Patent application number | Description | Published |
20110257167 | IDENTIFICATION OF LKB1 MUTATION AS A PREDICTIVE BIOMARKER FOR SENSITIVITY TO TOR KINASE INHIBITORS - Provided herein are methods for treating and/or preventing a cancer or a tumor syndrome in a patient, comprising administering an effective amount of a TOR kinase inhibitor to a patient having cancer or a tumor syndrome, characterized by a LKB1 and/or AMPK gene or protein loss or mutation. | 10-20-2011 |
20120230983 | METHODS OF TREATING CANCER USING 3-(5-AMINO-2-METHYL-4-OXO-4H-QUINAZOLIN-3-YL)-PIPERIDINE-2,6-DIONE - Provided herein are methods of treating, preventing and/or managing cancers, which comprise administering to a patient 3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof. | 09-13-2012 |
20130102613 | TREATMENT OF CANCER WITH TOR KINASE INHIBITORS - Provided herein are methods for treating or preventing a solid tumor, non-Hodgkin lymphoma or multiple myeloma in a patient, comprising administering an effective amount of a TOR kinase inhibitor to a patient having a solid tumor, non-Hodgkin lymphoma or multiple myeloma. | 04-25-2013 |
20130158023 | IDENTIFICATION OF GENE EXPRESSION AS A PREDICTIVE BIOMARKER FOR LKB1 STATUS - Provided herein are methods for predicting the LKB1 status of a patient or a biological sample, comprising the measurement of particular gene expression levels relative to a set of reference levels that represent the gene expression level of a biological wild-type sample without LKB1 gene or protein loss or mutation and the gene expression level of a reference sample with LKB1 gene or protein loss or mutation. Further provided herein are methods for treating and/or preventing a cancer or a tumor syndrome in a patient, comprising administering an effective amount of a TOR kinase inhibitor to a patient having cancer or a tumor syndrome, characterized by particular gene expression levels. | 06-20-2013 |
20140045844 | TREATMENT OF IMMUNE-RELATED AND INFLAMMATORY DISEASES - Provided herein are methods of using compounds and compositions for modulating leukocytic activity, including activity of B cells and/or T cells monocytes, macrophages, and other lymphoid or myeloid-derived cell types, in immune-related diseases or inflammatory diseases. Pharmaceutical compositions and dosing regimens for use in the methods are also provided herein. | 02-13-2014 |
20140162282 | METHODS FOR DETERMINING DRUG EFFICACY USING CEREBLON-ASSOCIATED PROTEINS - Use of cereblon-associated proteins as biomarkers for clinical sensitivity to cancer, inflammatory diseases, and patient response to drug treatment. | 06-12-2014 |
20140314751 | METHODS FOR TREATING CANCER USING TOR KINASE INHIBITOR COMBINATION THERAPY - Provided herein are methods for treating or preventing a cancer, comprising administering an effective amount of a TOR kinase inhibitor and an effective amount of N-(3-(5-fluoro-2-(4-(2-methoxyethoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide to a patient having a cancer. | 10-23-2014 |
20140314752 | METHODS FOR TREATING CANCER USING TOR KINASE INHIBITOR COMBINATION THERAPY - Provided herein are methods for treating or preventing a cancer, comprising administering an effective amount of a TOR kinase inhibitor and an effective amount of an IMiD® immunomodulatory drug to a patient having a cancer. | 10-23-2014 |
20140314753 | METHODS FOR TREATING CANCER USING TOR KINASE INHIBITOR COMBINATION THERAPY - Provided herein are methods for treating or preventing a cancer, comprising administering an effective amount of a TOR kinase inhibitor and an effective amount of a 5-Substituted Quinazolinone Compound to a patient having a cancer. | 10-23-2014 |
20140328832 | METHODS FOR TREATING CANCER USING COMBINATION THERAPY - Provided herein are methods for treating or preventing a cancer, comprising administering an effective amount of a substituted quinazolinone compound and an effective amount of N-(3-(5-fluoro-2-(4-(2-methoxyethoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide to a patient having a cancer. | 11-06-2014 |
20150038511 | TREATMENT OF IMMUNE-RELATED AND INFLAMMATORY DISEASES - Provided herein are methods of using compounds and compositions for modulating leukocytic activity, including activity of B cells and/or T cells monocytes, macrophages, and other lymphoid or myeloid-derived cell types, in immune-related diseases or inflammatory diseases. Pharmaceutical compositions and dosing regimens for use in the methods are also provided herein. | 02-05-2015 |
Patent application number | Description | Published |
