Patent application number | Description | Published |
20080202675 | Method for Handling Adhesive Laminate Sections - A method of handling an adhesive laminate, wherein the adhesive laminate is provided releasably adhered to a first web, comprising a plurality of cut or punched sections and wherein adjacent sections of the adhesive laminate remain joined to one another in the longitudinal direction of the web through one or more tie points. A first supporting structure and a second supporting structure adjacent to the first supporting structure are provided. The first web is led over the first supporting structure. A second web is provided and led over the second supporting structure, wherein the second web is oriented such that the release surface of the second web faces the first supporting structure. A leading portion of a first section of adhesive laminate from the first web is attached to the release surface of the second web and the second web is advanced such that the first section of the adhesive laminate is detached from a second section of adhesive laminate and the leading edge of the second section of adhesive laminate is adhered to the second web in a spaced apart configuration from the trailing edge of the first section of the adhesive laminate. A transdermal drug delivery device prepared by such a method. | 08-28-2008 |
20120114857 | METHOD OF CONTACT COATING A MICRONEEDLE ARRAY - A method of coating a microneedle array by applying a coating fluid using a flexible film in a brush-like manner. A method of coating a microneedle array comprising: providing a microneedle array having a substrate and a plurality of microneedles; providing a flexible film; providing a coating solution comprising a carrier fluid and a coating material; applying the coating solution onto a first major surface of the flexible film; performing a transfer step of bringing the first major surface of the flexible film into contact with the microneedles and removing the flexible film from contact with the microneedles; and allowing the carrier fluid to evaporate. | 05-10-2012 |
20130216694 | METHOD OF CONTACT COATING A MICRONEEDLE ARRAY - A method of coating a microneedle array by applying a coating fluid using a flexible film in a brush-like manner. A method of coating a microneedle array comprising: providing a microneedle array having a substrate and a plurality of microneedles; providing a flexible film; providing a coating solution comprising a carrier fluid and a coating material; applying the coating solution onto a first major surface of the flexible film; performing a transfer step of bringing the first major surface of the flexible film into contact with the microneedles and removing the flexible film from contact with the microneedles; and allowing the carrier fluid to evaporate. | 08-22-2013 |
20140066866 | METHOD FOR HANDLING ADHESIVE LAMINATE SECTIONS - A method of handling an adhesive laminate, wherein the adhesive laminate is provided releasably adhered to a first web, comprising a plurality of cut or punched sections and wherein adjacent sections of the adhesive laminate remain joined to one another in the longitudinal direction of the web through one or more tie points. A first supporting structure and a second supporting structure adjacent to the first supporting structure are provided. The first web is led over the first supporting structure. A second web is provided and led over the second supporting structure, wherein the second web is oriented such that the release surface of the second web faces the first supporting structure. A leading portion of a first section of adhesive laminate from the first web is attached to the release surface of the second web and the second web is advanced such that the first section of the adhesive laminate is detached from a second section of adhesive laminate and the leading edge of the second section of adhesive laminate is adhered to the second web in a spaced apart configuration from the trailing edge of the first section of the adhesive laminate. A transdermal drug delivery device prepared by such a method. | 03-06-2014 |
20140303574 | ADHESIVE PATCH ASSEMBLY WITH OVERLAY LINER AND SYSTEM AND METHOD FOR MAKING SAME - An adhesive patch assembly and method for making same. The assembly can include an adhesive patch and a release liner. The patch can include a backing and a skin-contact adhesive. The release liner can further include a first portion and a second portion separated by a hinge. The first portion can be positioned to overlay the backing of the patch when the release liner is folded upon the hinge, and the second portion can be positioned to underlie the skin-contact adhesive of the patch. The method can include positioning the patch on the release liner, such that patch is located on one of the first portion and the second portion of the release liner; and folding the release liner about to locate the patch between the first portion and the second portion of the release liner. | 10-09-2014 |
