Patent application number | Description | Published |
20080269272 | CYCLOPAMINE ANALOGUES AND METHODS OF USE THEREOF - The present invention provides compositions and methods for modulating smoothened-dependent pathway activation. The present invention provides analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-of-function mutations. The compounds of the present invention are particularly useful in treating cancers. | 10-30-2008 |
20080293754 | CYCLOPAMINE ANALOGS - The invention provides novel derivatives of cyclopamine having the following formula: | 11-27-2008 |
20080293755 | HETEROCYCLIC CYCLOPAMINE ANALOGS AND METHODS OF USE THEREOF - The present invention relates to steroidal alkaloids that can be used in the treatment of hedgehog pathway related disorders, particularly cancer. | 11-27-2008 |
20080306127 | Compounds and methods for inhibiting the interaction of BCL proteins with binding partners - One aspect of the present invention relates to heterocyclic compounds that bind to bcl proteins and inhibit Bcl function. Another aspect of the present invention relates to compositions comprising a heterocyclic compound of the invention. The present invention provides methods for treating and modulating disorders associated with hyperproliferation, such as cancer. | 12-11-2008 |
20090012109 | CYCLOPAMINE ANALOGS - The invention provides novel derivatives of cyclopamine having the following formula: | 01-08-2009 |
20090099131 | INHIBITORS OF FATTY ACID AMIDE HYDROLASE - The present invention provide compounds, and pharmaceutical compositions thereof, encompassed by the formulae (I), (II) or (III). | 04-16-2009 |
20090216022 | CYCLOPAMINE ANALOGS - The invention provides novel derivatives of cyclopamine having the following formula: | 08-27-2009 |
20100144775 | Heterocyclic Cyclopamine Analogs and Methods of Use Thereof - The present invention relates to steroidal alkaloids that can be used in the treatment of hedgehog pathway related disorders, particularly cancer. | 06-10-2010 |
20100190791 | Compounds and Methods for Inhibiting the Interaction of BCL Proteins with Binding Partners - The present invention relates to heterocyclic compounds that bind to Bcl proteins and inhibit Bcl function, compositions comprising such compounds, and methods for treating and modulating disorders associated with hyperproliferation, such as cancer. | 07-29-2010 |
20100286180 | METHODS OF USE OF CYCLOPAMINE ANALOGS - The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula: | 11-11-2010 |
20110028478 | ISOXAZOLINES AS INHIBITORS OF FATTY ACID AMIDE HYDROLASE - The present invention provides isoxazoline FAAH inhibitors of the formula (I): | 02-03-2011 |
20110028482 | ISOXAZOLINES AS INHIBITORS OF FATTY ACID AMIDE HYDROLASE - The present invention provides isoxazoline FAAH inhibitors of the formula (I): | 02-03-2011 |
20110034437 | ISOXAZOLINES AS INHIBITORS OF FATTY ACID AMIDE HYDROLASE - The present invention provides isoxazoline FAAH inhibitors of the formula (I): | 02-10-2011 |
20110160259 | Compounds and Methods for Inhibiting the Interaction of BCL Proteins with Binding Partners - One aspect of the present invention relates to heterocyclic compounds that bind to bcl proteins and inhibit Bcl function. Another aspect of the present invention relates to compositions comprising a heterocyclic compound of the invention. The present invention provides methods for treating and modulating disorders associated with hyperproliferation, such as cancer. | 06-30-2011 |
20110166353 | Cyclopamine Analogues and Methods of Use Thereof - The present invention provides compositions and methods for modulating smoothened-dependent pathway activation. The present invention provides analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-of-function mutations. The compounds of the present invention are particularly useful in treating cancers. | 07-07-2011 |
20110172186 | INHIBITORS OF FATTY ACID AMIDE HYDROLASE - The present invention provides compounds, and pharmaceutically acceptable compositions thereof, encompassed by any of formulae (I), (II), (III), (IV), (V), or (VI), or subgenera thereof. The present invention also provides methods for treating an FAAH mediated disease, disorder or condition by administering a therapeutically effective amount of a compound or composition comprising a compound of any of formulae (I), (II), (III), (IV), (V), or (VI), or subgenera thereof, to a patient in need thereof. Additionally, the present invention provides methods for inhibiting FAAH by administering a therapeutically effective amount of a compound or composition comprising a compound of any of formulae (I), (II), (III), (IV), (V), or (VI), or subgenera thereof, to a patient in need thereof. | 07-14-2011 |
20110213145 | Compounds and Methods for Inhibiting the Interaction of BCL Proteins with Binding Partners - The invention relates to isoxazolidine containing compounds that bind to bcl proteins and inhibit Bcl function. The compounds may be used for treating and modulating disorders associated with hyperproliferation, such as cancer. | 09-01-2011 |
20110224171 | INHIBITORS OF FATTY ACID AMIDE HYDROLASE - The present invention provide compounds, and pharmaceutical compositions thereof, encompassed by the formulae (I), (II) or (III). | 09-15-2011 |