20080213730 | TOOTH WHITENING DENTAL TRAY AND METHOD OF USE - A dental tray with a hydrophobic tooth whitening formulation where the tooth whitening formulation is substantially non-water soluble, and a method of using this dental tray to whiten the teeth. The tooth whitening formulation is primarily comprised of a hydrophobic polymer and a peroxide or a peroxide yielding compound. Preferably the hydrophobic polymer is the condensation product of a silicone resin and an organosiloxane. The dental tray is formed to encompass the front and the rear surfaces of the teeth. The dental tray is comprised of a thermoplastic or thermoset polymer. The teeth whitening formulation is placed into the dental tray and the tray placed against the teeth to be whitened. This is for a sufficient period of time to at least partially whiten teeth. This can be a period of time from about 0.5 hour to 2 hours or more. The substantially non-aqueous tooth whitening formulation is effective over a longer period of time since it is not significantly diluted or removed from the dental tray during the treatment time. | 09-04-2008 |
20080233058 | ORAL CARE COMPOSITIONS WITH FILM FORMING POLYMERS - Oral care compositions comprising:
| 09-25-2008 |
20120058059 | SINGLE PHASE WHITENING DENTIFRICE - The invention provides a single phase whitening dentifrice that includes (i) a whitening agent selected from the group consisting of hydrogen peroxide, a bound peroxide and a solid peroxide (ii) an abrasive and (iii) a substantially anhydrous orally acceptable carrier, for example, polyethylene glycol. The bound peroxide may be hydrogen peroxide and a polymer and/or any peroxide compound and a porous cross-linked polymer, such as polymers of polyvinyl pyrrolidone, polyacrylates, a polymethacrylates, and a polyitaconates. The solid peroxide may be sodium perborate or urea peroxide. The invention also provides methods of whitening the tooth surfaces by contacting the surface with the composition. | 03-08-2012 |
20130259811 | Tooth Whitening Dental Tray and Method of Use - A dental tray with a hydrophobic tooth whitening formulation where the tooth whitening formulation is substantially non-water soluble, and a method of using this dental tray to whiten the teeth. The tooth whitening formulation is primarily comprised of a hydrophobic polymer and a peroxide or a peroxide yielding compound. Preferably the hydrophobic polymer is the condensation product of a silicone resin and an organosiloxane. The dental tray is formed to encompass the front and the rear surfaces of the teeth. The dental tray is comprised of a thermoplastic or thermoset polymer. The teeth whitening formulation is placed into the dental tray and the tray placed against the teeth to be whitened. This is for a sufficient period of time to at least partially whiten teeth. This can be a period of time from about 0.5 hour to 2 hours or more. The substantially non-aqueous tooth whitening formulation is effective over a longer period of time since it is not significantly diluted or removed from the dental tray during the treatment time. | 10-03-2013 |
Patent application number | Description | Published |
20080267891 | Oral Care Composition To Reduce Or Eliminate Dental Sensitivity - The invention includes an oral care composition that reduces and/or eliminates the perception of tooth sensitivity. The composition includes an adherent material and particles having an average particle size of about 8 microns or less. The particles are present in the composition in an amount of about 5% by weight. Also included within the scope of the invention are related methods, such as methods of occluding a dentin tubule. | 10-30-2008 |
20080268001 | ORAL CARE COMPOSITION TO REDUCE OR ELIMINATE DENTAL SENSITIVITY - The invention includes an oral care composition that reduces and/or eliminates the perception of tooth sensitivity. The composition includes an adherent material and silica particles having an average particle size of about 8 microns or less. The silica particles are present in the composition in an amount of about 5% by weight. Also included within the scope of the invention are related methods, such as methods of occluding a dentin tubule. | 10-30-2008 |
20090092562 | Oral Care Composition To Reduce Or Eliminate Dental Sensitivity - The invention includes an oral care composition that reduces and/or eliminates the perception of tooth sensitivity. The composition includes an adherent material and particles having an average particle size of about 8 microns or less. The particles are present in the composition in an amount of about 5% by weight. Also included within the scope of the invention are related methods, such as methods of occluding a dentin tubule. | 04-09-2009 |
20090186090 | Oral Care Composition to Reduce or Eliminate Dental Sensitivity - The invention includes an oral care composition that reduces and/or eliminates the perception of tooth sensitivity. The composition includes an adherent material and includes, in part, particles having a particle size of 2-5 microns. Also included within the scope of the invention are methods comprising the use of such compositions, such as methods of reducing dental sensitivity. | 07-23-2009 |
