Patent application number | Description | Published |
20080274556 | DETECTING ISOMERS USING DIFFERENTIAL DERIVATIZATION MASS SPECTROMETRY - Methods of evaluating molecular isomers of branched-chain amino acids are featured. The methods can include: derivatizing one or more molecular isomers of branched-chain amino acids in a sample comprising a branched-chain amino acid labeled with one or more heavy atoms as a first standard; adding, to the sample, after derivatization, a nonderivatized or derivatized branched chain amino acid that is labeled with one or more heavy atoms, as a second standard; evaluating the sample using tandem mass spectrometry; and detecting peaks indicative of derivatized and nonderivatized forms of one or more branched-chain amino acids in the sample. | 11-06-2008 |
20080274563 | DETECTING SUCCINYLACETONE - This invention relates, inter alia, to detecting and/or measuring succinylacetone and one or more additional biological analytes using mass spectrometry. | 11-06-2008 |
20090068634 | SUBSTRATES AND INTERNAL STANDARDS FOR MASS SPECTROMETRY DETECTION - An inventive substrate is provided which includes a substrate compound of formula A-B | 03-12-2009 |
20090111137 | SIMULTANEOUS DETECTION OF METABOLIC ENZYME ACTIVITY AND METABOLITE LEVELS - Provided are methods for detecting a metabolic disorder in an individual using mass spectrometry. One method involves (a) contacting a sample containing (i) one or more metabolically indicative enzymes and (ii) one or more metabolic analytes, with one or more substrates for said one or more enzymes to produce a reaction admixture, under conditions wherein at least one of said enzymes is capable of acting on a corresponding substrate to generate at least one product, and wherein one or more protease inhibitors are present; (b) contacting said reaction admixture with a reagent that inhibits the ability of said one or more enzymes to act on a corresponding substrate, wherein said one or more metabolic analytes and said at least one product are soluble in said reagent; to produce a test sample and (c) determining the presence or amount of said one or more metabolic analytes and said at least one product contained in said test sample using mass spectrometry, wherein a determined presence or amount of said one or more metabolic analytes and said at least one product correlates with presence or absence of said metabolic disorder product correlates with presence or absence of said metabolic disorder. | 04-30-2009 |
20090253117 | ENZYMATIC SUBSTRATES FOR MULTIPLE DETECTION SYSTEMS - An inventive substrate is provided which includes a substrate compound of formula A-B | 10-08-2009 |
20100227412 | Simultaneous Detection of Estrogen and Non Estrogen Steroids - Methods for determining the amounts of estrogen and non-estrogen steroids in a sample are provided. The methods employ the selective derivatization of estrogen steroids present in a sample and detection of the molecular ions and fragments of the derivatized estrogens and non-estrogen steroids in the sample. The methods provided herein enable the simultaneous quantification of estrogen and non-estrogen steroids in a sample. | 09-09-2010 |
20110020942 | MEASURING LEVELS OF A METABOLITE - Described herein are methods for determining an amount of an analyte in a test sample. The methods involve preparing a calibration curve using standard samples containing an isotopically-labeled standard in a biological matrix. | 01-27-2011 |
20110189780 | DETECTING ISOMERS USING DIFFERENTIAL DERIVATIZATION MASS SPECTROMETRY - Methods of evaluating molecular isomers of branched-chain amino acids are featured. The methods can include: derivatizing one or more molecular isomers of branched-chain amino acids in a sample comprising a branched-chain amino acid labeled with one or more heavy atoms as a first standard; adding, to the sample, after derivatization, a nonderivatized or derivatized branched chain amino acid that is labeled with one or more heavy atoms, as a second standard; evaluating the sample using tandem mass spectrometry; and detecting peaks indicative of derivatized and nonderivatized forms of one or more branched-chain amino acids in the sample. | 08-04-2011 |
20110201539 | DETECTING SUCCINYLACETONE - This invention relates, inter alia, to detecting and/or measuring succinylacetone and one or more additional biological analytes using mass spectrometry. | 08-18-2011 |
20120122131 | SIMULTANEOUS DETECTION OF METABOLIC ENZYME ACTIVITY AND METABOLITE LEVELS - Provided are methods for detecting a metabolic disorder in an individual using mass spectrometry. One method involves (a) contacting a sample containing (i) a metabolically indicative enzyme and (ii) a metabolic analyte, with a substrate for the enzyme to produce a reaction admixture, under conditions wherein the enzyme is capable of acting on a corresponding substrate to generate a product, and wherein a protease inhibitor is present; (b) contacting the reaction admixture with a reagent that inhibits the ability of the enzyme to act on a corresponding substrate, wherein the metabolic analyte and the product are soluble in the reagent; to produce a test sample and (c) determining the presence or amount of the metabolic analyte and the product contained in the test sample using mass spectrometry, wherein a determined presence or amount of the metabolic analyte and the product correlates with presence or absence of the metabolic disorder. | 05-17-2012 |