20110230440 | INHIBITORS OF FATTY ACID AMIDE HYDROLASE - The present invention provide compounds, and pharmaceutical compositions thereof, encompassed by the formulae (I), (II) or (III). | 09-22-2011 |
20110230509 | METHODS OF USE FOR CYCLOPAMINE ANALOGS - The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula: | 09-22-2011 |
20110274654 | TRIAZOLES AS INHIBITORS OF FATTY ACID SYNTHASE - Provided herein are triazole FASN inhibitors of the formula (I): | 11-10-2011 |
20110274655 | TETRAZOLONES AS INHIBITORS OF FATTY ACID SYNTHASE - Provided herein are tetrazolone FASN inhibitors of the formula (I): | 11-10-2011 |
20120015934 | CYCLOPAMINE LACTAM ANALOGS AND METHODS OF USE THEREOF - The present invention relates to steroidal alkaloids useful in the treatment of hedgehog pathway related disorders, particularly cancer. | 01-19-2012 |
20120059000 | CHEMICAL COMPOUNDS, COMPOSITIONS AND METHODS FOR KINASE MODULATION - Chemical compounds that modulate kinase activity, including PI3 kinase activity, and chemical compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including P13 kinase activity, are described herein. | 03-08-2012 |
20120065218 | Heterocyclic Cyclopamine Analogs and Methods of Use Thereof - The present invention relates to steroidal alkaloids that can be used in the treatment of hedgehog pathway related disorders, particularly cancer. | 03-15-2012 |
20120077834 | Methods of Use of Cyclopamine Analogs - The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula: | 03-29-2012 |
20120088738 | INHIBITORS OF FATTY ACID AMIDE HYDROLASE - Provided herein are compounds of formula (I): or pharmaceutically acceptable salts, solvates or prodrugs thereof or mixtures thereof, wherein Z | 04-12-2012 |
20120094957 | INHIBITORS OF FATTY ACID AMIDE HYDROLASE - Provided herein are compounds of formula (I) or pharmaceutically acceptable salts, solvates or prodrugs thereof, or mixtures thereof, wherein Z | 04-19-2012 |
20120122838 | HETEROCYCLIC COMPOUNDS AND USES THEREOF - Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein. | 05-17-2012 |
20130029982 | HETEROCYCLIC COMPOUNDS AND USES THEREOF - Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein. | 01-31-2013 |
20130029984 | HETEROCYCLIC COMPOUNDS AND USES THEREOF - Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein. | 01-31-2013 |
20130053362 | HETEROCYCLIC COMPOUNDS AND USES THEREOF - Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including P13 kinase activity, are described herein. | 02-28-2013 |
20130059819 | INHIBITORS OF FATTY ACID AMIDE HYDROLASE - The present invention provide compounds, and pharmaceutical compositions thereof, encompassed by the formulae (I), (II) or (III). | 03-07-2013 |
20130108582 | METHODS OF USE OF CYCLOPAMINE ANALOGS | 05-02-2013 |
20130108583 | METHODS OF USE FOR CYCLOPAMINE ANALOGS | 05-02-2013 |
20130131063 | Compounds and Methods for Inhibiting the Interaction of BCL Proteins with Binding Partners - The invention relates to isoxazolidine containing compounds that bind to bcl proteins and inhibit Bcl function. The compounds may be used for treating and modulating disorders associated with hyperproliferation, such as cancer. | 05-23-2013 |
20130243727 | TRIAZOLES AS INHIBITORS OF FATTY ACID SYNTHASE - Provided herein are triazole FASN inhibitors of the formula (I): | 09-19-2013 |
20130267521 | HETEROCYCLIC COMPOUNDS AND USES THEREOF - Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein. | 10-10-2013 |
20130338107 | INHIBITORS OF FATTY ACID AMIDE HYDROLASE - Provided herein are compounds of formula (I): or pharmaceutically acceptable salts, solvates or prodrugs thereof or mixtures thereof, wherein Z | 12-19-2013 |
20130345173 | INHIBITORS OF FATTY ACID AMIDE HYDROLASE - Provided herein are compounds of formula (I) or pharmaceutically acceptable salts, solvates or prodrugs thereof, or mixtures thereof, wherein Z | 12-26-2013 |
20140079667 | TETRAZOLONES AS INHIBITORS OF FATTY ACID SYNTHASE - Provided herein are tetrazolone FASN inhibitors of the formula (I): | 03-20-2014 |
20140088099 | CHEMICAL COMPOUNDS, COMPOSITIONS AND METHODS FOR KINASE MODULATION - Chemical compounds that modulate kinase activity, including PI3 kinase activity, and chemical compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including P13 kinase activity, are described herein. | 03-27-2014 |
20140100214 | HETEROCYCLIC COMPOUNDS AND USES THEREOF - Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including P13 kinase activity, are described herein. | 04-10-2014 |
20140107142 | METHODS OF USE OF CYCLOPAMINE ANALOGS - The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula: | 04-17-2014 |
20140121183 | INHIBITORS OF FATTY ACID AMIDE HYDROLASE - The present invention provide compounds, and pharmaceutical compositions thereof, encompassed by the formulae (I), (II) or (III). | 05-01-2014 |
20140235580 | INHIBITORS OF MONOACYLGLYCEROL LIPASE AND METHODS OF THEIR USE - Provided herein are compounds which mediate the activity of monoacyglycerol lipase (MAGL). Also provided are pharmaceutical compositions comprising a compound provided herein, and methods for treating, preventing and/or managing a MAGL mediated condition using a compound or pharmaceutical composition as provided herein. | 08-21-2014 |
20140371253 | Cyclopamine Analogs - The invention provides novel derivatives of cyclopamine having the following formula: | 12-18-2014 |