20120020898 | NON-AQUEOUS DENTIFRICE COMPOSITION WITH BIOACCEPTABLE AND BIOACTIVE GLASS AND METHODS OF USE AND MANUFACTURE THEREOF - The invention encompasses non-aqueous dentifrice compositions containing a bioacceptable and bioactive glass with improved mouth-feel, foam, and product stability. More particularly, the invention encompasses non-aqueous compositions including combinations including carrageenan and/or carboxymethylcellulose gums, glycerin, ethylene oxide/propylene oxide copolymers, and a bioactive glass and methods of use the compositions in an oral care product, for example, a whitening tooth-paste, for hypersensitive teeth. | 01-26-2012 |
20120020899 | ORAL COMPOSITIONS FOR TREATING TOOTH SENSITIVITY AND METHODS OF USE AND MANUFACTURE THEREOF - The invention encompasses oral care compositions comprising one or more active component and one or more adhesive polymers, which cause the active component to adhere to the tooth surface. In certain embodiments the active agent is an occlusion agent. The invention also encompasses methods of treating the teeth or a teeth surface with an active agent. In certain embodiments, the invention encompasses treating the teeth with an occlusion agent to prevent or alleviate tooth sensitivity. | 01-26-2012 |
20120021031 | DUAL ACTION DENTIFRICE COMPOSITIONS TO PREVENT HYPERSENSITIVITY AND PROMOTE REMINERALIZATION - The invention encompasses combinations of bioactive glass composition and potassium salts that are useful in conjunction with delivery agent such as, for example, toothpastes, mouthwashes, and oral gels. In certain embodiments, the compositions of the invention form a rapid and continuous reaction with body fluids (e.g., saliva) to promote the immediate and long-tem release of Ca and P ions to produce a stable crystalline layer deposited onto and into the dentin tubules for the immediate and long term reduction of dentin hypersensitivity and tooth surface remineralization. | 01-26-2012 |
20120244091 | NON-AQUEOUS, SINGLE TUBE DENTRIFICE WHITENING COMPOSITIONS, METHODS OF USE AND MANUFACTURE THEREOF - This invention relates to oral care composition, methods of use and methods of manufacture thereof including a single-tube, non-aqueous dentifrice whitening composition containing at least an enzyme and a substrate. | 09-27-2012 |
20140335028 | HYDROPHOBIC TOOTH WHITENING SYSTEM AND METHODS OF USE - A tooth whitening system comprising a dental tray having a surface operable to confront a tooth surface, and a tooth whitening composition comprising a whitening agent and a hydrophobic polymer carrier. The tooth whitening composition is preferably substantially non-water soluble. A tooth whitening kit is also provided using a dental tray and the tooth whitening composition comprising a whitening composition and a hydrophobic polymer carrier. | 11-13-2014 |
Patent application number | Description | Published |
20110314623 | ORAL CARE SYSTEM, KIT AND METHOD - An oral care system and method for applying a fluid to an oral surface, including a method of manufacturing the same. In one embodiment, the invention can be an oral care system comprising: a toothbrush; and a dispenser detachably coupled to the toothbrush, the dispenser comprising: an internal reservoir containing a fluid; and a conduit in fluid communication with the reservoir and terminating in an orifice for dispensing the fluid; and a plug having a proximal plug portion disposed within the conduit and a distal plug portion disposed within a socket of the toothbrush. | 12-29-2011 |
20130251772 | Dentifrice Compositions Containing Calcium Silicate - An oral care composition includes an effective amount of calcium silicate particles. The calcium silicate particles have an average diameter of less than about 5 microns, such that they can occlude dentinal tubules of the teeth. An oral care method includes applying the composition to an oral cavity of a subject to reduce or inhibit hypersensitivity of the teeth and to achieve other benefits. | 09-26-2013 |
20130263395 | Non-Aqueous Oral Care Composition Containing Dental Occlusion Actives - A oral care composition includes: (a) a hydrophilic film-forming polymer; and (b) a hydrophobic carrier, wherein the hydrophilic film-forming polymer is a film-forming polymer effective to occlude dentinal tubules and the oral care composition contains 0-10 wt. % water. The hydrophilic film-forming polymer is preferably GANTREZ S. The hydrophobic carrier is preferably a vegetable oil. A method of cleaning teeth includes applying to the teeth the oral care composition such that the hydrophilic film-forming polymer occludes dentinal tubules. A toothbrush includes: a handle; a head mounted to the handle, the head comprising an outer surface and a plurality of tooth cleaning elements extending outwardly from the outer surface; and a gelatin capsule containing the oral care composition positioned on the head. | 10-10-2013 |