20120190043 | ENZYMATIC SUBSTRATES FOR MULTIPLE DETECTION SYSTEMS - An inventive substrate is provided which includes a substrate compound of formula A-B | 07-26-2012 |
20120295295 | DETECTING ISOMERS USING DIFFERENTIAL DERIVATIZATION MASS SPECTROMETRY - Methods of evaluating molecular isomers of branched-chain amino acids are featured. The methods can include: derivatizing one or more molecular isomers of branched-chain amino acids in a sample comprising a branched-chain amino acid labeled with one or more heavy atoms as a first standard; adding, to the sample, after derivatization, a nonderivatized or derivatized branched chain amino acid that is labeled with one or more heavy atoms, as a second standard; evaluating the sample using tandem mass spectrometry; and detecting peaks indicative of derivatized and nonderivatized forms of one or more branched-chain amino acids in the sample. | 11-22-2012 |
20120295361 | MEASURING LEVELS OF A METABOLITE - Described herein are methods for determining an amount of an analyte in a test sample. The methods involve preparing a calibration curve using standard samples containing an isotopically-labeled standard in a biological matrix. | 11-22-2012 |
20120309096 | DETECTING SUCCINYLACETONE - This invention relates, inter alia, to detecting and/or measuring succinylacetone and one or more additional biological analytes using mass spectrometry. | 12-06-2012 |
20130244269 | MEASURING LEVELS OF A METABOLITE - Described herein are methods for determining an amount of an analyte in a test sample. The methods involve preparing a calibration curve using standard samples containing an isotopically-labeled standard in a biological matrix. | 09-19-2013 |
20140045273 | METHODS AND APPARATUS FOR IDENTIFICATION OF POLYMERIC SPECIES FROM MASS SPECTROMETRY OUTPUT - Methods and apparatus are provided for the identification of one or more candidate chemical formulas from mass spectrometry data corresponding to an unidentified chemical compound. By restricting the generation of candidate formulas to those having repeating units and/or end units with specified limitations, the methods and apparatus may more efficiently iteratively search for a chemical formula having matching mass spectrometry output within a threshold tolerance. In another aspect, methods and apparatus are provided for the identification of one or more candidate chemical formulas from mass spectrometry data based at least in part upon neutral loss. | 02-13-2014 |
Patent application number | Description | Published |
20090238776 | Oral Care Compositions and Methods - The present invention relates to oral care compositions. The oral care compositions include an adhesive component and an oral care active, and are combined with a viscosity index improver and/or a water insoluble component. The present invention is also directed to methods relating to the oral care compositions. | 09-24-2009 |
20090239972 | Denture Adhesive Compositions and Methods - The present invention relates to denture adhesive compositions. The denture adhesive compositions include an adhesive component and a viscosity index improver. The present invention is also directed to methods relating to the denture adhesive compositions. | 09-24-2009 |
20100317763 | Denture Adhesive Articles - A denture adhesive article, comprising a denture adhesive component and a viscosity index improver, wherein the denture adhesive article is preformed. | 12-16-2010 |
20110094415 | DENTURE ADHESIVE ARTICLES - A denture adhesive article, comprising a denture adhesive component and a viscosity index improver, wherein the denture adhesive article is preformed. | 04-28-2011 |
20110104219 | DENTURE CARE COMPOSITION - A denture care composition comprising one or more denture care actives and one or more water insoluble carriers, wherein the composition is bioerodible, not a denture adhesive, and substantially free of polybutene with a molecular weight of about 300 to about 3000 when the composition is not an article, and is applied to dentures. | 05-05-2011 |
20120006859 | DEVICE FOR DISPENSING MATERIAL - A device for dispensing material comprising a pressurized container assembly, a tilt action valve connected to the container assembly, and a two-piece actuator, including a lower piece and an upper piece, where the upper piece has a discharge nozzle orifice and also a portion to be moved by a user in the single direction of the discharge orifice to open the tilt action valve and discharge the material in the single direction. | 01-12-2012 |
20120037038 | DENTURE ADHESIVE COMPOSITIONS AND METHODS - The present invention relates to denture adhesive compositions. The denture adhesive compositions include an adhesive component and a viscosity index improver. The present invention is also directed to methods relating to the denture adhesive compositions. | 02-16-2012 |
20140311527 | Device And Method For Cleaning Dental Appliances - A device for cleaning a dental appliance is disclosed. The device includes a holding container including an upper portion and a lower portion, the holding container adapted to receive at least one dental appliance; an electrolytic cell for generating chlorine dioxide from a chlorine dioxide precursor; and an electrical current supply including a circuit operably connecting the electrical current supply to the electrolytic cell. | 10-23-2014 |