Patent application number | Description | Published |
20120309045 | Composite Probes and Use Thereof in Super Resolution Methods - Composite probes for super resolution optical techniques using super resolution via transiently activated quenchers (STAQ) include a donor moiety and an acceptor moiety joined by a linker, wherein the acceptor moiety, when excited by incident radiation, is excited to a state which, for example, absorbs in the donor emission region, such that the acceptor moiety in its excited state quenches at least a portion of the donor moiety emission. Other transiently activated quenching mechanisms and moieties could accomplish the same task by reducing donor population. Also disclosed are methods for irradiating a selected region of a target material including the composite probe, wherein the composite probe enables improved resolution by point spread function modification and/or nanoscale chemical reactions. | 12-06-2012 |
20120320458 | AZICON BEAM POLARIZATION DEVICES - Polarizers and polarizing beam splitter include one or more pairs of axicons that are configured to separate an input beam into a radially polarized component and a tangentially (or azimuthally) polarized component. A second axicon pair can be provided to recombine the tangentially polarized component so as to provide a more uniform beam intensity. The radially polarized component can be reflected or otherwise directed so that one or both the radial and tangential components are available for use. | 12-20-2012 |
20130153788 | NON-CONTACT TOTAL EMISSION DETECTION METHOD AND SYSTEM FOR MULTI-PHOTON MICROSCOPY - A multi-photon microscope having an illumination source that transmits an illumination light into a housing having an objective lens arrangement for illuminating a sample disposed outside the housing and directing a first portion of emission light emitted from the sample to a detection system is disclosed. A light collection system is disposed proximate the objective lens arrangement for directing a second portion of emission light in a coaxial relationship with the first portion of emission light to the detection system such that substantially all of the emission light on, around and above the illumination region is detected. | 06-20-2013 |
20130308126 | LIGHTGUIDES TO SIMPLIFY TOTAL EMISSION DETECTION FOR MULTIPHOTON MICROSCOPY - Light collectors for fluorescence microscopy include slab light guides having a specimen volume such as a specimen well configured to retain a specimen. The specimen volume is bounded by a surface of the slab light guide that permits laterally propagating fluorescence to enter the slab light guide and propagate toward a detection or imaging system. Typically, the slab light guide has an elliptical perimeter and the sample volume is situated at a first focus of the elliptical perimeter. A reflector such as a conical reflector is situated at the second focus so as to direct the collected fluorescence to exit the slab light guide. | 11-21-2013 |
20130345391 | Composite Probes and Use Thereof in Super Resolution Methods - Composite probes for super resolution optical techniques using super resolution via transiently activated quenchers (STAQ) include a donor moiety and an acceptor moiety joined by a linker, wherein the acceptor moiety, when excited by incident radiation, is excited to a state which, for example, absorbs in the donor emission region, such that the acceptor moiety in its excited state quenches at least a portion of the donor moiety emission. Other transiently activated quenching mechanisms and moieties could accomplish the same task by reducing donor population. Also disclosed are methods for irradiating a selected region of a target material including the composite probe, wherein the composite probe enables improved resolution by point spread function modification and/or nanoscale chemical reactions. | 12-26-2013 |
Patent application number | Description | Published |
20120078967 | Integration of a Framework Application and a Task Database - A financial services enterprise may provide for integrating a framework application and a task database. A flat file is extracted from a framework application, wherein the flat file is associated with a task and the task is associated with a financial services project. The flat file is manipulated to form a relational database data structure associated with the task. The relational database data structure is communicated to a management module, and the management module stores the relational database data structure in the task database to facilitate modeling the financial services project associated with a financial services enterprise. | 03-29-2012 |
