Patent application number | Description | Published |
20080269685 | Solvent-cast microneedle arrays containing active - In an aspect of the invention, an array of microprotrusions is formed by providing a mold with cavities corresponding to the negative of the microprotrusions, casting atop the mold a first solution comprising a biocompatible material and a solvent, removing the solvent, casting a second solution atop the first cast solution, removing the solvent from the second solution, and demolding the resulting array from the mold. The first solution preferably contains an active ingredient. | 10-30-2008 |
20090155330 | Vaccine Delivery via Microneedle Arrays - A microprojection array is provided, comprising an approximately planar base and a plurality of microprojections, wherein the array comprises a vaccine and a polymeric material. The array may have multiple layers. The vaccine may be placed in only one layer. In another embodiment of the invention, a method of preventing a disease is provided, comprising insertion into the skin of a patient an array of microprojections comprising a layer which comprises a vaccine for that disease and a polymer. | 06-18-2009 |
20110006458 | METHODS FOR MANUFACTURING MICROPROJECTION ARRAYS - Methods for the manufacture of a microprojection array are provided. In the methods, a formulation is introduced into cavities of a microprojection array mold by means that achieve a uniform amount of formulation retained in each cavity. | 01-13-2011 |
20110276027 | APPLICATORS FOR MICRONEEDLES - An applicator for a microprojection array is described. In one embodiment, the applicator comprises an energy-storing element. Application of force causes the compressed energy-storing element to extend or transition from first and second configurations, releasing stored energy to deploy a holding member in the application which is configured to hold an array of microprojections. In another embodiment, the applicator comprises an energy storing element with two stable configurations, a first stable configuration and second stable configuration. Application of force causes the energy-storing element to transition from the higher energy first stable configuration to the lower energy second stable configuration, releasing the difference in energies of the two states to deploy a holding member in the application which is configured to hold an array of microprojections. | 11-10-2011 |
20110276028 | METHOD AND DEVICE FOR TRANSDERMAL DELIVERY OF PARATHYROID HORMONE USING A MICROPROJECTION ARRAY - A method and a drug delivery system for transdermally administering parathyroid hormone (PTH) in a pulsatile fashion are provided, where the drug delivery system comprises an array of microprojections each comprising PTH. | 11-10-2011 |
20130131598 | METHODS FOR MANUFACTURING MICROPROJECTION ARRAYS - Methods for the manufacture of a microprojection array are provided. In the methods, a formulation is introduced into cavities of a microprojection array mold by means that achieve a uniform amount of formulation retained in each cavity. | 05-23-2013 |
20130292868 | SOLVENT-CAST MICROPROTRUSION ARRAYS CONTAINING ACTIVE INGREDIENT - In an aspect of the invention, an array of microprotrusions is formed by providing a mold with cavities corresponding to the negative of the microprotrusions, casting atop the mold a first solution comprising a biocompatible material and a solvent, removing the solvent, casting a second solution atop the first cast solution, removing the solvent from the second solution, and demolding the resulting array from the mold. The first solution preferably contains an active ingredient. | 11-07-2013 |
20130292886 | METHODS FOR MANUFACTURING MICROPROJECTION ARRAYS - Methods for the manufacture of a microprojection array are provided. In the methods, a formulation is introduced into cavities of a microprojection array mold by means that achieve a uniform amount of formulation retained in each cavity. | 11-07-2013 |
20140180201 | MICROARRAY FOR DELIVERY OF THERAPEUTIC AGENT AND METHODS OF USE - Devices and methods for using and manufacturing microstructure arrays having at least a detachable distal area are described. | 06-26-2014 |
20140272101 | MICROARRAY FOR DELIVERY OF THERAPEUTIC AGENT, METHODS OF USE, AND METHODS OF MAKING - Devices and methods for using and manufacturing microstructure arrays are described. | 09-18-2014 |
20140276580 | MICROPROJECTION APPLICATORS AND METHODS OF USE - Applicators for a microprojection array and methods of using the applicators are described. | 09-18-2014 |
20150079133 | METHOD OF VACCINE DELIVERY VIA MICRONEEDLE ARRAYS - A microprojection array is provided, comprising an approximately planar base and a plurality of microprojections, wherein the array comprises a vaccine and a polymeric material. The array may have multiple layers. The vaccine may be placed in only one layer. In another embodiment of the invention, a method of preventing a disease is provided, comprising insertion into the skin of a patient an array of microprojections comprising a layer which comprises a vaccine for that disease and a polymer. | 03-19-2015 |