Porreca
Fedele Anthony Porreca, Henderson, NV US
Patent application number | Description | Published |
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20120186093 | SUPERIOR MEASURING SYSTEM ACCURATE INTERIOR MEASURMENTS OF LARGE OR VERY SMALL ENCLOSURES - A superior measuring system comprises three sidewinders and a cobra measure which allows the users to take inside measurement with the assistance for one else. Sidewinders are use to measure distance between 2′ to 23′ and comprise a casing, an upper blade, and a bottom blade. The cobra measure comprises a main body, a single blade and a hood. The sidewinders have three extending blades which extend from the front and the back sides. The both blades can be locked from a locking mechanism so the blades do not move freely. The cobra measure comprises an angle control which control the angle that the single blade so accurate measurements. The single blade in the cobra measure is a curved shaped blade which provides better stability when measurements are taken. | 07-26-2012 |
Frank Porreca, Tucson, AZ US
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20090163451 | METHODS FOR TREATING VISCERAL PAIN - The invention features methods of treating visceral pain in humans by administering an effective amount of a 5HT | 06-25-2009 |
20090239892 | PYRIDOMORPHINANS, PYRIDAZINOMORPHINANS AND USE THEREOF - Compounds represented by the formula: | 09-24-2009 |
20100166660 | METHODS OF MODELING MIGRAINE PAIN AND IDENTIFYING CANDIDATE COMPOUNDS FOR THE TREATMENT OF MIGRAINE - The present invention features animal models of migraine pain that can be used in a variety of ways, e.g., to identify compounds that reduce migraine pain or other migraine symptoms, to investigate behavioral changes correlated with the development and maintenance of a migraine-like state, and to better understand the mechanisms that underlie migraine pain. | 07-01-2010 |
Frank Porreca, Tuscon, AZ US
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20090221495 | TREATMENTS FOR NEUROLOGICAL DISORDERS - Disclosed are methods of improving impaired proprioception, treating brachial plexus injuries, regenerating large and small nerve fibers, treating dorsal root nerve injuries, and improving sensory neural responses in a subject by administration of a neublastin polypeptide. | 09-03-2009 |
Greg Porreca, Cambridge, MA US
Patent application number | Description | Published |
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20130324417 | DETERMINING THE CLINICAL SIGNIFICANCE OF VARIANT SEQUENCES - The present invention generally relates to determining the clinical significance of a variant nucleic acid sequence. The invention can involve sequencing a nucleic acid to generate at least one sequence read, identifying a variant sequence within the sequence read, determining the equivalent insertion/deletion region (EIR) of the variant sequence, identifying a functional region including at least a portion of the EIR, and associating the EIR with the identified functional region, thereby to determine the clinical significance of the variant. | 12-05-2013 |
Gregory Porreca, Ocean City, NJ US
Patent application number | Description | Published |
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20120252686 | METHODS FOR MAINTAINING THE INTEGRITY AND IDENTIFICATION OF A NUCLEIC ACID TEMPLATE IN A MULTIPLEX SEQUENCING REACTION - The invention generally relates to methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction. In certain embodiments, methods of the invention involve obtaining a solution including a template nucleic acid, introducing an identifier nucleic acid to the solution, incorporating the same barcode sequence into the template and the identifier nucleic acids, and sequencing the template and the identifier nucleic acids. | 10-04-2012 |
Gregory Porreca, Cambridge, MA US
Patent application number | Description | Published |
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20120164630 | METHODS FOR MAINTAINING THE INTEGRITY AND IDENTIFICATION OF A NUCLEIC ACID TEMPLATE IN A MULTIPLEX SEQUENCING REACTION - The invention generally relates to methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction. In certain embodiments, methods of the invention involve obtaining a template nucleic acid, incorporating a pair of sequence identifiers into the template, and sequencing the template. | 06-28-2012 |
20120165202 | METHODS AND COMPOSITIONS FOR EVALUATING GENETIC MARKERS - Aspects of the invention relates to methods and compositions that are useful to reduce bias and increase the reproducibility of multiplex analysis of genetic loci. In some configurations, predetermined preparative steps and/or nucleic acid sequence analysis techniques are used in multiplex analyses for a plurality of genetic loci in a plurality of samples. | 06-28-2012 |
20130268206 | SEQUENCE ASSEMBLY - The invention relates to assembly of sequence reads. The invention provides a method for identifying a mutation in a nucleic acid involving sequencing nucleic acid to generate a plurality of sequence reads. Reads are assembled to form a contig, which is aligned to a reference. Individual reads are aligned to the contig. Mutations are identified based on the alignments to the reference and to the contig. | 10-10-2013 |
20130274146 | CAPTURE REACTIONS - The invention generally relates to methods of performing a capture reaction. In certain embodiments, the method involves obtaining a nucleic acid, fragmenting the nucleic acid, and capturing a target sequence on the nucleic acid fragment using a capture moiety, such as a molecular inversion probe. | 10-17-2013 |
20130288901 | ANALYSIS METHODS - The invention generally relates to methods for analyzing nucleic acids to identify novel mutations associated with diseases. In certain embodiments, methods of the invention involve obtaining nucleic acid from a subject having a disease, identifying at least one mutation in the nucleic acid, and comparing the mutation to a database of mutations known to be associated with the disease, wherein mutations that do not match to the database are identified as novel mutations. | 10-31-2013 |
20140127688 | METHODS AND SYSTEMS FOR IDENTIFYING CONTAMINATION IN SAMPLES - Methods and systems for determining if a sample has been contaminated with other genetic material, for example, from another sample in a parallel workflow. The methods and systems compare measured allele fractions to predetermined distributions of allele fractions in order to calculate a likelihood that the sample has been contaminated. | 05-08-2014 |