20150293973 | MANAGING ELECTRONIC RECORDS - A system for managing electronic records comprises one or more memories comprising one or more databases, the databases configured to store a plurality of electronic records; one or more user interfaces configured to receive electronic records and criteria to associate the electronic records to one or more enterprise functions, technology platforms, and enterprise rules, and receive a query for one or more of the one or more electronic records, enterprise functions, technology platforms, and enterprise rules; and one or more processors configured to associate, according to the received criteria, the one or more electronic records with the one or more enterprise functions, technology platforms, and enterprise rules, and determine one or more electronic records, enterprise functions, technology platforms, and enterprise rules responsive to the received query. | 10-15-2015 |
Patent application number | Description | Published |
20080242038 | METHODS OF FORMING A MULTILAYER CAPPING FILM TO MINIMIZE DIFFERENTIAL HEATING IN ANNEAL PROCESSES - Methods and associated structures of forming a microelectronic device are described. Those methods may include implanting the source/drain region, forming a multilayer cap on the source/drain region, annealing the source/drain region, and removing the multilayer cap. | 10-02-2008 |
20090071918 | VERTICAL SEMICONDUCTOR WAFER CARRIER - A vertical semiconductor wafer carrier comprises a circular base, a first wafer support rod mounted at a first position proximate a perimeter of the circular base, a second wafer support rod mounted at a second position proximate the perimeter of the circular base, wherein an angle θ | 03-19-2009 |
20090323759 | Temperature measurement with reduced extraneous infrared in a processing chamber - Temperature measurement using a pyrometer in a processing chamber is described. The extraneous light received by the pyrometer is reduced. In one example, a photodetector is used to measure the intensity of light within the processing chamber at a defined wavelength. A temperature circuit is used to convert the measured light intensity to a temperature signal, and a doped optical window between a heat source and a workpiece inside processing chamber is used to absorb light at the defined wavelength directed at the workpiece from the heat source. | 12-31-2009 |
20090325392 | SUB-SECOND ANNEALING PROCESSES FOR SEMICONDUCTOR DEVICES - An annealing method and apparatus for semiconductor manufacturing is described. The method and apparatus allows an anneal that can span a thermal budget and be tailored to a specific process and its corresponding activation energy. In some cases, the annealing method spans a timeframe from about 1 millisecond to about 1 second. An example for this annealing method includes a sub-second anneal method where a reduction in the formation of nickel pipes is achieved during salicide processing. In some cases, the method and apparatus combine the rapid heating rate of a sub-second anneal with a thermally conductive substrate to provide quick cooling for a silicon wafer. Thus, the thermal budget of the sub-second anneal methods may span the range from conventional RTP anneals to flash annealing processes (including duration of the anneal, as well as peak temperature). Other embodiments are described. | 12-31-2009 |
Patent application number | Description | Published |
20100118206 | APPARATUS AND METHOD FOR USE IN MOBILE/HANDHELD COMMUNICATIONS SYSTEM - A signal comprises a sequence of fields, each field having a synchronization portion and a data portion, a transmitter inserts a pseudonoise (PN) sequence into the synchronization portion of a field for use in identifying a presence of mobile data in the data portion of that field; and transmits the signal. In complementary fashion, a receiver receives the signal and upon detecting the PN sequence in the synchronization portion of the received signal determines whether or not mobile data is in the data portion of that field of the received signal. | 05-13-2010 |
20100138877 | APPARATUS AND METHOD FOR USE IN A MOBILE/HANDHELD COMMUNICATIONS SYSTEM - An ATSC DTV mobile transmitter synchronizes their transmission with other associated stations. An ATSC DTV mobile receiver checks if it is in an area of poor reception and, if so, checks an associated station list for determining if the same programming can be received from an associated station. | 06-03-2010 |
20100165213 | APPARATUS AND METHOD FOR USE IN A MOBILE/HANDHELD COMMUNICATIONS SYSTEM - An ATSC DTV mobile transmitter synchronizes their transmissions with other associated stations. An ATSC DTV mobile receiver hops across channels during periods of idle time for forming a program guide including program guide information from channels besides a selected channel. | 07-01-2010 |