20130269132 | Gelatin Encapsulated Oral Care Composition Containing Dental Occlusion Actives, Hydrophobic Viscosity Modifier and Oil Carrier - A oral care composition includes: (a) a guanidine active; (b) a film-forming polymer; (c) a hydrophobic viscosity modifier in an amount sufficient to provide the oral care composition with a particle settling time greater than 20 minutes; and (d) an oil carrier. The guanidine active is preferably L-arginine. The film-forming polymer is preferably GANTREZ. The hydrophobic viscosity modifier is preferably a gelled mineral oil. The oil carrier is preferably a vegetable oil. A method of cleaning teeth includes applying to the teeth the oral care composition such that the oral care composition cleans the teeth. A oral care implement includes: a handle; a head mounted to the handle, the head having an outer surface and a plurality of tooth cleaning elements extending outwardly from the outer surface; and a gelatin capsule containing the oral care composition positioned on the head. | 10-17-2013 |
20130269133 | Gelatin Encapsulated Oral Care Composition Containing Hydrophilic Active, Hydrophobic Structuring Agent and Oil Carrier - An encapsulated oral care composition includes: (a) a gelatin capsule; and (b) a oral care composition contained within the capsule, and including: (i) a hydrophilic active; (ii) a hydrophobic structuring agent; and (iii) an oil carrier. The hydrophilic active is preferably cetylpyridinium chloride. The hydrophobic structuring agent is preferably a gelled mineral oil. The oil carrier is preferably a vegetable oil. A method of cleaning teeth includes applying to the teeth the encapsulated oral care composition such that the capsule releases the oral care composition to clean the teeth. A oral care implement includes: a handle; a head mounted to the handle, the head having an outer surface and a plurality of tooth cleaning elements extending outwardly from the outer surface; and the encapsulated oral care composition positioned on the head. | 10-17-2013 |
Patent application number | Description | Published |
20120143802 | Adaptive Pairwise Preferences in Recommenders - Methods, systems, and products adapt recommender systems with pairwise feedback. A pairwise question is posed to a user. A response is received that selects a preference for a pair of items in the pairwise question. A latent factor model is adapted to incorporate the response, and an item is recommended to the user based on the response. | 06-07-2012 |
20120150531 | SYSTEM AND METHOD FOR LEARNING LATENT REPRESENTATIONS FOR NATURAL LANGUAGE TASKS - Disclosed herein are systems, methods, and non-transitory computer-readable storage media for learning latent representations for natural language tasks. A system configured to practice the method analyzes, for a first natural language processing task, a first natural language corpus to generate a latent representation for words in the first corpus. Then the system analyzes, for a second natural language processing task, a second natural language corpus having a target word, and predicts a label for the target word based on the latent representation. In one variation, the target word is one or more word such as a rare word and/or a word not encountered in the first natural language corpus. The system can optionally assigning the label to the target word. The system can operate according to a connectionist model that includes a learnable linear mapping that maps each word in the first corpus to a low dimensional latent space. | 06-14-2012 |
20120150532 | SYSTEM AND METHOD FOR FEATURE-RICH CONTINUOUS SPACE LANGUAGE MODELS - Disclosed herein are systems, methods, and non-transitory computer-readable storage media for predicting probabilities of words for a language model. An exemplary system configured to practice the method receives a sequence of words and external data associated with the sequence of words and maps the sequence of words to an X-dimensional vector, corresponding to a vocabulary size. Then the system processes each X-dimensional vector, based on the external data, to generate respective Y-dimensional vectors, wherein each Y-dimensional vector represents a dense continuous space, and outputs at least one next word predicted to follow the sequence of words based on the respective Y-dimensional vectors. The X-dimensional vector, which is a binary sparse representation, can be higher dimensional than the Y-dimensional vector, which is a dense continuous space. The external data can include part-of-speech tags, topic information, word similarity, word relationships, a particular topic, and succeeding parts of speech in a given history. | 06-14-2012 |
