Patent application number | Description | Published |
20100074903 | NOVEL ANTIBODY FORMULATION - This invention relates to a pharmaceutical formulation of an antibody against P-Selectin, a process for the preparation of the formulation and uses of the formulation. | 03-25-2010 |
20100285011 | HIGH CONCENTRATION ANTIBODY-CONTAINING LIQUID FORMULATION - The problem to be solved is to provide an antibody-containing formulation which is stable and suited for subcutaneous administration, wherein dimerization and deamidation is prevented during long-term storage. The present application is directed to a stable antibody-containing liquid formulation characterized by containing arginine and methionine. | 11-11-2010 |
20110076273 | Highly Concentrated Pharmaceutical Formulations - The present invention relates to a highly concentrated, stable pharmaceutical formulation of a pharmaceutically active anti-CD20 antibody, such as e.g. Rituximab, Ocrelizumab, or HuMab, or a mixture of such antibody molecules for subcutaneous injection. In particular, the present invention relates to formulations comprising, in addition to a suitable amount of the anti-CD20 antibody, an effective amount of at least one hyaluronidase enzyme as a combined formulation or for use in form of a co-formulation. The said formulations comprise additionally at least one buffering agent, such as e.g. a histidine buffer, a stabilizer or a mixture of two or more stabilizers (e.g. a saccharide, such as e.g. α,α-trehalose dihydrate or sucrose, and optionally methionine as a second stabilizer), a nonionic surfactant and an effective amount of at least one hyaluronidase enzyme. Methods for preparing such formulations and their uses thereof are also provided. | 03-31-2011 |
20120321638 | FORMULATION COMPRISING AN ANTIBODY AGAINST P-SELECTIN - This invention relates to a pharmaceutical formulation of an antibody against P-Selectin, a process for the preparation of the formulation and uses of the formulation. | 12-20-2012 |
20130209478 | FORMULATION COMPRISING AN ANTIBODY AGAINST P-SELECTIN - This invention relates to a pharmaceutical formulation of an antibody against P-Selectin, a process for the preparation of the formulation and uses of the formulation. | 08-15-2013 |
20130216532 | Subcutaneous anti-HER2 Antibody Formulations and Uses Thereof - The present invention relates to a highly concentrated, stable pharmaceutical formulation of a pharmaceutically active anti-HER2 antibody, such as e.g. Trastuzumab (HERCEPTIN™), Pertuzumab or T-DM1, or a mixture of such antibody molecules for subcutaneous injection. In particular, the present invention relates to formulations comprising, in addition to a suitable amount of the anti-HER2 antibody, an effective amount of at least one hyaluronidase enzyme as a combined formulation or for use in form of a co-formulation. The formulations comprise additionally at least one buffering agent, such as e.g. a histidine buffer, a stabilizer or a mixture of two or more stabilizers (e.g. a saccharide, such as e.g. α,α-trehalose dihydrate or sucrose, and optionally methionine as a second stabilizer), a nonionic surfactant and an effective amount of at least one hyaluronidase enzyme. Methods for preparing such formulations and their uses thereof are also provided. | 08-22-2013 |
20130296807 | DRUG RECONSTITUTION AND DELIVERY DEVICE - A device for automatically delivering a drug to a user and method thereof are disclosed. The device ( | 11-07-2013 |
20140005367 | HIGH CONCENTRATION ANTIBODY-CONTAINING LIQUID FORMULATION | 01-02-2014 |
20150086537 | HIGHLY CONCENTRATED PHARMACEUTICAL FORMULATIONS - The present invention relates to a highly concentrated, stable pharmaceutical formulation of a pharmaceutically active anti-CD20 antibody, such as e.g. Rituximab, Ocrelizumab, or HuMab, or a mixture of such antibody molecules for subcutaneous injection. In particular, the present invention relates to formulations comprising, in addition to a suitable amount of the anti-CD20 antibody, an effective amount of at least one hyaluronidase enzyme as a combined formulation or for use in form of a co-formulation. The said formulations comprise additionally at least one buffering agent, such as e.g. a histidine buffer, a stabilizer or a mixture of two or more stabilizers (e.g. a saccharide, such as e.g. α,α-trehalose dihydrate or sucrose, and optionally methionine as a second stabilizer), a nonionic surfactant and an effective amount of at least one hyaluronidase enzyme. Methods for preparing such formulations and their uses thereof are also provided. | 03-26-2015 |
Patent application number | Description | Published |
20080269640 | Appliance for Recording Diagnostic Values in the Body - In an appliance for recording diagnostic values in the body, with at least one sensor element that is assigned to a housing, the housing is intended to be able to be implanted with the at least one sensor element. | 10-30-2008 |
20100228357 | GROWING PROSTHESIS - A growing prosthesis comprising a joint replacement part, a prosthesis stem, a stem-anchoring element, and an element with corresponding drive provided for the lengthening of the growing prosthesis. The element provided for the lengthening of the growing prosthesis is a spindle element arranged in the stem-anchoring element. | 09-09-2010 |
20130072932 | INTRAMEDULLARY NAIL - Intramedullary nail for distraction of a long bone with an at least partially hollow shank extending in an axial direction of the intramedullary nail, locking element for locking the shank in a first bone fragment of the long bone, a first inner section which is arranged in axially movable manner within the shank and has a through hole orientated in the radial direction for accommodating a segment bolt for fixing a bone segment of the long bone, wherein the shank has an elongated hole in the area of the inner section for passing through of the segment bolt, an actuator for axially moving the first inner section, wherein a second inner section is arranged within the shank so as to be axially movable. | 03-21-2013 |