20100242078 | APPARATUS AND METHOD FOR USE IN A MOBILE/HANDHELD COMMUNICATIONS SYSTEM - An Advanced Television Systems Committee Digital Television (ATSC DTV) transmitter transmits a digital multiplex that includes a legacy DTV channel and a mobile DTV channel. The mobile DTV channel is conveyed in mobile packets that comprise mobile data and additional mobile training information. A mobile packet comprises 207 bytes wherein 2 bytes are header information, 20 bytes are Reed-Solomon (RS) parity information and 185 bytes convey mobile data and mobile training information. The mobile training information is inserted into mobile packets such that the additional training information appears in contiguous positions after convolutional interleaving. | 09-23-2010 |
Patent application number | Description | Published |
20130042290 | METHOD AND APPARATUS FOR TRANSMITTING DATA - An implementation exits a power saving mode for fixed and periodic active periods of time to receive a separate burst transmission from a first stream during each of the corresponding active periods of time. The first stream is received at a first-stream burst data rate. The first stream includes data configured to be displayed at a first playback rate that is substantially less than the first-stream burst data rate. During the active periods of time, data is received from a second stream at a second-stream rate. The second stream includes data configured to be displayed at a second playback rate that is substantially the same as the second-stream rate. After receiving each of the burst transmissions from the first stream during the active periods of time, the power saving mode is entered for corresponding fixed and periodic power-saving periods of time while waiting for another burst from the first stream. | 02-14-2013 |
20130108275 | DIRECTIONAL REMOTE CONTROL | 05-02-2013 |
20140078396 | METHOD AND APPARATUS FOR TRANSMITTING DATA - An implementation exits a power saving mode for fixed and periodic active periods of time to receive a separate burst transmission from a first stream during each of the corresponding active periods of time. The first stream is received at a first-stream burst data rate. The first stream includes data configured to be displayed at a first playback rate that is substantially less than the first-stream burst data rate. During the active periods of time, data is received from a second stream at a second-stream rate. The second stream includes data configured to be displayed at a second playback rate that is substantially the same as the second-stream rate. After receiving each of the burst transmissions from the first stream during the active periods of time, the power saving mode is entered for corresponding fixed and periodic power-saving periods of time while waiting for another burst from the first stream. | 03-20-2014 |
20140189751 | BROADBAND ASSISTED CHANNEL CHANGE - A receiver reduces a time delay associated with a change between two broadcast channels by detecting an activity associated with a channel change operation and requesting, via a broadband interface, data corresponding to the newly requested broadcast channel. The broadband data corresponding to the new broadcast channel is displayed while the broadcast channel is tuned and processed by the receiver. Upon processing the broadcast channel, the displayed broadband data is replaced by the processed broadcast data. | 07-03-2014 |
20150065185 | METHOD AND APPARATUS FOR DETECTING TRANSMITTERS FOR A WHITE SPACE DEVICE - The invention relates to a wireless home gateway apparatus and methods of wirelessly delivering audio and/or video programs between a home gateway and a client and mitigating interference thereon. Specifically, the present invention relates to transmitting an audio/video program on two white space channels and alternately stopping transmission on one of said channels to search for external transmissions on the white space channel. The present invention permits the wireless home gateway to continuously transmit an audio/video program to a client while periodically searching for transmitters on each of the white space channels. | 03-05-2015 |
20150237527 | REDUCING CORE NETWORK TRAFFIC CAUSED BY MIGRANT USERS - A method and apparatus for reducing core network traffic caused by migrant users of a public wireless network are described including receiving a DHCP discover request from a wireless client device, determining if there are enough IP addresses available to assign one of the plurality of IP addresses to the wireless client device, transmitting a DHCP acknowledgement including the assigned IP address and a lease duration to the wireless client device, determining if a lease timeout has occurred, releasing the assigned IP address if the lease timeout has occurred, receiving a first hypertext transfer protocol (HTTP) request or first hypertext transfer protocol secure (HTTPS) request from the wireless client device, transmitting a media access control (MAC) pre-authentication request from the wireless client to an authentication, authorization and accounting (AAA) server, receiving a MAC pre-authentication response from the AAA server and providing access to the Internet via the wireless client device. | 08-20-2015 |
