Le Pendu
Jacoues Le Pendu, Nantes FR
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20120071436 | METHOD, COMPOSITION AND KIT FOR ANTIGENIC BINDING OF NORWALK-LIKE VIRUSES - A method for preventing or treating an active Norwalk-Like Virus (NLV) infection in the gastrointestinal (GI) tract of a host, comprising the step of administering orally a fucosyl α1→2 carbohydrate compound to the host, the compound having a binding specificity of the antigenic determinant of a human histo-blood group antigen and competitively binds with a NLV at the determinant binding site of the NLV. The compound inhibits binding of the NLV in vivo to a histo-blood group antigen of the host, thereby inhibiting the active infection or preventing infection of the GI tract of the host by the NLV. | 03-22-2012 |
Jacques Le Pendu, Nantes FR
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20080274984 | METHOD, COMPOSITION AND KIT FOR ANTIGENIC BINDING OF NORWALK-LIKE VIRUSES - A method for detecting a Norwalk-Like Virus (NLV) in a biological sample, comprising the steps of: obtaining a biological sample suspected of containing a NLV; contacting the biological sample with at least one human histo-blood group antigen to allow formation of a complex of the NLV with the antigen; and detecting the antigen-NLV complex. The antigen-NLV complex can be detected by contacting the NLV-antigen complex with a NLV antibody that binds at an epitope of the NLV, and detecting the NLV antibody. The invention also includes a method for identifying compounds, and the compounds, that can inhibit the binding between a Norwalk-Like Virus (NLV) and a histo-blood group antigen. The method includes the steps of contacting the NLV target with a compound; subsequently contacting the NLV with a standard compound that is known to be bound at a determinant binding site of the NLV; and determining whether the binding of the standard compound is decreased in the presence of the test compound, the decrease in binding being an indication that the test compound inhibits the binding activity of the NLV with the standard compound. In preferred embodiments, the standard compound is a histo-blood group antigen. | 11-06-2008 |
Mikael Le Pendu, Rennes FR
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20150365701 | METHOD FOR ENCODING AND DECODING IMAGE BLOCK, ENCODER AND DECODER - A method for encoding and decoding an image block, an encoder, and a decoder are provided. The method for encoding an image block comprises: determining a local dynamic range of the block; adaptively precision-extending pixel values of the block based on the local dynamic range of the block; and encoding the block with an adaptively extended precision. The method for decoding an image block comprises: determining a minimum pixel value of the block and an indicating value for indicating a precision extension factor according to precision extension information; decoding the block according to the indicating value; and de-extending precision of the decoded block based on the minimum pixel value of the block and the precision extension factor. The precision of the intermediate calculations may be improved without increasing an original intermediate bit depth used in intermediate calculations. | 12-17-2015 |