20140129201 | VALIDATION OF GENETIC TESTS - The invention provides a method for validating a genetic test by introducing a simulated mutation into sequence reads. By editing the information in one or more sequence read files, a set of sequence reads can be manipulated to represent an expected genotype. An analysis of those sequence reads produces an observed genotype and concordance between the expected and observed genotypes validates the analysis. Thus, the invention provides methods for validating new genetic tests. | 05-08-2014 |
20140255931 | SEQUENCE ASSEMBLY - The invention relates to assembly of sequence reads. The invention provides a method for identifying a mutation in a nucleic acid involving sequencing nucleic acid to generate a plurality of sequence reads. Reads are assembled to form a contig, which is aligned to a reference. Individual reads are aligned to the contig. Mutations are identified based on the alignments to the reference and to the contig. | 09-11-2014 |
Gregory J. Porreca, Ocean City, NJ US
Patent application number | Description | Published |
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20080269068 | MULTIPLEX DECODING OF SEQUENCE TAGS IN BARCODES - Methods and compositions for performing multiplex reactions are provided. | 10-30-2008 |
20090018024 | NANOGRID ROLLING CIRCLE DNA SEQUENCING - The present invention relates to methods for sequencing a polynucleotide immobilized on an array having a plurality of specific regions each having a defined diameter size, including synthesizing a concatemer of a polynucleotide by rolling circle amplification, wherein the concatemer has a cross-sectional diameter greater than the diameter of a specific region, immobilizing the concatemer to the specific region to make an immobilized concatemer, and sequencing the immobilized concatemer. | 01-15-2009 |
Gregory J. Porreca, Cambridge, MA US
Patent application number | Description | Published |
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20090318298 | Methods for Sequencing DNA - The invention is directed to methods for using sequence by ligation to sequence DNA immobilized on miniaturized, high density bead-based arrays. Methods are provided to fabricate an array of beads where the beads are coupled directly to a solid support. Methods are also provided to improve signal and reduce background in ligation-mediated DNA sequencing. In addition, methods are provided to improve the accuracy of reported tag counts when performing DNA sequencing by fluorescent nonamer ligation. | 12-24-2009 |
20130337447 | METHODS AND COMPOSITIONS FOR EVALUATING GENETIC MARKERS - Aspects of the invention relates to methods and compositions that are useful to reduce bias and increase the reproducibility of multiplex analysis of genetic loci. In some configurations, predetermined preparative steps and/or nucleic acid sequence analysis techniques are used in multiplex analyses for a plurality of genetic loci in a plurality of samples. | 12-19-2013 |
Matteo Porreca, Parma IT
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20120061197 | CANTILEVER FOR SUPPORTING LIVE CABLES OF RAILWAY, TROLLEY AND SUBWAY LINES - A cross arm for supporting live railway, trolley and subway lines comprising a cross-member ( | 03-15-2012 |
Paul J. Porreca, Marlborough, MA US
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20110267776 | CONDUCTION-COOLED APPARATUS AND METHODS OF FORMING SAID APPARATUS - A circuit card enclosure comprises a backplane including a plurality of connectors. First and second conduction rails are thermally coupled to a heat exchanger, the first and second conduction rails each comprising an inner body at least partially encapsulated by an outer body. The inner body comprises a thermally conductive material. The outer body comprises a structural material. Card slots of the circuit card enclosure are defined between opposed card channels of the first and second conduction rails. Each card slot is constructed and arranged to register an inserted circuit card with at least one of the connectors, the card channels including a thermally conductive region constructed and arranged to thermally interface with a thermal frame of an inserted circuit card, the thermally conductive region of the card channels being thermally coupled to the inner body of the conduction rail. | 11-03-2011 |
Paul Vincent Porreca, Temecula, CA US
Patent application number | Description | Published |
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20120186093 | SUPERIOR MEASURING SYSTEM ACCURATE INTERIOR MEASURMENTS OF LARGE OR VERY SMALL ENCLOSURES - A superior measuring system comprises three sidewinders and a cobra measure which allows the users to take inside measurement with the assistance for one else. Sidewinders are use to measure distance between 2′ to 23′ and comprise a casing, an upper blade, and a bottom blade. The cobra measure comprises a main body, a single blade and a hood. The sidewinders have three extending blades which extend from the front and the back sides. The both blades can be locked from a locking mechanism so the blades do not move freely. The cobra measure comprises an angle control which control the angle that the single blade so accurate measurements. The single blade in the cobra measure is a curved shaped blade which provides better stability when measurements are taken. | 07-26-2012 |
Robert Porreca, Hillsborough, NJ US
Patent application number | Description | Published |
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20130151398 | PORTFOLIO RISK MANAGER - There is provided a method for portfolio risk management. The method includes (a) updating a transaction database with data relating to an operation of an entity, (b) synchronizing a reporting database to the transaction database, where the synchronizing comprises copying the data from the transaction database to the reporting database, (c) receiving a request to prepare a report, (d) obtaining the data from the reporting database, (e) preparing the report from the data obtained from the reporting database, and (f) outputting the report to a user interface. There is also provided a system that performs a method, and a storage device that includes instructions that control a processor to perform the method. | 06-13-2013 |