Patent application number | Description | Published |
20100132894 | FLEXIBLE INSULATED DOOR PANELS WITH INTERNAL BAFFLES - An example of a vertically operating door includes a flexible panel comprising two pliable sheets of material with a plurality of pads or mats of thermal insulation between the two sheets. In some examples, a plurality of horizontally elongate baffles made of pliable strips of material are installed between the two sheets. The baffles effectively divide one large interior volume between the sheets into more manageable smaller volumes or chambers. The baffles restrict the air between the sheets from being forced to the bottom of the panel as the panel ascends and bends across an overhead roller. Without the baffles and smaller chambers, the panel sheets in the area near the bottom of the panel would tend to bulge outward as the door opens. | 06-03-2010 |
20130340953 | INSULATED DOOR PANELS - Example insulated pliable door panels or curtains include various internal vapor barriers. The vapor barriers have a relatively high water vapor transmission rate that inhibits water vapor from permeating through the door panel. With such vapor barriers, outer sheets of the door panel can be made of polyurethane or other tough materials that might have an inadequate water vapor transmission rate. In some examples, the vapor barrier encircles or encloses a thermally insulating pad. In some examples, the door panel includes a sleeve or pocket that holds the vapor barrier in place. Some examples include means for draining water that might condense within the door panel. | 12-26-2013 |
20140305600 | SYSTEMS AND METHODS TO RETAIN AND REFEED DOOR CURTAINS - Systems and methods to retain and refeed door curtains are disclosed. An example door is disclosed that includes first and second tracks. The example door includes a retainer borne by the first track and an alignment guide associated with the first track. The example door also includes a curtain extending laterally between the first and second tracks. The curtain has a leading edge selectively movable between a closed position and an open position. The example door includes a primary projection borne by the curtain that is in guiding engagement with the retainer within the first track. The primary projection is dislodged from the track when the curtain is in the breakaway state. The example door includes a secondary projection borne by the curtain and arranged to travel outside of the alignment guide when the leading edge is traveling between the open position and the closed position. | 10-16-2014 |
20140345812 | Systems and Methods to Retain and Refeed Door Curtains - Systems and methods to retain and refeed door curtains are disclosed. An example door is disclosed that includes a track and a curtain that includes a leading section. The curtain is to be in at least one of a breakaway state or a normal state, and in at least one of a folded condition or an unfolded condition while in the breakaway state such that: (a) in the normal state, a lateral section in an area proximate the leading section is in guiding engagement with the track; (b) in the breakaway state while in the folded condition, the lateral section in the area proximate the leading section is dislodged from the track and folded over onto the main section to define an enfolded space; and (c) in the breakaway state while in the unfolded condition, the lateral section in the area proximate the leading section is dislodged from the track but not folded over onto the main section. The example door also includes an unfolder to be in a position to engage the lateral section proximate the enfolded space as the leading section moves toward an open position while the curtain is in the folded condition. | 11-27-2014 |
20160040469 | Methods and Systems to Indicate the Status of Door Operations - Example methods and systems to indicate the status of door operations are disclosed. An example door system includes a door panel having a leading edge to be moved in a travel direction between an open position and a closed position relative to the doorframe. The door panel to block the passageway when the leading edge is at the closed position. The door panel to unblock the passageway when the leading edge is at the open position. The example door system also includes a series of lights distributed along the travel direction proximate the doorframe. The example door system further includes a controller to switch the lights between a first state and a second state to provide a visual effect of movement corresponding to the operating status of the door system. | 02-11-2016 |
