produced by plasma coating with dual layers of metals such as silver, gold or titanium to provide micro thin leads such as those used for pacemakers that are resistant to flexing breakage, and are conductive. The metal surfaces can be engineered to promote cell adhesion so that tissue scarring in vivo is greatly reduced. Nanostructure and thickness of the metal coating can be controlled to provide radiopaque surfaces on nonmetal medical devices and lead wires. | 03-04-2010 |
20100204777 | INHIBITORY CELL ADHESION SURFACES - Nanostructured surfaces on selected substrates are described which are highly resistant to cell adhesion. Such surfaces on medical implants inhibit fibroblast adhesion particularly on nanorough titanium deposited on smooth silicone surfaces. The nanostructured deposited metal coatings can also be engineered so that several cell types, including endothelial, osteoblast, and fibroblast cells, show little if any tendency to attach to the coated surface in vivo. | 08-12-2010 |
20100298925 | SPINULOSE METAL SURFACES - Spinulose metal surfaces are produced by a modified nanoplasma cyclic deposition process. The unique spinulose surfaces are highly adherent toward polymer and bioactive molecules and cells, including osteoblast, fibroblast and endothelial cells. The nanostructured spinulose surfaces can be coated with a wide range of polymers to form polymer surface coatings that are particularly useful on implants, catheters, guidewires, stents and other medical devices intended for in vivo applications. | 11-25-2010 |
20110003172 | Spinulose Titanium Nanoparticulate Surfaces - Vapor plasma deposition of titanium (Ti) metal onto a substrate forms a structured surface that exhibits enhanced cell attachment properties. Initially deposited round nanoparticulate surface structures develop tentacles with a spine or thorn-like appearance upon continued deposition under special conditions. The density and size of the formed spinulose particles can be controlled by timing the deposition intervals. A significant increase in osteoblast, fibroblast and endothelial cell attachment is observed on Ti spinulose surfaces compared to attachment on nanoparticulate surfaces lacking spinulous nanostructure. | 01-06-2011 |
20110054633 | Nanofilm Protective and Release Matrices - A modified atomic plasma deposition (APD) procedure is used to produce amorphous, nonconformal thin metal film coatings on a variety of substrates. The films are porous, mesh-like lattices with imperfections such as pinholes and pores, which are useful as scaffolds for cell attachment, controlled release of bioactive agents and protective coatings. | 03-03-2011 |