20120281885 | SYSTEM AND METHOD FOR DYNAMIC FACIAL FEATURES FOR SPEAKER RECOGNITION - Disclosed herein are systems, methods, and non-transitory computer-readable storage media for performing speaker verification. A system configured to practice the method receives a request to verify a speaker, generates a text challenge that is unique to the request, and, in response to the request, prompts the speaker to utter the text challenge. Then the system records a dynamic image feature of the speaker as the speaker utters the text challenge, and performs speaker verification based on the dynamic image feature and the text challenge. Recording the dynamic image feature of the speaker can include recording video of the speaker while speaking the text challenge. The dynamic feature can include a movement pattern of head, lips, mouth, eyes, and/or eyebrows of the speaker. The dynamic image feature can relate to phonetic content of the speaker speaking the challenge, speech prosody, and the speaker's facial expression responding to content of the challenge. | 11-08-2012 |
20130103402 | SYSTEM AND METHOD FOR COMBINING FRAME AND SEGMENT LEVEL PROCESSING, VIA TEMPORAL POOLING, FOR PHONETIC CLASSIFICATION - Disclosed herein are systems, methods, and non-transitory computer-readable storage media for combining frame and segment level processing, via temporal pooling, for phonetic classification. A frame processor unit receives an input and extracts the time-dependent features from the input. A plurality of pooling interface units generates a plurality of feature vectors based on pooling the time-dependent features and selecting a plurality of time-dependent features according to a plurality of selection strategies. Next, a plurality of segmental classification units generates scores for the feature vectors. Each segmental classification unit (SCU) can be dedicated to a specific pooling interface unit (PIU) to form a PIU-SCU combination. Multiple PIU-SCU combinations can be further combined to form an ensemble of combinations, and the ensemble can be diversified by varying the pooling operations used by the PIU-SCU combinations. Based on the scores, the plurality of segmental classification units selects a class label and returns a result. | 04-25-2013 |
20140040176 | Adaptive Pairwise Preferences in Recommenders - Methods, systems, and products adapt recommender systems with pairwise feedback. A pairwise question is posed to a user. A response is received that selects a preference for a pair of items in the pairwise question. A latent factor model is adapted to incorporate the response, and an item is recommended to the user based on the response. | 02-06-2014 |
20140109123 | METHOD AND APPARATUS FOR MANAGING ADVERTISING - A system that incorporates teachings of the subject disclosure may include, for example, determining identified impressions that are detected from consumption data collected from a group of media processors where the identified impressions represent viewing of selected content and where the consumption data indicates channel tuning events at the group of media processors including changing of channels, applying a ridge regression analysis to the identified impressions to determine a predicted number of target impressions per advertisement slot, and generating a media plan based on a ratio of an advertisement slot cost to the predicted number of target impressions per advertisement slot. Other embodiments are disclosed. | 04-17-2014 |
20150081302 | SYSTEM AND METHOD FOR DYNAMIC FACIAL FEATURES FOR SPEAKER RECOGNITION - Disclosed herein are systems, methods, and non-transitory computer-readable storage media for performing speaker verification. A system configured to practice the method receives a request to verify a speaker, generates a text challenge that is unique to the request, and, in response to the request, prompts the speaker to utter the text challenge. Then the system records a dynamic image feature of the speaker as the speaker utters the text challenge, and performs speaker verification based on the dynamic image feature and the text challenge. Recording the dynamic image feature of the speaker can include recording video of the speaker while speaking the text challenge. The dynamic feature can include a movement pattern of head, lips, mouth, eyes, and/or eyebrows of the speaker. The dynamic image feature can relate to phonetic content of the speaker speaking the challenge, speech prosody, and the speaker's facial expression responding to content of the challenge. | 03-19-2015 |