20160108666 | Systems and Methods for Aligning Roll-Up Door Curtains - Example systems and methods for aligning roll-up door curtains are disclosed. An example door includes a roller that is rotatable about an axis. The door further includes a curtain having a wrapped section wrapped around the roller and an unwrapped section extending tangentially away from the wrapped section. The unwrapped section adjoins the wrapped section at a first point proximate a first end of the roller and at a second point proximate a second end of the roller. The axis is closer to the second point than to the first point when the curtain is at the intermediate position. In some examples, the door includes a guide member to guide the curtain on to the roller. | 04-21-2016 |
Patent application number | Description | Published |
20090191057 | Multi-Axis Wind Turbine With Power Concentrator Sail - A wind energy to electrical power conversion device provides a protected multiple turbine mechanism axially aligned to convert kinetic energy of air movement, i.e. wind (or other moving fluid such as water), into rotational mechanical power to directly create electrical energy by the reaction of the wind with the turbine. The present wind energy to electrical power conversion device may either be configured as a vertical axis wind turbine (VAWT) or horizontal axis wind turbine (HAWT). An associated wind gathering sail automatically repositions itself to maximize wind intake and to collect and concentrate the wind prior to converting the wind into energy via the axially aligned multi-turbine mechanism into electrical energy. The remaining wind is released via a leeward-facing exhaust. The present axially aligned multi-turbine mechanism avoids interference by birds and other outside objects due to its inherent structural visibility. | 07-30-2009 |
20100131296 | Internet Health Data System - An Internet based health data system for providing patient medical, health, insurance and related data via the Internet, to a plurality of potential users including the patient based on profile and security that complies with all regulations including the HIPAA Act. The system registers and maintains an individual's health data by adding a meta-data wrapper thereto that then determines applicability-to-use cases defined by system logic. A patient profile is also used to recommend and independently search the Internet for appropriate information to benefit the patient and potential stakeholders and caretakers of the patient. Each profile and related data is interactively developed with regard to the individual patient and the other participant users including physicians, insurance institutions, hospitals, laboratories, family genetics, health care facilities, government agencies, etc. and stored in a relational database to be continuously updated through a patient's lifetime. The profiled health material is converted into contemporary, multi-tiered object oriented content utilizing Internet browser technology (i.e. HTML, VRML, HTTP/IIOP, Visual Basic, Active X, XML, RDF, Java-script, etc.) and integrated to the presentation level using object oriented technology and standards (e.g. OODBMS, Java, .jt, SQL, SOAP, CORBA, OLE, COM, etc.). The system is patient centric with a free web interface provided to the individual. Financial support is derived from the other stakeholders that can use this data. The system will constitute a single source of patient data that is secure and immediately accessible over the WWW to the appropriate stakeholders. The data is registered to the system and does not necessarily need to reside in a separate duplicated environment. All this data is converted in real time for standards based viewing across the WWW using standard browser technology. | 05-27-2010 |
20100213778 | Magnetic Motor With Associated Alternator - An electromechanical device or magnetic motor includes a plurality of rotor magnet assemblies, a plurality of drive magnet assemblies that are laterally moveable with respect to the rotor magnet assemblies, a timing assembly for generating power pulses selectively supplied to the drive magnet assemblies, and electromagnetic coils associated with the drive magnet assemblies to receive the power pulses from the timing assembly to momentarily disrupt the magnetic field of such assemblies at selected times. The magnetic assemblies of the rotor mechanically rotate a shaft and interact with alternator windings to generate electrical power. The magnetic motor is self-contained with start/stop, rotational speed, diagnostics, global positioning, CPU and interface capability. | 08-26-2010 |
Patent application number | Description | Published |
20120071418 | Inhibitors of Human EZH2 and Methods of Use Thereof - The invention relates to inhibition of wild-type and certain mutant forms of human histone methyltransferase EZH2, the catalytic subunit of the PRC2 complex which catalyzes the mono- through tri-methylation of lysine 27 on histone H3 (H3-K27). In one embodiment the inhibition is selective for the mutant form of the EZH2, such that trimethylation of H3-K27, which is associated with certain cancers, is inhibited. The methods can be used to treat cancers including follicular lymphoma and diffuse large B-cell lymphoma (DLBCL). Also provided are methods for identifying small molecule selective inhibitors of the mutant forms of EZH2 and also methods for determining responsiveness to an EZH2 inhibitor in a subject. | 03-22-2012 |
20130040906 | Inhibitors of Human EZH2, and Methods of Use Thereof - The invention relates to inhibition of wild-type and certain mutant forms of human histone methyltransferase EZH2, the catalytic subunit of the PRC2 complex which catalyzes the mono- through tri-methylation of lysine 27 on histone H3 (H3-K27). In one embodiment the inhibition is selective for the mutant form of the EZH2, such that trimethylation of H3-K27, which is associated with certain cancers, is inhibited. The methods can be used to treat cancers including follicular lymphoma and diffuse large B-cell lymphoma (DLBCL). Also provided are methods for identifying small molecule selective inhibitors of the mutant forms of EZH2 and also methods for determining responsiveness to an EZH2 inhibitor in a subject. | 02-14-2013 |
20130303555 | Inhibitors of Human EZH2 and Methods of Use Thereof - The invention relates to determining the presence of an EZH2 gene mutation in a sample from a subject and inhibition of wild-type and certain mutant forms of human histone methyltransferase EZH2, the catalytic subunit of the PRC2 complex which catalyzes the mono-through tri-methylation of lysine 27 on histone H3 (H3-K27). In one embodiment the inhibition is selective for the mutant form of the EZH2, such that trimethylation of H3-K27, which is associated with certain cancers, is inhibited. The methods can be used to treat cancers including follicular lymphoma and diffuse large B-cell lymphoma (DLBCL). Also provided are methods for identifying small molecule selective inhibitors of the mutant forms of EZH2 and also methods for determining responsiveness to an EZH2 inhibitor in a subject. | 11-14-2013 |
20140128393 | Methods of Treating Cancer - The present invention relates to methods of treating cancer by administering the EZH2 inhibitor compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes. | 05-08-2014 |
20140142083 | Substituted Benzene Compounds - The present invention relates to substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes. | 05-22-2014 |
20150141362 | Inhibitors of Human EZH2, and Methods of Use Thereof - The invention relates to inhibition of wild-type and certain mutant forms of human histone methyltransferase EZH2, the catalytic subunit of the PRC2 complex which catalyzes the mono- through tri-methylation of lysine 27 on histone H3 (H3-K27). In one embodiment the inhibition is selective for the mutant form of the EZH2, such that trimethylation of H3-K27, which is associated with certain cancers, is inhibited. The methods can be used to treat cancers including follicular lymphoma and diffuse large B-cell lymphoma (DLBCL). Also provided are methods for identifying small molecule selective inhibitors of the mutant forms of EZH2 and also methods for determining responsiveness to an EZH2 inhibitor in a subject. | 05-21-2015 |
Patent application number | Description | Published |
20130123234 | Aryl- or Heteroaryl-Substituted Benzene Compounds - The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes. | 05-16-2013 |
20140275081 | INHIBITORS OF HUMAN EZH2, AND METHODS OF USE THEREOF - The invention relates to inhibition of wild-type and certain mutant forms of human histone methyltransferase EZH2, the catalytic subunit of the PRC2 complex which catalyzes the mono- through tri-methylation of lysine 27 on histone H3 (H3-K27). In one embodiment the inhibition is selective for the mutant form of the EZH2, such that trimethylation of H3-K27, which is associated with certain cancers, is inhibited. The methods can be used to treat cancers including follicular lymphoma and diffuse large B-cell lymphoma (DLBCL). Also provided are methods for identifying small molecule selective inhibitors of the mutant forms of EZH2 and also methods for determining responsiveness to an EZH2 inhibitor in a subject. | 09-18-2014 |
20140288041 | Aryl- or Heteroaryl-Substituted Benzene Compounds - The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes. | 09-25-2014 |
20150051163 | COMBINATION THERAPY FOR TREATING CANCER - The present invention relates to compositions comprising inhibitors of human histone methyltransferase EZH2 and one or more other therapeutic agents, particularly anticancer agents such as prednisone, and methods of combination therapy for administering to subjects in need thereof for the treatment of cancer. | 02-19-2015 |
20150353494 | ARYL- OR HETEROARYL-SUBSTITUTED BENZENE COMPOUNDS - The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes. | 12-10-2015 |
20160022693 | ARYL- OR HETEROARYL-SUBSTITUTED BENZENE COMPOUNDS - The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes. | 01-28-2016 |
Patent application number | Description | Published |
20090131199 | IRON-TYPE GOLF CLUB - A golf club including a club head having a club head main body including a hitting face and a face support, and a support extension. The support extension extends between the face support and a back flange to define a lower cavity. | 05-21-2009 |
20090298612 | GOLF CLUB HEAD AND REMOVABLE WEIGHT - A golf club head and a removable weight that is received in a receptacle of the golf club head. The weight includes a cap and a slug. The cap is removably coupled to the receptacle and includes a recess that receives a portion of the slug so that the cap and slug are able to rotate relative to each other. The slug includes an anti-rotation feature that prevents relative rotation between the slug and the receptacle and a curved abutment surface. | 12-03-2009 |
20100069170 | INTERCHANGEABLE SHAFT SYSTEM - A golf club incorporating an interchangeable shaft system includes a shaft, a shaft sleeve, a club head. The shaft sleeve is coupled to an end of the shaft and is received in a hosel included in the club head. The shaft sleeve is removably coupled to the club head. Hosel and shaft sleeve alignment features provide discreet orientations between the shaft and club head. | 03-18-2010 |
20100304883 | WEDGE TYPE GOLF CLUB HEAD - A wedge type golf club head is disclosed herein where the wedge type golf club head has enhanced performance characteristics such as improved backspin, ball speed, and launch angle. More specifically, the present invention relates to a wedge type golf club head having a lower center of gravity, where the center of gravity is located substantially behind the hitting surface and substantially along a neutral axis behind the point of impact. | 12-02-2010 |
20110143854 | INTERCHANGEABLE SHAFT SYSTEM - A golf club incorporating an interchangeable shaft system includes a shaft, a shaft sleeve, a club head. The shaft sleeve is coupled to an end of the shaft and is received in a hosel included in the club head. The shaft sleeve is removably coupled to the club head. Hosel and shaft sleeve alignment features provide discreet orientations between the shaft and club head. | 06-16-2011 |
20110177876 | INTERCHANGEABLE SHAFT SYSTEM - A golf club incorporating an interchangeable shaft system includes a shaft, a shaft sleeve, a club head. The shaft sleeve is coupled to an end of the shaft and is received in a hosel included in the club head. The shaft sleeve is removably coupled to the club head. Hosel and shaft sleeve alignment features provide discreet orientations between the shaft and club head. | 07-21-2011 |
20120010015 | INTERCHANGEABLE SHAFT SYSTEM - A golf club incorporating an interchangeable shaft system includes a shaft, a shaft sleeve, a club head. The shaft sleeve is coupled to an end of the shaft and is received in a hosel included in the club head. The shaft sleeve is removably coupled to the club head. Hosel and shaft sleeve alignment features provide discreet orientations between the shaft and club head. | 01-12-2012 |
20120202619 | IRON-TYPE GOLF CLUB - A golf club including a club head having a club head main body including a hitting face and a face support, and a support extension. The support extension extends between the face support and a back flange to define a lower cavity. | 08-09-2012 |
20120252602 | WEDGE TYPE GOLF CLUB HEAD - A wedge type golf club head is disclosed herein where the wedge type golf club head has enhanced performance characteristics such as improved backspin, ball speed, and launch angle. More specifically, the present invention relates to a wedge type golf club head having a lower center of gravity, where the center of gravity is located substantially behind the hitting surface and substantially along a neutral axis behind the point of impact. | 10-04-2012 |
20120295732 | INTERCHANGEABLE SHAFT SYSTEM - A golf club incorporating an interchangeable shaft system includes a shaft, a shaft sleeve, a club head. The shaft sleeve is coupled to an end of the shaft and is received in a hosel included in the club head. The shaft sleeve is removably coupled to the club head. Hosel and shaft sleeve alignment features provide discreet orientations between the shaft and club head. | 11-22-2012 |
20120295733 | INTERCHANGEABLE SHAFT SYSTEM - A golf club incorporating an interchangeable shaft system includes a shaft, a shaft sleeve, a club head. The shaft sleeve is coupled to an end of the shaft and is received in a hosel included in the club head. The shaft sleeve is removably coupled to the club head. Hosel and shaft sleeve alignment features provide discreet orientations between the shaft and club head. | 11-22-2012 |